EXHIBIT 5.1


                                            [ROSS & HARDIES LETTERHEAD]


                                                   July 25, 1997


Enzon, Inc.
5601 West Howard Street
Niles, Illinois  60714

             Re:      Registration Statement on Form S-3

Ladies and Gentlemen:

          You have  requested  our opinion with respect to the  registration  by
Enzon,  Inc. (the  "Company")  pursuant to a Registration  Statement on Form S-3
(the "Registration Statement") under the Securities Act of 1933, as amended (the
"Act"),  of an aggregate of 1,015,228 shares of the Company's Common Stock, $.01
par value per share (the  "Common  Stock"),  issued upon the  conversion  of the
Company's  previously  outstanding  Series D Preferred Stock,  200,000 shares of
Common  Stock  issuable  upon  the  exercise  of  an  outstanding  warrant  (the
"Warrant") and up to 836,623 shares of Common Stock issuable upon the occurrence
of certain triggering events (herein a "Triggering  Event") specified in (i) the
Certificate of  Designations,  Rights and Preferences  relating to the Company's
Series D Preferred  Stock (the  "Certificate of  Designations")  and/or (ii) the
Registration Rights Agreement (the "Registration  Rights Agreement") dated March
15, 1996, by and among the Company and the other parties thereto.

          In so acting,  we have  examined  originals  or copies,  certified  or
otherwise identified to our satisfaction, of such documents,  corporate records,
certificates of public  officials and other  instruments and have conducted such
other investigations of fact and law as we have deemed relevant and necessary to
form a  basis  for  the  opinions  hereinafter  expressed.  In  conducting  such
examination,  we have assumed (i) that all signatures are genuine, (ii) that all
documents and instruments  submitted to us as copies conform with the originals,
and (iii) the due execution  and delivery of all  documents  where due execution
and delivery are a prerequisite to the  effectiveness  thereof.  As to any facts
material to this opinion,  we have relied upon statements and representations of
officers and other  representatives  of the Company and  certificates  or public
officials and have not independently verified such facts.

          Based upon the  foregoing,  it is our  opinion  that the Common  Stock
issued upon conversion of the previously outstanding Series D Preferred Stock is
validly issued fully paid and  non-assessable and that the Common Stock issuable
upon  the  proper  exercise  of the  Warrant  and/or  upon the  occurrence  of a
Triggering  Event will be validly  issued,  fully paid and  non-assessable  when
issued  in  accordance  with  the  terms of such  Warrant,  the  Certificate  of
Designations or the Registration Rights Agreement.

          We express no  opinion as to the laws of any  jurisdiction  other than
the State of New York and the United States of America. Insofar as the foregoing
opinion relates to matters that would be controlled by the  substantive  laws of
any  jurisdiction  other than the  United  States of America or the State of New
York, we have assumed that the substantive laws of such jurisdiction  conform in
all respects to the internal laws of the State of New York.



          We hereby  consent to the  reference  to our firm in the  Registration
Statement relating to the registration of 2,051,851 shares of Common Stock.

                                                      Very truly yours,

                                                      ROSS & HARDIES


                                                      By:  /S/KEVIN T. COLLINS
                                                      ------------------------
                                                           Kevin T. Collins
                                                           A Partner