<ARTICLE>                     5
<LEGEND>
THIS  SCHEDULE  CONTAINS  SUMMARY  FINANCIAL   INFORMATION  EXTRACTED  FROM  THE
UNAUDITED   CONDENSED   CONSOLIDATED   FINANCIAL   STATEMENTS  INCLUDED  IN  THE
REGISTRANT'S  FORM 10-Q FOR THE PERIOD  ENDED JUNE 30, 1999 AND IS  QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FORM 10-Q.
</LEGEND>
<CIK>                         0001012270
<NAME>                        CollaGenex Pharmaceuticals, Inc.
<MULTIPLIER>                                   1,000
<CURRENCY>                                     U. S. Dollars

                                            
<PERIOD-TYPE>                                  6-mos
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   JUN-30-1999
<EXCHANGE-RATE>                                1
<CASH>                                         21,640
<SECURITIES>                                   0
<RECEIVABLES>                                  1,373
<ALLOWANCES>                                   337
<INVENTORY>                                    634
<CURRENT-ASSETS>                               24,046
<PP&E>                                         796
<DEPRECIATION>                                 183
<TOTAL-ASSETS>                                 24,698
<CURRENT-LIABILITIES>                          5,943
<BONDS>                                        0
<PREFERRED-MANDATORY>                          0
<PREFERRED>                                    2
<COMMON>                                       86
<OTHER-SE>                                     18,524
<TOTAL-LIABILITY-AND-EQUITY>                   24,698
<SALES>                                        5,620
<TOTAL-REVENUES>                               5,856
<CGS>                                          1,253
<TOTAL-COSTS>                                  15,254
<OTHER-EXPENSES>                               2
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             189
<INCOME-PRETAX>                                (9,230)
<INCOME-TAX>                                   0
<INCOME-CONTINUING>                            (9,230)
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                0
<CHANGES>                                      0
<NET-INCOME>                                   (9,230)
<EPS-BASIC>                                  (1.10)
<EPS-DILUTED>                                  (1.10)