EXHIBIT 99.4

          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
        NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
          (THE "SECURITIES ACT"), AND MAY NOT BE OFFERED OR SOLD IN THE
       UNITED STATES OR TO U.S. PERSONS (AS DEFINED IN REGULATION S UNDER
           THE SECURITIES ACT) UNLESS IN ACCORDANCE WITH REGULATION S,
         PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR PURSUANT TO
            AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS
           UNDER THE SECURITIES ACT. IN ADDITION, HEDGING TRANSACTIONS
             INVOLVING THE SECURITIES MAY NOT BE CONDUCTED UNLESS IN
                       COMPLIANCE WITH THE SECURITIES ACT.


                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

              -----------------------------------------------------


                  This   certifies   that,   for   value   received,   RBB  BANK
AKTIENGESELLSCHAFT,  or  registered  assigns  ("Warrantholder"),  is entitled to
purchase from ADVANCED  VIRAL  RESEARCH CORP.  (the  "Company"),  subject to the
provisions  of this  Warrant,  at any time and from time to time until 5:00 p.m.
Eastern  Standard  Time on October 31,  2008,  375,000  shares of the  Company's
Common Stock, par value $.00001 per share ("Warrant Shares"). The purchase price
payable upon the exercise of this Warrant shall be $0.24 per Warrant Share.  The
Warrant  Price and the  number of  Warrant  Shares  which the  Warrantholder  is
entitled  to  purchase  is  subject to  adjustment  upon the  occurrence  of the
contingencies set forth in Section 3 of this Warrant,  and as adjusted from time
to time, such purchase price is hereinafter referred to as the "Warrant Price."

                  This Warrant is subject to the following terms and conditions:

           1.     EXERCISE OF WARRANT.

                  (1)      This Warrant may be exercised in whole or in part but
                           not for a  fractional  share.  Upon  delivery of this
                           Warrant  at the  offices  of the  Company  or at such
                           other  address as the Company may designate by notice
                           in writing to the  registered  holder hereof with the
                           Subscription   Form  annexed  hereto  duly  executed,
                           accompanied  by payment of the Warrant  Price for the
                           number of Warrant Shares







                           purchased (in cash, by certified,  cashier's or other
                           check  acceptable to the Company,  by Common Stock of
                           the  Company  having a Market  Value (as  hereinafter
                           defined) equal to the aggregate Warrant Price for the
                           Warrant Shares to be purchased, or any combination of
                           the foregoing), the registered holder of this Warrant
                           shall  be  entitled  to  receive  a  certificate   or
                           certificates  for the  Warrant  Shares so  purchased.
                           Such  certificate or  certificates  shall be promptly
                           delivered  to the  Warrantholder.  Upon  any  partial
                           exercise of this  Warrant,  the Company shall execute
                           and  deliver  a new  Warrant  of like  tenor  for the
                           balance of the Warrant Shares purchasable hereunder.

                  (2)      In  lieu  of  exercising  this  Warrant  pursuant  to
                           Section 1(1),  the holder may elect to receive shares
                           of Common  Stock  equal to the value of this  Warrant
                           determined  in the  manner  described  below  (or any
                           portion thereof remaining  unexercised) upon delivery
                           of this  Warrant at the  offices of the Company or at
                           such other  address as the Company may  designate  by
                           notice in writing  to the  registered  holder  hereof
                           with the Notice of  Cashless  Exercise  Form  annexed
                           hereto duly executed. In such event the Company shall
                           issue  to  the  holder  a  number  of  shares  of the
                           Company's  Common Stock  computed using the following
                           formula:

                                   X = Y (A-B)
                                       -------
                                        A


Where    X = the number of shares of Common Stock to be issued to the holder.
         Y = the number of shares of Common Stock purchasable under this Warrant
             (at the date of such calculation).
         A = the Market Value of the Company's  Common Stock on the business day
             immediately  preceding  the day on which  the  Notice  of  Cashless
             Exercise is received by the Company.
         B = Warrant Price (as adjusted to the date of such calculation).


                  (3)      The Warrant Shares deliverable  hereunder shall, upon
                           issuance,  be fully paid and  non-assessable  and the
                           Company  agrees that at all times  during the term of
                           this  Warrant  it  shall  cause  to be  reserved  for
                           issuance such number of shares of its Common Stock as
                           shall be required  for  issuance  and  delivery  upon
                           exercise of this Warrant.

