UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING

(Check One): [_] Form 10-K and Form 10-KSB  [_] Form 20-F  [_] Form 11-K  [X]
Form 10-Q and Form 10-QSB [_] Form N-SAR

For Period Ended: March 31, 2002

[_] Transition Report on Form 10-K

[_] Transition Report on Form 20-F

[_] Transition Report on Form 11-K

[_] Transition Report on Form 10-Q

[_] Transition Report on Form N-SAR

For the Transition Period Ended: _______________________

    Nothing in this form shall be construed to imply that the Commission has
                   verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify
the items(s) to which the notification relates:

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PART I - REGISTRANT INFORMATION

Calypte Biomedical Corporation
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Full Name of Registrant:

______________________________
Former Name if Applicable

1265 Harbor Bay Parkway
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Address of Principal Executive Office (Street and Number)

Alameda, CA  94502
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City, State and Zip Code



PART II - Rules 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)

[X]          (a)  The reasons described in reasonable detail in Part III of this
             form could not be eliminated without unreasonable effort or
             expense;

[X]          (b)  The subject annual report, semi-annual report, transition
             report on Form 10-K, Form 20-F, 11-K, Form N-SAR, or portion
             thereof, will be filed on or before the fifteenth calendar day
             following the prescribed due date; or the subject quarterly report
             of transition report on Form 10-Q, or portion thereof will be filed
             on or before the fifth calendar day following the prescribed due
             date; and

[_]          (c)  The accountant's statement or other exhibit required by Rule
             12b-25(c) has been attached if applicable.

PART III - NARRATIVE

State below in reasonable detail the reasons why the Form 10-K, 11-K, 10-Q,
N-SAR, or the transition report or portion thereof, could not be filed within
the prescribed time period.

The Registrant was previously in the process of "winding up" its business and
has recently received a commitment for new financing so that it can continue its
operations. In conjunction with the financing commitment it appointed a new
executive chairman responsible for directing overall operations. Accordingly,
the Registrant is proceeding to obtain certain confirmations necessary for it to
resume and implement its business plan.

PART IV - OTHER INFORMATION

(1)  Name and telephone number of person to contact in regard to this
     notification
         Joseph A. Baratta              212                 750-9700
         -----------------              ---                 --------
         (Name)                 (Area Code)       (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or 15(d) of
     the Securities Exchange Act of 1934 or Section 30 of the Investment
     Company Act of 1940 during the preceding 12 months or for such shorter
     period that the registrant was required to file such report(s) been
     filed? If answer is no, identify report(s). [X]  Yes  [_]  No

(3)  Is it anticipated that any significant change in results of operations from
     the corresponding period for the last fiscal year will be reflected by the
     earnings statements to be included in the subject report or portion
     thereof? [X] Yes [_] No

     If so, attach an explanation of the anticipated change, both
     narratively and quantitatively, and, if appropriate, state the reasons
     why a reasonable estimate of the results cannot be made.

     Registrant expects to report a loss from operations for both periods
     presented, however, the first quarter 2002 loss will be approximately
     one third less than the first quarter 2001 loss, even though revenue
     for the first quarter of 2002 is 17% below that of the first quarter of
     2001. Additionally, the registrant expects to report an extraordinary
     gain of approximately $1.3 million in the first quarter of 2002
     resulting from the restructuring of trade payables with certain of its
     vendors and patent licensors.



                         Calypte Biomedical Corporation
                         ------------------------------
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Date  May 15, 2002
                                         By: /s/  Nancy E. Katz
                                            ------------------------------------
                                            Nancy E. Katz, President

INSTRUCTION: The form may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

Intentional misstatements or omissions of fact constitute Federal Criminal
Violations (See 18 U.S.C. 1001).