UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

       Date of Report (Date of earliest event reported): February 27, 2007

                          Medefile International, Inc.
             (Exact name of registrant as specified in its charter)



         Nevada                   033-25126                    85-0368333
(State or Other Jurisdiction   (Commission File             (I.R.S. Employer
       of Incorporation)            Number)              Identification Number)

                          2 Ridgedale Avenue, Suite 217
                             Cedar Knolls, NJ 07927
               (Address of principal executive offices) (zip code)

                                 (973) 993-8001
              (Registrant's telephone number, including area code)

                                   Copies to:
                            Richard A. Friedman, Esq.
                       Sichenzia Ross Friedman Ference LLP
                           1065 Avenue of the Americas
                            New York, New York 10018
                              Phone: (212) 930-9700
                               Fax: (212) 930-9725

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)
[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))
[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))



Item 8.01 Other Events

On February 27, 2007, Medefile International, Inc. ("Medefile" or the "Company")
issued a press release regarding an agreement with HSA Bank, a copy of which is
filed herewith.

In accordance with General  Instruction B.2 of Form 8-K, the information in this
Current Report on Form 8-K,  including  Exhibit 99.1,  shall not be deemed to be
"filed" for purposes of Section 18 of the  Securities  Exchange Act of 1934,  as
amended (the  "Exchange  Act"),  or otherwise  subject to the  liability of that
section,  and shall  not be  incorporated  by  reference  into any  registration
statement or other document  filed under the Act or the Exchange Act,  except as
shall be expressly set forth by specific reference in such filing.

Item 9.01 Exhibits

99.1     Press Release


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                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                   Medefile International, Inc.


Dated: February 27, 2007           By: /s/ Milton Hauser
                                       -----------------
                                       Name: Milton Hauser
                                       Title: President, Chief Executive Officer



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