As filed with the Securities and Exchange Commission on February 26, 2002 Registration No. 333-82012 - -------------------------------------------------------------------------------- SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ---------------------- POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ---------------------- ZYMOGENETICS, INC. (Exact name of registrant as specified in its charter) WASHINGTON 91-1144498 (State or other jurisdiction of (I.R.S. Employer Identification No.) incorporation or organization) 1201 EASTLAKE AVENUE E. SEATTLE, WA 98102 (206) 442-6600 (Address, including zip code, and telephone number, including area code of principal executive offices) AMENDED AND RESTATED 2000 STOCK INCENTIVE PLAN 2001 STOCK INCENTIVE PLAN (Full title of the plan) JAMES A. JOHNSON SENIOR VICE PRESIDENT, CHIEF FINANCIAL OFFICER AND TREASURER ZYMOGENETICS, INC. 1201 EASTLAKE AVENUE E. SEATTLE, WA 98102 (206) 442-6600 (Name, address and telephone number, including area code, of agent for service) ---------------------- COPIES TO: ANDREW BOR PERKINS COIE LLP 1201 THIRD AVENUE, SUITE 4800 SEATTLE, WASHINGTON 98101-3099 (206) 583-8888 ---------------------- POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 ZymoGenetics, Inc., a Washington corporation (the "Registrant"), is filing this Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 (Registration No. 333-82012) of the Registrant for the sole purpose of correcting a typographical error in the I.R.S. Employer Identification No. ("EIN") on the cover page of the Registration Statement on Form S-8 filed with the Securities and Exchange Commission on February 1, 2002. The correct EIN of the Registrant is 91-1144498. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Seattle, State of Washington, on the 25th day of February, 2002. ZYMOGENETICS, INC. By: /s/ James A. Johnson ---------------------------------------- James A. Johnson Senior Vice President, Chief Financial Officer and Treasurer Pursuant to the requirements of the Securities Act of 1933, as amended, this Post-Effective Amendment No. 1 to the Registration Statement has been signed by the following persons in the capacities indicated below on the 25th day of February, 2002. SIGNATURE TITLE Bruce L. A. Carter* President, - ---------------------------------------------- Chief Executive Officer, and Director Bruce L. A. Carter, Ph.D. (Principal Executive Officer) /s/ James A. Johnson Senior Vice President, - ---------------------------------------------- Chief Financial Officer and Treasurer James A. Johnson (Principal Accounting and Financial Officer) George B. Rathman* - ---------------------------------------------- George B. Rathman, Ph.D. Chairman of the Board of Directors David I. Hirsh* - ---------------------------------------------- David I. Hirsh, Ph.D. Director Jonathan S. Leff* - ---------------------------------------------- Jonathan S. Leff Director Kurt Anker Nielsen* - ---------------------------------------------- Kurt Anker Nielsen Director Edward E. Penhoet* - ---------------------------------------------- Edward E. Penhoet, Ph.D. Director Lori F. Rafield* - ---------------------------------------------- Lori F. Rafield, Ph.D. Director Lars Rebien Sorensen* - ---------------------------------------------- Lars Rebien Sorensen Director *By: /s/ James A. Johnson ------------------------------------------ James A. Johnson (Attorney-In-Fact)