Exhibit 8.1 [Dechert Price & Rhoads Letterhead] June 7, 1999 Board of Directors AmeriSource Health Corporation 300 Chester Field Parkway Malvern, PA 19355 Re: Amended and Restated Agreement and Plan of Reorganization dated as of April 28, 1999 by and among AMERISOURCE HEALTH CORPORATION, HAWK ACQUISITION CORP., and C.D. SMITH HEALTHCARE, INC., as amended and restated as of May 27, 1999 Ladies and Gentlemen: We have acted as counsel to AmeriSource Health Corporation, a Delaware corporation ("Parent") in connection with the proposed merger (the "Merger") of Hawk Acquisition Corp. ("Sub"), a Missouri corporation and wholly-owned subsidiary of Parent with and into C.D. Smith Healthcare, Inc. ("Company"), a Missouri corporation pursuant to the Amended and Restated Agreement and Plan of Reorganization by and among Parent, Sub and the Company dated as of April 28, 1999, as amended and restated as of May 27, 1999 (the "Reorganization Agreement"). This opinion is being delivered in response to your request for our opinion regarding certain federal income tax consequences of the Merger. Except as otherwise provided, capitalized terms used but not defined herein shall have the meanings set forth in the Reorganization Agreement. All section references, unless otherwise indicated, are to the Internal Revenue Code of 1986, as amended (the "Code"). Pursuant to the Reorganization Agreement, Sub will be merged with and into the Company, and each share of Company Capital Stock (other than Dissenting Shares) will be exchanged solely for shares of Parent Common Stock. Only whole shares of Parent Common Stock will be issued in the Merger, and any fractional shares of Parent Common Stock will be rounded to the nearest whole share For the purpose of rendering this opinion, we have examined, and are relying upon (without any independent investigation or review thereof) the truth and accuracy, at all relevant times, of the statements, covenants, representations and warranties contained in the following documents (including all exhibits and schedules attached thereto): (a) the Reorganization Agreement; Board of Directors AmeriSource Health Corporation Page 2 (b) the Proxy Statement/Prospectus included in the Registration Statement on Form S-4 of the Company, as filed with the Securities and Exchange Commission (the "SEC") on May 28, 1999, and as amended (the "Proxy Statement'); (c) those certain tax representation letters dated on or about the date hereof delivered to us by Parent and Sub and by the Company containing certain representations of Parent, Sub and the Company (the "Tax Representation Letters"); and (d) such other instruments and documents related to the formation, organization and operation of Parent, Sub and the Company and related to the consummation of the Merger and the other transactions contemplated by the Reorganization Agreement as we have deemed necessary or appropriate. In connection with rendering this opinion, we have assumed (without any independent investigation or review thereof) that: 1. Original documents submitted to us (including signatures thereto) are authentic, documents submitted to us as copies conform to the original documents, and that all such documents have been (or will be by the Effective Time) duly and validly executed and delivered where due execution and delivery are a prerequisite to the effectiveness thereof; 2. All representations, warranties and statements made or agreed to by Parent, Sub and the Company, their managements, employees, officers, directors and stockholders in connection with the Merger, including, but not limited to, those set forth in the Reorganization Agreement (including the exhibits thereto) and the Tax Representation Letters are true, correct and complete at all relevant times; 3. All covenants contained in the Reorganization Agreement (including exhibits thereto) and the Tax Representation Letters have been or will be performed without waiver or breach of any material provision thereof; and 4. Any representation or statement made "to the best of knowledge" or similarly qualified is correct without such qualification. Based on our examination of the foregoing items and subject to the limitations, qualifications, assumptions and caveats set forth herein, we are of the opinion that, provided the Merger is consummated in accordance with the terms and conditions of the Reorganization Agreement and as set forth in the Proxy Statement, for federal income tax purposes, the Merger will constitute a reorganization within the meaning of Section 368(a) of the Code. Furthermore, it is our opinion that the description of the federal income tax consequences of the Merger under the caption "The Merger - Federal Income Tax Consequences" is true and accurate in all material respects. Board of Directors AmeriSource Health Corporation Page 3 This opinion does not address the various state, local or foreign tax consequences that may result from the Merger or the other transactions contemplated by the Reorganization Agreement. In addition, no opinion is expressed as to any federal income tax consequence of the Merger or the other transactions contemplated by the Reorganization Agreement except as specifically set forth herein, and this opinion may not be relied upon except with respect to the consequences specifically discussed herein. No opinion is expressed as to any transaction other than the Merger as described in the Reorganization Agreement, or as to any other transaction whatsoever, including the Merger, if all of the transactions described in the Reorganization Agreement are not consummated in accordance with the terms of the Reorganization Agreement and without waiver of any material provision thereof. To the extent that any of the representations, warranties, statements and assumptions material to our opinion and upon which we have relied are not accurate and complete in all material respects at all relevant times, our opinion could be adversely affected and should not be relied upon. This opinion may not apply to holders of Company Capital Stock who have received their shares for services rendered (for example, if the shares are substantially non-vested within the meaning of Section 83 of the Code or were acquired upon the exercise of incentive stock options under Section 422 of the Code). This opinion only represents our best judgment as to the federal income tax consequences of the Merger and is not binding on the Internal Revenue Service or any court of law, tribunal, administrative agency or other governmental body. The conclusions are based on the Code, existing judicial decisions, administration regulations and published rulings, all of which are subject to change, possibly with retroactive effect. No assurance can be given that future legislative, judicial or administrative changes or interpretations would not adversely affect the accuracy of the conclusions stated herein. Nevertheless, by rendering this opinion, we undertake no responsibility to advise you of any new developments in the application or interpretation of the federal income tax laws. Except as set forth below, this opinion is intended for your benefit, is not to be quoted, circulated or otherwise referred to without our express permission, and may not be relied upon or utilized for any other purpose or by any other person and may not be made available to any other person without our prior written consent. We hereby consent to the filing of this opinion as an exhibit to the Registration Statement on Form S-4 and to the reference to our firm under "Legal Matters" and "Federal Income Tax Consequences" in the Board of Directors AmeriSource Health Corporation Page 4 Proxy Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the SEC. Very truly yours, /s/ Dechert Price & Rhoads