                  (4)      For purposes of this  Warrant,  the Market Value of a
                           share of Common  Stock on any date  shall be equal to
                           (i) the closing  sale price per share as published by
                           a national  securities  exchange  on which  shares of
                           Common  Stock (or other  units of the  security)  are
                           traded (an  "Exchange")  on such date or, if there is
                           no sale of Common Stock on such date,  the average of
                           the bid and asked







                           prices on such  exchange  at the close of  trading on
                           such date or, (ii) if shares of Common  Stock are not
                           listed  on a  national  securities  exchange  on such
                           date, the closing price per share as published on the
                           National  Association of Securities Dealers Automatic
                           Quotation System ("NASDAQ") National Market System if
                           the shares are quoted on such system on such date, or
                           (iii) the average of the bid and asked  prices in the
                           over-the-counter  market at the close of  trading  on
                           such date if the shares are not traded on an exchange
                           or listed on the NASDAQ  National  Market System,  or
                           (iv) if the Common  Stock is not traded on a national
                           securities   exchange  or  in  the   over-the-counter
                           market,  the fair  market  value of a share of Common
                           Stock on such date as determined in good faith by the
                           Board of Directors.  If the holder disagrees with the
                           determination  of the Market Value of any  securities
                           of the Company  determined  by the Board of Directors
                           under  Section  1(4)(iv)  the  Market  Value  of such
                           securities  shall  be  determined  by an  independent
                           appraiser  acceptable  to the  Company and the holder
                           (or, if they cannot agree on such an appraiser, by an
                           independent  appraiser  selected by each of them, and
                           Market  Value  shall be the median of the  appraisals
                           made by such appraisers).  If there is one appraiser,
                           the cost of the  appraisal  shall be  shared  equally
                           between the Company and the holder.  If there are two
                           appraisers,  each of the Company and the holder shall
                           pay for its own appraisal.

         2.       TRANSFER OR ASSIGNMENT OF WARRANT.

                  (1)      Any  assignment  or transfer of this Warrant shall be
                           made by  surrender  of this Warrant at the offices of
                           the  Company or at such other  address as the Company
                           may  designate  in writing to the  registered  holder
                           hereof with the  Assignment  Form annexed hereto duly
                           executed and  accompanied by payment of any requisite
                           transfer  taxes,  and  the  Company  shall,   without
                           charge,  execute  and  deliver a new  Warrant of like
                           tenor in the name of the  assignee for the portion so
                           assigned in case of only a partial assignment, with a
                           new  Warrant  of like tenor to the  assignor  for the
                           balance of the Warrant Shares purchasable.

                  (2)      Prior to any  assignment or transfer of this Warrant,
                           the  holder  thereof  shall  deliver  an  opinion  of
                           counsel  to  the  Company  to  the  effect  that  the
                           proposed    transfer   may   be   effected    without
                           registration under the Act.

          3.       ADJUSTMENT OF WARRANT PRICE AND WARRANT SHARES -- 
                   ANTI-DILUTION PROVISIONS.

                           A. (1) Except as  hereinafter  provided,  in case the
                  Company  shall at any time  after  the date  hereof  issue any
                  shares of Common Stock





                  (including  shares  held in the  Company's  treasury)  without
                  consideration,  then,  and thereafter  successively  upon each
                  issuance,  the Warrant  Price in effect  immediately  prior to
                  each such  issuance  shall  forthwith  be  reduced  to a price
                  determined  by   multiplying   the  Warrant  Price  in  effect
                  immediately prior to such issuance by a fraction:

                           (a)      the  numerator  of which  shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately prior to such issuance, and

                           (b)      the  denominator of which shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately after such issuance.

                  For the purposes of any  computation  to be made in accordance
with the  provisions  of this  clause (1),  the  following  provisions  shall be
applicable:

                                    (i)      Shares of Common Stock  issuable by
                                             way   of    dividend    or    other
                                             distribution  on any  stock  of the
                                             Company  shall  be  deemed  to have
                                             been  issued and to be  outstanding
                                             at the  close  of  business  on the
                                             record    date    fixed   for   the
                                             determination    of    stockholders
                                             entitled to receive  such  dividend
                                             or other  distribution and shall be
                                             deemed to have been issued  without
                                             consideration.   Shares  of  Common
                                             Stock  issued  otherwise  than as a
                                             dividend,  shall be  deemed to have
                                             been  issued and to be  outstanding
                                             at the  close  of  business  on the
                                             date of issue.

