EXHIBIT 16.1 September 8, 1998 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, DC 20549 Gentlemen: We have read Item 4 of the Form 8-K/A dated September 8, 1998, of Ophthalmic Imaging Systems and are in agreement with the statements contained in the first, second and third paragraphs on page 2 therein. We have no basis to agree or disagree with other statements of the registrant contained therein. ERNST & YOUNG LLP