- -------------------------------------------------------------------------------- SECURITIES PURCHASE AGREEMENT - -------------------------------------------------------------------------------- SUNPHARM CORPORATION 200,000 shares of Series B Redeemable Convertible Preferred Stock and 550,000 shares of Common Stock issued in exchange for an aggregate of $1,500,000 and up to 366,667 Warrants to purchase Common Stock - -------------------------------------------------------------------------------- Dated as of March 31, 1999 - -------------------------------------------------------------------------------- SECURITIES PURCHASE AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of this 31st day of March, 1999, by and among SunPharm Corporation, a Delaware corporation (the "Company"), and the Persons listed on SCHEDULE A attached hereto (individually, a "Purchaser" and, collectively, the "Purchasers"). WHEREAS, certain of the Purchasers entered into a Unit Purchase Agreement with the Company dated March 28, 1997 (the "Unit Purchase Agreement"), pursuant to which the Purchasers purchased units, each unit consisting of one share of the Company's Common Stock (as defined below) and one Warrant (as defined below) to purchase one share of the Company's Common Stock; WHEREAS, the Company desires to issue and sell to the Purchasers, and the Purchasers desire to acquire on the terms and subject to the conditions set forth herein, up to an aggregate of 200,000 shares of Series B Redeemable Convertible Preferred Stock, par value $.001 per share (the "Series B Preferred Stock"), and up to an aggregate of 550,000 shares of Common Stock; NOW, therefore, in consideration of the premises and the mutual covenants contained in this Agreement, the parties agree as follows: ARTICLE I DEFINITIONS SECTION 1.01 DEFINITIONS. As used in this Agreement, references to either gender shall include the other gender, and the following terms shall have the following meanings (such meanings to be equally applicable to both the singular and plural forms of the terms defined): "Affiliate" shall have the meaning given to such term in Rule 12b-2 of the Rules and Regulations under the Exchange Act. "Agreement" means this Securities Purchase Agreement, as amended, modified or supplemented from time to time. "Business Day" means any day on which commercial banks are not authorized or required by law to close in New York, New York. "Commission" means the United States Securities and Exchange Commission, or any other agency successor thereto. "Common Shares" means shares of Common Stock. "Conversion Shares" means those shares of Common Stock issuable upon the conversion of the Series B Preferred Stock. "Common Stock" shall mean the Common Stock, par value $.0001 per share, of the Company, and shall include any stock into which such Common Stock shall have been changed or any stock resulting from any reclassification of such Common Stock and all other stock of any class or classes (however designated) of the Company the holders of which have the right, without limitation as to amount, either to all or to a share of the balance of current dividends and liquidating dividends after the payment of dividends and distributions on any shares entitled to preference. "Company" means and shall include SunPharm Corporation, a Delaware corporation, and its successors and permitted assigns. "Exchange Act" means the Securities Exchange Act of 1934 or any successor Federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. "Guarantee" shall mean any obligation, contingent or otherwise, of any Person guaranteeing or having the economic effect of guaranteeing any Indebtedness of any other Person in any manner, whether directly or indirectly, and including, without limitation, any obligation of such Person, direct or indirect, (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or to purchase (or to advance or supply funds for the purchase of) any security for the payment of such Indebtedness, (ii) to purchase property, securities or services for the purpose of assuring the owner of such Indebtedness of the payment of such Indebtedness, or (iii) to maintain working capital, equity capital or other financial statement condition of the primary obligor so as to enable the primary obligor to pay such Indebtedness; provided, however, that the term "Guarantee" shall not include endorsements for collection or deposit, in either case, in the ordinary course of business. "Indebtedness" shall mean, with respect to any Person, (i) all obligations of such Person for borrowed money, or with respect to deposits or advances of any kind (other than deposits, advances or excess payments accepted in connection with the sale by such Person of products or services in the ordinary course of business), (ii) all obligations of such Person evidenced by bonds, debentures, notes or similar instruments, (iii) all obligations of such Person upon which interest charges are customarily paid (other than obligations accepted in connection with the purchase by such Person of products or services in the ordinary course of business), (iv) all obligations of such Person under conditional sale or other title retention agreements relating to property purchased by such Person, (v) all obligations of such Person issued or assumed as the deferred purchase price of property or services (other than accounts payable to suppliers incurred in the ordinary course of business and paid when due), (vi) all Indebtedness of others secured 2 by (or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any Lien or security interest on property owned or acquired by such Person whether or not the obligations secured thereby have been assumed, (vii) all obligations of such Person under leases required to be accounted for as capital leases under generally accepted accounting principles, and (viii) all Guarantees of such Person. "Lien" shall mean: (i) any interest in property (whether real, personal or mixed and whether tangible or intangible) which secures an obligation owed to, or a claim by, a Person other than the owner of such property, whether such interest is based on the common law, statute or contract, including, without limitation, any such interest arising from a lease, mortgage, charge, pledge, security agreement, conditional sale, trust receipt or deposit in trust, or arising from a consignment of bailment given for security purposes (other than a trust receipt or deposit given in the ordinary course of business which does not secure any obligation for borrowed money), (ii) any encumbrance upon such property which does not secure such an obligation, and (iii) any exception to or defect in the title to or ownership interest in such property, including, without limitation, reservations, rights of entry, possibilities of reverter, encroachments, easements, rights of way, restrictive covenants, licenses and PROFITS A PRENDRE. For purposes of this Agreement, any Person shall be deemed to be the owner of the leasehold or other interest in any property which it has acquired or holds subject to a lease and the owner of any property which it has acquired or holds subject to a conditional sale agreement or other similar arrangement pursuant to which title to the property has been retained by or vested in some other Person for security purposes. "Person" means an individual, corporation, partnership, association, joint venture, trust, or unincorporated organization, or a government or any agency or political subdivision thereof. "Preferred Shares" means shares of Series B Preferred Stock. "Purchaser" has the meaning specified in the introduction to this Agreement, and its successors and permitted assigns. "Recapitalization Event" means any stock dividend, stock split, combination, reorganization, recapitalization, reclassification, consolidation, merger or similar event involving a change in the Company's corporate structure. "Registrable Shares" means (i) the Shares, (ii) the Conversion Shares, (iii) any shares of Common Stock issued to the Purchasers upon a redemption of the Series B Preferred Stock and (iv) any other shares of Common Stock issued to the Purchasers in respect of the foregoing Shares because of any Recapitalization Event. "Securities Act" means the Securities Act of 1933 or any successor Federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 3 "Shares" or "Securities" means the Common Shares and the Preferred Shares, collectively. "Subsidiary" or "Subsidiaries" shall mean any corporation, partnership, trust or other entity of which the Company and/or any of its other Subsidiaries directly or indirectly owns at the time a majority of the outstanding shares of any class of equity security of such corporation, partnership, trust or other entity. "Warrants" shall mean the stock purchase warrants issued pursuant to the Warrant Agreement dated as of March 28, 1997 entitling the record holders thereof to purchase from the Company shares of Common Stock, subject to adjustment as provided in the Warrant Agreement; individually, a "Warrant". "Warrant Agreement" shall mean the Warrant Agreement dated as of March 28, 1997 by and between the Company and the Purchasers identified therein, pursuant to which the Warrants have been issued and have been exercisable at the Exercise Price (as defined therein) at any time after each respective Closing Date and before 5:00 P.M., New York time, on the Expiration Date (as defined therein), as amended, modified or supplemented from time to time. ARTICLE II PURCHASE AND SALE OF THE SECURITIES SECTION 2.01 AUTHORIZATION OF THE SHARES. The Company has authorized the issuance and sale of 200,000 shares of Series B Preferred Stock having the rights, restrictions and privileges and preferences set forth in the Certificate of Designation attached hereto as EXHIBIT A (the "Series B Certificate of Designation") and an aggregate of 550,000 shares of Common Stock. SECTION 2.02 CLOSING. The initial closing of the transactions contemplated by this Agreement (the "INITIAL CLOSING") and any subsequent closings (each, a "SUBSEQUENT CLOSING"; the Initial Closing and each Subsequent Closing, are each herein referred to as a "Closing") for the sale of additional shares of Series B Preferred Stock and Common Stock pursuant to the terms of this Agreement shall take place at the offices of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. at 5:00 p.m. on March 31, 1999, or at such other place or on such other date as the Company and the Purchasers set forth on SCHEDULE A (as amended from time to time by the Company and the Purchasers set forth therein) shall agree. At the Initial Closing and at any Subsequent Closing, subject to the terms and conditions set forth in this Agreement, the Company agrees to issue and sell to the Purchasers set forth on SCHEDULE A (as amended from time to time) and the Purchasers, severally but not jointly, agree to purchase from the Company, (i) that number of Preferred Shares set forth opposite their respective names on SCHEDULE A under the caption "Number of Preferred Shares Purchased at Closing" at a purchase price equal to Four Dollars and Zero Cents ($4.00) per share of Series B Preferred Stock and (ii) that number of Common Shares set forth opposite their respective names on 4 SCHEDULE A under the caption "Number of Common Shares Purchased at Closing" (A) at a purchase price equal to One Dollar and Two Hundred Seventy-Three Thousandth cents ($1.273) per share of Common Stock or (B) represented by the Warrants surrendered by the Purchasers, such number as set forth opposite their respective names on SCHEDULE A under the caption "Number of Warrants Surrendered at Closing." At each Closing, the Company will, subject to Article V, deliver to each Purchaser certificates for the number of Preferred Shares and Common Shares being purchased by such Purchaser registered in such Purchaser's name (or its nominee), against (i) delivery of a check or checks payable to the order of the Company, or a transfer of funds to the account of the Company by wire transfer, representing the purchase price paid by such Purchaser for shares of Series B Preferred Stock and either (A) the purchase price paid by Purchaser for shares of Common Stock as set forth on SCHEDULE A or (B) surrender by such Purchaser of the number of Warrants set forth opposite such Purchaser's name, if any, on SCHEDULE A under the caption "Number of Warrants Surrendered at Closing," representing the purchase price for shares of Common Stock. At each Closing or as soon as practicable after such Closing, each Purchaser with Warrants to surrender as set forth on SCHEDULE A shall surrender such Purchaser's certificates representing such Purchaser's Warrants to the Company (acting, until such time as all certificates representing such Warrants shall have been exchanged in accordance herewith, as Exchange Agent hereunder (the "Exchange Agent")) in exchange for certificates representing such Purchaser's Common Shares; PROVIDED that, notwithstanding the foregoing, on the Closing Date, by virtue of the Closing and without any further action on the part of the Purchasers, the Company or any other Person, (i) the Preferred Shares and the Common Shares being purchased by the Purchasers shall be issued by the Company and shall be deemed issued and outstanding capital stock of the Company for all intents and purposes and (ii) any Warrants being surrendered by the Purchasers shall be deemed to be surrendered and canceled by the Purchasers, whether or not the certificates representing such Warrants have been physically surrendered or delivered to the Company or its agent. ARTICLE III COMPANY REPRESENTATIONS AND WARRANTIES In order to induce the Purchasers to enter into this Agreement and to consummate the transactions contemplated hereby, the Company hereby represents and warrants to the Purchasers as follows: SECTION 3.01. ORGANIZATION AND GOOD STANDING. