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     AS  FILED  WITH  THE  SECURITIES AND EXCHANGE COMMISSION ON AUGUST 10, 2001
                                           REGISTRATION  NO.  333-56621

                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC  20549
                                 ______________

                        POST-EFFECTIVE AMENDMENT NO. 1 TO
                                    FORM S-3

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                             ASCENT PEDIATRICS, INC.
             (Exact name of registrant as specified in its charter)


                                    DELAWARE
         (State or other Jurisdiction of Incorporation or Organization)


                                    043047405
                     (I.R.S. Employer Identification Number)


                       187 Ballardvale Street, Suite B125
                              Wilmington, MA  01887
                                 (978) 658-2500
          (Address, including zip code, and telephone number, including
             area code, of registrant's principal executive offices)


                               Dr. Emmett Clemente
                             President and Chairman
                       187 Ballardvale Street, Suite B125
                              Wilmington, MA  01887
                                 (978) 658-2500
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                 With a copy to:
                             Stuart M. Falber, Esq.
                                Hale and Dorr LLP
                                 60 State Street
                           Boston, Massachusetts 02109
                                 (617) 526-6000

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     Approximate  date  of  commencement  of  proposed  sale  to the public: N/A
If  the only securities being registered on this form are being offered pursuant
to  dividend  or  interest  reinvestment  plans, please check the following box.
If  any  of  the securities being registered on this form are to be offered on a
delayed  or  continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment  plans,  check  the  following  box.
If this form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number  of  the earlier effective
registration  statement  for  the  same  offering.  __________
If  this  form is a post-effective amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box  and  list  the Securities Act
registration statement number of the earlier registration statement for the same
offering.  __________
If  delivery  of  the  prospectus  is  expected to be made pursuant to Rule 434,
please  check  the  following  box.

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                          DEREGISTRATION OF SECURITIES
     On  June  11,  1998,  Ascent  Pediatrics,  Inc.  (the  "Company")  filed  a
Registration  Statement  on  Form  S-3,  File  No.  333-56621 (the "Registration
Statement"),  for  the resale of an aggregate of 779,628 shares of common stock,
par value $.00004 per share, of the Company, each such share of common stock now
represented  by  a  depositary  share  and  represented by a depositary receipt,
pursuant  to  a  Securities Purchase Agreement, dated as of January 31, 1997, as
amended,  by  and among the Company, Triumph-Connecticut Limited Partnership and
the  other  purchasers identified therein. Pursuant to the Company's undertaking
contained  in the Registration Statement, this Post-Effective Amendment No. 1 to
the  Registration  Statement  is  being  filed  to  deregister all of the unsold
securities  formerly  registered  for  resale  under the Registration Statement.

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SIGNATURE

     Pursuant  to  Rule  478  promulgated  under the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of  the  requirements for filing this Post-Effective Amendment No. 1 on Form S-3
and has duly caused this Post-Effective Amendment No. 1 on Form S-3 to be signed
on  its  behalf  by  the  undersigned, thereunto duly authorized, in the Town of
Wilmington, in the Commonwealth of Massachusetts, as of this 10th day of August,
2001.
Ascent  Pediatrics,  Inc.
(Registrant)

By:  /s/  Dr.  Emmett  Clemente
- -------------------------------
Dr.  Emmett  Clemente
President  and  Chairman  of  the  Board
(Principal  Executive  Officer)