Exhibit 10.5(e)

                                                [GRAPHIC OMITTED]
                                                    Cephalon, Inc.

                                                      145 Brandywine Parkway
                                                        West Chester, PA 19380
                                                          (215) 344-0200
                                                            Fax (215) 344-0065

                                 July 21, 1993


Genelco S.A.
8, Route de Beaumont
1701 Fribourg
Switzerland

                      Re: Amendment to Trademark Agreement
                          --------------------------------

Gentlemen:

     This letter agreement shall serve as an amendment to the Trademark
Agreement dated January 20, 1993 ("Trademark Agreement") between Cephalon, Inc.
("Cephalon") and Genelco S.A. ("Licensee"). All capitalized terms not otherwise
defined herein shall be used as defined in the Trademark Agreement.

     1. The term "Territory," for all purposes under the Trademark Agreement is
hereby expanded to include Ireland and the United Kingdom of England, Scotland,
Northern Ireland and Wales (collectively, the "U.K. Territory").

     2. Article III(1) of the Trademark Agreement is hereby amended and restated
in its entirety as follows:

     "For and in consideration of the Exclusive License to use the Licensed
     Trademark granted herein, Licensee shall pay Licensor a royalty as follows:

     a) four percent (4%) of Net Sales by CEPHALON and/or its sublicensees in a
     country within the Territory, during the first fifteen (15) years from the
     date of first commercial sale of the first Licensed Product in such
     country; and

     b) two percent (2%) of Net Sales by CEPHALON and/or its sublicensees in a
     country within the Territory during the next succeeding five (5) years of
     the term of this Agreement.

     3. Except as modified by this letter agreement, all provisions of the
Trademark Agreement are confirmed to be and shall remain in full force and
effect.


Genelco S.A.
Page 2

     If the foregoing is acceptable, please indicate your agreement in the space
provided below.

                                             CEPHALON, INC.

                                             By: /s/ Frank Baldino
                                                 ----------------------------
                                                 Frank Baldino, Jr., Ph.D.
                                                 President

Accepted and agreed to this
_____ day of July, 1993.

Genelco S.A.

By: /s/ ILLEGIBLE
    ----------------------------