LOAN AGREEMENT

         This LOAN  AGREEMENT  ("Agreement")  is made and entered into effective
the 11 day of January,  1991, by and between  STEPHEN F. BRANDON  ("Lender") and
NICHE PHARMACEUTICALS, INC., a Texas corporation ("Borrower").

         WHEREAS,  Borrower  desires to obtain a loan from  Lender and Lender is
willing to make such loan on the terms and conditions hereinafter set forth;

         NOW, THEREFORE, in consideration of the mutual covenants and conditions
herein contained, the parties agree as follows:

         1. LOAN.  Lender shall make  available to Borrower an aggregate  sum of
Five Hundred Thousand Dollars  ($500,000.00) for loan to Borrower.  Borrower may
from time to time during the term of this  Agreement  make requests for advances
on the loan,  such  advances not to exceed in the aggregate the principal sum of
Five Hundred Thousand Dollars ($500,000.00). Any amounts advanced under the loan
shall bear interest at the rate of ten percent (10%) per annum.

         2. REPAYMENT. Borrower shall repay any or all amounts advanced by 
Lender hereunder upon demand by Lender therefor.  Borrower's obligation to repay
to Lender any amounts advanced hereunder shall be represented by Borrower's 
promissory note to Lender executed contemporaneously herewith and attached 
hereto.

         3. TERM. This Agreement shall be in effect for a period of one (1) year
from the effective date hereof.  This Agreement shall be automatically renewed 
and extended for successive one year






periods  unless either party shall give written  notice of  termination at least
thirty (30) days prior to the end of the initial or any renewal term.

         4. SUCCESSORS AND ASSIGNS. The rights and obligations of the parties 
under this Agreement shall inure to the benefit of and shall be binding upon the
successors and assigns of the parties.

         5. PARAGRAPH HEADINGS. The paragraph headings contained herein  are for
convenience only, and do not purport to accurately summarize the contents of the
paragraph they head, and shall not modify, or in any way affect the provisions
of this Agreement or be of any relevance in the construction thereof.

         6. APPLICATION LAW. This Agreement shall be subject to, construed in 
accordance with, and governed by, the laws of the State of Texas.  Venue of any
legal proceeding hereunder shall be in Tarrant County, Texas.

         7. MUTUAL PREPARATION. Each party has read the foregoing Agreement, 
fully understands the contents thereof, and is under no duress or pressure of 
any sort to execute it.  This Agreement was mutually prepared and shall not be 
construed against any party by reason of his role in such preparation.

         8. MISCELLANEOUS.  In case any one or more of the provisions  contained
in this Agreement  shall,  for any reason,  be held to be invalid,  illegal,  or
unenforceable in any respect, such invalidity,  illegality,  or unenforceability
shall not affect any other  provisions  of this  Agreement,  but this  Agreement
shall be construed as if such invalid,  illegal, or unenforceable provisions had
never





been contained herein. If, moreover, any one or more of the provisions contained
in this Agreement shall,  for any reason,  be held to be excessively as to time,
duration,  geographical scope,  activity, or subject, it shall be construed,  by
limiting and reducing it, so as to be enforceable to the extent  compatible with
the applicable law as it shall then appear.

         9. COUNTERPARTS. This Agreement may be executed in multiple counter-
parts, but all counterparts taken together shall constitute one and the same 
agreement, binding upon all of the parties hereto.

         IN WITNESS  WHEREOF,  the parties  have  executed  this Loan  Agreement
effective the date set forth above.

                                         LENDER:

                                          /s/ Stephen F. Brandon
                                         ----------------------
                                         STEPHEN F. BRANDON


                                         BORROWER:

                                         NICHE PHARMACEUTICALS, INC.,
                                         A Texas corporation

                                         By:    /s/  Stephen F. Brandon
                                         ------------------------------
                                         STEPHEN F. BRANDON, President