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      As filed with the Securities and Exchange Commission on June 26, 2001
                                             Registration No. 333-
         ===============================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                 ______________

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933
                             ASCENT PEDIATRICS, INC.
            (Exact Name of Registration as Specified in Its Charter)
DELAWARE     04-3047405
(State  or  Other  Jurisdiction  of     (I.R.S.  Employer
Incorporation  or  Organization)     Identification  No.)
       187 BALLARDVALE STREET, SUITE B125, WILMINGTON, MASSACHUSETTS 01887
             (Address of Principal Executive Offices)     (Zip Code)
                            1999 STOCK INCENTIVE PLAN
                          CALIFORNIA STOCK OPTION PLAN
                            (Full Title of the Plan)

                             EMMETT CLEMENTE, PH.D.
                       PRESIDENT AND CHAIRMAN OF THE BOARD
                             ASCENT PEDIATRICS, INC.
                       187 BALLARDVALE STREET, SUITE B125
                         WILMINGTON, MASSACHUSETTS 01887
                     (Name and address of agent for service)
                                 (978) 658-2500
          (Telephone Number, Including Area Code, of Agent for Service)
         ===============================================================






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CALCULATION  OF  REGISTRATION  FEE




                                               PROPOSED
TITLE OF                         AMOUNT         MAXIMUM           PROPOSED          AMOUNT OF
SECURITIES TO BE                  TO BE     OFFERING PRICE    MAXIMUM AGGREGATE    REGISTRATION
REGISTERED                     REGISTERED      PER SHARE       OFFERING PRICE          FEE
- -----------------------------  -----------  ---------------  -------------------  --------------
                                                                      
Depositary Shares, each
representing one share of
Common Stock,
 .00004 par value per share,
subject to a call option and
evidenced by a depositary
receipt                         950,000(1)              (2)  $        388,650(2)  $     97.16(2)
- -----------------------------  -----------  ---------------  -------------------  --------------
Common Stock
 .00004 par value per share            (3)        N/A              N/A                    (4)
- -----------------------------  -----------  ---------------  -------------------  --------------


 (1)     Consists  of  750,000  shares  issuable  pursuant  to  the  1999  Stock
Incentive  Plan  and  200,000  shares  issuable pursuant to the California Stock
Option  Plan.
 (2)     Estimated  solely  for  the purpose of calculating the registration fee
pursuant  to  Rules 457(c) and 457(h) of the Securities Act of 1933, as amended,
and based upon, where an exercise price has not been established, the average of
the  high  and  low closing per share prices of Depositary Shares as reported on
the  Over-The-Counter  Bulletin  Board on June 20, 2001.  In such cases where an
exercise  price  has  been  established, the weighted average exercise price has
been  used.
 (3)     Such  number  of  shares  of  Common  Stock  as  are represented by the
Depositary  Shares  registered  hereby.
 (4)     Because  the  Common  Stock  is  issued  for  no  consideration,  no
registration  fee  is  required  with  respect  thereto.



Exhibit  Index  on  page  8.
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          PART I.  INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

ITEM  1.  PLAN  INFORMATION.
     The  information  required by Part I is included in documents sent or given
to participants in the 1999 Stock Incentive Plan and the California Stock Option
Plan of Ascent Pediatrics, Inc. (the "Registrant") pursuant to Rule 428(b)(1) of
the  Securities  Act  of  1933,  as  amended  (the  "Securities  Act").
PART  II.  INFORMATION  REQUIRED  IN  THE  REGISTRATION  STATEMENT
ITEM  3.  INCORPORATION  OF  CERTAIN  DOCUMENTS  BY  REFERENCE.
     The  Registrant  is subject to the informational and reporting requirements
of  Sections  13(a),  14,  and  15(d) of the Securities Exchange Act of 1934, as
amended  (the  "Exchange Act"), and in accordance therewith files reports, proxy
statements  and  other  information  with the Securities and Exchange Commission
(the  "Commission").  The  following  documents,  which  are  filed  with  the
Commission,  are  incorporated  in  this  Registration  Statement  by reference:
     (1)        The  registrant's latest annual report filed pursuant to Section
13(a)  or  15(d) of the Exchange Act, or the latest prospectus filed pursuant to
Rule 424(b) of the Securities Act that contains audited financial statements for
the  Registrant's  latest fiscal year for which such statements have been filed.
     (2)     All  other  reports filed pursuant to Section 13(a) or 15(d) of the
Exchange Act since the end of the fiscal year covered by the prospectus referred
to  in  (1)  above.
     (3)     The  description  of  the Common Stock of the Registrant, par value
$.00004  per share, contained in the Registrant's registration statement on Form
8-A  dated  April  4,  1997  and  filed  under  the  Exchange Act, including any
amendment  or  report  filed  for  the  purpose  of  updating  such description.
     (4)     The  description  of  the  Depositary Shares of the Registrant, par
value $.00004 per share, contained in the Registrant's Registration Statement on
Form  8-A  dated  May  27,1999  and  filed under the Exchange Act, including any
amendment  or  report  filed  for  the  purpose  of  updating  such description.
     All  documents  subsequently  filed  by the Registrant pursuant to Sections
13(a),  13(c),  14,  and  15(d)  of  the  Exchange Act, prior to the filing of a
post-effective  amendment  which indicates that all Securities offered have been
sold  or which deregisters all Securities then remaining unsold, shall be deemed
to  be  incorporated  by reference herein and to be part hereof from the date of
the  filing  of  such  documents.  Any  statement  contained  in  a  document
incorporated or deemed to be incorporated by reference herein shall be deemed to
be modified or superseded for the purposes of this Registration Statement to the
extent  a statement contained herein or in any other subsequently filed document
which  also  is  or is deemed to be incorporated by reference herein modifies or
supersedes such statement.  Any statement so modified or superseded shall not be
deemed,  except  as  so  modified  or  superseded,  to constitute a part of this
Registration  Statement.