                                    (ii)     The  number  of  shares  of  Common
                                             Stock at any time outstanding shall
                                             not  include  any shares then owned
                                             or held by or for  the  account  of
                                             the Company.

                                    (2) In case  the  Company  shall at any time
                           subdivide or combine the outstanding shares of Common
                           Stock,   the  Warrant   Price  shall   forthwith   be
                           proportionately   decreased   in  the   case  of  the
                           subdivision or proportionately  increased in the case
                           of  combination  to the  nearest  one cent.  Any such
                           adjustment  shall  become  effective  at the close of
                           business  on  the  date  that  such   subdivision  or
                           combination shall become effective.

                           B. In the event that the number of outstanding shares
                  of Common Stock is increased  by a stock  dividend  payable in
                  shares of Common Stock or by a subdivision of the  outstanding
                  shares of Common Stock,  which may include a stock split, then
                  from and after the time at which the  adjusted  Warrant  Price
                  becomes





                  effective  pursuant  to the  foregoing  Subsection  A of  this
                  Section by reason of such dividend or subdivision,  the number
                  of shares  issuable upon the exercise of this Warrant shall be
                  increased  in  proportion  to  such  increase  in  outstanding
                  shares. In the event that the number of outstanding  shares of
                  Common Stock is decreased by a combination of the  outstanding
                  shares of Common Stock, then, from and after the time at which
                  the adjusted Warrant Price becomes effective  pursuant to such
                  Subsection  A of this  Section by reason of such  combination,
                  the  number  of  shares  issuable  upon the  exercise  of this
                  Warrant  shall be decreased in  proportion to such decrease in
                  outstanding shares.

                           C.  In the  event  of an  adjustment  of the  Warrant
                  Price,  the number of shares of Common Stock (or  reclassified
                  stock)  issuable  upon  exercise  of this  Warrant  after such
                  adjustment  shall  be  equal  to  the  number   determined  by
                  dividing:

                                    (1)      an amount  equal to the  product of
                                             (i) the  number of shares of Common
                                             Stock  issuable  upon  exercise  of
                                             this Warrant  immediately  prior to
                                             such   adjustment,   and  (ii)  the
                                             Warrant Price  immediately prior to
                                             such adjustment, by

                                    (2)      the Warrant Price immediately after
                                             such adjustment.

                           D.   In   the   case   of   any   reorganization   or
                  reclassification  of the  outstanding  shares of Common  Stock
                  (other than a change in par value, or from par value to no par
                  value,  or from no par value to par value, or as a result of a
                  subdivision   or   combination)   or  in  the   case   of  any
                  consolidation  of the Company  with,  or merger of the Company
                  with, another  corporation,  or in the case of any sale, lease
                  or conveyance of all, or  substantially  all, of the property,
                  assets, business and goodwill of the Company as an entity, the
                  holder of this Warrant  shall  thereafter  have the right upon
                  exercise  to  purchase  the kind and amount of shares of stock
                  and  other  securities  and  property   receivable  upon  such
                  reorganization,  reclassification,  consolidation,  merger  or
                  sale by a holder of the number of shares of Common Stock which
                  the holder of this Warrant would have received had all Warrant
                  Shares  issuable  upon  exercise of this  Warrant  been issued
                  immediately  prior to such  reorganization,  reclassification,
                  consolidation, merger or sale, at a price equal to the Warrant
                  Price then in effect  pertaining  to this  Warrant  (the kind,
                  amount  and price of such  stock and  other  securities  to be
                  subject to adjustment as herein provided).

