WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

            ---------------------------------------------------------



               This  Warrant  has not been  registered  under the
               Securities  Act of 1933,  as amended  (the "Act"),
               because  the  issuance  thereof is  believed to be
               exempt from registration under various regulations
               promulgated under such Act.

     This certifies that, for value received, RBB Bank AG, or registered assigns
("Warrantholder"),  is entitled to purchase from ADVANCED  VIRAL  RESEARCH CORP.
(the "Company"), subject to the provisions of this Warrant, at any time and from
time to time until 5:00 p.m. Eastern  Standard Time on August 30, 2007,  600,000
shares of the  Company's  Common Stock,  par value  $.00001 per share  ("Warrant
Shares").  The purchase price payable upon the exercise of this Warrant shall be
$0.20 per  Warrant  Share.  The Warrant  Price and the number of Warrant  Shares
which the  Warrantholder  is entitled to purchase is subject to adjustment  upon
the occurrence of the contingencies set forth in Section 3 of this Warrant,  and
as adjusted from time to time, such purchase price is hereinafter referred to as
the "Warrant Price."

     This Warrant is subject to the following terms and conditions:







     1.   Exercise of Warrant.

     (a)  This  Warrant  may be  exercised  in  whole  or in part  but not for a
fractional share. Upon delivery of this Warrant at the offices of the Company or
at such other  address as the Company may  designate by notice in writing to the
registered  holder  hereof  with  the  Subscription  Form  annexed  hereto  duly
executed,  accompanied by payment of the Warrant Price for the number of Warrant
Shares purchased (in cash, by certified,  cashier's or other check acceptable to
the  Company,  by  Common  Stock  of the  Company  having  a  Market  Value  (as
hereinafter defined) equal to the aggregate Warrant Price for the Warrant Shares
to be purchased, or any combination of the foregoing),  the registered holder of
this Warrant shall be entitled to receive a certificate or certificates  for the
Warrant Shares so purchased.  Such certificate or certificates shall be promptly
delivered to the Warrantholder.  Upon any partial exercise of this Warrant,  the
Company shall execute and deliver a new Warrant of like tenor for the balance of
the Warrant Shares purchasable hereunder.

     (b) In lieu of exercising this Warrant pursuant to Section 1(a), the holder
may elect to receive  shares of Common  Stock equal to the value of this Warrant
determined  in the manner  described  below (or any  portion  thereof  remaining
unexercised)  upon  delivery of this Warrant at the offices of the Company or at
such other  address as the  Company  may  designate  by notice in writing to the
registered  holder  hereof with the Notice of  Cashless  Exercise  Form  annexed
hereto  duly  executed.  In such event the  Company  shall issue to the holder a
number of shares of the  Company's  Common Stock  computed  using the  following
formula:


                                        2




                                   X = Y (A-B)
                                       -------
                                       A

Where X = the number of shares of Common Stock to be issued to the holder.

          Y  =    the number of shares of Common Stock  purchasable under this
                  Warrant (at the date of such calculation).

          A  =    the  Market  Value  of the  Company's  Common  Stock  on the
                  business day immediately preceding the day on which the Notice
                  of Cashless Exercise is received by the Company.

          B  =    Warrant Price (as adjusted to the date of such calculation).

     (c) The Warrant Shares deliverable hereunder shall, upon issuance, be fully
paid and non-assessable and the Company agrees that at all times during the term
of this Warrant it shall cause to be reserved for issuance such number of shares
of its Common Stock as shall be required for issuance and delivery upon exercise
of this Warrant.

     (d) For  purposes of this  Warrant,  the Market  Value of a share of Common
Stock on any date  shall be equal to (i) the  closing  sale  price  per share as
published by a national  securities exchange on which shares of Common Stock (or
other  units of the  security)  are traded (an  "Exchange")  on such date or, if
there is no sale of Common Stock on such date,  the average of the bid and asked
prices on such exchange at the close of trading on such date


                                        3





or,  (ii) if shares of Common  Stock  are not  listed on a  national  securities
exchange on such date,  the closing price per share as published on the National
Association of Securities Dealers Automatic Quotation System ("NASDAQ") National
Market System if the shares are quoted on such system on such date, or (iii) the
average of the bid and asked prices in the over-the-counter  market at the close
of trading on such date if the shares are not traded on an exchange or listed on
the NASDAQ National Market System,  or (iv) if the Common Stock is not traded on
a national  securities  exchange  or in the  over-the-counter  market,  the fair
market value of a share of Common Stock on such date as determined in good faith
by the Board of Directors. If the holder disagrees with the determination of the
Market  Value  of any  securities  of the  Company  determined  by the  Board of
Directors under Section  1(d)(iv) the Market Value of such  securities  shall be
determined by an independent  appraiser acceptable to the Company and the holder
(or, if they cannot  agree on such an  appraiser,  by an  independent  appraiser
selected by each of them, and Market Value shall be the median of the appraisals
made by such appraisers).  If there is one appraiser,  the cost of the appraisal
shall be shared  equally  between the  Company and the holder.  If there are two
appraisers, each of the Company and the holder shall pay for its own appraisal.