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ITEM  4.  DESCRIPTION  OF  SECURITIES.
     Not  applicable.
ITEM  5.  INTERESTS  OF  NAMED  EXPERTS  AND  COUNSEL.
     The  Assistant  Secretary  to  the Registrant, David E. Redlick, Esq., is a
senior  partner of Hale and Dorr LLP, counsel to the corporation.  Hale and Dorr
LLP  has  opined  as  to  the  securities  being  offered  by  this Registration
Statement.
ITEM  6.  INDEMNIFICATION  OF  DIRECTORS  AND  OFFICERS.
     Article  EIGHTH  of  the  Registrant's  Amended and Restated Certificate of
Incorporation  provides  that  no director of the Registrant shall be personally
liable  for any monetary damages for any breach of fiduciary duty as a director,
except  to  the  extent  that the Delaware General Corporation law prohibits the
elimination  or  limitation  of  liability  of directors for breach of fiduciary
duty.
     Article  NINTH  of  the  Registrant's  Amended  and Restated Certificate of
Incorporation provides that a director or officer of the Registrant (a) shall be
indemnified  by the Registrant against all expenses (including attorneys' fees),
judgments,  fines and amounts paid in settlement incurred in connection with any
litigation or other legal proceeding (other than an action by or in the right of
the  Registrant)  brought against him by virtue of his position as a director or
officer  of  the  Registrant  if  he  acted  in  good  faith  and in a manner he
reasonably  believed  to  be  in,  or  not opposed to, the best interests of the
Registrant,  and,  with  respect  to  any  criminal action or proceeding, has no
reasonable  cause  to  believe  his  conduct  was  unlawful  and  (b)  shall  be
indemnified  by  the Registrant against all expenses (including attorneys' fees)
and  amounts  paid in settlement incurred in connection with any action by or in
the  right  of the Registrant brought against him by virtue of his position as a
director  or officer of the Registrant if he acted in good faith and in a manner
he  reasonably  believed  to be in, or not opposed to, the best interests of the
Registrant,  except  that  no  indemnification shall be made with respect to any
matter  as  to  which  such  person shall have been adjudged to be liable to the
Registrant,  unless  a  court  determines that, despite such adjudication but in
view  of  all  of  the  circumstances, he is entitled to indemnification of such
expenses.  Notwithstanding  the  foregoing,  to  the  extent  that a director or
officer  has  been  successful,  on  the merits or otherwise, including, without
limitation,  the  dismissal of an action without prejudice, he is required to be
indemnified  by  the Registrant against all expenses (including attorneys' fees)
incurred  in  connection therewith.  Expenses shall be advanced to a director or
officer at his request, provided that he undertakes to repay the amount advanced
if  it  is  ultimately determined that he is not entitled to indemnification for
such  expenses.
     Indemnification  is  required  to  be made unless the Registrant determines
that  the  applicable  standard  of conduct required for indemnification has not
been  met.  In  the event of a determination by the Registrant that the director
or  officer  did  not  meet  the  applicable  standard  of  conduct required for
indemnification,  or  if the Registrant fails to make an indemnification payment
within  60  days  after  such  payment is claimed by such person, such person is
permitted  to  petition  the  court  to  make an independent determination as to
whether such person is entitled to indemnification.  As a condition precedent to
the  right  of indemnification, the director or officer must give the Registrant
notice  of  the  action for which indemnity is sought and the Registrant has the
right  to  participate  in  such  action  or  assume  the  defense  thereof.

