SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                  SCHEDULE TO
                                (RULE 14d-100)

         TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF
                      THE SECURITIES EXCHANGE ACT OF 1934

                            (AMENDMENT NO. 2)




                            Laboratorio Chile S.A.
                      (Name of Subject Company (Issuer))

                              IVAX Holdings C.I.
                         a wholly-owned Subsidiary of
                               IVAX Corporation

                   (Name of Filing Persons (Offerors))


                          American Depositary Shares
                 (Each Representing 20 Shares of Common Stock)
                          Common Stock, no par value
                       (Titles of Classes of Securities)

                    (50540H104) American Depositary Shares
                           (P6121Q106) Common Stock
                   (CUSIP Numbers of Classes of Securities)

                          Adrienne Fauz Cornejo, Esq.
                           Associate General Counsel
                               IVAX Corporation
                            4400 Biscayne Boulevard
                             Miami, Florida 33137
                                (305) 575-6000
                     (Name, Address and Telephone Number of
                    Person Authorized to Receive Notices
                      and Communications on Behalf of the
                          Person(s) Filing Statement)

                                  COPIES TO:


                                                  Jose Maria Eyzaguirre. Esq.
Laurie Green, Esq.                                Matias de Marchena, Esq.
Kara L. MacCullough, Esq.                         Claro y Cia.
Akerman, Senterfitt & Eidson, P.A.                Apoquindo 3721 - 13th floor
SunTrust International Center, 28th Floor         P.O. Box 1867
One Southeast Third Avenue                        Postal Code 6760352
Miami, Florida 33131-1714                         Santiago Chile
(305) 374-5600                                    (56-2) 367 30 00



================================================================================

  TRANSACTION VALUATION                         AMOUNT OF FILING FEE
- --------------------------------------------------------------------------------
           $ 518,350                                       $ 104(2)

================================================================================

(1)    The filing fee has been calculated pursuant to Rule 0-11(d) under the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), based upon
U.S. $25.00 per American Depositary Share ("ADS") with respect to 20,734
outstanding ADSs as of July 30, 2001, excluding ADSs beneficially owned by IVAX
Corporation ("IVAX") or its affiliates. The number of outstanding ADSs is based
upon information provided to the bidder by Laboratorio Chile S.A. ("LabChile").
Based upon information provided to the bidder by LabChile, there are no shares
of common stock, no par value (the "Shares"), excluding Shares represented by
ADSs and Shares beneficially owned by IVAX or its affiliates, held by U.S.
holders, as defined in Rule 14d-1(d) under the Exchange Act. Therefore, no fee
is being paid with respect to the acquisition of Shares.

(2)    The filing fee was paid on July 31, 2001, when the Schedule TO was
filed.


[_]    Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
       and identify the filing with which the offsetting fee was previously
       paid. Identify the previous filing by registration statement number on
       the Form or Schedule and the date of its filing.

       Amount Previously Paid:   N/A            Filing Party: N/A
       Form or Registration No.: N/A            Date Filed:   N/A

[_]    Check the box if the filing relates solely to preliminary communication
       made before the commencement of a tender offer.

       Check the appropriate boxes below to designate any transactions to which
       the statement relates:

       [X]   third-party tender offer subject to Rule 14d-1.

       [_]   issuer tender offer subject to Rule 13e-4.

       [_]   going-private transaction subject to Rule 13e-3.


    [_]   amendment to Schedule 13D under Rule 13d-E


[_]    Check the following box if the filing is a final amendment reporting the
       results of the tender offer:



       This Amendment No.2 to the Tender Offer Statement on Schedule TO, filed
initially on July 31, 2001, (the "Schedule TO") relates to an offer by IVAX
Holdings C.I. ("Purchaser"), a Cayman Islands company and a wholly-owned
subsidiary of IVAX Corporation, a Florida corporation ("IVAX"), to purchase all
outstanding American Depositary Shares (the "ADSs") of Laboratorio Chile S.A.
("LabChile") and all shares of common stock, no par value (the "Shares") of
LabChile held by U.S. holders within the meaning of Rule 14d-1(d) of the
Exchange Act, in each case not beneficially owned by IVAX or its affiliates,
upon the terms and subject to the conditions set forth in the U.S. Offer to
Purchase dated July 31, 2001 (the "Offer to Purchase"), and in the related ADS
Letter of Transmittal and Form of Acceptance, copies of which are attached to
the Schedule TO as Exhibits (a)(1), (a)(2) and (a)(8) (which are collectively
referred to as the "U.S. Offer Documents"). Each ADS represents 20 shares.


       The Purchaser and IVAX hereby amend and supplement the Schedule TO as
follows:


                                       2





ITEM 12.  EXHIBITS.

  (a)(12)  Press Release, dated September 6, 2001, issued by Ivax
           Corporation.


                                       3


                                   SIGNATURE

     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this Amendment No. 2 to the Schedule TO is
true, complete and correct.


                                        IVAX Corporation

September 6, 2001                       By:  /s/ Neil Flanzraich

                                           -----------------------------------
                                        Neil Flanzraich
                                        Vice Chairman and President

                                  SIGNATURE

     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this Amendment No. 2 to the Schedule TO is
true, complete and correct.


                                        IVAX Holdings C.I.

September 6, 2001                       By:  /s/ Neil Flanzraich

                                           -----------------------------------
                                        Neil Flanzraich
                                        President

                                       4



                                 Exhibit Index

Ex. No.     Exhibit Description
- --------    -------------------

99(a)(12)   Press Release, dated September 6, 2001, issued by IVAX Corporation.