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company has the requisite corporate power and authority to own and operate its properties and assets and to carry on its business as currently conducted. The Company is qualified to do business in the State of Florida. The Company is not qualified to do business as a foreign corporation in any other jurisdiction and such qualification is not now required, 5 except to the extent that the failure to so qualify would not have a material adverse effect on the Company's business as currently conducted. SECTION 3.02. CORPORATE POWER AND AUTHORIZATION. The Company has the corporate power and authority to execute and deliver this Agreement, to issue and sell the Shares hereunder and to issue and deliver the Conversion Shares upon conversion of the Preferred Shares, and to perform its obligations under the terms of this Agreement. All corporate action on the part of the Company, its directors and stockholders necessary for the authorization, execution, delivery and performance by the Company of this Agreement and the authorization, sale, issuance and delivery of the Shares and the Conversion Shares has been taken or will be taken prior to Closing. This Agreement constitutes the valid and binding obligation of the Company, enforceable in accordance with its terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or other laws relating to or affecting creditors' rights generally and by general equitable principles. The Shares have been and the Conversion Shares will be duly authorized and, when issued in compliance with the provisions of this Agreement, will be validly issued, fully paid and nonassessable; and the Shares and the Conversion Shares when issued and delivered in accordance with the terms of this Agreement and (in the case of the Conversion Shares) the Series B Certificate of Designation, will be free of any Liens or encumbrances created by the Company; PROVIDED, HOWEVER, that the Shares and the Conversion Shares may be subject to restrictions on transfer under state or federal securities laws as set forth herein. SECTION 3.03. CAPITALIZATION. The authorized capital stock of the Company consists of 27,500,000 shares, divided into 25,000,000 shares of Common Stock, par value $0.0001 per share, of which 6,731,395 shares are issued and outstanding, and 2,500,000 shares of undesignated blank check preferred stock, par value $0.001 per share ("Preferred Stock"), of which 300,000 shares have been designated as Series A Redeemable Convertible Preferred Stock and of which, 200,000 shares shall be designated as Series B Preferred Stock in accordance with the Series B Certificate of Designation prior to the Initial Closing. All of the outstanding shares of Common Stock have been duly authorized and validly issued and are fully paid and nonassessable. The Company has reserved (i) up to 200,000 shares of Common Stock for issuance upon exercise or conversion of the Preferred Shares, (ii) up to 2,962,676 shares of Common Stock for issuance upon exercise of warrants issued by the Company (including any Warrants being surrendered pursuant hereto) and (iii) up to 1,075,723 shares of Common Stock for issuance upon the exercise of options to purchase Common Stock issued by the Company. SCHEDULE 3.03 sets forth the outstanding capitalization of the Company as of the date hereof, including the material terms (expiration date, exercise price, etc.) of such outstanding options and warrants and, except for such outstanding options and warrants, there are no other options, warrants or other rights outstanding to purchase or acquire, or any securities convertible into, nor has the Company agreed to issue or reissue, other than pursuant to this Agreement, any of the Company's authorized and unissued capital stock. Except as set forth in the Certificate of Designations, Preferences and Rights of Series A Redeemable Convertible Preferred Stock, there are no agreements or understandings that affect or relate to the voting or giving of written consent with respect to any of the Company's outstanding securities. There are no preemptive rights with respect to the issuance or sale of 6 the Company's capital stock, and there are no restrictions on the transfer of the Company's capital stock other than those arising from federal and state securities laws. SECTION 3.04. SEC REPORTS; FINANCIAL STATEMENTS. The Company has filed with the Commission all forms, reports and documents required to be filed by it pursuant to the Exchange Act, all of which, when filed, complied in all material respects with all applicable requirements of the Exchange Act. The Purchasers have been provided true and correct copies (not including exhibits) of the Company's (i) Annual Report on Form 10-KSB for the fiscal year ended December 31, 1997, as filed with the Commission, (ii) Quarterly Reports on Form 10-QSB for the quarters ended March 31, 1998 and June 30, 1998, in each case as filed with the Commission, and (iii) proxy statements relating to all meetings of its stockholders (whether annual or special) since December 31, 1997 and prior to the date hereof (collectively, the "Company's SEC Reports"). As of their respective dates, the Company's SEC Reports (not including any exhibits and schedules thereto and documents incorporated by reference therein) did not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. The audited financial statements and unaudited interim financial statements of the Company included in the Company's SEC Reports or incorporated by reference therein were prepared in accordance with generally accepted accounting principles ("GAAP") (subject, in the case of such unaudited financial statements, to the absence of complete footnotes) applied on a consistent basis (except as indicated therein or in the notes thereto) and fairly present in all material respects the financial position of the Company at the dates thereof and the results of its operations and cash flows for the periods then ended (subject in the case of the unaudited interim financial statements, to normal year-end audit adjustments). SECTION 3.05. ABSENCE OF CERTAIN DEVELOPMENTS. Since December 31, 1998, there has been no change in the assets, liabilities, condition (financial or otherwise), operating results, business or prospects of the Company from that reflected in the Company's SEC Reports, except changes in the ordinary course of business that have not been, individually or in the aggregate, materially adverse to the assets, properties, condition (financial or otherwise), operating results, business or prospects of the Company. Since December 31, 1998, the Company has not (i) directly or indirectly declared or paid any dividend or ordered or made any other distribution on account of any shares of any class of the capital stock of the Company, (ii) directly or indirectly redeemed, purchased or otherwise acquired any such shares or agreed to do so or set aside any sum or property for any such purpose, (iii) made any capital expenditures exceeding $100,000, or (iv) incurred any indebtedness exceeding $100,000. SECTION 3.06. COMPLIANCE WITH OTHER INSTRUMENTS. The Company is not in violation or default of any provision of its Certificate of Incorporation or By-Laws or of any material mortgage, indenture, contract, agreement, instrument, judgment or decree to which the Company is a party or by which it is bound. The execution, delivery and performance by the Company of this Agreement and the consummation of the transactions contemplated hereby will not result in any violation of or conflict with the Company's Certificate of Incorporation 7 or By-Laws, and will not result in any violation of or conflict with, or constitute a default under, any material mortgage, indenture, contract, agreement, instrument, judgment or decree to which the Company is a party or by which it is bound or in the creation of any material mortgage, pledge, Lien, encumbrance or charge upon any of the properties or assets of the Company. SECTION 3.07. REGISTRATION RIGHTS. Except as set forth in SCHEDULE 3.07 hereto, and the provisions of Article VII of this Agreement, the Company is not under any contractual obligation to register under the Securities Act any of its currently outstanding securities or any of its securities which may hereafter be issued. SECTION 3.08. GOVERNMENTAL CONSENT. No consent, approval or authorization of or registration, qualification, designation, declaration or filing with any governmental authority on the part of the Company is required in connection with the valid execution, delivery and performance of this Agreement or the offer, sale or issuance of the Shares and the Conversion Shares or the consummation of any other transaction contemplated hereby, except for filings that may be required to comply with applicable federal and state securities laws. SECTION 3.09. OFFERING. Subject to the accuracy of the representations of the Purchasers in Article IV, the offer, sale and issuance of the Shares as contemplated by this Agreement will constitute transactions exempt from the registration requirements of Section 5 of the Securities Act. SECTION 3.10. SUBSIDIARIES. The Company has no subsidiaries and does not otherwise own or control, directly or indirectly, any equity interest in any corporation, association, partnership or business entity, nor has the Company made any commitment or subscribed for the purchase of any such equity interest. SECTION 3.11. ABSENCE OF UNDISCLOSED LIABILITIES. The Company does not have any liability or obligation, absolute or contingent, that is not reflected in the financial statements included in the Company's SEC Reports, other than obligations and liabilities which taken individually or in the aggregate would not have a material adverse effect on the Company's assets, liabilities, condition (financial or otherwise), operating results, business or prospects. SECTION 3.12. TAXES. The Company has filed all tax returns and reports required by law to be filed, and has paid all taxes, assessments and other governmental charges that are due and payable, except for those matters reasonably being contested by the Company and those matters which, individually and in the aggregate, would not have a material adverse effect on the Company's assets, liabilities, condition (financial or otherwise), operating results, business or prospects. The charges, accruals and reserves on the books of the Company in respect of taxes are considered adequate by the Company, and the Company knows of no assessment for additional taxes or any basis therefor. SECTION 3.13. TITLE TO PROPERTIES: LIENS AND ENCUMBRANCES. The Company has good title to all properties and assets which it owns or purports to own, both real and personal, tangible and intangible, reflected on the balance sheet included in the financial statements 8 included in the Company's SEC Reports or acquired after the date thereof (except inventory or other personal property disposed of in the ordinary course of business subsequent to the date thereof), and such properties and assets are not subject to any mortgage, pledge, Lien, security interest, encumbrance or charge other than (i) Liens for current taxes not yet due and payable, (ii) Liens and encumbrances that do not materially detract from the value of the property subject thereto or materially impair the operations of the Company, or (iii) Liens securing obligations reflected in such financial statements. With respect to properties or