EXHIBIT 3.1

                          CERTIFICATE OF INCORPORATION

                                       OF

                           NICHE PHARMACEUTICALS, INC.

         The  undersigned, being of legal age, in order to form a corporation
pursuant  to the  provisions  of the  General  Corporation  Law of the  State of
Delaware, does hereby certify as follows:

                                    ARTICLE I
         The  name of the corporation (hereinafter referred to as the
"Corporation") is NICHE PHARMACEUTICALS, INC.

                                   ARTICLE II
         The  registered  office of the  Corporation is located in the County of
Kent  at  15  East  North  Street,  Dover,  Delaware  19901.  The  name  of  the
Corporations's  registered agent at said address is United  Corporate  Services,
Inc.

                                   ARTICLE III
         The nature of the  business  of the  Corporation,  and the  objects and
purposes  proposed to be transacted,  promoted and carried on by it, shall be to
engage in any lawful act or activity  for which  corporations  may be  organized
under the General Corporation Law of Delaware.

                                   ARTICLE IV
         (a) The aggregate number of shares of stock which the Corporation shall
have the authority to issue is  17,000,000,  of which  15,000,000  are shares of
Common  Stock,  with a par value of $.01 per share,  and 2,000,000 are shares of
Preferred Stock, with a par value of $.01 per share.

         (b) The  Board of  Directors  hereby is vested  with the  authority  to
provide for the issuance of the  Preferred  Stock,  at any time and from time to
time, in one or more series, each of such series

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to  have  such   voting   powers,   designations,   preferences   and   relative
participating,  optional,  conversion and other rights, and such qualifications,
limitations or restrictions  thereon as expressly  provided in the resolution or
resolutions duly adopted by the Board of Directors providing for the issuance of
such shares or series thereof. The authority which hereby is vested in the Board
of Directors shall include,  but not be limited to, the authority to provide for
the following matters relating to each series of the Preferred Stock:

                     (i)  The designation of any series.

                     (ii)  The number of shares initially constituting any such
series.

                     (iii)  The increase, and the decrease, to a number not less
than the number of the outstanding shares of any such series, of the number of 
shares constituting such series theretofore fixed.
                     
                     (iv)  The rate or rates and the times at which dividends 
on the shares of Preferred Stock or any series  thereof  shall be paid,  and 
whether or not such dividends shall be cumulative, and, if such dividends shall
be cumulative, the date or dates from and after which they shall accumulate.

                     (v)  Whether or not the shares of Preferred Stock or series
thereof shall be redeemable, and, if such shares shall be redeemable, the terms
and conditions of such  redemption,  including  but not limited to the date or
dates upon or after which such shares  shall be  redeemable  and the amount per
share which shall be payable upon such redemption,  which amount may vary under
different conditions and at different redemption dates.

                     (vi)  The amount payable on the shares of Preferred Stock
or series thereof in the event of the voluntary or involuntary liquidation, 
dissolution or winding up of the Corporation; provided, however, that the 
holders of shares ranking senior to other shares shall be entitled to be

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paid, or to have set apart for payment,  not less than the liquidation  value of
such shares  before the holders of shares of the Common  Stock or the holders of
any other series of Preferred Stock ranking junior to such shares.

                     (vii)  Whether or not the shares of Preferred Stock or 
series thereof shall have voting  rights,  in addition to the voting rights 
provided by law, and, if such shares  shall  have  such  voting  rights,  the 
terms  and  conditions  thereof, including  but not limited to the right of the
holders of such shares to vote as a separate class either alone or with the 
holders of shares of one or more other class or series of Preferred  Stock and 
the right to have more than one vote per share.

                     (viii)  Whether or not a sinking fund shall be provided for
the redemption of the shares of Preferred Stock or series  thereof, and, if such
a sinking fund shall be provided, the terms and conditions thereof.

                     (ix)  Whether or not a purchase fund shall be provided for
the shares of Preferred Stock or series thereof, and, if such a purchase fund 
shall be provided, the terms and conditions thereof.

                     (x)  Whether or not the shares of Preferred Stock or series
thereof shall have conversion privileges, and, if such shares shall have 
conversion privileges, the terms and conditions of  conversion,  including but 
not limited to any provision for the adjustment of the conversion rate or the 
conversion price.

                     (xi)  Any other relative rights, preferences, qualifica-
tions, limitations and restrictions.


