EXHIBIT 99.1

                                  ARQULE, INC.

         CERTIFICATE OF THE CHIEF EXECUTIVE AND CHIEF FINANCIAL OFFICERS

The undersigned, Stephen A. Hill, President and Chief Executive Officer of
ArQule, Inc. (the "Company") and David C. Hastings, Vice President, Chief
Financial Officer and Treasurer of the Company, both duly elected and currently
serving, do each hereby certify that, to the best of his knowledge:

         1. the quarterly report on Form 10-Q for the period ending September
            30, 2002, filed on behalf of the Company pursuant to the Securities
            Exchange Act of 1934 (the "Exchange Act") and containing the
            financial statements of the Company, fully complies with the
            requirements of section 13(a) of the Securities Exchange Act of
            1934; and

         2. the information contained in such quarterly report fairly presents,
            in all material respects, the financial condition and results of
            operations of the Company for the dates and periods covered by such
            quarterly report.

IN WITNESS WHEREOF, the undersigned have executed this Certificate as of the
13th day of November, 2002.

/s/ Stephen A. Hill
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Name:  Stephen A. Hill
Title: President and Chief Executive Officer

/s/ David C. Hastings
- --------------------------------------------
Name:  David C. Hastings
Title: Vice President, Chief Financial Officer
       and Treasurer