Exhibit 32.1 CERTIFICATION OF PERIODIC REPORT Pursuant to 18 U.S.C. ss. 1350 Pursuant to, and for purposes only of, 18 U.S.C. ss. 1350, each of the undersigned hereby certifies that (i) the Quarterly Report of Shore Bancshares, Inc. on Form 10-Q for the quarter ended September 30, 2004 filed with the Securities and Exchange Commission (the "Report") fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and (ii) information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Shore Bancshares, Inc. Date: November 9, 2004 /s/ W. Moorhead Vermilye ------------------------------------ W. Moorhead Vermilye President/Chief Executive Officer Date November 9, 2004 /s/ Susan E. Leaverton ------------------------------------ Susan E. Leaverton Treasurer/Principal Accounting Officer