NICHE PHARMACEUTICALS, INC.

                     1996 Senior Executive Stock Option Plan
                     ---------------------------------------

                  1.  Purpose of the Plan.  The Niche Pharmaceuticals, Inc.
1996 Senior  Executive Stock Option Plan (the "Plan") is intended to advance the
interests  of Niche  Pharmaceuticals,  Inc.  (the  "Company")  by  providing  an
incentive and reward for certain senior executives (the "Senior Executives") who
are in a position to contribute substantially to the progress and success of the
Company,  to  closely  align the  interests  of the Senior  Executives  with the
interests  of  stockholders  of  the  Company  by  linking   benefits  to  stock
performance  and to retain  the  services  of such  Senior  Executives.  This is
accomplished   by  providing  for  the  granting  of  "Options"  to  the  Senior
Executives.

                  2. Administration. The Plan shall be administered by the Board
of Directors of the Company (the "Board of  Directors")  or by a committee  (the
"Committee")  chosen by the Board of  Directors.  Except as herein  specifically
provided,  the  interpretation and construction by the Board of Directors or the
Committee of any  provision of the Plan or of any Option  granted under it shall
be final and conclusive.  The receipt of Options by Directors, or any members of
the Committee,  shall not preclude their vote on any matters in connection  with
the administration or interpretation of the Plan.



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                  3.     Shares Subject to the Plan.  The stock subject to
Options  granted under the Plan shall be shares of the  Company's  common stock,
par value $.01 per share (the "Common Stock"),  whether  authorized but unissued
or held  in the  Company's  treasury,  or  shares  purchased  from  stockholders
expressly for use under the Plan.  The maximum  number of shares of Common Stock
which may be issued  pursuant to Options granted under the Plan shall not exceed
in the  aggregate  four  hundred  five  thousand  (405,000)  shares,  subject to
adjustment in accordance  with the provisions of Section 11 hereof.  The Company
shall, at all times while the Plan is in force, reserve such number of shares of
Common  Stock  as  will  be  sufficient  to  satisfy  the  requirements  of  all
outstanding Options granted under the Plan.

                  4.     Participation; Number of Options.

                         (a) The Senior Executives that shall be eligible to
receive Options under the Plan shall be Stephen F. Brandon
("Brandon"), Thomas F. Reed ("Reed"), Jean Sperry ("Sperry") and
Allan Avery ("Avery").

                         (b) The Board of Directors may grant to the following
Senior Executives  Options covering the number of shares set forth next to their
respective names below:

                  Name               Number of Shares Underlying Options
                  ----               -----------------------------------

                  Brandon                        283,500
                  Reed                            72,900
                  Sperry                          24,300
                  Avery                           24,300

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                  5.     Options under the Plan.  The Options granted under
the Plan shall be subject to the following terms and conditions:

                         (a)  The option price of the shares subject to an
Option  shall be Five  Dollars  ($5.00)  per  share,  subject to  adjustment  in
accordance with the provisions of Section 11 hereof.

                         (b) The Options shall vest to the extent of one-third
(1/3) of the number of shares  covered  thereby in each of 1999,  2000 and 2001,
respectively,  upon the date that the Company's audited financial statements for
the fiscal  years ended  December  31, 1998,  1999 and 2000,  respectively,  are
issued,  provided that the Company's  cumulative  pre-tax income from operations
from January 1, 1997 through  December 31, 1997,  1998 or 1999,  as the case may
be, as reflected in the Company's audited financial  statements  through the end
of the  particular  fiscal year,  exceeds  $300,000,  $3,000,000 or  $7,500,000,
respectively,  without giving effect to any deferred  financing  costs resulting
from the  issuance  by the  Company to Dominant  Construction  Corp.  of 100,000
shares of Common Stock,  in the Company's  bridge  financing  transaction  which
closed on December 9, 1996 (the "Cumulative Goals"), provided, however, that, in
the event a Cumulative Goal through the end of a particular year is not met, the
installment of Options which would have vested for that  particular year had the
Cumulative Goal been met will nevertheless

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vest in a future  year if the  Cumulative  Goal which  relates to the vesting of
Options  through  the end of that  future  year is  met.  As an  example  of the
foregoing,  in the  event the  Company's  pre-tax  income  from  operations  (as
determined  above) for the first  fiscal  year ended  December  31,  1997 equals
$200,000,  the initial  one-third  installment of the Option will not then vest;
however,  in the event the  cumulative  pre-tax  income from  operations for the
fiscal  year ended  December  31, 1997 and 1998 equal  $3,100,000,  then at such
time,  the Option will vest to the extent of  two-thirds  of the shares  covered
thereby.

                         (c) The Options granted under the Plan shall expire
on  December  31,  2006 at 5:00 p.m.  Roanoke,  Texas time  (subject  to earlier
termination as expressly provided in Section 9 hereof).

                  6.     Stock Option Agreement.  Each Option granted under
the Plan shall be authorized by the Board of Directors or the
Committee, and shall be evidenced by a Stock Option Agreement which
shall be executed by the Company and by the Senior Executive to
whom such Option is granted.

