EXHIBIT 99.2

           THIS DEBENTURE AND THE SHARES OF COMMON STOCK ISSUABLE UPON
        THE CONVERSION OF THIS DEBENTURE (COLLECTIVELY, THE "SECURITIES")
          HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
        AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN
        THE UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S
         UNDER THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION
         S, PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT
          TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.

                  7% CONVERTIBLE DEBENTURE DUE OCTOBER 31, 2008


$1,500,000                                                     November 16, 1998
                                                              New York, New York

              FOR VALUE  RECEIVED,  ADVANCED  VIRAL  RESEARCH  CORP., a Delaware
corporation (the "undersigned" or the "Company"),  hereby promises to pay to the
order of RBB BANK  AKTIENGESELLSCHAFT,  at its offices  located at Burgring  16,
8010 Graz,  Austria or at such other place as the holder hereof shall  designate
to the  undersigned in writing,  in lawful money of the United States of America
or in New York Clearing  House Funds,  the principal  amount of One Million Five
Hundred  Thousand  Dollars,  and to pay  interest  (computed  on the  basis of a
360-day  year and the actual  number of days  elapsed)  on the unpaid  principal
amount  hereof at the rate of seven  (7%)  percent  per annum.  The  undersigned
promises to pay the said principal sum and interest as follows:

              Until this Debenture is completely  retired the undersigned  shall
make payments of accrued  interest on this Debenture on the first day of January
and July in each year (commencing with January 1, 1999), computed at the rate of
7% per annum on the unpaid  principal  balance of this  Debenture for the period
from the date of this  Debenture  until the date of such  interest  payment.  On
October 31, 2008 the undersigned  shall pay the holder all unpaid  principal and
interest on this Debenture.

              Interest on the  indebtedness  evidenced by this  Debenture  after
default or maturity  accelerated  or  otherwise  shall be due and payable at the
rate of ten (10%) percent per annum,  subject to the  limitations  of applicable
law.

              If  this  Debenture  or any  installment  hereof  becomes  due and
payable on a Saturday,  Sunday or public  holiday under the laws of the State of
New York, the due date hereof shall be extended to the next succeeding  business
day and interest shall be payable at the rate of seven (7%)





percent per annum during such  extension.  All  payments  received by the holder
shall be applied first to the payment of all accrued interest payable hereunder.

              Subject  to and in  compliance  with the  provisions  hereof,  the
holder  shall  have the right to  convert  all or a portion  of the  outstanding
principal  amount of this  Debenture into such number of shares of Common Stock,
par value  $.00001 per share,  of the Company  ("Common  Stock")  (the shares of
Common Stock issuable upon conversion of this Debenture are hereinafter referred
to as the "Conversion  Shares") as shall equal the quotient obtained by dividing
(x) the principal amount of this Debenture to be converted by (y) the Applicable
Conversion  Price (as  hereinafter  defined) and by surrender of this Debenture,
such surrender to be made in the manner provided herein; provided, however, that
the right to convert outstanding  principal of this Debenture shall terminate at
the close of business on the third  calendar  day  preceding  the date fixed for
prepayment unless the Company shall default in making such prepayment.

          For purposes hereof the term "Applicable  Conversion Price" shall mean
the lesser of (q) $0.20 and (r) the  product  obtained  by  multiplying  (i) the
Average Closing Price (as hereinafter defined) by (iii) .72.

          For purposes  hereof the "Average  Closing  Price" with respect to any
conversion  elected to be made by the holder  shall be the  average of the daily
closing  prices for the three  consecutive  trading  days,  as  selected  by the
holder, out of the ten trading days immediately  preceding the date on which the
holder gives the Company a written  notice of the  holder's  election to convert
outstanding  principal of this  Debenture.  The closing price on any trading day
shall be (a) if the  Common  Stock is then  listed or quoted on either  the NASD
Bulletin Board,  the NASDAQ SmallCap Market or the NASDAQ National  Market,  the
reported closing bid price for the Common Stock on such day or (b) if the Common
Stock is  listed  on  either  the  American  Stock  Exchange  or New York  Stock
Exchange, the last reported sales price for the Common Stock on such exchange on
such day.

          On the date notice is delivered  in order to exercise  its  conversion
right,  the holder shall  surrender this Debenture to the Company at its office,
accompanied  by written  notice to the Company that the holder  hereof elects to
convert  all  or a  specified  portion  of the  outstanding  principal  of  this
Debenture (the "Conversion Notice"). Within five (5) business days after receipt
of this Debenture and the Conversion  Notice, the Company will pay to the holder
all interest  accrued on the principal  amount of this Debenture to be converted
to the effective date of conversion or, at the sole option of the Company, issue
to the holder in lieu thereof such  additional  number of shares of Common Stock
as shall equal the  quotient  obtained by dividing  the total  amount of accrued
interest  on the  principal  amount of this  Debenture  to be  converted  by the
Applicable  Conversion Price.  Within five (5) business days after the surrender
of this Debenture,  as aforesaid,  the Company shall cause its transfer agent to
issue and deliver to such holder,  or on its written  order,  a  certificate  or
certificates  without any restrictive legend thereon for the number of shares of
Common  Stock  issuable  upon  the  conversion  hereof  in  accordance  with the
provisions of this Debenture,  and any fractional interest in respect of a share
of Common Stock  arising upon such  conversion  shall be settled as  hereinafter
provided.  If the  Company  fails to  deliver  to the  holder a  certificate  or
certificates  for shares of Common Stock as aforesaid prior to the expiration of
five (5) business days after receipt of the  Conversion  Notice and surrender to
the Company of the Debenture, the Company