assets it leases, the Company is in compliance with such leases (except for such defaults or breaches that would not have a material adverse affect on the Company) and holds valid leasehold interests free of any Liens, claims or encumbrances except for those described in subsections (i) through (iii) hereof. SECTION 3.14. LITIGATION, ETC. There are no actions, suits, proceedings or investigations (i) pending or, to the Company's knowledge, threatened against the Company or which otherwise involve the Company's business or operations, or (ii) to the Company's knowledge, pending or threatened against any of its officers, directors or principal stockholders in their capacities as officers, directors or stockholders. SECTION 3.15. EMPLOYEES. To the Company's knowledge, no employee of the Company is in violation of any term of any employment contract or any other contract or agreement between such employee and the Company. None of the employees of the Company is represented by any labor union, and there is no strike or other labor dispute pending or, to the knowledge of the Company, threatened, with respect to the Company. SECTION 3.16. COMPLIANCE WITH LAW. The Company is conducting its business and operations in material compliance with all governmental rules and regulations applicable thereto, including without limitation those relating to occupational safety, environmental, health and employment practices, and is not in violation or default in any material respect under any statute, law, ordinance, rule, regulation, judgment, order, decree, concession, grant, franchise, license or other governmental authorization or approval applicable to it or any of its properties. SECTION 3.17. PERMITS. The Company has all permits, licenses, orders and approvals of any federal, state, local or foreign governmental or regulatory body (collectively, the "Permits") that are material to or necessary in the conduct of its business as now conducted; all such Permits are in full force and effect; no violations have been recorded in respect of any such Permits; and no proceeding is pending or, to the knowledge of the Company, threatened to revoke or limit any such Permits. SECTION 3.18. BROKERS OR FINDERS. The Company has not retained any investment banker, broker or finder in connection with the transactions contemplated by this Agreement, and there are no brokerage commissions, finder's fees or similar items of compensation payable in connection therewith based on any arrangement or agreement made by or on behalf of the Company. 9 SECTION 3.19. DISCLOSURE. This Agreement, including the schedules hereto, was prepared in good faith by the Company and does not contain any untrue statement of a material fact or omit a material fact necessary to make the statements therein not misleading. SECTION 3.20. INTELLECTUAL PROPERTY. The Company owns or possesses the requisite licenses or rights to all trademarks, service marks, service names, trade names, patents and patent applications, copyrights and other rights (collectively the "Intangibles") described as owned or licensed by the Company in the SEC Reports. There is no claim, action or proceeding by any person pending or, to the Company's knowledge, threatened which pertains to or challenges the validity, enforceability or exclusive right of the Company with respect to any Intangibles used in the conduct of the Company's business except as described in the SEC Reports. To the Company's knowledge, the Company's current products, services and processes do not infringe on any Intangibles held by any third party. Except as set forth in the agreements disclosed in the SEC Reports, the Company is not under any obligation to pay royalties or fees of any kind whatsoever to any third party with respect to technology it has developed, uses, employs or intends to use or employ. SECTION 3.21. MATERIAL CONTRACTS. All contracts, agreements (including license agreements and any other agreements relative to the Company's technology), leases or other commitments, written or oral, absolute or contingent, to which the Company is a party are filed or incorporated by reference as exhibits to the Company's SEC Reports, other than (i) contracts entered into in the ordinary course of business, requiring the expenditure by the Company or the payment to the Company of no more than $100,000 and (ii) contracts terminable by the Company on no more than 30 days' notice without material cost or liability to the Company. Each such material contract (including, without limitation, contracts between the Company and each of (i) the University of Florida Research Foundation, (ii) Warner-Lambert Co. and (iii) Raymond Bergeron) is valid and in full force and effect, and no event of default (or event or circumstance which, with the lapse of time or giving of notice, or both, would constitute an event of default) exists under any such material contract. The Company is not in breach of any of the material provisions of any such material contract and, to the Company's knowledge, no other party to any such material contract is in breach of any of the material provisions thereof. SECTION 3.22. INTERESTED PARTY TRANSACTIONS. The Company is not a guarantor or indemnitor of any indebtedness of any other person, firm or corporation. Except as set forth in SCHEDULE 3.22 hereto, no stockholder, executive officer or director of the Company, nor any immediate family member of such person, is a party to any transaction with the Company which is or would be required to disclose in the Company's SEC Reports pursuant to Item 404 of Regulation S-K of the rules and regulations under the Securities Act and the Exchange Act. SECTION 3.23. BOOKS AND RECORDS. The minute books of the Company reflect, in all material respects, all meetings and other corporate actions of the stockholders and Board of Directors (and any committees thereof) of the Company. 10 SECTION 3.24. ERISA. Each employee benefit plan (within the meaning of Section 3(3) the Employment Retirement Income Security Act of 1974, as amended ("ERISA")) which is subject to ERISA and/or the Internal Revenue Code of 1986, as amended (the "Code") conforms to, and its operation and administration are in compliance with, all applicable requirements of ERISA and/or the Code, as applicable. There are no actions, suits or claims pending (other than routine claims for benefits) or threatened against any employee plan or against the assets of any employee plan. Each "Employee Welfare Benefit Plan" (as defined in Section 3(1) of ERISA) covering any present or former employee of the Company subject to the requirements of COBRA has complied with all requirements for continuation coverage under group health benefit plans under COBRA and there are no claims against the Company for a failure or alleged failure to comply with the COBRA continuation requirements. The Company does not and has not ever contributed to a "multiemployer plan" (as defined in Section 3(37) of ERISA) and no amount is due or owing on account of any withdrawal therefrom. Notwithstanding anything else set forth herein, the Company has incurred no liability with respect to any such plan under ERISA (including, without limitation Title I or Title IV of ERISA, other than liability for premiums due to the Pension Benefit Guaranty Corporation), the Code or other applicable law, which has not been satisfied in full, and no event has occurred, and there exists no condition or set of circumstances which could result in the imposition of any liability under ERISA (including, without limitation Title I or Title IV of ERISA), the Code or other applicable law with respect to any such plan. SECTION. 3.25 ENVIRONMENTAL LAWS. (a) The Company is in compliance with all limitations, restrictions, conditions, standards, prohibitions, requirements, obligations, schedules and timetables contained in any Applicable Environmental Laws, or in any plan, order, decree, judgment, notice or demand letter issued, entered, promulgated or approved thereunder. For purposes of this Agreement, the term "Applicable Environmental Laws" shall mean Comprehensive Environmental Response, Compensation and Liability Act of 1980,42 U.S.C. 9601 ET. SEQ. ("CERCLA"); Resource Conservation and Recovery Act of 1976,42 U.S.C. 6901 ET. SEQ. ("RCRA"); Federal Water Pollution Control Act, 33 U.S.C. 1251 ET. SEQ.; and Clean Air Act, 42 U.S.C. 7401 ET. SEQ. and any similar provisions of state or local law in any jurisdictions where the properties of the Company are located, and the regulations thereunder, and any other local, state and or federal laws or regulations, whether currently in existence or hereafter enacted that govern. (b) The Company is not aware of, nor has the Company received notice of, any past present or future events, conditions, circumstances, activities, practices, incidents, actions or plans which may interfere with or prevent continued compliance, or which may give rise to any common law or legal liability, or otherwise form the basis of any claim, action, suit, proceeding, hearing or investigation, based on or related to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling, or the emission, discharge, release or threatened release into the environment, of any pollutant, contaminant, or hazardous or toxic material or waste. 11 (c) No Hazardous Material has been incorporated in, used on, stored on or under, released from, treated on, transported to or from, or disposed of on or from any property owned or leased by the Company such that, under Applicable Environmental Laws (i) any such Hazardous Material would be required to be removed, cleaned-up or remediated before the property could be altered, renovated, demolished or transferred, or (ii) the owner or lessee of the property could be subjected to liability for the removal, clean-up or remediation of such Hazardous Material; and the Company has not received any notification from any Governmental Bodies or other third parties relating to Hazardous Material on or affecting any property owned or leased by the Company or relating to any potential or known liability under Applicable Environmental Laws arising from the ownership or leasing of any property. For purposes of this Agreement, "Hazardous Material" shall mean any substance which as of the date of this Agreement shall be identified as "hazardous" or "toxic" or otherwise regulated under CERCLA or RCRA or which has been or shall be determined at any tine by any agency or court to be a hazardous or toxic substance under Applicable Environmental Law. The term "Hazardous Material" shall also include, without limitation, raw materials, building components, the products of any manufacturing or other activities on the properties, wastes, petroleum, and source, special nuclear or by-product material as defined by the Atomic Energy Act of 1954,42 U.S.C. ss.ss. 3011 ET. seq., as amended. ARTICLE IV PURCHASER REPRESENTATIONS AND WARRANTIES SECTION 4.01 REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS. Each Purchaser represents and warrants to the Company as follows: (a) INVESTMENT INTENT. Such Purchaser is acquiring the Shares as indicated on Schedule A for its own account for the purpose of investment and not with a view to, or for sale in connection with, the distribution thereof, and that it has no present intention of distributing or selling such Shares. (b) TRANSFER RESTRICTIONS. Such Purchaser understands that the Shares and the Conversion Shares have not been registered under the Securities Act, or the securities laws of any state or other jurisdiction, and hereby agrees not to make any sale, transfer or other disposition of the same in the absence of (i) an effective registration statement covering such securities under the Securities Act and any securities laws of any applicable state or other jurisdiction or (ii) an applicable exemption from registration under the Securities Act (including, without limitation, pursuant to Rule 144 under the Securities Act) and other applicable securities laws. (c) OPPORTUNITY TO INVESTIGATE. Such Purchaser (i) has had the opportunity to ask questions concerning the Company (including, without limitation, the Company's prior financings) and all such questions posed have been answered to such Purchaser's satisfaction; (ii) has been given the opportunity to obtain any additional information it deems necessary to verify the accuracy of any information obtained concerning the Company; and (iii) has such 12 knowledge and experience in financial and business matters that it is able to evaluate the merits and risks of purchasing the Shares and to make an informed investment decision relating thereto. (d) ACCREDITED INVESTOR. Such Purchaser is an "accredited