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                                    ARTICLE V

                     The  name and mailing  address  of the  incorporator of the
Corporation is:

                  Name                            Mailing Address

                  Gavin C. Grusd         Certilman Balin Adler & Hyman, LLP
                                         90 Merrick Avenue
                                         East Meadow, New York 11554

                                   ARTICLE VI

                  No action  required or  permitted to be taken at any annual or
special  meeting  of  stockholders  of the  Corporation  may be taken  without a
meeting, except upon the written consent of the holders of 100% of the shares of
capital stock of the  Corporation  entitled to vote on such action,  unless such
action has been authorized by the Board of Directors, in which event such action
may be taken by the  written  consent of the holders of not less than a majority
of the shares of capital stock entitled to vote on such action.

                                   ARTICLE VII

                  The following  provisions  are inserted for the  management of
the  business  and for the  conduct of the affairs of the  Corporation,  and for
further  definition,  limitation and regulation of the powers of the Corporation
and of its directors and stockholders.

                  (a) The number of directors of the  Corporation  shall be such
as from time to time  shall be fixed  by,  or in the  manner  provided  in,  the
By-Laws.  Election  of  directors  need not be by ballot  unless the  By-Laws so
provide.

                  (b) The Board of Directors shall have the power without the
assent or vote of the stockholders:

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                     (i)  To make, alter, amend, change, add to or repeal the
By-Laws of the Corporation;  to fix and vary the amount to be reserved for any 
proper  purpose; to authorize  and cause to be executed  mortgages and liens 
upon all or any part of the property of the Corporation;  to determine the use
and disposition of any surplus or net profits;  and to fix the time for the  
declaration and payment of dividends.

                     (ii) To determine from time to time whether, and to what 
times and places, and under what conditions the accounts and books of the 
Corporation  (other than the stock ledger) or any of them, shall be open to the
inspection  of the stockholders.
                 
                  (c) The Board of Directors in their  discretion may submit any
contract  or act for  approval  or  ratification  at any  annual  meeting of the
stockholders,  at any  meeting of the  stockholders  called  for the  purpose of
considering any such act or contract,  or through a written consent in lieu of a
meeting in accordance with the  requirements  of the General  Corporation Law of
Delaware as amended from time to time,  and any contract or act that shall be so
approved or be so ratified by the vote of the holders of a majority of the stock
of the  Corporation  which is  represented in person or by proxy at such meeting
(or by  written  consent  whether  received  directly  or  through a proxy)  and
entitled to vote thereon (provided that a lawful quorum of stockholders be there
represented  in person or by proxy)  shall be as valid and as  binding  upon the
Corporation  and upon  all the  stockholders  as  though  it had been  approved,
ratified,  or consented to by every  stockholder of the Corporation,  whether or
not the  contract  or act would  otherwise  be open to legal  attack  because of
directors' interest, or for any other reason.

                  (d)      In addition to the powers and authority hereinbefore
or by statute expressly conferred upon them, the directors are hereby empowered
to exercise all such powers

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and do all such acts and things as may be exercised or done by the  Corporation;
subject,  nevertheless,  to the  provisions  of the statutes of  Delaware,  this
Certificate of  Incorporation,  and to any By-Laws from time to time made by the
stockholders;  provided,  however,  that no ByLaws so made shall  invalidate any
prior act of the  directors  which  would have been valid if such By-Law had not
been made.

                                  ARTICLE VIII

                  Whenever a compromise or arrangement  is proposed  between the
Corporation  and  its  creditors  or  any  class  of  them  and/or  between  the
Corporation  and its  stockholders  or any class of them, any court of equitable
jurisdiction  within the State of Delaware may, on the  application in a summary
way of the  Corporation  or of any  creditor  or  stockholder  thereof or on the
application of any receiver  appointed for the Corporation  under the provisions
of Section 291 of Title 8 of the Delaware Code or on the application of trustees
in  dissolution  or of any receiver or receivers  appointed for the  Corporation
under the  provisions  of Section 279 of Title 8 of the Delaware  Code,  order a
meeting of the  creditors or class of creditors  and/or of the  stockholders  or
class of stockholders of the Corporation,  as the case may be, to be summoned in
such  manner as the said court  directs.  If a majority  in number  representing
three-fourths  in value of the  creditors or class of  creditors,  and/or of the
stockholders or class of stockholders  of the  Corporation,  as the case may be,
agree  to  any  compromise  or  arrangement  and to  any  reorganization  of the
Corporation  as a  consequence  of such  compromise  or  arrangement,  the  said
compromise or arrangement  and the said  reorganization  shall, if sanctioned by
the court to which the said  application  has been  made,  be binding on all the
creditors,  and/or  on all the  stockholders  or class of  stockholders,  of the
Corporation, as the case may be, and also on the Corporation.