shall  pay to  the  holder  a  penalty.  The  penalty  shall  be  $1,000  if the
certificate or certificates are not delivered until the sixth business day after
the  delivery  of the  Conversion  Notice and the  penalty  shall  double  every
business day until the certificate or certificates  are so delivered,  but in no
event shall such penalty exceed $100,000.  For example,  if the certificates are
delivered on the eighth business day after delivery of the Conversion Notice and
surrender of the Debenture the penalty shall be $4,000.

          If the entire  outstanding  principal  amount of this Debenture is not
converted,  the  Company  shall  also  issue and  deliver  to such  holder a new
Debenture of like tenor in the principal amount equal to the principal which was
not converted and dated the effective date of conversion.  Each conversion shall
be deemed to have been  effected  immediately  prior to the close of business on
the date on which this  Debenture  shall have been  surrendered  and such notice
received by the Company as aforesaid, and the person or persons in whose name or
names any  certificate  of  certificates  for  shares of Common  Stock  shall be
issuable  upon such  conversion  shall be deemed to have  become  the  holder or
holders of record of the shares  represented  thereby at such time on such date.
All shares of Common Stock  delivered upon  conversion of this  Debenture  will,
upon  delivery,   be  duly  authorized,   validly  issued  and  fully  paid  and
nonassessable.  No  fractional  shares of  Common  Stock  shall be  issued  upon
conversion of this  Debenture.  Instead of any fractional  share of Common Stock
which would otherwise be deliverable  upon the conversion of a principal of this
Debenture the Company shall pay to the holder an amount in cash (computed to the
nearest cent) equal to the Average Closing Price multiplied by the fraction of a
share of Common Stock represented by such fractional interest.

              The issuance of  certificates  for shares of Common Stock upon any
conversion of this  Debenture  shall be made without  charge to the payee hereof
for any tax or other  expense in respect to the  issuance of such  certificates,
all of  which  taxes  and  expenses  shall  be paid  by the  Company,  and  such
certificates  shall be issued only in the name of the registered  holder of this
Debenture.

              This Debenture has been issued pursuant to and shall be subject to
all of the  provisions of the Purchase  Agreement.  The payee is entitled to the
benefits  of the  Purchase  Agreement,  and this  Debenture  may be  prepaid  as
provided in the Purchase Agreement. Reference is made to Sections 7.2 and 7.3 of
the Purchase  Agreement  with respect to certain rights of the holder to convert
this Debenture into Common Stock upon receipt of a notice of prepayment.

              Upon the  occurrence  of any one or more of the  events of default
specified or referred to in the Purchase  Agreement or in the other documents or
instruments executed in connection therewith,  all amounts then remaining unpaid
on this Debenture may be declared to be immediately  due and payable as provided
in the Purchase Agreement.

              In the event that this  Debenture  shall be placed in the hands of
an attorney  for  collection  by reason of any event of default  hereunder,  the
undersigned agrees to pay reasonable attorney's fees and disbursements and other
reasonable  expenses  incurred by the payee in connection with the collection of
this Debenture.





              The  rights,  powers and  remedies  given to the payee  under this
Debenture shall be in addition to all rights, powers and remedies given to it by
virtue of the  Purchase  Agreement,  any  document  or  instrument  executed  in
connection therewith, or any statute or rule of law.

              Any  forbearance,  failure or delay by the payee in exercising any
right,  power or remedy  under  this  Debenture,  the  Purchase  Agreement,  any
documents or instruments executed in connection therewith or otherwise available
to the payee shall not be deemed to be a waiver of such right,  power or remedy,
nor shall any single or partial exercise of any right,  power or remedy preclude
the further exercise thereof.

              No modification or waiver of any provision of this Debenture,  the
Purchase  Agreement  or any  documents  or  instruments  executed in  connection
therewith  shall be  effective  unless it shall be in writing  and signed by the
payee,  and any such  modification  or waiver  shall apply only in the  specific
instance for which given.

              This  Debenture  and the rights  and  obligations  of the  parties
hereto,  shall be governed,  construed and interpreted  according to the laws of
the State of New York,  and the  undersigned  consents and agrees that the State
and Federal Courts which sit in the State of New York,  County of New York shall
have exclusive jurisdiction of all controversies and disputes arising hereunder.

              The term  "payee" as used  herein  shall be deemed to include  the
payee and its successors, endorsees and assigns.

              The  undersigned  hereby waives  presentment,  demand for payment,
protest, notice of protest and notice of non-payment hereof.



                  By:   \s\ Shalom Hirschman
                     -----------------------------------------
                      Shalom Z. Hirschman, M.D., President and
                      Chief Executive Officer