investor" as such term is defined in Regulation D under the Securities Act. (e) ORGANIZATION AND GOOD STANDING. If such Purchaser is not an individual, such Purchaser is duly organized, validly existing and in good standing under the laws of the State or country of its formation. (f) POWER AND AUTHORIZATION. If such Purchaser is not an individual, such Purchaser has the power and authority to enter into this Agreement, and the execution, delivery and performance by such Purchaser of this Agreement have been duly authorized by all necessary corporate or partnership action. This Agreement constitutes the valid and binding obligation of such Purchaser, enforceable in accordance with its terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or other laws relating to or affecting creditors' rights generally and by general equitable principles. (g) BROKERS OR FINDERS. There are, and there will be, no brokerage commissions, finder's fees or similar items of compensation payable by the Company in connection with any broker's or finder's arrangement or agreement made by or on behalf of such Purchaser, and such Purchaser hereby indemnifies the Company against the same. ARTICLE V CONDITIONS TO CLOSINGS SECTION 5.01. CONDITIONS TO THE PURCHASERS' OBLIGATIONS. Each Purchaser's obligation to purchase and pay for the Securities to be purchased by it at the Closing is subject to the complete satisfaction by the Company, on or before such Closing, of the following conditions: (a) OPINION OF COMPANY'S COUNSEL. The Purchasers shall have received from counsel for the Company, an opinion, dated the date of the Closing Date for each Closing, an opinion dated the date of such Closing, in the form set forth in EXHIBIT B hereto with respect to the Closing. (b) REPRESENTATIONS AND WARRANTIES; OFFICER'S CERTIFICATE. The Company's representations and warranties contained in Article III shall be true and correct on and as of the date of each Closing with the same effect as if made on and as of the date of such Closing. All agreements and conditions to be performed or satisfied by the Company hereunder on or before the date of such Closing shall have been duly performed or satisfied. The Company shall have delivered to the Purchasers a certificate, dated the date of each Closing and signed by the President of the Company, to such effect. 13 (c) CONSENTS AND APPROVALS. The Company shall have delivered to the Purchasers a certificate, dated the date of Initial Closing and for any Subsequent Closing, dated as of the Subsequent Closing, signed by the President of the Company, listing any consents, waivers, approvals, authorizations, registrations, filings and notifications (including, without limitation those of the character referred to in Section 3.08) which are necessary, to which shall be attached evidence, satisfactory to the Purchasers, that the same have been obtained or made and are in full force and effect, including the consent of the two-thirds of the holders of Series A Redeemable Convertible Preferred Stock. (d) CHARTER OF THE COMPANY. The Purchasers shall have received a copy of the Company's Certificate of Incorporation thereof, certified as of a recent date by the Delaware Secretary of State. (e) CLOSING DOCUMENTS. The Purchasers shall have received (i) certificates representing the Shares registered in the names of the Purchasers, (ii) such certificates as to the good standing of the Company and certificates of officers of the Company as counsel to the Purchasers may reasonably request. (f) SUFFICIENCY OF PROCEEDS. The Purchasers shall be satisfied that the net proceeds from the issuance and sale of the Shares will be sufficient to fund the Company's operations for a period of not less than three (3) months following the Closing. (g) PROCEEDINGS AND DOCUMENTS. All corporate and other proceedings and all documents incident to the transactions contemplated by this Agreement and the other agreements contemplated hereby shall be satisfactory in form and substance to the Purchasers and their counsel, and the Purchasers and the counsel shall have received copies of all documents and records relating thereto. In addition, all financial, legal and other due diligence shall have been completed to the reasonable satisfaction of the Purchasers. (h) OTHER PURCHASERS. Each other Purchaser purchasing more than 10,000 Preferred Shares shall have tendered the purchase price and accepted delivery of the Shares to be issued to them at the Closing as set forth in SCHEDULE A. (i) PAYMENT OF FEES AND DISBURSEMENTS OF PURCHASERS. The costs, fees and expenses of counsel to the Purchasers identified in Section 9.14 shall have been paid in full. (j) BOARD OF DIRECTORS. Upon the Closing, the Company shall have caused to be appointed or elected to the Company's Board of Directors a designated representative of the holders of the Series B Preferred Stock. SECTION 5.02. CONDITIONS TO THE COMPANY'S OBLIGATIONS. The Company's obligation to issue the Securities to the Purchasers at the Closing is subject to the satisfaction of the following conditions: (a) REPRESENTATIONS AND WARRANTIES. The representations and warranties of each Purchaser contained in Article IV shall be true, correct and complete in all material respects 14 on and as of the date of the Closing with the same force and effect as if they had been made on and as of the date of the Closing. (b) PAYMENT OF PURCHASE PRICE. Each Purchaser shall have delivered to the Company and the Company shall have received payment in full of the cash portion of the purchase price relating to the number of Securities to be purchased by such Purchaser at the Closing. (d) PROCEEDINGS AND DOCUMENTS. All corporate and other proceedings and all documents incident to the transactions contemplated by this Agreement and the other agreements contemplated hereby shall be satisfactory in form and substance to the Company and its counsel, and the Company and its counsel shall have received copies of all documents and records relating thereto. 15 ARTICLE VI COVENANTS OF THE COMPANY SECTION 6.01 AFFIRMATIVE COVENANTS. The Company covenants and agrees that, from the date of the Closing and thereafter so long as Fifteen Percent (15%) of the number of Preferred Shares originally issued shall remain outstanding, it shall, unless it has received the prior written consent or written waiver of at least 66-2/3% of the holders of such outstanding Preferred Shares, perform and observe the following covenants and provisions, and shall cause each Subsidiary, if and when such Subsidiary exists, to perform and observe the following covenants and provisions as applicable to such Subsidiary: (a) FINANCIAL STATEMENTS; OTHER REPORTS. The Company and each Subsidiary will maintain proper books of account and records in accordance with GAAP applied on a consistent basis, and will deliver to each holder of Series B Preferred Stock (or Affiliate transferee thereof) owning at least fifty thousand Preferred Shares (each, a "Rights Holder"): (i) as soon as available and in any event within forty-five (45) days after the end of each of the first three quarters of each fiscal year of the Company, a copy of the Company's quarterly Report on Form 10-Q or Form 10-QSB, prepared in accordance with GAAP consistently applied (subject to year-end audit adjustments), and duly certified by the Chief Financial Officer of the Company; (ii) as soon as available and in any event within ninety (90) days after the end of each fiscal year of the Company, a copy of Company's Annual report on Form 10-K or Form 10-KSB, prepared in accordance with GAAP consistently applied, together with the annual audit report for such year by one of the "big six" independent public accountants of recognized standing; (iii) promptly after sending, making available, or filing the same, such other reports and financial statements as the Company shall send or make available to the stockholders of the Company; and (iv) in the event that the Company ceases to become subject to the provisions of Section 13 or 15(d) of the Exchange Act, all reports and other documents that would be required to be filed by the Company under the Securities Act and the Exchange Act if the Company were then subject to the provisions of Section 13 or 15(d) of the Exchange Act, at the times and in the manner that such reports and documents would be required to be so filed. Neither the foregoing provisions of this Section 6.01(a) nor any other provision of this Agreement shall be in limitation of any rights which a Purchaser may have with respect to the books and records of the Company and its Subsidiaries, or to inspect their properties or discuss their affairs, finances and accounts, under the laws of the jurisdictions in which they are incorporated. 16 (b) BOARD OBSERVATION; INSPECTION. Each Rights Holder and such agents, advisors and counsel as such Rights Holder may designate, may, at its expense, (i) attend and observe each meeting (whether physical or telephonic) of the Company's Board of Directors or any committee thereof (and with respect to which the Company covenants and agrees to provide each Rights Holder with reasonable advance notice) or (ii) visit and inspect any of the properties of the Company and each Subsidiary, examine the books of account of the Company and each Subsidiary, take extracts therefrom and discuss the affairs, finances and accounts of the Company and each Subsidiary with its officers and employees and public accountants (and by this provision the Company and each Subsidiary hereby authorizes said accountants to discuss with such Rights Holder and such persons its finances and accounts), at reasonable times and with reasonable prior notice during normal business hours. All such visits and inspections shall be conducted in a manner which will not unreasonably interfere with the normal business operations of the Company and each Subsidiary. (c) PRESERVATION OF CORPORATE EXISTENCE. The Company and each Subsidiary will preserve and maintain its corporate existence, rights, franchises and privileges in the jurisdiction of its incorporation, and qualify and remain qualified, as a foreign corporation in each jurisdiction in which such qualification is necessary or desirable in view of its business and operations or the ownership of its properties. The Company and each Subsidiary shall preserve and maintain all licenses and other rights to use patents, processes, licenses, trademarks, trade names, inventions, copyrights and other Intangibles owned or possessed by it and necessary to the conduct of its business. (d) COMPLIANCE WITH LAWS. The Company will comply, and cause each of its Subsidiaries to comply, with all applicable laws, rules, regulations and orders of any governmental authority, noncompliance with which could materially adversely affect its business or condition, financial or otherwise. (e) BOARD OF DIRECTORS. The Company shall at all times maintain provisions in its By-laws or certificate of incorporation indemnifying all directors against liability and providing for the advancement of expenses to the maximum extent permitted under the laws of the jurisdiction of its incorporation. (f) AVAILABILITY OF COMMON STOCK. The Company shall, from time to time, in accordance with the laws of the state of its incorporation increase the authorized amount of Common Stock if at any time the number of shares of Common Stock remaining unissued and available for issuance shall be insufficient to permit the conversion of all the then outstanding Preferred Shares. (g) USE OF PROCEEDS. The Company shall use the net proceeds from the issuance and sale of the Shares solely to fund ordinary operating expenses of the Company. (h) CERTAIN PATENT MATTERS. The Company represents that certain of its intellectual property is licensed to it by the University of Florida Research Foundation (the "UFRF"). The Company agrees to comply with its royalty and other contractual obligations 17 to UFRF in order to maintain its rights to the intellectual property licensed by UFRF, in each case to the extent it is commercially reasonable for the Company to do so. (i) INDEMNIFICATION. The Company shall indemnify, defend and hold each Purchaser and its officers, directors, partners, employees and agents and each other Person which controls (within the meaning of the Securities Act) such Purchaser or any of its partners harmless against all liability, loss or damage, together with all reasonable costs and expenses related thereto (including legal and accounting fees and expenses), arising from, relating to, or connected with (i) the untruth, inaccuracy or breach of any representations, warranties or covenants contained herein or (ii) the