     2.   Transfer or Assignment of Warrant.

     (a) Any  assignment  or transfer of this Warrant shall be made by surrender
of this  Warrant at the offices of the  Company or at such other  address as the
Company  may  designate  in writing to the  registered  holder  hereof  with the
Assignment  Form annexed hereto duly executed and  accompanied by payment of any
requisite  transfer taxes,  and the Company shall,  without charge,  execute and
deliver a new Warrant of like tenor in the name of


                                        4





the assignee  for the portion so assigned in case of only a partial  assignment,
with a new Warrant of like tenor to the  assignor for the balance of the Warrant
Shares purchasable.

                           (b)      Prior to any assignment or transfer of this 
Warrant,  the holder  thereof shall deliver an opinion of counsel to the Company
to the effect that the proposed  transfer may be effected  without  registration
under the Act.


     3.   Adjustment  of  Warrant  Price and  Warrant  Shares  --  Anti-Dilution
          Provisions.

     A. (1) Except as  hereinafter  provided,  in case the Company  shall at any
time after the date hereof  issue any shares of Common Stock  (including  shares
held in the Company's  treasury)  without  consideration,  then,  and thereafter
successively upon each issuance,  the Warrant Price in effect  immediately prior
to each such  issuance  shall  forthwith  be  reduced to a price  determined  by
multiplying the Warrant Price in effect  immediately prior to such issuance by a
fraction:

          (a) the  numerator  of which  shall be the  total  number of shares of
     Common Stock outstanding immediately prior to such issuance, and


                                        5





          (b) the  denominator  of which shall be the total  number of shares of
     Common Stock outstanding immediately after such issuance.

                  For the purposes of any  computation  to be made in accordance
with the  provisions  of this  clause (1),  the  following  provisions  shall be
applicable:

               (i) Shares of Common  Stock  issuable by way of dividend or other
          distribution  on any stock of the Company shall be deemed to have been
          issued and to be  outstanding  at the close of  business on the record
          date fixed for the  determination of stockholders  entitled to receive
          such dividend or other  distribution  and shall be deemed to have been
          issued without consideration.  Shares of Common Stock issued otherwise
          than as a  dividend,  shall be deemed to have  been  issued  and to be
          outstanding at the close of business on the date of issue.

               (ii) The number of shares of Common Stock at any time outstanding
          shall not include any shares


                                        6





          then owned or held by or for the account of the Company.

          (2) In case the  Company  shall at any time  subdivide  or combine the
     outstanding  shares of Common Stock,  the Warrant Price shall  forthwith be
     proportionately decreased in the case of the subdivision or proportionately
     increased  in the case of  combination  to the nearest  one cent.  Any such
     adjustment shall become effective at the close of business on the date that
     such subdivision or combination shall become effective.

     B. In the event that the number of  outstanding  shares of Common  Stock is
increased  by a stock  dividend  payable  in  shares  of  Common  Stock  or by a
subdivision of the outstanding shares of Common Stock, which may include a stock
split,  then from and after the time at which the adjusted Warrant Price becomes
effective  pursuant to the  foregoing  Subsection A of this Section by reason of
such dividend or subdivision, the number of shares issuable upon the exercise of
this Warrant shall be increased in  proportion  to such increase in  outstanding
shares.  In the event that the number of  outstanding  shares of Common Stock is
decreased by a combination of the outstanding shares of Common Stock, then, from
and  after  the time at which  the  adjusted  Warrant  Price  becomes  effective
pursuant to such Subsection A of this Section by reason of such


                                        7




combination,  the number of shares  issuable  upon the  exercise of this Warrant
shall be decreased in proportion to such decrease in outstanding shares.

     C. In the event of an adjustment of the Warrant Price, the number of shares
of Common Stock (or  reclassified  stock) issuable upon exercise of this Warrant
after such adjustment shall be equal to the number determined by dividing:

          (1) an  amount  equal to the  product  of (i) the  number of shares of
     Common Stock  issuable upon exercise of this Warrant  immediately  prior to
     such  adjustment,  and (ii) the  Warrant  Price  immediately  prior to such
     adjustment, by

          (2) the Warrant Price immediately after such adjustment.