                           E. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof,  dissolve,  liquidate  or  wind up its  affairs,  the
                  Warrantholder shall be entitled, upon the exercise thereof, to
                  receive, in lieu of the Warrant Shares of the Company which it
                  would have been entitled to receive,  the same kind and amount
                  of assets as would have been issued, distributed or paid to it
                  upon  such  Warrant  Shares  of the  Company,  had it been the
                  holder of





                  record of shares of Common Stock  receivable upon the exercise
                  of this  Warrant on the record date for the  determination  of
                  those entitled to receive any such  liquidating  distribution.
                  After any such  dissolution,  liquidation  or winding up which
                  shall  result in any  distribution  in  excess of the  Warrant
                  Price provided for by this Warrant,  the  Warrantholder may at
                  its option  exercise  the same without  making  payment of the
                  aggregate  Warrant  Price and in such case the  Company  shall
                  upon the distribution to said Warrantholder  consider that the
                  aggregate  Warrant  Price  has been  paid in full to it and in
                  making settlement to said Warrantholder, shall deduct from the
                  amount  payable to such  Warrantholder  an amount equal to the
                  aggregate Warrant Price.

                           F. In case the  Company  shall,  at any time prior to
                  the  expiration  of this  Warrant  and  prior to the  exercise
                  thereof  make a  distribution  of assets  (other than cash) or
                  securities   of  the   Company   to  its   stockholders   (the
                  "Distribution") the Warrantholder shall be entitled,  upon the
                  exercise  thereof,  to  receive,  in  addition  to the Warrant
                  Shares it is entitled to receive,  the same kind and amount of
                  assets or securities as would have been  distributed  to it in
                  the Distribution had it been the holder of record of shares of
                  Common Stock  receivable  upon exercise of this Warrant on the
                  record date for determination of those entitled to receive the
                  Distribution.

                           G.  Irrespective  of any adjustments in the number of
                  Warrant  Shares and the Warrant Price or the number or kind of
                  shares purchasable upon exercise of this Warrant, this Warrant
                  may  continue to express the same price and number and kind of
                  shares as originally issued.

                  4.  OFFICER'S  CERTIFICATE.  Whenever  the  number of  Warrant
Shares and the  Warrant  Price  shall be  adjusted  pursuant  to the  provisions
hereof,  the Company shall forthwith file, at its principal  executive  office a
statement,  signed by the Chairman of the Board,  President,  or one of the Vice
Presidents  of the  Company  and by its Chief  Financial  Officer  or one of its
Treasurers  or  Assistant  Treasurers,  stating the  adjusted  number of Warrant
Shares and the new Warrant  Price  calculated  to the nearest one  hundredth and
setting  forth in  reasonable  detail  the method of  calculation  and the facts
requiring  such  adjustment  and upon  which  such  calculation  is based.  Each
adjustment  shall remain in effect until a  subsequent  adjustment  hereunder is
required.
A copy of such statement shall be mailed to the Warrantholder.

                  5. CHARGES,  TAXES AND EXPENSES.  The issuance of certificates
for Warrant  Shares  upon any  exercise of this  Warrant  shall be made  without
charge to the  Warrantholder  for any tax or other  expense  in  respect  to the
issuance of such certificates,  all of which taxes and expenses shall be paid by
the  Company,  and such  certificates  shall be  issued  only in the name of the
Warrantholder.





                  6.       MISCELLANEOUS.

                                    (1) The  terms  of  this  Warrant  shall  be
                           binding  upon and shall  inure to the  benefit of any
                           successors  or  assigns  of  the  Company  and of the
                           holder or holders  hereof and of the shares of Common
                           Stock issued or issuable upon the exercise hereof.

                                    (2) No  holder  of this  Warrant,  as  such,
                           shall be entitled to vote or receive  dividends or be
                           deemed to be a  stockholder  of the  Company  for any
                           purpose, nor shall anything contained in this Warrant
                           be  construed  to  confer  upon  the  holder  of this
                           Warrant,  as such, any rights of a stockholder of the
                           Company  or any  right  to  vote,  give  or  withhold
                           consent to any corporate  action,  receive  notice of
                           meetings,  receive dividends or subscription  rights,
                           or otherwise.

                                    (3)  Receipt  of this  Warrant by the holder
                           hereof shall constitute acceptance of an agreement to
                           the foregoing terms and conditions.

                                    (4) The Warrant and the  performance  of the
                           parties  hereunder shall be construed and interpreted
                           in accordance  with the laws of the State of New York
                           and the parties  hereunder consent and agree that the
                           State and  Federal  Courts  which sit in the State of
                           New  York  and the  County  of New  York  shall  have
                           exclusive    jurisdiction   with   respect   to   all
                           controversies and disputes arising hereunder.