                  7.     Rights of Option Holders.  The holder of any Option
granted under the Plan shall have none of the rights of a
stockholder with respect to the stock covered by his Option until
such stock shall be transferred to him upon the exercise of his
Option.

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                  8. Transferability.  No Option granted under the Plan shall be
transferable  by the Senior  Executive to whom it was granted  otherwise than by
Will or the laws of descent and  distribution,  and, during the lifetime of such
Senior Executive, shall not be exercisable by any other person, but only by him.

                  9.     Termination of Employment or Death.

                         (a)  Subject to the terms of the Stock Option
Agreement,  if the  employment  or  services  of a  Senior  Executive  shall  be
terminated  for cause or voluntarily  by the Senior  Executive,  then his Option
shall expire forthwith.  Subject to the terms of the Stock Option Agreement, and
except  as  provided  in  subsections  (b) and (c) of  this  Section  9, if such
employment or services  shall  terminate for any other reason,  then such Option
may be exercised  at any time within  three (3) months  after such  termination,
subject to the  provisions of subsection  (d) of this Section 9. For purposes of
the Plan, the retirement of a Senior  Executive  either pursuant to a pension or
retirement  plan  adopted  by the  Company  or at  the  normal  retirement  date
prescribed from time to time by the Company shall be deemed to be termination of
such Senior  Executive's  employment  other than  voluntarily or for cause.  For
purposes of this  subsection  (a), a Senior  Executive  who leaves the employ or
services of the Company to become an employee or non-employee  Director of, or a
consultant or advisor to, a

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subsidiary  corporation of the Company or a corporation (or subsidiary or parent
corporation of the corporation) which has assumed the Option of the Company as a
result of a corporate  reorganization,  etc.,  shall not be  considered  to have
terminated his employment.

                         (b)  If the Senior Executive holding an Option under
the Plan dies (i) while employed by, or while serving as a non-employee Director
for or a consultant  or advisor to, the Company or a subsidiary  corporation  of
the  Company,  or (ii)  within  three (3) months  after the  termination  of his
employment or services  other than  voluntarily  by the Senior  Executive or for
cause, then such Option may, subject to the provisions of subsection (d) of this
Section 9, be  exercised by the estate of the Senior  Executive,  or by a person
who acquired the right to exercise such Option by bequest or  inheritance  or by
reason of the death of such  Senior  Executive  at any time  within one (1) year
after such death.

                         (c)  Subject to the terms of the Stock Option
Agreement,  if the  Senior  Executive  holding an Option  under the Plan  ceases
employment  or services  because of permanent and total  disability  (within the
meaning of Section  22(e)(3) of the Code) while employed by, or while serving as
a  non-employee  Director  for or  consultant  or advisor  to, the  Company or a
subsidiary corporation of the Company, then such Option may, subject to the

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provisions of subsection  (d) of this Section 9, be exercised at any time within
one (1) year after his termination of employment, termination of Directorship or
termination of consulting or advisory  services,  as the case may be, due to the
disability.

                         (d)  An Option may not be exercised pursuant to this
Section 9 except  to the  extent  that the  Senior  Executive  was  entitled  to
exercise the Option at the time of  termination  of  employment,  termination of
Directorship,  termination of consulting or advisory services,  or death, and in
any event may not be exercised after the expiration of the Option.

                         (e)  For purposes of this Section 9, the employment
relationship of the Senior Executive will be treated as continuing  intact while
he is on  military  or sick leave or other  bona fide leave of absence  (such as
temporary  employment  by the  Government)  if such leave does not exceed ninety
(90) days,  or, if longer,  so long as his right to  reemployment  is guaranteed
either by statute or by contract.

                  10.    Exercise of Options.

                         (a) Upon vesting, any Option granted under the Plan
shall be exercisable as provided  herein,  in whole at any time, or in part from
time to time, prior to expiration.  The Board of Directors or the Committee,  in
its  absolute  discretion,  may provide in any Stock Option  Agreement  that the


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exercise of any Options granted  under the Plan shall be subject (i) to such 
condition or conditions as it may impose, and (ii) to such limitations as it may
impose.

                         (b)  An Option granted under the Plan shall be
exercised by the delivery by the holder  thereof to the Company at its principal
office  (attention of the  Secretary) of written  notice of the number of shares
with  respect  to which the  Option is being  exercised.  Such  notice  shall be
accompanied, or followed within ten (10) days of delivery thereof, by payment of
the full option price of such shares,  and payment of such option price shall be
made by the  holder's  delivery  of (i) his  check  payable  to the order of the
Company,  or (ii)  previously  acquired  Common Stock,  the fair market value of
which  shall  be  determined  as of the  date of  exercise,  or by the  holder's
delivery of any  combination  of the foregoing  (i) and (ii).  In addition,  the
holder shall,  upon  notification of the amount due and prior to or concurrently
with  delivery to the holder of a  certificate  representing  such  shares,  pay
promptly any amount necessary to satisfy applicable Federal,  state or local tax
withholding requirements (the "Withholding Tax"). Alternatively,  the Holder and
the  Company  can agree  prior to the  delivery  to the Holder of a  certificate
representing  such shares,  that the Company can withhold  such number of shares
issuable upon the exercise of the Option having a fair market value as 
determined as of the date of exercise equal to the amount necessary to satisfy 
the Withholding Tax.