     D. In the case of any reorganization or reclassification of the outstanding
shares of Common Stock  (other than a change in par value,  or from par value to
no par value, or from no par value to par value, or as a result of a subdivision
or  combination)  or in the case of any  consolidation  of the Company  with, or
merger of the Company  with,  another  corporation,  or in the case of any sale,
lease or  conveyance  of all, or  substantially  all, of the  property,  assets,
business  and  goodwill of the Company as an entity,  the holder of this Warrant
shall thereafter have the right upon exercise to purchase the kind and amount of


                                        8





shares  of  stock  and  other  securities  and  property  receivable  upon  such
reorganization,  reclassification,  consolidation, merger or sale by a holder of
the number of shares of Common Stock which the holder of this Warrant would have
received  had all Warrant  Shares  issuable  upon  exercise of this Warrant been
issued   immediately   prior   to   such    reorganization,    reclassification,
consolidation,  merger or sale,  at a price equal to the  Warrant  Price then in
effect  pertaining to this Warrant (the kind, amount and price of such stock and
other securities to be subject to adjustment as herein provided).

     E. In case the Company  shall,  at any time prior to the expiration of this
Warrant and prior to the exercise  thereof,  dissolve,  liquidate or wind up its
affairs,  the Warrantholder  shall be entitled,  upon the exercise  thereof,  to
receive,  in lieu of the Warrant  Shares of the Company which it would have been
entitled  to  receive,  the same kind and  amount  of assets as would  have been
issued,  distributed or paid to it upon such Warrant Shares of the Company,  had
it been the  holder of record of  shares  of Common  Stock  receivable  upon the
exercise  of this  Warrant on the  record  date for the  determination  of those
entitled  to  receive  any  such  liquidating   distribution.   After  any  such
dissolution, liquidation or winding up which shall result in any distribution in
excess of the Warrant Price provided for by this Warrant,  the Warrantholder may
at its option exercise the same without making payment of the aggregate  Warrant
Price  and in  such  case  the  Company  shall  upon  the  distribution  to said
Warrantholder consider that the aggregate Warrant Price has been paid in full to
it and in making settlement to


                                        9





said  Warrantholder,  shall deduct from the amount payable to such Warrantholder
an amount equal to the aggregate Warrant Price.

     F. In case the Company  shall,  at any time prior to the expiration of this
Warrant and prior to the exercise  thereof make a distribution  of assets (other
than cash) or securities of the Company to its stockholders (the "Distribution")
the Warrantholder  shall be entitled,  upon the exercise thereof, to receive, in
addition  to the Warrant  Shares it is  entitled  to receive,  the same kind and
amount of assets  or  securities  as would  have been  distributed  to it in the
Distribution  had it been the  holder  of  record  of  shares  of  Common  Stock
receivable upon exercise of this Warrant on the record date for determination of
those entitled to receive the Distribution.

     G.  Irrespective of any adjustments in the number of Warrant Shares and the
Warrant Price or the number or kind of shares  purchasable upon exercise of this
Warrant, this Warrant may continue to express the same price and number and kind
of shares as originally issued.

     4.  Officer's  Certificate.  Whenever the number of Warrant  Shares and the
Warrant Price shall be adjusted pursuant to the provisions  hereof,  the Company
shall forthwith file, at its principal  executive office a statement,  signed by
the  Chairman  of the Board,  President,  or one of the Vice  Presidents  of the
Company and by its Chief Financial Officer or one of its Treasurers or Assistant
Treasurers, stating the adjusted number of Warrant Shares and


                                       10





the new Warrant Price  calculated to the nearest one hundredth and setting forth
in reasonable  detail the method of  calculation  and the facts  requiring  such
adjustment  and upon which such  calculation  is based.  Each  adjustment  shall
remain in effect until a subsequent  adjustment hereunder is required. A copy of
such statement shall be mailed to the Warrantholder.

     5. Charges,  Taxes and Expenses.  The issuance of certificates  for Warrant
Shares upon any  exercise of this Warrant  shall be made  without  charge to the
Warrantholder  for any tax or other  expense in respect to the  issuance of such
certificates,  all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued only in the name of the Warrantholder.

     6. Miscellaneous.

     (a) The terms of this Warrant  shall be binding upon and shall inure to the
benefit of any successors or assigns of the Company and of the holder or holders
hereof and of the shares of Common  Stock  issued or issuable  upon the exercise
hereof.

     (b) No  holder  of this  Warrant,  as such,  shall be  entitled  to vote or
receive  dividends  or be  deemed to be a  stockholder  of the  Company  for any
purpose,  nor shall  anything  contained  in this Warrant be construed to confer
upon the holder of this Warrant,  as such,  any rights of a  stockholder  of the
Company or any right to vote, give or withhold consent to any corporate  action,
receive  notice of  meetings,  receive  dividends  or  subscription  rights,  or
otherwise.


