As filed with the Securities and Exchange Commission on November 12, 2003
                                                      Registration No. 333-

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM S-8

             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933


                        CELL ROBOTICS INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)

            COLORADO                                      84-1153295
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)

     2715 BROADBENT PARKWAY, N.E.                             87107
       ALBUQUERQUE, NEW MEXICO                              (Zip Code)
(Address of principal executive offices)

                            2002 STOCK PURCHASE PLAN
                            (Full title of the plan)

                         Eutimio Sena, President and CEO
                        Cell Robotics International, Inc.
                          2715 Broadbent Parkway, N.E.
                          Albuquerque, New Mexico 87107
                                 (505) 343-1131
                    (Name and address of agent for service)




                                               CALCULATION OF REGISTRATION FEE


===================================== =================== ================== ==================== ==================
       TITLE OF EACH CLASS OF                             PROPOSED MAXIMUM    PROPOSED MAXIMUM        AMOUNT OF
          SECURITIES TO BE               AMOUNT TO BE      OFFERING PRICE    AGGREGATE OFFERING     REGISTRATION
           REGISTERED (1)                 REGISTERED        PER SHARE (2)         PRICE (2)              FEE
===================================== =================== ================== ==================== ==================
                                                                                             
Common Stock, $.004 par value         2,000,000 Shares          $.30              $600,000               $49
===================================== =================== ================== ==================== ==================


(1)      Shares of common stock of Cell Robotics International, Inc. (the
         "Company"), $.004 par value per share (the "Common Stock"), being
         registered hereby relate to shares issuable upon purchase by the
         Company's employees, directors and consultants pursuant to the
         Company's 2002 Stock Purchase Plan (the "Plan"). Pursuant to Rule 416
         promulgated under the Securities Act of 1933, as amended (the
         "Securities Act"), there are also being registered such additional
         shares of Common Stock as may become issuable pursuant to the
         anti-dilution provisions of the Plan.

(2)      Estimated pursuant to Rule 457(h) solely for the purpose of calculating
         the registration fee. The fee is calculated on the basis of the average
         of the bid and ask prices per share of Common Stock on the OTC Bulletin
         Board on November 10, 2003 ($.30), in accordance with Rule 457(c).





                           INCORPORATION BY REFERENCE

         The 2,000,000 shares of Common Stock being registered hereby shall be
issued under the 2002 Stock Purchase Plan, which was amended as of November 4,
2003, to increase the number of shares of Common Stock available for issuance
under the 2002 Stock Purchase Plan. Pursuant to Instruction E of Form S-8, the
contents of the Company's Registration Statements on Forms S-8 as filed with
Securities and Exchange Commission on September 30, 2002, Registration No.
333-100191 and March 26, 2003, Registration No. 333-104041, are incorporated by
reference herein.

ITEM 8.  EXHIBITS

EXHIBIT NO.                   TITLE
- -----------                   -----

4.1(1)             Specimen Certificate of Common Stock
5.1(2)             Legal Opinion of Neuman & Drennen, LLC
23.1(2)            Consent of Grant Thornton LLP
23.2(2)            Consent of KPMG LLP
23.2(2)            Consent of Neuman & Drennen, LLC (included in Exhibit 5.1)
24.1(2)            Power of Attorney (included on signature page)

_____________

(1)  Incorporated by reference from the Company's Pre-Effective Amendment No. 1
     to Registration Statement on Form SB-2 which was declared effective by the
     SEC on February 14, 1996.
(2)  Filed herewith.


                                      -2-



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Albuquerque, State of New Mexico, on November 10,
2003.

                             CELL ROBOTICS INTERNATIONAL, INC.


                             By: /s/ Eutimio Sena
                                 -----------------------------------------------
                                 Eutimio Sena
                                 Chief Executive Officer, President and Director


                                POWER OF ATTORNEY

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated. Each person whose signature appears below
hereby authorizes and appoints as his attorney-in-fact to sign on his behalf
individually and in the capacity stated below all amendments and post-effective
amendments to this Registration Statement as that attorney-in-fact may deem
necessary or appropriate.


/s/ Eutimio Sena                                               November 10, 2003
- ------------------------------------------
Eutimio Sena, Chief Executive Officer,
President and Director


/s/ Paul C. Johnson                                            November 10, 2003
- ------------------------------------------
Paul C. Johnson, Chief Financial Officer, Chief
Accounting Officer, Secretary and Director


/s/ Oton Tisch                                                 November 10, 2003
- ------------------------------------------
Oton Tisch, Director


/s/ Gary Oppedahl                                              November 10, 2003
- ------------------------------------------
Gary Oppedahl, Director


                                      -3-




                        CELL ROBOTICS INTERNATIONAL, INC.
                                INDEX TO EXHIBITS

EXHIBIT NO.                   TITLE
- -----------                   -----


4.1(1)             Specimen Certificate of Common Stock
5.1(2)             Legal Opinion of Neuman & Drennen, LLC
23.1(2)            Consent of Grant Thornton LLP
23.2(2)            Consent of KPMG LLP
23.2(2)            Consent of Neuman & Drennen, LLC (included in Exhibit 5.1)
24.1(2)            Power of Attorney (included on signature page)

_____________

(1)  Incorporated by reference from the Company's Pre-Effective Amendment No. 1
     to Registration Statement on Form SB-2 which was declared effective by the
     SEC on February 14, 1996.
(2)  Filed herewith.