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                  11.    Adjustment Upon Change in Capitalization.

                         (a)  In the event that the outstanding Common Stock
is  hereafter  changed  by  reason  of  reorganization,  merger,  consolidation,
recapitalization,  reclassification,  stock  split-up,  combination  of  shares,
reverse split,  stock dividend or the like, an appropriate  adjustment  shall be
made by the Board of  Directors  or the  Committee  in the  aggregate  number of
shares  available  under the Plan,  and in the number of shares and option price
per share subject to outstanding  Options.  If the Company shall be reorganized,
consolidated,  or merged with another corporation, the holder of an Option shall
be entitled to receive  upon the exercise of his Option the same number and kind
of shares of stock or the same  amount of  property,  cash or  securities  as he
would have been  entitled to receive upon the  happening  of any such  corporate
event as if he had been,  immediately  prior to such  event,  the  holder of the
number of shares covered by his Option.

                         (b)  Any adjustment in the number of shares shall
apply  proportionately  to only the  unexercised  portion of the Option  granted
hereunder.  If fractions of a share would result from any such  adjustment,  the
adjustment shall be revised to the next lower whole number of shares.

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                  12.    Further Conditions of Exercise.

                         (a)  Unless prior to the exercise of the Option the
issuance of the shares issuable upon such exercise have been registered with the
Securities  and Exchange  Commission  pursuant to the Securities Act of 1933, as
amended,  the notice of exercise  shall be accompanied  by a  representation  or
agreement  of the person or estate  exercising  the Option to the Company to the
effect that such shares are being acquired for investment  purposes and not with
a view to the  distribution  thereof,  or  such  other  documentation  as may be
required by the  Company,  unless in the opinion of counsel to the Company  such
representation,  agreement or documentation is not necessary to comply with such
Act.

                         (b)  The Company shall not be obligated to deliver
any Common Stock until it has been listed on each  securities  exchange on which
the Common Stock may then be listed and until there has been qualification under
or  compliance  with such  federal or state laws,  rules or  regulations  as the
Company may deem applicable.  The Company shall use reasonable efforts to obtain
such listing, qualification and compliance.

                  13.    Effectiveness of the Plan.  The Plan was adopted by
the Board of Directors on December 11, 1996.


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                  14.    Termination, Modification and Amendment.

                         (a)  The Plan (but not Options previously granted
under the Plan) shall  terminate on December 10, 2006,  which is within ten (10)
years  from the date of its  adoption  by the Board of  Directors,  or sooner as
hereinafter  provided,  and no Option shall be granted after  termination of the
Plan.

                         (b)  The Board of Directors may at any time, on or
before the termination  date referred to in Section 14(a) hereof,  terminate the
Plan, or from time to time make such  modifications or amendments to the Plan as
it may deem advisable.

                         (c)  No termination, modification, or amendment of
the Plan may,  without  the consent of the Senior  Executive  to whom any Option
shall have been granted, adversely affect the rights conferred by such Option.

                  15. Not a Contract of  Employment.  Nothing  contained  in the
Plan or in any Stock Option Agreement  executed  pursuant hereto shall be deemed
to confer  upon any  Senior  Executive  to whom an  Option is or may be  granted
hereunder  any right to remain in the  employ or  service  of the  Company  or a
subsidiary  corporation of the Company or any entitlement to any remuneration or
other benefit pursuant to any consulting or advisory arrangement.

                  16.    Use of Proceeds.  The proceeds from the sale of
shares pursuant to Options granted under the Plan shall constitute general funds
of the Company.

                 

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                  17.    Indemnification of Board of Directors or Committee.
In  addition  to such  other  rights of  indemnification  as they may have,  the
members of the Board of Directors or the Committee, as the case may be, shall be
indemnified by the Company to the extent  permitted under applicable law against
all  costs and  expenses  reasonably  incurred  by them in  connection  with any
action,  suit,  or  proceeding  to  which  they or any of them may be a party by
reason of any action  taken or failure  to act under or in  connection  with the
Plan or any rights  granted  thereunder  and against all amounts paid by them in
settlement  thereof or paid by them in  satisfaction  of a judgment  of any such
action, suit or proceeding, except a judgment based upon a finding of bad faith.
Upon the  institution  of any such action,  suit, or  proceeding,  the member or
members of the Board of  Directors or the  Committee,  as the case may be, shall
notify the Company in writing, giving the Company an opportunity at its own cost
to defend the same before such member or members undertake to defend the same on
his or their own behalf.

                  18.    Definitions.  For purposes of the Plan, the terms
"parent corporation" and "subsidiary corporation" shall have the meanings set
forth in Sections 424(e) and 424(f) of the Code, respectively, and the masculine
shall include the feminine and the neuter as the context requires.

                  19.    Governing Law.  The Plan shall be governed by, and all
questions arising hereunder shall be determined in accordance with, the laws of
the State of Delaware.

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