use, generation, storage, release, threatened release, discharge, disposal or presence of Hazardous Materials (as defined below) on, under or about any properties owned or leased by the Company by any Person during the period that the Company was the legal or equitable owner of any properties owned or leased by the Company or which occurred prior to such time and was otherwise actually known by, or should have been known by, the Company. The obligation of the Company to indemnify each Purchaser and its officers, directors, partners, employees and agents and each other Person which controls (within the meaning of the Securities Act) such Purchaser or any of its partners shall specifically cover and include, without limitation, all fines and penalties imposed by federal, state or local authorities, costs of removing or neutralizing the Hazardous Materials, injury to the property adjoining any properties owned or leased by the Company, injury to persons living or working on or about any properties owned or leased by the Company or adjoining or otherwise affecting property, and all other indirect or consequential damages incurred by each Purchaser and its officers, directors, partners, employees and agents and each other Person which controls (within the meaning of the Securities Act) such Purchaser or any of its partners. SECTION 6.02 CERTAIN NEGATIVE COVENANTS. Without limiting any other covenants or provisions hereof, the Company covenants and agrees that it will comply with and observe the following negative covenants and provisions, and will cause each Subsidiary to comply with and observe such of the following covenants and provisions as are applicable to such Subsidiary, if and when such Subsidiary exists, and will not without the written consent or written waiver of the holders of at least 66-2/3% of the holders of the Series B Preferred Stock, do any of the actions set forth in the following covenants and provisions so long as any Series B Preferred Stock remains outstanding: (a) NO AVOIDANCE. The Company will not, by amendment of its Certificate of Incorporation or through any consolidation, merger, reorganization, transfer of assets, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Agreement or the certificates evidencing the issuance of the Conversion Shares. Without limiting the generality of the foregoing, the Company (i) will not permit the par value or the determined or stated value of any shares of the Company's Common Stock receivable upon the conversion of the Preferred Shares to exceed the amount payable therefor upon such exercise, (ii) will take all such action as may be necessary or appropriate in order that the Company may validly and legally issue fully paid and non-assessable shares of the Company's Common Stock, upon the conversion of the Preferred Shares 18 from time to time outstanding, including, without limitation, amending its Certificate of Incorporation to reduce or eliminate the par value of the Common Stock and (iii) will not take any action which results in an adjustment in the number of Conversion Shares obtainable upon the conversion of the Preferred Shares if the total number of shares of the Company's Common Stock (or other securities) issuable after such action upon the exercise or conversion of all of the then-outstanding Preferred Shares would exceed the total number of shares of the Company's Common Stock (or other securities) then authorized by the Company's Certificate of Incorporation and available for purpose of issuance upon such exercise. (b) PROTECTIVE PROVISIONS. The Company shall not engage in any of the actions specified in Section 5 of the Series B Certificate of Designation. (c) TRANSACTIONS WITH RELATED PARTIES. Other than in the ordinary course of business of the Company, neither the Company nor any Subsidiary will engage in any transaction with, or enter into any contract, agreement or other arrangement providing for, the employment of, furnishing of services by, rental of real or personal property from, or otherwise requiring payments to, any officer, employee or director of the Company or any Related Party of such persons or entities (other than pursuant to the terms of employment or consulting arrangements by the Company disclosed in the Company's SEC Reports or any such agreements that hereafter shall be approved by the Company's Board of Directors). For purposes of this Agreement, "Related Party" shall mean any individual who is a director or officer of the Company; any Person who is an "affiliate" of the Company, as such term is defined in Rule 405 under the Securities Act; any Person that owns five percent or more of the outstanding equity stock of any class of the Company; any member of the family (as defined in Section 267(c)(4) of the Internal Revenue Code) of, or any individual who has the same home as, any individual (or the spouse of any such individual) described above; and any trust, estate or partnership of which an individual described above is a guarantor, fiduciary, beneficiary or partner. (d) BUSINESS. The Company will only engage in the business of research, development and production of pharmaceutical products and activities ancillary thereto. (e) CONFLICTING AGREEMENTS. The Company will not enter into any agreement which by its terms might restrict the performance of the Company's obligations pursuant to the terms of this Agreement or the provisions relating to the Series B Preferred Stock included in the Series B Certificate of Designation, including, but not limited to, registration rights and the payment of dividends on, the redemption, voting or conversion of the Series B Preferred Stock. (f) EMPLOYEE STOCK AND STOCK OPTIONS. The Company will not issue Common Stock or stock options to its officers, directors, employees or others who render services to the Company except for issuances of stock options and issuances of shares of Common Stock upon exercise of such stock options which, in each case, constitute Excluded Shares (as defined in the Series B Certificate of Designation). 19 (g) NO CHANGES. Between the date of execution of this Agreement and the Closing Date, and except for the filing of the Series B Certificate of Designation, the Company shall not, without the prior written consent of the Purchasers: (a) issue any capital stock or any option, warrant or right to acquire capital stock; (b) organize any Subsidiary; (c) make any change in its capital stock; (d) declare or pay any dividends or make any distributions in respect of its capital stock; (e) enter into any merger or consolidation or other business combination, (f) repurchase any stock, or (g) enter into any material transaction, agreement, understanding or commitment; provided that, for purposes of (g) above, the prior written consent of the Purchasers shall not be required in the event that the directors selected by the Purchasers consent to such action. (h) ENVIRONMENTAL MATTERS. (i) The Company shall promptly advise each holder of the Series B Preferred Stock in writing of any pending or threatened claim, demand or action by any governmental body or third party relating to any Hazardous Materials affecting any properties owned or leased by the Company of which it has knowledge. The Company shall not discharge, place, release, spill or dispose of any Hazardous Materials or any other pollutants or effluents upon any properties owned or leased by the Company or elsewhere (including, but not limited to, underground injection of such substances) other than in compliance with the Applicable Environmental Laws and the Company shall not discharge into the air any emission which would require a permit under the Clean Air Act or its state counterparts or any other Applicable Environmental Laws. The stockholders of the Company shall have no control over, or authority with respect to, the waste disposal operations of the Company. (ii) The use of any property by the Company, and any future development, construction and operation of property purchased, leased or otherwise acquired by the Company, shall, in all respects, comply with, and are or shall be, lawful, permitted and conforming uses in all material respects under all applicable building, fire, safety, subdivision, zoning, sewer, environmental, securities, health, insurance and other laws, ordinances, rules, regulations and plan approval conditions of any governmental or public body or authority. SECTION 6.03 CERTAIN ADDITIONAL NEGATIVE COVENANTS. Without limiting any other covenants or provisions hereof, the Company covenants and agrees that it will comply with and observe the following negative covenants and provisions, and will cause each Subsidiary to comply with and observe such of the following covenants and provisions as are applicable to such Subsidiary, if and when such Subsidiary exists, and will not without the written consent or written waiver (which consent or waiver shall not be unreasonably withheld) of the holders of at least 66-2/3% of the holders of the Series B Preferred Stock, do any of the actions set forth in the following covenants and provisions so long as any Series B Preferred Stock remains outstanding: (a) INDEBTEDNESS: COMMITMENTS. The Company will not incur (a) Indebtedness in excess of $100,000, or (b) Commitments (defined below) in excess of $100,000 in the aggregate. For purposes of this Agreement, "Commitments" shall mean all obligations of the Company and its Subsidiaries, contingent or otherwise, pursuant to long-term leases (other 20 than leases for real property), or other obligations pursuant to similar agreements which, in each case, are required to be capitalized in accordance with GAAP. (b) GUARANTEES. The Company will not incur any guarantee or similar contingent obligation in respect of the Indebtedness of others in excess of $100,000, whether or not classified on the Company's balance sheet as a liability. (c) NO ACQUISITIONS. The Company shall not, nor shall it permit any of its Subsidiaries to, acquire or agree to acquire by merging or consolidating with, or by purchasing a substantial equity interest in or a substantial portion of the assets of, or by any other manner, any business or any corporation, partnership, association or other business organization or division thereof or otherwise acquire or agree to acquire, or permit any of its Subsidiaries to acquire or agree to acquire, any assets for a purchase price which is in excess of ten percent (10%) of the Company's net worth. (d) NO DISPOSITIONS. Other than in the ordinary course of business and other than dispositions of obsolete assets, the Company will not, nor shall it permit any of its Subsidiaries to, sell, lease, encumber or otherwise dispose of or agree to sell, lease, encumber or otherwise dispose of, in any transaction or series of related transactions, assets having an aggregate book value in excess of ten percent (10%) of the Company's net worth. SECTION 6.04. (a) TERMINATION OF SECTION 6.03 CERTAIN ADDITIONAL NEGATIVE COVENANTS. The Company's obligations under the provisions set forth in Section 6.03 above shall terminate on the earlier to occur of (i) the second anniversary of the Closing Date or (ii) the date on which the closing price of the Common Shares of the Company on NASDAQ (or, if not then listed on NASDAQ, listed on any other national securities market) shall have exceeded $10.00 per share (subject to adjustment) for a period of 60 consecutive days. ARTICLE VII REGISTRATION RIGHTS SECTION 7.01. (a) INCIDENTAL REGISTRATION. If the Company at any time (other than pursuant to subsection (b) below)) proposes to register any of its securities under the Securities Act for sale to the public, whether for its own account or for the account of other security holders or both (except with respect to registration statements on Forms S-4, S-8 or any successor to such forms or another form not available for registering the Registrable Securities for sale to the public), each such time it will promptly give written notice to all holders of the Registrable Securities of its intention so to do. Upon the written request of any such holder, received by the Company within thirty (30) days after the giving of any such notice by the Company, to register any or all of its Registrable Securities, the Company will use its best efforts to cause the Registrable 21 Securities as to which registration shall have been so requested to be included in the securities to be covered by the registration statement proposed to be filed by the Company, all to the extent requisite to permit the sale or other disposition by the holder (in accordance with its written request) of such Registrable Securities so registered. If the registration of which the Company