UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC  20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934


        Date of Report (Date of Earliest Event Reported October 7, 2004)


                              PHARMAFRONTIERS CORP.
                              ---------------------
              (Exact name of registrant as specified in its charter)


                                      TEXAS
                                      -----
                  (State or other jurisdiction of incorporation)


           000-25513                                   760333165
           ---------                                   ---------
    (Commission File Number)             (I.R.S. Employer Identification No.)


                    18205 Burkhardt Rd., Tomball Texas, 77377
                    -----------------------------------------
           (Address of principal executive offices, including zip code)


                                 (281) 272-9331
                                 --------------
              (Registrant's telephone number, including area code)



ITEM 1.01.     ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

     On  October  7,  2004,  PharmaFrontiers  Corp.,  a  Texas  corporation (the
"Company")  entered  into  an  Agreement  and  Plan  of  Reorganization ("Merger
Agreement").  Pursuant  to  the  Merger  Agreement,  the  Company's wholly owned
subsidiary,  Pharma  Acquisition  Corp., a Delaware corporation, will merge (the
"Merger")  with  and  into  Opexa  Pharmaceuticals, Inc., a Delaware corporation
("Opexa"). Following the consummation of the Merger, Opexa will be the surviving
corporation  in  the  Merger  and  a  wholly  owned  subsidiary  of the Company.

     The  shareholders  of  Opexa  will  be  issued  2.5  million  shares of the
Company's  common stock in exchange for all of the outstanding shares of capital
stock  of  Opexa  as  of  the closing of the Merger.  Prior to the closing, each
Opexa  option  shall  be either accelerated and exercised or terminated and each
Opexa  warrant  shall  be  terminated.

     Upon the closing of the merger, assuming no issuance by the Company of any
of its shares of common stock from the date hereof until closing, the Company
will have 9,866,838 shares outstanding of which shareholders of Opexa will own
approximately 25%.

     Concurrently  with the execution of the Merger Agreement and as a condition
and  inducement  to  Company's  willingness to enter into this Merger Agreement,
certain  shareholders owning in excess of 50% of Opexa common stock entered into
voting  agreements  with the Company to (i) approve the Merger Agreement and the
Merger,  (ii)  vote  in favor of any matter that could reasonably be expected to
facilitate  the  Merger,  and  (iii)  vote  against  any  acquisition  proposal.

     The  Merger Agreement also provides that the shares of Company common stock
issued  to  Opexa  will  be  subject  to  a  three-year  contractual restriction
precluding  transfer,  assignment, disposition, hypothecation, engaging in short
sales  or  any  hedging  activity  as follows: for a period of one year from the
execution  of  the  Merger  Agreement, no shares can be transferred; thereafter,
during  each  subsequent  three  month period, each Opexa holder can transfer an
amount  equal to one-eighth of the shares of Company common stock issued to such
Opexa  holder  hereunder.

     The  Company  agreed  to  loan  Opexa  up  to  $200,000 for working capital
purposes  on  the  date  of the Merger Agreement, which note shall mature at the
earlier of closing or termination and shall be secured by all of Opexa's assets,
except  its  intellectual  property.

     The  Company  and certain Opexa shareholders entered into a one-year escrow
agreement  where  certain Opexa shareholders agreed to escrow a total of 250,000
shares  of  Company  common  stock to be used to satisfy Opexa's indemnification
obligation  as  described  in  the  Merger  Agreement.



ITEM 9.01.     FINANCIAL STATEMENTS AND EXHIBIT

     (c)  Exhibits

The following exhibits are to be filed as part of this 8-K:



EXHIBIT NO.  IDENTIFICATION OF EXHIBIT
- -----------  -------------------------
          
   2.1       Agreement and Plan of Reorganization among PharmaFrontiers Corp., Pharma
             Acquisition Corp., and Opexa Pharmaceuticals, Inc. dated as of October 7, 2004 (the
             exhibits and schedules have been omitted pursuant to Item 601(b)(2) of Regulation S-K
             and will be provided to the Securities and Exchange Commission upon request).




                                   SIGNATURES


     Pursuant  to  the  requirements of the Securities Exchange Act of 1934, the
registrant  has  duly  caused  this  report  to  be  signed on its behalf by the
undersigned  hereunto  duly  authorized.


                         PHARMAFRONTIERS CORP.


                         By:  /s/ David McWilliams
                         -------------------------
                         David McWilliams, Chief Executive Officer


DATE:  October 7, 2004





                                           EXHIBIT INDEX


EXHIBIT NO.  IDENTIFICATION OF EXHIBIT
- -----------  -------------------------
          
   2.1       Agreement and Plan of Reorganization among PharmaFrontiers Corp., Pharma
             Acquisition Corp., and Opexa Pharmaceuticals, Inc. dated as of October 7, 2004.