<ARTICLE>                     5
<LEGEND>
THIS  SCHEDULE  CONTAINS  SUMMARY  FINANCIAL   INFORMATION  EXTRACTED  FROM  THE
UNAUDITED   CONDENSED   CONSOLIDATED   FINANCIAL   STATEMENTS  INCLUDED  IN  THE
REGISTRANT'S  FORM 10-Q FOR THE PERIOD  ENDED MARCH 31, 2000 AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FORM 10-Q.
</LEGEND>
<CIK>                         0001012270
<NAME>                        CollaGenex Pharmaceuticals, Inc.
<MULTIPLIER>                                   1,000
<CURRENCY>                                     U.S. Dollars

                             
<PERIOD-TYPE>                   3-Mos
<FISCAL-YEAR-END>                              Dec-31-2000
<PERIOD-START>                                 Jan-01-2000
<PERIOD-END>                                   Mar-31-2000
<EXCHANGE-RATE>                                1
<CASH>                                         8,300
<SECURITIES>                                   3,181
<RECEIVABLES>                                  2,656
<ALLOWANCES>                                   375
<INVENTORY>                                    381
<CURRENT-ASSETS>                               15,499
<PP&E>                                         1,035
<DEPRECIATION>                                 324
<TOTAL-ASSETS>                                 16,236
<CURRENT-LIABILITIES>                          4,858
<BONDS>                                        0
<PREFERRED-MANDATORY>                          0
<PREFERRED>                                    2
<COMMON>                                       87
<OTHER-SE>                                     11,190
<TOTAL-LIABILITY-AND-EQUITY>                   16,236
<SALES>                                        5,510
<TOTAL-REVENUES>                               6,160
<CGS>                                          1,170
<TOTAL-COSTS>                                  8,784
<OTHER-EXPENSES>                               0
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             5
<INCOME-PRETAX>                                (2,443)
<INCOME-TAX>                                   0
<INCOME-CONTINUING>                            (2,443)
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                0
<CHANGES>                                      0
<NET-INCOME>                                   (2,443)
<EPS-BASIC>                                    (0.33)
<EPS-DILUTED>                                  (0.33)