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     Article  NINTH  of  the  Registrant's  Amended  and Restated Certificate of
Incorporation  further provides that the indemnification provided therein is not
exclusive,  and provides that in the event that the Delaware General Corporation
Law is amended to expand the indemnification permitted to directors or officers,
the Registrant must indemnify those persons to the full extent permitted by such
law  as  so  amended.
     Section  145  of  the  Delaware  General  Corporation  Law  provides that a
corporation has the power to indemnify a director, officer, employee or agent of
the  corporation  and  certain  other  persons  serving  at  the  request of the
corporation  in related capacities against amounts paid and expenses incurred in
connection  with  an  action or proceeding to which he is or is threatened to be
made a party by reason of such position, if such person shall have acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests  of  the  corporation, and, in any criminal proceeding, if such person
had  no  reasonable cause to believe his conduct was unlawful; provided that, in
the  case  of  actions  brought  by  or  in  the  right  of  the corporation, no
indemnification shall be made with respect to any matter as to which such person
shall  have been adjudged to be liable to the corporation unless and only to the
extent  that  the  adjudicating  court  determines  that such indemnification is
proper  under  the  circumstances.
ITEM  7.  EXEMPTION  FROM  REGISTRATION  CLAIMED.
     Not  applicable.
ITEM  8.  EXHIBITS.
     The Exhibit Index immediately preceding the exhibits is incorporated herein
by  reference.
ITEM  9.  UNDERTAKINGS.
     1.     The  undersigned  Registrant  hereby  undertakes:
     (a)     To file, during any period in which offers or sales are being made,
a  post-effective  amendment  to  this  registration  statement:
(i)     To include any prospectus required by Section 10(a)(3) of the Securities
Act;
(ii)     To  reflect  in  the  prospectus  any facts or events arising after the
effective  date of the registration statement (or the most recent post-effective
amendment  thereof)  which,  individually  or  in  the  aggregate,  represent  a
fundamental  change  in the information set forth in the registration statement.
Notwithstanding  the foregoing, any increase or decrease in volume of securities
offered  (if  the total dollar value of securities offered would not exceed that
which  was  registered)  and  any  deviation  from  the  low  or high end of the
estimated  maximum  offering  range  may  be reflected in the form of prospectus
filed  with  the  Commission  pursuant  to Rule 424(b) if, in the aggregate, the
changes  in  volume and price represent no more than a 20% change in the maximum
aggregate  offering  price  set  forth  in the "Calculation of Registration Fee"
table  in  the  effective  registration  statement;  and

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(iii)     To  include  any  material  information  with  respect  to the plan of
distribution  not  previously  disclosed  in  the  registration statement or any
material  change  to  such  information  in  the  registration  statement;
provided, however, that paragraphs (i) and (ii) do not apply if the registration
- --------  -------
statement  is  on  Form  S-3  or  Form  S-8,  and the information required to be
included  in  a  post-effective  amendment  by  those paragraphs is contained in
periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d)
of  the  Exchange  Act  that  are  incorporated by reference in the registration
statement.
     (b)     That,  for  the  purpose  of  determining  any  liability under the
Securities  Act,  each such post-effective amendment shall be deemed to be a new
registration  statement  relating  to  the  securities  offered therein, and the
offering  of such securities at that time shall be deemed to be the initial bona
fide  offering  thereof.
(c)     To  remove  from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.
     2.     The  Registrant  hereby undertakes that, for purposes of determining
any  liability  under the Securities Act, each filing of the Registrant's annual
report  pursuant  to  Section  13(a)  or Section 15(d) of the Exchange Act (and,
where  applicable,  each  filing  of  an  employee  benefit plan's annual report
pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference
in the registration statement shall be deemed to be a new registration statement
relating  to the securities offered therein, and the offering of such securities
at  that  time  shall be deemed to be in the initial bona fide offering thereof.
3.     Insofar  as  indemnification for liabilities arising under the Securities
Act  may  be  permitted  to  directors,  officers and controlling persons of the
Registrant  pursuant  to  the foregoing provisions, or otherwise, the Registrant
has  been  advised that in the opinion of the Commission such indemnification is
against  public  policy  as  expressed  in the Securities Act and is, therefore,
unenforceable.  In  the  event  that  a  claim  for indemnification against such
liabilities  (other  than  the payment by the Registrant of expenses incurred or
paid  by  a  director,  officer  or  controlling person of the Registrant in the
successful  defense  of  any  action,  suit  or  proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has  been  settled  by  controlling  precedent, submit to a court of appropriate
jurisdiction  the  question whether such indemnification by it is against public
policy  as  expressed  in  the  Securities Act and will be governed by the final
adjudication  of  such  issue.