gives notice is for a registered public offering involving an underwriting, the Company shall so advise the holders of Registrable Securities as a part of the written notice given pursuant to this Section 7.01(a). In such event the right of any holder of Registrable Securities to registration pursuant to this Section 7.01(a) shall be conditioned upon such holder's participation in such underwriting to the extent provided herein. All holders of Registrable Securities proposing to distribute their securities through such underwriting shall (together with the Company and the Other Shareholders (as defined below) distributing their securities through such underwriting) enter into an underwriting agreement in customary form with the underwriter or underwriters selected for underwriting by the Company. Notwithstanding any other provision of this Section 7.01(a), if the underwriter determines that marketing factors require a limitation on the number of shares to be underwritten, the Company shall so advise all holders of securities requesting registration of any limitations on the number of shares to be underwritten, and the number of shares of securities that are entitled to be included in the registration and underwriting shall be allocated (i) first to the Company with respect to shares of Common Stock being sold for its own account; and (ii) then, to holders of Registrable Securities and Other Shareholders requesting registration in proportion, as nearly as practicable, to the respective amounts of securities owned by them. Notwithstanding the foregoing provisions, the Company may withdraw any registration statement referred to in this Section 7.01(a) without thereby incurring any liability to the holders of Registrable Securities. If any holder of Registrable Securities disapproves of the terms of any such underwriting, it may elect to withdraw therefrom by written notice to the Company and the underwriter. Any Registrable Securities or other securities excluded or withdrawn from such underwriting shall be withdrawn from such registration. (b) REGISTRATION ON FORM S-3. (i) In addition to the rights provided in Section 7.01(a), subject to a limit of one (1) registration hereunder in any six (6) month period, if at any time (A) any holder or holders of the Registrable Securities request that the Company file a registration statement on Form S-3 or any comparable or successor form thereto for a public offering of all or any portion of the shares of Registrable Securities held by such requesting holder or holders, the reasonably anticipated aggregate price to the public of which would exceed US $500,000, and (B) the Company is a registrant entitled to use Form S-3 or any comparable or successor form thereto to register such shares, then the Company shall use its best efforts to register under the Securities Act on Form S-3 or any comparable or successor form thereto, for public sale in accordance with the method of disposition specified in such notice, the number of shares of Registrable Securities specified in such notice. (ii) Following receipt of any notice under this Section 7.01(b), the Company shall immediately notify all holders of Registrable Securities from whom notice has not been received and such holders shall then be entitled within thirty (30) days after 22 receipt of such notice from the Company to request the Company to include in the requested registration all or any portion of their shares of Registrable Securities. The Company shall use its best efforts to register under the Securities Act, for public sale in accordance with the method of disposition specified in the notice from requesting holders described in paragraph (a) above, within 45 days of its receipt of such notice, the number of shares of Registrable Securities specified in such notice (and in all notices received by the Company from other holders within thirty (30) days after the receipt of such notice by such holders). Notwithstanding anything to the contrary contained herein, no request may be made under this Section 7.01(b) after the effective date of a registration statement filed by the Company covering a firm commitment underwritten public offering and prior to the later to occur of the completion of the period of distribution for such offering or 90 days after the effective date of such registration statement. (iii) If the holders requesting such registration intend to distribute the Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 7.01(b) and the Company shall include such information in the written notice referred to in paragraph (ii) above. The right of any holder to registration pursuant to this Section 7.01(b) shall be conditioned upon such holder's agreeing to participate in such underwriting and to permit inclusion of such holder's Registrable Securities in the underwriting. If such method of disposition is an underwritten public offering, the holders of at least a majority in interest of the shares of Registrable Securities to be sold in such offering may designate the managing underwriter of such offering, which managing underwriter shall be reasonably acceptable to the Company. A holder may elect to include in such underwriting all or a part of the Registrable Securities it holds. (iv) A registration statement filed pursuant to this Section 7.01(b) may, subject to the following provisions, include (A) shares of Common Stock for sale by the Company for its own account, (B) shares of Common Stock held by officers or directors of the Company and (C) shares of Common Stock held by persons who are entitled to include such shares in such registration (the "Other Shareholders"), in each case for sale in accordance with the method of disposition specified by the requesting holders; PROVIDED, HOWEVER, that if the number of shares so included pursuant to clauses (A), (B) and (C) above exceeds the number of Registrable Securities presented by the holders requesting registration thereof, then such registration shall be deemed to be a registration in accordance with Section 7.01(a). If such registration shall be underwritten, the Company, such officers and directors and Other Shareholders proposing to distribute their shares through such underwriting shall enter into an underwriting agreement in customary form with the representative of the underwriter or underwriters selected for such underwriting on terms no less favorable to such officers, directors or Other Shareholders than the terms afforded the holders of Registrable Securities. If and to the extent that the managing underwriter determines that marketing factors 23 require a limitation on the number of shares to be included in such registration, then the shares of Common Stock held by officers or directors (other than Registrable Securities) of the Company or by Other Shareholders (other than Registrable Securities) and shares of Common Stock to be sold by the Company for its own account shall be excluded from such registration to the extent so required by such managing underwriter, and unless the holders of such shares and the Company have otherwise agreed in writing, such exclusion shall be applied first to the shares held by the directors and officers and the Other Shareholders to the extent required by the managing underwriter, then to the shares of Common Stock of the Company to be included for its own account to the extent required by the managing underwriter. If the managing underwriter determines that marketing factors require a limitation of the number of Registrable Securities to be registered under this Section 7.01(a), then Registrable Securities shall be excluded in such manner that the securities to be sold shall be allocated among the selling holders pro rata based on their ownership of Registrable Securities. In any event all securities to be sold other than Registrable Securities will be excluded prior to any exclusion of Registrable Securities. No Registrable Securities or any other security excluded from the underwriting by reason of the underwriter's marketing limitation shall be included in such registration. If any holder of Registrable Securities, officer, director or Other Shareholder who has requested inclusion in such registration as provided above, disapproves of the terms of the underwriting, such holder of securities may elect to withdraw therefrom by written notice to the Company and the managing underwriter. The securities so withdrawn shall also be withdrawn from registration. Except for registration statements on Form S-4, S-8 or any comparable form or successor thereto, the Company will not file with the Commission any other registration statement with respect to its Common Stock, whether for its own account or that of other stockholders, from the date of receipt of a notice from requesting holders pursuant to this Section 4.3 until the completion of the period of distribution of the registration contemplated thereby or 120 days after the effective date of such registration, whichever is later. SECTION 7.02. REGISTRATION PROCEDURES. In connection with the Company's requirement to use its best efforts to effect the registration of any Registrable Shares under the Securities Act, the Company will, as expeditiously as possible: (a) prepare and file with the Commission such amendments and supplements to such registration statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective for the period specified herein and comply with the provisions of the Securities Act with respect to the disposition of all Registrable Shares covered by such registration statement in accordance with the sellers' intended method of disposition set forth in such registration statement for such period; (b) furnish to each seller of Registrable Shares such number of copies of the registration statement and each such amendment and supplement thereto (in each case including all exhibits) and the prospectus included therein (including each preliminary 24 prospectus) as such persons reasonably may request in order to facilitate the public sale or other disposition of the Registrable Shares covered by such registration statement; (c) use its best efforts to register or qualify the Registrable Shares covered by such registration statement under the securities or "blue sky" laws of such jurisdictions as the sellers of Registrable Shares reasonably shall request, PROVIDED, HOWEVER, that the Company shall not for any such purpose be required to qualify generally to transact business as a foreign corporation in any jurisdiction where it is not so qualified or to consent to general service of process in any such jurisdiction, unless the Company is already subject to service in such jurisdiction; (d) use its best efforts to list the Registrable Shares covered by such registration statement with any securities exchange on which the Common Stock of the Company is then listed; (e) comply with all applicable rules and regulations under the Securities Act and Exchange Act; (f) immediately notify each seller of Registrable Shares under such registration statement, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the happening of any event of which the Company has knowledge as a result of which the prospectus contained in such registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing, and promptly prepare and furnish to such seller a reasonable number of copies of a prospectus supplemented or amended so that, as thereafter delivered to the purchasers of such Registrable Shares, such prospectus shall not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing; (g) make available for inspection by each seller of Registrable Shares, and any attorney, accountant or other agent retained by such seller reasonable access to all financial and other records, pertinent corporate documents and properties of the Company, as such parties may reasonably request, and cause the Company's officers, directors and employees to supply all information reasonably requested by any such seller, attorney, accountant or agent in connection with such registration statement; (h) cooperate with the selling holders of Registrable Shares to facilitate the timely preparation and delivery of certificates representing Registrable Shares to be sold, such certificates to be in such denominations and registered in such names as such holders or the managing underwriter may request at least two business days prior to any sale of Registrable Shares; and (i) permit any holder of Registrable Shares which holder, in the sole and exclusive judgment, exercised in good faith, of such holder, might be deemed to be a 25 controlling person of the Company, to participate in good faith in the preparation of such registration or comparable statement and