                                       11






     (c)  Receipt  of  this  Warrant  by  the  holder  hereof  shall  constitute
acceptance of an agreement to the foregoing terms and conditions.

     (d) The  Warrant and the  performance  of the  parties  hereunder  shall be
construed and  interpreted in accordance  with the laws of the State of New York
and the parties  hereunder  consent and agree that the State and Federal  Courts
which  sit in the  State of New  York and the  County  of New  York  shall  have
exclusive  jurisdiction  with respect to all  controversies and disputes arising
hereunder.

     (e)  Shares  issued  upon  exercise  of  this  Warrant  shall  be  legended
substantially as follows:

                  "The  shares  evidenced  by this  certificate  have  not  been
                  registered  under the Securities Act of 1933, as amended,  and
                  must be held indefinitely unless they are transferred pursuant
                  to an effective registration statement under that Act or after
                  receipt of an opinion of counsel  satisfactory  to the Company
                  that registration is not required."


     IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its
duly authorized officer and its corporate seal to be affixed hereto.

Dated: September 26, 1997


                                       12





                                       ADVANCED VIRAL RESEARCH CORP.

                                       BY:
                                           Shalom Hirschman, M.D.
                                           President


                                       13





                                SUBSCRIPTION FORM


                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)


         To:      ADVANCED VIRAL RESEARCH CORP.


                  The  undersigned   hereby  exercises  the  right  to  purchase
_________  shares of Common Stock,  par value $.00001 per share,  covered by the
attached  Warrant  in  accordance  with the terms and  conditions  thereof,  and
herewith makes payment of the Warrant Price for such shares in full.



                                             SIGNATURE



                                             ADDRESS





DATED:







                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS


                                                                          , 199



Advanced Viral Research Corp.             Aggregate Price of            $
a Delaware corporation                    of Warrant
200 Corporate Boulevard South
Yonkers, New York 10701                   Aggregate Price Being
                                          Exercised:                    $
Attention:
                                          Warrant Price
                                          (per share):                  $
                                          Number of Shares of
                                          Common Stock to be
                                          Issued Under this
                                          Notice:






                                CASHLESS EXERCISE


Gentlemen:

                  The undersigned,  registered holder of the Warrant to Purchase
Common Stock delivered herewith  ("Warrant")  hereby irrevocably  exercises such
Warrant for, and  purchases  thereunder,  shares of the Common Stock of ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation,  as provided  below.  Capitalized
terms used herein,  unless  otherwise  defined  herein,  shall have the meanings
given in the  Warrant.  The  portion  of the  Aggregate  Price  (as  hereinafter
defined)  to be applied  toward the  purchase of Common  Stock  pursuant to this
Notice of Exercise is $ , thereby  leaving a remainder  Aggregate Price (if any)
equal  to $ .  Such  exercise  shall  be  pursuant  to the  net  issue  exercise
provisions  of Section  1(b) of the  Warrant;  therefore,  the  holder  makes no
payment with this Notice of Exercise. The number of shares to be issued pursuant
to this exercise shall be determined by reference to the formula in Section 1(b)
of the Warrant which requires the use of the Market Value (as defined in Section
1(d)  of the  Warrant)  of the  Company's  Common  Stock  on  the  business  day
immediately  preceding  the day on which this Notice is received by the Company.
To the extent the foregoing  exercise is for less than the full Aggregate  Price
of the Warrant,  the  remainder of the Warrant  representing  a number of Shares
equal to the quotient  obtained by dividing the remainder of the Aggregate Price
by the  Warrant  Price (and  otherwise  of like form,  tenor and  effect) may be
exercised under Section 1(a) of the Warrant. For purposes of this






Notice the term "Aggregate  Price" means the product obtained by multiplying the
number of shares of Common Stock for which the Warrant is exercisable  times the
Warrant Price.




                                                     SIGNATURE



DATE:
                                                     ADDRESS



                                        2





                                   ASSIGNMENT


                    (To be Executed by the Registered Holder
                     if he Desires to Transfer the Warrant)


                  FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and
transfers  unto the right to purchase  shares of Common Stock of ADVANCED  VIRAL
RESEARCH  CORP.,  evidenced by the within Warrant,  and does hereby  irrevocably
constitute and appoint Attorney to transfer the said Warrant on the books of the
Company, with full power of substitution.


                                                     SIGNATURE




                                                     ADDRESS

DATED:

IN THE PRESENCE OF: