EXHIBIT 4.27

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THIS
WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE
OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR
PURSUANT TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS UNDER THE
SECURITIES ACT.

                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

     This certifies that, for value received, [Name of Purchaser], or registered
assigns ("Warrantholder"), is entitled to purchase from ADVANCED VIRAL RESEARCH
CORP. (the "Company"), subject to the provisions of this Warrant, at any time
and from time to time until 5:00 p.m. Eastern Standard Time on February 28,
2005, _______ shares of the Company's Common Stock, par value $.00001 per share
("Warrant Shares"). The purchase price payable upon the exercise of this Warrant
shall be $.33 per Warrant Share. The Warrant Price and the number of Warrant
Shares which the Warrantholder is entitled to purchase is subject to adjustment
upon the occurrence of the contingencies set forth in Section 3 of this Warrant,
and as adjusted from time to time, such purchase price is hereinafter referred
to as the "Warrant Price."

         This Warrant is subject to the following terms and conditions:

1.   Exercise of Warrant.
     -------------------

         (a)  This Warrant may be exercised in whole or in part but not for a
              fractional share. Upon delivery of this Warrant at the offices of
              the Company or at such other address as the Company may designate
              by notice in writing to the registered holder hereof with the
              Subscription Form annexed hereto duly executed, accompanied by
              payment of the Warrant Price for the number of Warrant Shares
              purchased (in cash, by certified, cashier's or other check
              acceptable to the Company, by Common Stock of the Company having a
              Market Value (as hereinafter defined) equal to the aggregate
              Warrant Price for the Warrant Shares to be purchased, or any
              combination of the foregoing), the registered holder of this
              Warrant shall be entitled to receive a certificate or certificates
              for the Warrant Shares so purchased. Such certificate or
              certificates shall be promptly delivered




              to the Warrantholder. Upon any partial exercise of this Warrant,
              the Company shall execute and deliver a new Warrant of like tenor
              for the balance of the Warrant Shares purchasable hereunder.

         (b)  In lieu of exercising this Warrant pursuant to Section 1(a), the
              holder may elect to receive shares of Common Stock equal to the
              value of this Warrant determined in the manner described below (or
              any portion thereof remaining unexercised) upon delivery of this
              Warrant at the offices of the Company or at such other address as
              the Company may designate by notice in writing to the registered
              holder hereof with the Notice of Cashless Exercise Form annexed
              hereto duly executed. In such event the Company shall issue to the
              holder a number of shares of the Company's Common Stock computed
              using the following formula:

                                   X = Y (A-B)
                                       -------
                                        A

Where X = the number of shares of Common Stock to be issued to the holder.

      Y = the number of shares of Common Stock purchasable under this Warrant
          (at the date of such calculation).

      A = the Market Value of the Company's Common Stock on the business day
          immediately preceding the day on which the Notice of Cashless Exercise
          is received by the Company.

      B = Warrant Price (as adjusted to the date of such calculation).

         (c)  The Warrant Shares deliverable hereunder shall, upon issuance, be
              fully paid and non_assessable and the Company agrees that at all
              times during the term of this Warrant it shall cause to be
              reserved for issuance such number of shares of its Common Stock as
              shall be required for issuance and delivery upon exercise of this
              Warrant.

         (d)  For purposes of this Warrant, the Market Value of a share of
              Common Stock on any date shall be equal to (i) the closing bid
              price per share as published by a national securities exchange on
              which shares of Common Stock (or other units of the security) are
              traded (an "Exchange") on such date or, if there is no bid for
              Common Stock on such date, the bid price on such exchange at the
              close of trading on the next earlier date or, (ii) if shares of
              Common Stock are not listed on a national securities exchange on
              such date, the closing bid price per share as published on the
              National Association of Securities Dealers Automatic Quotation
              System ("NASDAQ") National Market System if the shares are quoted
              on such system on such date, or (iii) the closing bid price in the
              over-the-counter market at the close of trading on such date if
              the shares are not traded on an exchange or listed on the NASDAQ
              National Market System, or (iv) if the Common Stock is not traded
              on a national securities exchange or in the over-the-counter
              market, the fair market value of a share of Common Stock on such
              date as determined in good faith by the Board of Directors. If the
              holder disagrees with the determination of the Market Value of any
              securities of the Company determined by the Board of Directors
              under Section 1(d)(iv) the Market Value of such securities shall
              be determined by an independent appraiser acceptable to the
              Company and the holder (or, if they cannot agree on such an
              appraiser,



              by an independent appraiser selected by each of them, and Market
              Value shall be the median of the appraisals made by such
              appraisers). If there is one appraiser, the cost of the appraisal
              shall be shared equally between the Company and the holder. If
              there are two appraisers, each of the Company and the holder shall
              pay for its own appraisal.

2.       Transfer or Assignment of Warrant.
         ---------------------------------

              (a) Any assignment or transfer of this Warrant shall be made by
                  surrender of this Warrant at the offices of the Company or at
                  such other address as the Company may designate in writing to
                  the registered holder hereof with the Assignment Form annexed
                  hereto duly executed and accompanied by payment of any
                  requisite transfer taxes, and the Company shall, without
                  charge, execute and deliver a new Warrant of like tenor in the
                  name of the assignee for the portion so assigned in case of
                  only a partial assignment, with a new Warrant of like tenor to
                  the assignor for the balance of the Warrant Shares
                  purchasable.

              (b) Prior to any assignment or transfer of this Warrant, the
                  holder thereof shall deliver an opinion of counsel to the
                  Company to the effect that the proposed transfer may be
                  effected without registration under the Act.

3.       Adjustment of Warrant Price and Warrant Shares -- Anti-Dilution
         ---------------------------------------------------------------
         Provisions.
         -----------

         A. (1) Except as hereinafter provided, in case the Company shall at any
time after the date hereof issue any shares of Common Stock (including shares
held in the Company's treasury) without consideration, then, and thereafter
successively upon each issuance, the Warrant Price in effect immediately prior
to each such issuance shall forthwith be reduced to a price determined by
multiplying the Warrant Price in effect immediately prior to such issuance by a
fraction:

                  (a)      the numerator of which shall be the total number of
                           shares of Common Stock outstanding immediately prior
                           to such issuance, and
                  (b)      the denominator of which shall be the total number of
                           shares of Common Stock outstanding immediately after
                           such issuance.

     For the purposes of any computation to be made in accordance with the
provisions of this clause (1), the following provisions shall be applicable:

                  (i)          Shares of Common Stock issuable by way of
                               dividend or other distribution on any stock of
                               the Company shall be deemed to have been issued
                               and to be outstanding at the close of business on
                               the record date fixed for the determination of
                               stockholders entitled to receive such dividend or
                               other distribution and shall be deemed to have
                               been issued without consideration. Shares of
                               Common Stock issued otherwise than as a dividend,
                               shall be deemed to have been issued and to be
                               outstanding at the close of business on the date
                               of issue.

                  (ii)         The number of shares of Common Stock at any time
                               outstanding shall not include any shares then
                               owned or held by or for the account of the
                               Company.





                      (2) In case the Company shall at any time subdivide or
                  combine the outstanding shares of Common Stock, the Warrant
                  Price shall forthwith be proportionately decreased in the case
                  of the subdivision or proportionately increased in the case of
                  combination to the nearest one cent. Any such adjustment shall
                  become effective at the close of business on the date that
                  such subdivision or combination shall become effective.

         B. In the event that the number of outstanding shares of Common Stock
is increased by a stock dividend payable in shares of Common Stock or by a
subdivision of the outstanding shares of Common Stock, which may include a stock
split, then from and after the time at which the adjusted Warrant Price becomes
effective pursuant to the foregoing Subsection A of this Section by reason of
such dividend or subdivision, the number of shares issuable upon the exercise of
this Warrant shall be increased in proportion to such increase in outstanding
shares. In the event that the number of outstanding shares of Common Stock is
decreased by a combination of the outstanding shares of Common Stock, then, from
and after the time at which the adjusted Warrant Price becomes effective
pursuant to such Subsection A of this Section by reason of such combination, the
number of shares issuable upon the exercise of this Warrant shall be decreased
in proportion to such decrease in outstanding shares.

         C. In the event of an adjustment of the Warrant Price, the number of
shares of Common Stock (or reclassified stock) issuable upon exercise of this
Warrant after such adjustment shall be equal to the number determined by
dividing:

                  (1) an amount equal to the product of (i) the number of shares
                      of Common Stock issuable upon exercise of this Warrant
                      immediately prior to such adjustment, and (ii) the Warrant
                      Price immediately prior to such adjustment, by

                  (2) the Warrant Price immediately after such adjustment.

         D. In the case of any reorganization or reclassification of the
outstanding shares of Common Stock (other than a change in par value, or from
par value to no par value, or from no par value to par value, or as a result of
a subdivision or combination) or in the case of any consolidation of the Company
with, or merger of the Company with, another corporation, or in the case of any
sale, lease or conveyance of all, or substantially all, of the property, assets,
business and goodwill of the Company as an entity, the holder of this Warrant
shall thereafter have the right upon exercise to purchase the kind and amount of
shares of stock and other securities and property receivable upon such
reorganization, reclassification, consolidation, merger or sale by a holder of
the number of shares of Common Stock which the holder of this Warrant would have
received had all Warrant Shares issuable upon exercise of this Warrant been
issued immediately prior to such reorganization, reclassification,
consolidation, merger or sale, at a price equal to the Warrant Price then in
effect pertaining to this Warrant (the kind, amount and price of such stock and
other securities to be subject to adjustment as herein provided).



         E. In case the Company shall, at any time prior to the expiration of
this Warrant and prior to the exercise thereof, dissolve, liquidate or wind up
its affairs, the Warrantholder shall be entitled, upon the exercise thereof, to
receive, in lieu of the Warrant Shares of the Company which it would have been
entitled to receive, the same kind and amount of assets as would have been
issued, distributed or paid to it upon such Warrant Shares of the Company, had
it been the holder of record of shares of Common Stock receivable upon the
exercise of this Warrant on the record date for the determination of those
entitled to receive any such liquidating distribution. After any such
dissolution, liquidation or winding up which shall result in any distribution in
excess of the Warrant Price provided for by this Warrant, the Warrantholder may
at its option exercise the same without making payment of the aggregate Warrant
Price and in such case the Company shall upon the distribution to said
Warrantholder consider that the aggregate Warrant Price has been paid in full to
it and in making settlement to said Warrantholder, shall deduct from the amount
payable to such Warrantholder an amount equal to the aggregate Warrant Price.

         F. In case the Company shall, at any time prior to the expiration of
this Warrant and prior to the exercise thereof make a distribution of assets
(other than cash) or securities of the Company to its stockholders (the
"Distribution") the Warrantholder shall be entitled, upon the exercise thereof,
to receive, in addition to the Warrant Shares it is entitled to receive, the
same kind and amount of assets or securities as would have been distributed to
it in the Distribution had it been the holder of record of shares of Common
Stock receivable upon exercise of this Warrant on the record date for
determination of those entitled to receive the Distribution.

         G. Irrespective of any adjustments in the number of Warrant Shares and
the Warrant Price or the number or kind of shares purchasable upon exercise of
this Warrant, this Warrant may continue to express the same price and number and
kind of shares as originally issued.

4.   Officer's Certificate. Whenever the number of Warrant Shares and the
     Warrant Price shall be adjusted pursuant to the provisions hereof, the
     Company shall forthwith file, at its principal executive office a
     statement, signed by the Chairman of the Board, President, or one of the
     Vice Presidents of the Company and by its Chief Financial Officer or one of
     its Treasurers or Assistant Treasurers, stating the adjusted number of
     Warrant Shares and the new Warrant Price calculated to the nearest one
     hundredth and setting forth in reasonable detail the method of calculation
     and the facts requiring such adjustment and upon which such calculation is
     based. Each adjustment shall remain in effect until a subsequent adjustment
     hereunder is required. A copy of such statement shall be mailed to the
     Warrantholder.

5.   Charges, Taxes and Expenses. The issuance of certificates for Warrant
     Shares upon any exercise of this Warrant shall be made without charge to
     the Warrantholder for any tax or other expense in respect to the issuance
     of such certificates, all of which taxes and expenses shall be paid by the
     Company, and such certificates shall be issued only in the name of the
     Warrantholder.



6.       Miscellaneous.
         --------------

         (a)  The terms of this Warrant shall be binding upon and shall inure to
              the benefit of any successors or assigns of the Company and of the
              holder or holders hereof and of the shares of Common Stock issued
              or issuable upon the exercise hereof.

         (b)  No holder of this Warrant, as such, shall be entitled to vote or
              receive dividends or be deemed to be a stockholder of the Company
              for any purpose, nor shall anything contained in this Warrant be
              construed to confer upon the holder of this Warrant, as such, any
              rights of a stockholder of the Company or any right to vote, give
              or withhold consent to any corporate action, receive notice of
              meetings, receive dividends or subscription rights, or otherwise.

              (c) Receipt of this Warrant by the holder hereof shall constitute
              acceptance of an agreement to the foregoing terms and conditions.

         (d)  The Warrant and the performance of the parties hereunder shall be
              construed and interpreted in accordance with the laws of the State
              of New York and the parties hereunder consent and agree that the
              State and Federal Courts which sit in the State of New York and
              the County of New York shall have exclusive jurisdiction with
              respect to all controversies and disputes arising hereunder.

     IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its
duly authorized officer and its corporate seal to be affixed hereto.

Dated: February 16, 2000

                           ADVANCED VIRAL RESEARCH CORP.

                           BY: /s/ Shalom Hirschman, M.D.
                               ------------------------------
                               Shalom Hirschman, M.D.
                               President