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                                   SIGNATURES
     Pursuant  to  the  requirements  of  the  Securities  Act,  the  Registrant
certifies  that  it  has  reasonable grounds to believe that it meets all of the
requirements  for  filing  on  Form  S-8  and  has duly caused this Registration
Statement  to  be  signed  on  its  behalf  by  the  undersigned, thereunto duly
authorized, in the Town of Wilmington, Commonwealth of Massachusetts on the 26th
day  of  June,  2001.
                                       ASCENT PEDIATRICS, INC.


                                       By:  /s/  Emmett  Clemente,  Ph.D.
                                       --------------------------------------
                                            Emmett  Clemente,  Ph.D.
                                            President and Chairman of the Board

                                POWER OF ATTORNEY
     We,  the  undersigned  officers  and  directors of Ascent Pediatrics, Inc.,
hereby  severally  constitute  Emmett Clemente, Ph.D. and Stuart M. Falber, Esq.
and  each of them singly, our true and lawful attorneys with full power to them,
and  each  of  them  singly,  to  sign for us and in our names in the capacities
indicated  below,  the Registration Statement on Form S-8 filed herewith and any
and  all  subsequent amendments to said Registration Statement, and generally to
do  all  such  things  in our names and behalf in our capacities as officers and
directors  to  enable Ascent Pediatrics, Inc. to comply with all requirements of
the  Securities  and  Exchange  Commission,  hereby ratifying and confirming our
signatures  as  they  may  be  signed by said attorneys, or any of them, to said
Registration  Statement  and  any  and  all  amendments  thereto.
     Pursuant  to  the  requirements  of  the  Securities Act, this Registration
Statement  has  been  signed  below  by  the following persons in the capacities
indicated  below  and  on  the  26th  day  of  June,  2001.






Signature                                               Title
- -----------------------------  -------------------------------------------------------
                            

/s/ Emmett Clemente, Ph.D.     President and Chairman of the Board
- -----------------------------
Emmett Clemente, Ph.D.         (Principal Executive, Financial and Accounting Officer)
___________________
- -----------------------------
Robert E. Baldini
                               Vice Chairman of the Board of Directors
/s/ Raymond F. Baddour, Sc.D.
- -----------------------------
Raymond F. Baddour, Sc.D.
                               Director
/s/ Nicholas Daraviras
- -----------------------------
Nicholas Daraviras
                               Director
___________________
- -----------------------------
James E. Flynn
                               Director
___________________
- -----------------------------
Brian P. Friedman
                               Director
/s/ Joseph R. Ianelli
- -----------------------------
Joseph R. Ianelli
                               Director
___________________
- -----------------------------
Andre L. Lamotte, Sc.D.
                               Director
/s/ James L. Luikart
- -----------------------------
James L. Luikart
                               Director


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                                INDEX TO EXHIBITS
NUMBER     DESCRIPTION
- ------     -----------
4.1(1)     Amended  and Restated Certificate of Incorporation of the Registrant.
4.2(2)     Certificate  of Designation, Voting Powers, Preferences and Rights of
Series  G  Convertible  Exchangeable  Preferred  Stock  of  the  Registrant.
 4.3(3)     Certificate of Designation, Voting Powers, Preferences and Rights of
Series  H  Convertible  Exchangeable  Preferred  Stock  of  the  Registrant.
4.4(1)     Amended  and  Restated  By-laws  of  the  Registrant.
4.5(1)     Specimen  Certificate  for  shares of Common Stock, par value $.00004
per  share,  of  the  Registrant.
4.6(2)     Specimen Certificate for Depositary Shares, $.00004 par value, of the
Registrant.
5.1     Opinion  of  Hale  and  Dorr  LLP,  counsel  to  the  Registrant.
23.1     Consent  of  Hale  and  Dorr  LLP  (included  in  Exhibit  5.1).
23.2     Consent  of  PricewaterhouseCoopers  LLP,  independent  accountants.
24.1     Power of Attorney (included in the signature pages of this Registration
Statement).
______________________
(1)     Previously  filed  with the Commission as an Exhibit to the Registrant's
Registration  Statement  on  Form  S-1,  as  amended  (File  No. 333-23319), and
incorporated  herein  by  reference.
(2)     Previously  filed  with  the Commission on May 27, 2000 as an Exhibit to
the  Registrant's  Registration  Statement  on  Form  S-4,  as amended (File No.
333-79383),  and  incorporated  herein  by  reference.
(3)     Previously  filed  with the Commission on January 16, 2001 as an Exhibit
to  the  Registrant's  Current  Report  on  Form  8-K  (File  No. 333-22347) and
incorporated  herein  by  reference.