to require the insertion therein of material, furnished to the Company in writing, which in the reasonable judgment of such holder and its counsel should be included. In connection with each registration hereunder, the sellers of Registrable Shares will furnish to the Company in writing such information requested by the Company with respect to themselves and the proposed distribution by them as shall be necessary in order to assure compliance with Federal and applicable state securities laws; and such sellers shall provide the Company with appropriate representations with respect to the accuracy of such information. SECTION 7.03. EXPENSES. All expenses incurred in complying with Sections 7.01 and 7.02, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel and independent public accountants for the Company, fees and expenses (including counsel fees) incurred in connection with complying with state securities or "blue sky" laws, fees of the National Association of Securities Dealers, Inc., transfer taxes, fees of transfer agents and registrars, and reasonable fees and disbursements of one counsel selected by a majority in interest of the sellers of Registrable Shares, shall be paid by the Company. SECTION 7.04. INDEMNIFICATION AND CONTRIBUTION. (a) In the event of a registration of any of the Registrable Shares under the Securities Act pursuant to this Article VII, the Company will indemnify and hold harmless each holder of Registrable Shares, its officers, directors and partners, and each other person, if any, who controls such holder within the meaning of the Securities Act, against any losses, claims, damages or liabilities, joint or several, to which such holder, officer, director, partner or controlling person may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon (i) any untrue statement or alleged untrue statement of any material fact contained in any prospectus, offering circular or other document incident to such registration (including any related notification, registration statement under which such Registrable Shares were registered under the Securities Act pursuant to Section 7.01, any preliminary prospectus or final prospectus contained therein, or any amendment or supplement thereof), (ii) any blue sky application or other document executed by the Company specifically for that purpose or based upon written information furnished by the Company filed in any state or other jurisdiction in order to qualify any or all of the Registrable Shares under the securities laws thereof (any such application, document or information herein called a "Blue Sky Application"), (iii) any omission or alleged omission to state in any such registration statement, prospectus, amendment or supplement or in any Blue Sky Applications executed or filed by the Company, a material fact required to be stated therein or necessary to make the statements therein not misleading, (iv) any violation by the Company or its agents of the Securities Act or any rule or regulation promulgated under the Securities Act applicable to the Company or its agents and relating to action or inaction required of the Company in connection with such registration, or 26 (v) any failure to register or qualify the Registrable Shares in any state where the Company or its agents has affirmatively undertaken or agreed in writing that the Company will undertake such registration or qualification (provided that in such instance the Company shall not be so liable if it has used its best efforts to so register or qualify the Registrable Shares) and will reimburse each such seller, and such officer, director and partner, and each such controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action, promptly after being so incurred, PROVIDED, HOWEVER, that the Company will not be liable in any such case if and to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission so made in conformity with written information furnished by any such holder or any such controlling person in writing specifically for use in such registration statement or prospectus. (b) In the event of a registration of any of the Registrable Shares under the Securities Act pursuant to this Article VII, each seller of such Registrable Shares thereunder, severally and not jointly, will indemnify and hold harmless the Company, each person, if any, who controls the Company within the meaning of the Securities Act, each officer of the Company who signs the registration statement, each director of the Company, each other seller of Registrable Shares against all losses, claims, damages or liabilities, joint or several, to which the Company or such officer, director or other seller may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in any prospectus offering circular or other document incident to such registration (including any related notification, registration statement under which such Registrable Shares were registered under the Securities Act pursuant to Section 7.01, any preliminary prospectus or final prospectus contained therein, or any amendment or supplement thereof), or any Blue Sky Application or arise out of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and will reimburse the Company and each such officer, director and other seller for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action, promptly after being so incurred, PROVIDED, HOWEVER, that such seller will be liable hereunder in any such case if and only to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with information pertaining to such seller, as such, furnished in writing to the Company by such seller specifically for use in such registration statement or prospectus; and PROVIDED, FURTHER, HOWEVER, that the liability of each seller hereunder shall be limited to the proportion of any such loss, claim, damage, liability or expense which is equal to the proportion that the public offering price of the securities sold by such seller under such registration statement bears to the total public offering price of all securities sold thereunder, but not in any event to exceed the proceeds received by such seller from the sale of Registrable Shares covered by such registration statement. (c) Promptly after receipt by an indemnified party hereunder of notice of the commencement of any action, such indemnified party shall, if a claim in respect thereof is to 27 be made against the indemnifying party hereunder, notify the indemnifying party in writing thereof, but the omission so to notify the indemnifying party shall not relieve it from any liability which it may have to such indemnified party other than under this Section and shall only relieve it from any liability which it may have to such indemnified party under this Section if and to the extent the indemnifying party is prejudiced by such omission. In case any such action shall be brought against any indemnified party and it shall notify the indemnifying party of the commencement thereof, the indemnifying party shall be entitled to participate in and, to the extent it shall wish, to assume and undertake the defense thereof with counsel satisfactory to such indemnified party, and, after notice from the indemnifying party to such indemnified party of its election so to assume and undertake the defense thereof, the indemnifying party shall not be liable to such indemnified party under this Section for any legal expenses subsequently incurred by such indemnified party in connection with the defense thereof other than reasonable costs of investigation and of liaison with counsel so selected, PROVIDED, HOWEVER, that, if the defendants in any such action include both the indemnified party and the indemnifying party and the indemnified party shall have reasonably concluded that there may be reasonable defenses available to it which are different from or additional to those available to the indemnifying party or that the interests of the indemnified party reasonably may be deemed to conflict with the interests of the indemnifying party, the indemnified party shall have the right to select a separate counsel and to assume such legal defenses and otherwise to participate in the defense of such action, with the expenses and fees of such separate counsel and other expenses related to such participation to be reimbursed by the indemnifying party as incurred. No indemnifying party, in the defense of any such claim or action, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect to such claim or action. Each indemnified party shall furnish such information regarding itself or the claim in question as an indemnifying party may reasonably request in writing and as shall be reasonably required in connection with defense of such claim and litigation resulting therefrom. (d) In order to provide for just and equitable contribution to joint liability under the Securities Act in any case in which either (i) the Company, any holder of Registrable Shares exercising rights under this Agreement, or any controlling person of any such holder, makes a claim for indemnification pursuant to this Section but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case notwithstanding the fact that this Section provides for indemnification in such case, or (ii) contribution under the Securities Act may be required on the part of the Company, any such selling holder or any such controlling person in circumstances for which indemnification is provided under this Section; then, and in each such case, the Company and such holder will contribute to the aggregate losses, claims, damages or liabilities to which they may be subject (after contribution from others) in such proportion so that such holder is responsible for the portion represented by the percentage that the public offering price of its Registrable Shares offered by the registration statement bears to the public offering price of all securities offered by such registration statement, and the Company is responsible for the 28 remaining portion; PROVIDED, HOWEVER, that, in any such case, (A) no such holder of Registrable Shares will be required to contribute any amount in excess of the proceeds received from the sale of all such Registrable Shares offered by it pursuant to such registration statement; and (B) no person or entity guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any person or entity who was not guilty of such fraudulent misrepresentation. (e) The indemnities and obligations provided in this Section shall survive the transfer of any Registrable Shares by such holder. ARTICLE VIII LIMITATIONS AND RESTRICTIONS SECTION 8.01. RESTRICTIONS ON SALES BY PURCHASERS. Each Purchaser agrees that until the first anniversary of the Closing hereunder, it will not, nor will it permit any of its Affiliates to sell or propose to sell any Shares purchased at the Closing except as follows: (a) A Purchaser may transfer Shares to any of its Affiliates; (b) A Purchaser may sell its Shares pursuant to a tender offer or exchange offer for all outstanding shares of the Company's Common Stock approved by the Company's Board of Directors; (c) A Purchaser may (i) if such Purchaser is a partnership, distribute Shares to the partners of such partnership, (ii) transfer Shares to such Purchaser's children and/or grandchildren and/or such Purchaser's spouse's children and/or grandchildren, whether biological or adopted (collectively, such Purchaser's "descendants"), (iii) transfer Shares to the trustee or trustees of a trust revocable solely by such Purchaser, (iv) transfer Shares to the trustee or trustees of an irrevocable trust the sole beneficiaries of which are such Purchaser, his spouse and/or his descendants, (v) transfer Shares to a guardian or conservator, or (vi) transfer any such shares in the event of death to such Purchaser's heirs or the beneficiaries or the legal representative of his estate; and (d) A Purchaser may sell all or any part of the Shares owned by Purchaser or its Affiliates pursuant to the registration rights provisions contained in Article VII. 29 ARTICLE IX MISCELLANEOUS SECTION 9.01. NOTICES. All notices, requests, consents and other communications hereunder shall be in writing, shall be addressed to the receiving party's address set forth below or to such other address as a party may designate by notice hereunder, and shall be either (i) delivered by hand, (ii) made by telecopy or facsimile transmission (receipt confirmed) or (iii) sent by international overnight or express courier. 