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                                   ARTICLE IX

                  The original  By-Laws shall be adopted by the  incorporator of
the  Corporation.  Thereafter,  the Board of Directors or the  stockholders  may
adopt,  amend or repeal the  By-Laws in such  manner as may be by law or therein
provided, but any By-Laws made by the Board of Directors is subject to amendment
or repeal by the stockholders of the Corporation.

                                    ARTICLE X

                  No  director  of  the  Corporation  shall  be  liable  to  the
Corporation  or its  stockholders  for monetary  damages for breach of fiduciary
duty as a director,  except for liability  (i) for any breach of the  director's
duty or  loyalty  to the  Corporation  or its  stockholders,  (ii)  for  acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law,  (iii) under Section 174 of the Delaware  General  Corporation
Law, or (iv) for any  transaction  from which the  director  derived an improper
personal  benefit,  it  being  the  intention  of the  foregoing  provisions  to
eliminate the liability of the Corporation's directors to the Corporation or its
stockholders  to the  fullest  extent  permitted  by  Section  102(b)(7)  of the
Delaware General Corporation Law, as amended from time to time.

                                   ARTICLE XI

                  The  directors  of the  Corporation  shall be elected in three
classes.  The number of directors in each class shall be fixed from time to time
by the Board of Directors of the corporation;  provided, however that the number
of  directors in any class shall not exceed the number of directors in any other
class by more  than one.  The  initial  term of  office  of the  first  class of
directors shall expire at the first annual meeting of  stockholders  after their
election,  the initial  term of office of the second  class of  directors  shall
expire at the second annual meeting of

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stockholders  after their  election  and the initial term of office of the third
class of  directors  shall expire at the third  annual  meeting of  stockholders
after their  election.  At each annual meeting of  stockholders  after 1999, the
directors  elected to succeed those whose terms have expired shall be identified
as being of the same class as the directors they succeed and shall be elected to
hold office until the third  succeeding  annual  meeting of  stockholders  after
their election. Notwithstanding the foregoing, however, each director shall hold
office until his successor shall have been duly elected and qualified, unless he
shall resign, become disqualified, disabled or shall otherwise be removed.

                     If the number of directors is changed, any increase or 
decrease in directors shall be apportioned among the classes so as to maintain 
all classes as equal in number as possible,  and any additional director elected
to any class shall hold office for a term which shall  coincide with the term of
the other directors in such class. No increase in the number of directors shall
shorten the term of any incumbent director.

                     Any vacancy occurring in the Board of Directors caused by 
the death, resignation,  or  removal  of a  director,  and any newly  created  
directorship resulting  from an  increase  in the  number  of  directors, may be
filled by a majority of the  directors  then in office,  although  less than a 
quorum.  Each director  chosen to fill a vacancy  or newly  created directorship
shall  hold office until the next election of the class for which such  director
shall have been chosen and until his successor shall be duly elected and 
qualified.


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                     Notwithstanding the foregoing paragraphs of this Article, 
whenever the holders of any preferred stock issued by the  Corporation  shall 
have the right, voting as a class or otherwise,  to elect directors,  the then 
authorized number of  directors  of the  Corporation  shall  be increased by the
number of the additional  directors so to be elected,  and the holders of such 
preferred stock shall be entitled, as a class or otherwise,  to elect such 
additional directors. Any  directors  so elected  shall hold office  until the 
next annual meeting of stockholders or until their rights to hold such office 
shall terminate pursuant to the provisions of such preferred stock, whichever is
earlier.

                                   ARTICLE XII

                  (a) Each person who was or is made a party or is threatened to
be made a party to or is  involved in any action,  suit or  proceeding,  whether
civil, criminal,  administrative or investigative  (hereinafter a "proceeding"),
by reason of the fact that he or she, or a person of whom he or she is the legal
representative,  is or was a  director  or  officer,  employee  or  agent of the
Corporation  or is or  was  serving  at the  request  of  the  Corporation  as a
director, officer, employee or agent of another corporation or of a partnership,
joint  venture,  trust or other  enterprise,  including  service with respect to
employee  benefit plans,  whether the basis of such proceeding is alleged action
in an  official  capacity as a  director,  officer,  employee or agent or in any
other capacity while serving as a director, officer, employee or agent, shall be
indemnified  and  held  harmless  by  the  Corporation  to  the  fullest  extent
authorized by the Delaware  General  Corporation  Law, as the same exists or may
hereafter be amended (but, in the case of any such amendment, only to the extent
that such amendment permits the Corporation to provide broader

