EXHIBIT 99.1


SIMULATIONS PLUS
Integrating Science and Software

For Further Information:
SIMULATIONS PLUS, INC.
42505 10th Street West
Lancaster, CA 93534-7059
661.723.7723
www.simulations-plus.com

CONTACT:
Investor Relations
- ------------------
Ms. Renee Bouche
Simulations Plus, Inc.
661.723.7723
info@simulations-plus.com

For Immediate Release:
July 18, 2008

                    SIMULATIONS PLUS EXPLAINS ARS INVESTMENTS

LANCASTER, CA, JULY 18, 2008 - Simulations Plus, Inc. (NASDAQ: SLP), a leading
provider of software for pharmaceutical discovery and development, today
explained its position on auction rate securities (ARS).

Ms. Momoko Beran, chief financial officer for Simulations Plus, said, "We've had
a number of contacts by investors asking about our potential exposure through
auction rate securities (ARSs). We are issuing this press release in the
interest of full disclosure and to put to rest the speculation regarding how the
current ARS situation might affect Simulations Plus."

Ms. Beran continued, "We currently have 4 ARSs in our UBS account, each with a
face value of $250,000. One is a Kern County municipal security that is paying
about 5.9% interest. Another is a State of Missouri student loan bond that is
paying about 2.8% interest. The other two are State of Iowa student loan bonds
that currently pay zero percent because they had to pay as much as 17% earlier
in the year and the total interest for the year reached a cap. The cap is
indexed to the LIBOR, so if the LIBOR goes up they would begin paying interest
again. In any event, beginning January 1, they will again pay interest. All of
these bonds are rated AA+ or higher, with their principal insured in the event
of the failure of the issuer. As long as we hold all of the bonds, we should not
experience an actual loss. We have included the unrealized loss of $57,925 in
our financial reports for the 3rd quarter to reflect the reduction in market
value as reported by UBS. As of May 31, 2008, the market value of our ARSs was
$942,075. Further changes in market value subsequent to May 31, 2008, will be
recorded as they are reported to us by UBS.

"Investors may be aware of the $3.5 billion fund UBS has established to buy back
certain ARSs. This fund is being used to buy back tax-free, closed-end bonds and
does not currently apply to the bonds we have. On the other hand, our UBS
advisor has indicated that the Kern County and Missouri student loan bonds may
be called, in which case we would be paid the full face value. The Iowa bonds
are not likely to be called at this time; however they could be sold in less
than 12 months, although we are advised that the selling price would probably be
55-60% of face value. With our other cash well over $5 million, there is
currently no need for the Company to sell these securities at such a discount.
Even if we did, our cash position would be about $6.5 million instead of over
$6.7 million."



Walt Woltosz, chairman and chief executive officer of Simulations Plus, added,
"We understand the concern investors have in the current banking climate. The
detailed information we're providing regarding this issue is in the interest of
quelling the speculation that can get out of hand when the complete facts are
not known."

Mr. Woltosz added, "I want to make one other statement, this time concerning our
chief financial officer, Ms. Beran. Some investors have expressed concern about
her credentials. Although she is not a CPA, she passed all of her CPA exams the
first time, except for the legal exam, which she passed the second time. She
came to this country in her early 20's barely speaking English, so the legal
exam was a bit tougher. I've heard of CPA's who took the exams as many as five
or six times before passing them. She chose not to serve the required internship
in an auditing capacity to become a CPA. So I want investors to know that Ms.
Beran is extremely well-qualified to handle the company's finances. The timely
submittal of our SEC financial reports and the consistent compliments we've
received over the years from our auditing firms speak well to the hard work she
and her small staff do quarter after quarter."

ABOUT SIMULATIONS PLUS, INC.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery
and development software, which is licensed to and used in the conduct of drug
research by pharmaceutical, biotechnology, and drug delivery companies
worldwide. The Company has two other businesses, Words+, Inc. and FutureLab(TM),
which are based on its proprietary software technologies. Simulations Plus,
Inc., is headquartered in Southern California and trades on the NASDAQ under the
symbol "SLP." For more information, visit our Web site at
www.simulations-plus.com.

SAFE HARBOR STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995
- - With the exception of historical information, the matters discussed in this
press release are forward-looking statements that involve a number of risks and
uncertainties. Our actual future results could differ significantly from those
statements. Factors that could cause or contribute to such differences include,
but are not limited to: our ability to maintain our competitive advantages,
continued acceptance of our software, the general economics of the
pharmaceutical and disability industries, our ability to continue to attract and
retain highly qualified technical staff, and a sustainable market. Further
information on our risk factors is contained in our quarterly and annual reports
as filed with the Securities and Exchange Commission.


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