UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

       Date of Report (Date of earliest event reported): October 25, 2006

                          Medefile International, Inc.
             (Exact name of registrant as specified in its charter)



        Nevada                     033-25126 D                85-0368333
(State or Other Jurisdiction    (Commission File           (I.R.S. Employer
       of Incorporation)            Number)              Identification Number)

                          2 Ridgedale Avenue, Suite 217
                             Cedar Knolls, NJ 07927
               (Address of principal executive offices) (zip code)

                                 (973) 993-8001
              (Registrant's telephone number, including area code)

                                   Copies to:
                            Richard A. Friedman, Esq.
                       Sichenzia Ross Friedman Ference LLP
                           1065 Avenue of the Americas
                            New York, New York 10018
                              Phone: (212) 930-9700
                               Fax: (212) 930-9725

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)
[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))
[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))


Item 5.02 Election of Directors

Effective  August 25,  2006,  William R.  Cullen was  appointed  to the Board of
Directors  of  Medefile  International,  Inc.  (the  "Company").  There  are  no
understandings or arrangements  between Mr. Cullen and any other person pursuant
to which Mr.  Cullen was  selected as a director.  Mr.  Cullen will serve as the
Chairman  of  the  Audit  Committee,  and  co-Chairman  of  the  Nominating  and
Governance Committees,  of the Board of Directors.  Mr. Cullen does not have any
family relationship with any director,  executive officer or person nominated or
chosen by the Company to become an officer or director.

On November 3, 2006,  John R. Bason was  appointed  to the Board of Directors of
the Company.  There are no understandings or arrangements  between Mr. Bason and
any other person  pursuant to which Mr.  Bason was  selected as a director.  Mr.
Bason does not have any family relationship with any director, executive officer
or person nominated or chosen by the Company to become an officer or director.

From  1998  through  2004,  Mr.  Cullen  served  in  various  executive  officer
capacities  for  Webb  Interactive  Services,   Inc.,  (OTCBB:  WEBB)  including
Chairman,  President,  Chief Executive Officer and Chief Financial Officer. From
2004 to the present,  Mr. Cullen has been active as Founder and President of two
private companies: Sports Fans, Incorporated and Book Network, Inc. In addition,
Mr.   Cullen   consults   primarily  in  the  area  of  capital   formation  and
restructuring.

From 2002  through  2003,  Mr.  Bason  served as the  Chief  Executive  Officer,
President  and a Director  of Novatrix  Medical  Corporation,  a medical  device
company  focused in  obstetrics.  From 2002 through 2003, Mr. Bason served as an
executive  vice  president  of  CardioNet,  Inc.,  a provider of mobile  cardiac
outpatient telemetry. From 2003 through 2006, Mr. Bason served as the President,
Chief Executive Officer and a Director of Navitas Cancer Rehabilitation  Centers
of America, Inc.



                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                      Medefile International, Inc.


Dated: November 9, 2006                By: /s/ Milton Hauser
                                       ---------------------
                                       Name: Milton Hauser
                                       Title: President, Chief Executive Officer