                                    (5)  Shares  issued  upon  exercise  of this
                           Warrant shall be legended substantially as follows:

         "The  shares  evidenced  by this  certificate  have  not  been
         registered  under the Securities Act of 1933, as amended,  and
         must be held indefinitely unless they are transferred pursuant
         to an effective registration statement under that Act or after
         receipt of an opinion of counsel  satisfactory  to the Company
         that registration is not required."

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
signed by its duly  authorized  officer  and its  corporate  seal to be  affixed
hereto.

Dated: November 16, 1998

                                  ADVANCED VIRAL RESEARCH CORP.


                                  BY: \s\ Shalom Hirschman 
                                       Shalom Hirschman, M.D., President





                                SUBSCRIPTION FORM


                    (TO BE EXECUTED BY THE REGISTERED HOLDER
                     IF HE DESIRES TO EXERCISE THE WARRANT)


         To:      ADVANCED VIRAL RESEARCH CORP.


                  The  undersigned   hereby  exercises  the  right  to  purchase
_________  shares of Common Stock,  par value $.00001 per share,  covered by the
attached  Warrant  in  accordance  with the terms and  conditions  thereof,  and
herewith makes payment of the Warrant Price for such shares in full.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

                                    --------------------------------------------



DATED:
      --------------------





                   NOTICE OF EXERCISE OF COMMON STOCK WARRANT
             PURSUANT TO NET ISSUE ("CASHLESS") EXERCISE PROVISIONS


                                                                        , 199   
                                                            ------------     ---


Advanced Viral Research Corp.        Aggregate Price of          $
a Delaware corporation               of Warrant                   --------------
200 Corporate Boulevard South
Yonkers, New York 10701              Aggregate Price Being
                                     Exercised:                  $
Attention:                                                        --------------
          --------------------       Warrant Price
                                     (per share):                $
                                     Number of Shares of          --------------
                                     Common Stock to be
                                     Issued Under this
                                     Notice:



                                CASHLESS EXERCISE


Gentlemen:

                  The undersigned,  registered holder of the Warrant to Purchase
Common Stock delivered herewith  ("Warrant")  hereby irrevocably  exercises such
Warrant for, and  purchases  thereunder,  shares of the Common Stock of ADVANCED
VIRAL RESEARCH CORP., a Delaware  corporation,  as provided  below.  Capitalized
terms used herein,  unless  otherwise  defined  herein,  shall have the meanings
given in the  Warrant.  The  portion  of the  Aggregate  Price  (as  hereinafter
defined)  to be applied  toward the  purchase of Common  Stock  pursuant to this
Notice of Exercise is $ , thereby  leaving a remainder  Aggregate Price (if any)
equal to $
        . Such exercise shall be pursuant to the net issue  exercise  provisions
of Section 1(b) of the Warrant; therefore, the holder makes no payment with this
Notice of Exercise.  The number of shares to be issued pursuant to this exercise
shall be  determined  by reference to the formula in Section 1(b) of the Warrant
which  requires  the use of the Market  Value (as defined in Section 1(d) of the
Warrant) of the Company's Common Stock on the business day immediately preceding
the day on which  this  Notice is  received  by the  Company.  To the extent the
foregoing exercise is for less than the full Aggregate Price of the Warrant, the
remainder of the Warrant  representing  a number of Shares equal to the quotient
obtained by dividing the remainder of the  Aggregate  Price by the Warrant Price
(and otherwise of like form, tenor and effect) may be exercised under Section





1(a) of the  Warrant.  For  purposes of this Notice the term  "Aggregate  Price"
means the product  obtained by multiplying  the number of shares of Common Stock
for which the Warrant is exercisable times the Warrant Price.


                                    -------------------------------------------
                                    SIGNATURE

DATE:
     --------------------           --------------------------------------------
                                    ADDRESS


                                        2




                                   ASSIGNMENT


                    (To be Executed by the Registered Holder
                     if he Desires to Transfer the Warrant)


                  FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and
transfers  unto                          the right to purchase  shares of Common
Stock of ADVANCED VIRAL RESEARCH  CORP.,  evidenced by the within  Warrant,  and
does hereby irrevocably constitute and appoint                          Attorney
to transfer  the said  Warrant on the books of the  Company,  with full power of
substitution.


                                    -------------------------------------------
                                    SIGNATURE


                                    --------------------------------------------
                                    ADDRESS

DATED:
      ---------------------

IN THE PRESENCE OF:


- ---------------------------