SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549




                                    FORM 8-K

     0 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
ACT OF 1934

        Date of report (Date of earliest event reported) November 16, 1998
                                                         -----------------

                          ADVANCED VIRAL RESEARCH CORP.
               (Exact Name of Registrant as Specified in Charter)


           Delaware                 33-2262-A                 59-2646820
 ------------------------------    ------------           -------------------
       (State or Other             (Commission              (IRS Employer
 Jurisdiction of Incorporation)    File Number)           Identification No.)


     1250 East Hallandale Beach Blvd., Suite 501, Hallandale, Florida 33009
     ----------------------------------------------------------------------
                    (Address of Principal Executive Offices)


        Registrant's telephone number, including area code (954) 458-7636
                                                           ---------------

                                       N/A
          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





Item 7.    Financial Statements, Pro Forma Financial Information and Exhibits.

           99.1  Securities  Purchase  Agreement dated November 16, 1998, by and
           between  Advanced  Viral  Research  Corp.  and RBB Bank  AG.  Certain
           documents attached to Exhibit C (Schedule of Exceptions) are omitted.
           The Company agrees to furnish  supplementally  to the Commission upon
           request a copy of any of the omitted attachments.

           99.2     7% Convertible Debenture dated November 16, 1998.

           99.3 Warrant dated  November 16, 1998 to purchase  375,000  shares of
           common stock at $.20 per share.

           99.4 Warrant dated  November 16, 1998 to purchase  375,000  shares of
           common stock at $.24 per share.


Item 9.    Sales of Equity Securities Pursuant to Regulation S.

           On November 16, 1998 Advanced Viral Research  Corp.  (the  "Company")
for an aggregate  purchase  price of  $1,500,000  sold to RBB Bank AG ("RBB") as
agent for the accounts of certain persons, (i) a 7% Convertible Debenture in the
principal  amount of  $1,500,000  (the  "Debenture")  and (ii) two  Warrants  to
purchase shares of common stock of the Company (the "Warrants"). The sale of the
Debenture and the Warrants was made pursuant to Regulation S promulgated  by the
Securities and Exchange  Commission under the Securities Act of 1933, as amended
(the "Securities  Act"). The Company relied on the  representations,  warranties
and  covenants  of the  purchaser  made  in the  Securities  Purchase  Agreement
relating  to the  sale of the  Debenture  and  the  Warrants  for all the  facts
necessary to make the  Regulation S exemption to the  registration  requirements
under the Securities Act available.

           In connection  with the sale of the  Debenture and the Warrants,  the
Company paid RBB a placement  fee equal to 7% of the aggregate  purchase  price.
All or a portion of the Debenture  may be converted  into shares of common stock
of  the  Company  pursuant  to a  formula  more  particularly  described  in the
Debenture,  a copy of which is attached  hereto as Exhibit  99.2.  The Debenture
will mature on October 31, 2008. One of the Warrants entitles the holder thereof
to purchase in the aggregate 375,000 shares of common stock of the Company at an
exercise price of $0.20 per share. The other Warrant entitles the holder thereof
to purchase in the aggregate 375,000 shares of common stock of the Company at an
exercise  price of $0.24 per share.  Both Warrants are  exercisable  at any time
until October 31, 2008.





                                   SIGNATURES


           Pursuant to the requirements of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                              ADVANCED VIRAL RESEARCH CORP.
                                              ------------------------------
                                                      (Registrant)


Date:  November 20, 1998                      By: /s/ William Bregman
    -------------------------                 ------------------------------
                                              William Bregman, Secretary