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indemnification  rights than said law permitted the Corporation to provide prior
to such amendment),  against all expense,  liability and loss (including without
limitation,  attorneys fees,  judgments,  fines, ERISA excise taxes or penalties
and amounts paid or to be paid in settlement) reasonably incurred or suffered by
such person in connection therewith and such  indemnification  shall continue as
to a person  who has ceased to be a  director,  officer,  employee  or agent and
shall inure to the benefit of his or her heirs,  executors  and  administrators;
provided,  however,  that,  except as provided  in  paragraph  (b)  hereof,  the
Corporation  shall  indemnify  any  such  person  seeking   indemnification   in
connection with a proceeding (or part thereof)  initiated by such person only if
such  proceeding  (or part thereof) was  authorized by the Board of Directors of
the Corporation. The right to indemnification conferred in this Article shall be
a contract right and shall include the right to be paid by the  Corporation  the
expenses  incurred  in  defending  any such  proceeding  in advance of its final
disposition;  provided,  however,  that, if the Delaware General Corporation Law
requires,  the payment of such expenses incurred by a director or officer in his
or her capacity as a director or officer (and not in any other capacity in which
service  was or is  rendered  by  such  person  while  a  director  or  officer,
including,  without limitation,  service to an employee benefit plan) in advance
of the final  disposition  of a proceeding,  shall be made only upon delivery to
the Corporation of an undertaking,  by or on behalf of such director or officer,
to repay all amounts so advanced if it shall  ultimately be determined that such
director or officer is not  entitled  to be  indemnified  under this  Article or
otherwise.  The  Corporation  may, by action of its Board of Directors,  provide
indemnification  to employees and agents of the Corporation  with the same scope
and effect as the foregoing indemnification of directors and officers.

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                  (b) If a claim under paragraph (a) of this Article is not paid
in full by the  Corporation  within  thirty days after a written  claim has been
received by the Corporation,  the claimant may at any time thereafter bring suit
against  the  Corporation  to  recover  the unpaid  amount of the claim and,  if
successful in whole or in part,  the claimant  shall be entitled to be paid also
the expense of prosecuting  such claim. It shall be a defense to any such action
(other  than an action  brought  to  enforce a claim for  expenses  incurred  in
defending any proceeding in advance of its final  disposition where the required
undertaking,  if any is required, has been tendered to the Corporation) that the
claimant has not met the  standards of conduct which make it  permissible  under
the Delaware  General  Corporation  Law for the  Corporation  to  indemnify  the
claimant for the amount claimed, but the burden of proving such defense shall be
on the Corporation.  Neither the failure of the Corporation (including its Board
of Directors,  independent  legal counsel,  or its  stockholders) to have made a
determination  prior to the commencement of such action that  indemnification of
the  claimant  is  proper  in the  circumstances  because  he or she has met the
applicable  standard of conduct set forth in the  Delaware  General  Corporation
Law, nor an actual  determination  by the  Corporation  (including  its Board of
Directors, independent legal counsel, or its stockholders) that the claimant has
not met such applicable standard or conduct, shall be a defense to the action or
create a presumption  that the claimant has not met the  applicable  standard of
conduct.
                  (c) The right to  indemnification  and the payment of expenses
incurred in defending a proceeding in advance of its final disposition conferred
in this  Article  shall not be exclusive of any other right which any person may
have or hereafter acquire under any statute,

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provision  of the  Certificate  of  Incorporation,  By-Law,  agreement,  vote of
stockholders or disinterested directors or otherwise.

                  (d) The Corporation may maintain insurance, at its expense, to
protect itself and any director,  officer,  employee or agent of the Corporation
or another corporation,  partnership,  joint venture,  trust or other enterprise
against any such  expense,  liability  or loss,  whether or not the  Corporation
would have the power to indemnify such person against such expense, liability or
loss under the Delaware General Corporation Law.

                                  ARTICLE XIII

                  The Corporation  reserves the right to amend, alter, change or
repeal any provision of this  Certificate of  Incorporation in the manner now or
hereafter  prescribed  by law,  and all rights and  powers  conferred  herein on
stockholders, directors and officers are subject to this reserved power.

                  IN WITNESS  WHEREOF,  the  undersigned  hereby  executes  this
document and affirms that the facts set forth herein are true under penalties of
perjury this 4th day of October, 1996.



                                                   /s/Gavin C. Grusd
                                                   Gavin C. Grusd, Incorporator
















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