30 If to the Company: SunPharm Corporation The Veranda, Suite 301 814 Highway AIA Ponte Vedra Beach, FL 32082 Attn: President FAX: (904) 394-2727 with a copy to: Cecilia Bryant, General Counsel 1400 Prudential Drive, Suite 7 Jacksonville, FL 32207 FAX: (904) 398-5477 If to a Purchaser: at its address on Schedule A hereto with a copy to: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. One Financial Center Boston, MA 02111 Attn: Lewis J. Geffen, Esq. FAX: (617) 542-2241 All notices, requests, consents and other communications hereunder shall be deemed to have been given either (i) if by hand, at the time of the delivery thereof to the receiving party at the address of such party set forth above, (ii) if made by telecopy or facsimile transmission, at the time that receipt thereof has been acknowledged by electronic confirmation or otherwise, or (iii) if sent by overnight or express courier, on the Business Day following the day such notice is delivered to the courier service. SECTION 9.02. LEGENDS. Each Purchaser acknowledges that, until registered under the Securities Act and any applicable state securities laws or transferred pursuant to the provisions of Rule 144 promulgated under the Securities Act ("Rule 144"), each certificate representing a Share, whether upon initial issuance or upon any transfer thereof, shall bear a legend (and the Company and its transfer agent shall make a notation on its books of transfer to such effect), prominently stamped or printed thereon, in substantially the following form: "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF ANY APPLICABLE STATE OR OTHER JURISDICTION, HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE AND MAY NOT BE SOLD, MORTGAGED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF (1) AN EFFECTIVE REGISTRATION STATEMENT COVERING SUCH SECURITIES UNDER THE ACT AND ANY 31 SECURITIES LAWS OF ANY APPLICABLE STATE OR OTHER JURISDICTION, (2) AN EXEMPTION FROM REGISTRATION , PURSUANT TO RULE 144 UNDER THE ACT OR (3) A WRITTEN OPINION IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY TO THE EFFECT THAT REGISTRATION IS NOT REQUIRED PURSUANT TO SOME OTHER APPLICABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR UNDER OTHER APPLICABLE SECURITIES LAWS." SECTION 9.03. ENTIRE AGREEMENT. This Agreement embodies the entire agreement and understanding between the parties hereto with respect to the provisions hereof and supersedes all prior oral or written agreements and understandings relating to the provisions hereof, and no other statement, representation, warranty, covenant or agreement of any kind not expressly set forth in this Agreement shall affect, or be used to interpret, change or restrict, the express terms and provisions of this Agreement. SECTION 9.04. MODIFICATIONS AND AMENDMENTS. The terms and provisions of this Agreement may be modified or amended only by written agreement executed by the Company and the holders of not less than a majority of the outstanding, with the Series B Preferred Stock and the Common Stock voting together as a single class. SECTION 9.05. WAIVERS AND CONSENTS. Except as otherwise expressly provided herein, the terms and provisions of this Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the Company and the holders of not less than a majority of the outstanding Shares. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent. SECTION 9.06. ASSIGNMENT. The rights and obligations under this Agreement may not be assigned by either party hereto without the prior written consent of the other party (which consent shall not be unreasonably withheld), except that a Purchaser without the consent of the Company may assign this Agreement or any of its rights or obligations (i) to an Affiliate of the Purchaser or to an entity with which the Purchaser shall merge or consolidate or to which the Purchaser shall sell or assign all or substantially all of its assets or (ii) in compliance with the provisions of Section 4.01(b) or Section 8.01. SECTION 9.07. BENEFIT. All statements, representations, warranties, covenants and agreements in this Agreement shall be binding on the parties hereto and shall inure to the benefit of the respective successors and permitted assigns of each party hereto. Nothing in this Agreement shall be construed to create any rights or obligations except among the parties hereto, and no person or entity shall be regarded as a third-party beneficiary of this Agreement, except for the persons entitled to indemnification pursuant to the provisions of Article VII. 32 SECTION 9.08. GOVERNING LAW. This Agreement and the rights and obligations of the parties hereunder shall be construed in accordance with and governed by the law of the State of Delaware, without giving effect to the conflict of law principles thereof. SECTION 9.09. SEVERABILITY. In the event that any court of competent jurisdiction shall determine that any provision, or any portion thereof, contained in this Agreement shall be unenforceable in any respect, then such provision shall be deemed limited to the extent that such court deems it enforceable, and as so limited shall remain in full force and effect. In the event that such court shall deem any such provision, or portion thereof, wholly unenforceable, the remaining provisions of this Agreement shall nevertheless remain in full force and effect. SECTION 9.10. INTERPRETATION. The parties hereto acknowledge and agree that: (i) each party and its counsel reviewed and negotiated the terms and provisions of this Agreement and have contributed to its revision; (ii) the rule of construction to the effect that any ambiguities are resolved against the drafting party shall not be employed in the interpretation of this Agreement; and (iii) the terms and provisions of this Agreement shall be construed fairly as to all parties hereto and not in favor of or against any party, regardless of which party was generally responsible for the preparation of this Agreement. SECTION 9.11. HEADINGS AND CAPTIONS. The headings and captions of the various subdivisions of this Agreement are for convenience of reference only and shall in no way modify, or affect the meaning or construction of any of the terms or provisions hereof. SECTION 9.12. ENFORCEMENT. Each of the parties hereto acknowledges and agrees that the rights acquired by each party hereunder are unique and that irreparable damage would occur in the event that any of the provisions of this Agreement to be performed by the other party were not performed in accordance with their specific terms or were otherwise breached. Accordingly, in addition to any other remedy to which the parties hereto are entitled at law or in equity, each party hereto shall be entitled to an injunction or injunctions to prevent breaches of this Agreement by the other party. SECTION 9.13. NO WAIVER OF RIGHTS, POWERS AND REMEDIES. No failure or delay by a party hereto in exercising any right, power or remedy under this Agreement, and no course of dealing between the parties hereto, shall operate as a waiver of any such right, power or remedy of the party. No single or partial exercise of any right, power or remedy under this Agreement by a party hereto, nor any abandonment or discontinuance of steps to enforce any such right, power or remedy, shall preclude such party from any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. The election of any remedy by a party hereto shall not constitute a waiver of the right of such party to pursue other available remedies. No notice to or demand on a party not expressly required under this Agreement shall entitle the party receiving such notice or demand to any other or further notice or demand in similar or other circumstances or constitute a waiver of the rights of the party giving such notice or demand to any other or further action in any circumstances without such notice or demand. 33 SECTION 9.14. EXPENSES. Each of the parties hereto shall pay its own fees and expenses in connection with this Agreement and the transactions contemplated hereby whether or not the transactions contemplated hereby are consummated, except that (i) the Company shall pay the reasonable fees and expenses for one legal counsel for the Purchasers and (ii) in the event that the Closing does not occur through no fault of the Purchasers after execution of this Agreement, the Company shall be responsible for the reasonable and documented out of pocket expenses of the Purchasers. SECTION 9.15 CONFIDENTIALITY. Each of the Purchasers, on the one hand, and the Company, on the other hand, acknowledge and agree that any information or data it has acquired from the other, not otherwise properly in the public domain, was received in confidence. Each such party agrees not to divulge, communicate or disclose, or use to the detriment of the disclosing party or for the benefit of any other person or persons, or misuse in any way, any confidential information of the disclosing party concerning the subject matter hereof; PROVIDED that (i) the foregoing obligation with respect to the disclosure and use of such information shall not apply to any information which such party can demonstrate (A) was at the time of disclosure to such party or thereafter, but prior to its disclosure by such party to any third party, through no fault of such party, publicly available (other than as a result of disclosure by such party), (B) has been disclosed to such party on a non-confidential basis from a source other than any other party which, to such party's knowledge, was not prohibited from disclosing such information to such party by a legal, contractual, fiduciary or other obligation, (C) has been independently developed by the such party without the violation of any of my obligations under this Agreement or (D) is required to be disclosed by applicable law (including, without limitation, the federal securities laws), rule, regulation or regulatory body (including, without limitation, the National Association of Insurance Commissioners) and (ii) such party may, if required by subpoena or valid legal process, disclose any such information, but only to the extent so required and only after using its best efforts to give the other party or parties (as the case may be) prior notice of such required disclosure in order to afford such party or parties an opportunity to obtain an injunction, a protective order or other relief. SECTION 9.16. COUNTERPARTS. This Agreement may be executed in one or more counterparts, and by different parties hereto on separate counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. IN WITNESS WHEREOF, the parties hereto have executed this Agreement or caused this Agreement to be executed by their duly authorized representatives, as of the date first written above. SUNPHARM CORPORATION By: /s/ STEFAN BORG ----------------------------------- Name: Stefan Borg 34 Title: President Counterpart Signature Pages Begin on Next Page 35 COUNTERPART SIGNATURE PAGE FOR PURCHASERS The undersigned hereby agrees to become a party to that certain Securities Purchase Agreement dated as of March 31, 1999 (the "Agreement") among SunPharm Corporation (the "Company") and others. From and after the undersigned's execution and delivery and the Company's acceptance of this Counterpart Signature Page, the undersigned shall be a party to the Agreement. UNI-VEST ---------------------------------------- Printed Name of Purchaser ---------------------------------------- Signature of Purchaser Total Investment Amount: $500,000.00 --------------- Number of shares of Series B Redeemable Convertible Preferred Stock: 66,667 ------------ Aggregate Purchase Price for shares of Series B Redeemable Convertible Stock: $4.00 --------------------------------- Number of shares of Common Stock: 183,333 --------------------------------- Alternative a ------------- Aggregate Purchase Price for Shares of Common Stock: 1,273 ------------ Alternative B ------------- Number of 1997 Warrants Surrendered: ---------------------------------------- By: Claus Jorgensen ----------------------------- Title: Managing Director ----------------------------- Address: Nyropsgade 17 ----------------------------- 1602 Copenhagen ----------------------------- Denmark ------- Date: March 31, 1999 --------------------------------- Agreed and accepted as to 66,667 shares of Series B Redeemable - ------ Convertible Preferred Stock 183,333 shares of Common Stock - ------- SUNPHARM CORPORATION BY: /s/ STEFAN BORG ----------------------------- Title: President ------------------------- Date: March 31, 1999 ------------------------- SCHEDULE A Number of Number of Number of Cash Portion of Preferred Shares 1997 Warrants Common Shares Purchase Price Purchaser Purchased At Closing Surrendered At Closing Purchased At Closing Paid At Closing --------- -------------------- ---------------------- -------------------- --------------- Uni-Invest 66,667 183,333 $ 500,000 Niopsgade 17 Copenhagen V DK 1602 TOTAL 66,667 183,333 $ 500,000