<Page>
EXHIBIT 3.45
CERTIFIED TO BE A TRUE AND CORRECT COPY FILED
AS TAKEN FROM AND COMPARED WITH THE
ORIGINAL ON FILE IN THIS OFFICE FEB 25 2003
MAR 05 2003 MARK HAMMOND
SECRETARY OF STATE
/s/ Mark Hammond
- ---------------------------------------
SECRETARY OF STATE OF SOUTH CAROLINA
STATE OF SOUTH CAROLINA
SECRETARY OF STATE
ARTICLES OF INCORPORATION
TYPE OR PRINT CLEARLY IN BLACK INK
1. The name of the proposal corporation is AmeriPath SC, Inc.
2. The initial registered office of the corporation is
5000 Thurmond Mall Boulevard
-------------------------------
Street Address
Columbia, Richland, SC 29201
---------------------------------------------------------------------------
City County State Zip Code
and the initial registered agent at such address is
Corporation Service Company
--------------------------------
Print Name
I hereby consent to the appointment as registered agent of the
corporation:
-----------------------------------------
Agent's Signature
3. The corporation is authorized to issue shares of stock as follows. Complete
"a" or "b", whichever is applicable:
a. /X/ The corporation is authorized to issue a single class of shares,
the total number of shares authorized is 1,000
b. / / The corporation is authorized to issue more that one class of
shares:
Class of Shares Authorized No. of Each Class
---------------------------- ------------------------------
---------------------------- ------------------------------
---------------------------- ------------------------------
The relative right, preference, and limitations of the shares of each
class, and of each series within a class, are as follows:
4. The existence of the corporation shall begin as of the filing date with the
Secretary of State unless a delayed date is indicated (See Section
33-1-230(b) of the 1976 South Carolina Code of Laws, as amended)
_____________________________________________________________________
<Page>
AmeriPath SC, Inc
---------------------------
Name of Corporation
5. The optional provisions, which the corporation elects to include in the
articles of incorporation, are as follows (See the applicable provisions of
Section 33-2-102, 35-2-105, and 35-2-221 of the 1976 South Carolina Code of
Laws, as amended).
See attached.
6. The name, address, and signature of each incorporator is as follows (only
one is required):
a. Joe DeLisle
---------------------------------------------
Name
Alston & Bird LLP
1201 West Peachtree Street, Atlanta, GA 30309
---------------------------------------------
Address
/s/ Joe DeLisle
---------------------------------------------
Signature
b.
---------------------------------------------
Name
---------------------------------------------
Address
---------------------------------------------
Signature
c.
---------------------------------------------
Name
---------------------------------------------
Address
---------------------------------------------
Signature
7. I, Stephanie Jonhston Thomas, an attorney licensed to practice in the state
of South Carolina, certify that the corporation, to whose articles of
incorporation this certificate is attached, has complied with the
requirements of Chapter 2, Title 33 of the 1976 South Carolina Code of
Laws, as amended, relating to the articles of incorporation.
Date: February 24, 2003
/s/ Stephanie Johnston Thomas
-----------------------------------
Signature
Stephanie Johnston Thomas
-----------------------------------
Type or Print Name
Alston & Bird LLP
1201 West Peachtree Street
-----------------------------------
Address
Atlanta, GA 30309
-----------------------------------
(404) 881-7966
-----------------------------------
Telephone Number
<Page>
ATTACHMENT TO
ARTICLES OF INCORPORATION
OF
AMERIPATH SC, INC.
5. The initial Board of Directors shall consist of three (3) members whose
names and addresses are as follows:
James C. New
c/o AmeriPath, Inc.
7289 Garden Road, Suite 200
Riviera Beach, FL 33404
James E. Billington
c/o AmeriPath, lnc. 7289 Garden Road
Suite 200
Riviera Beach, FL 33404
Gregory A. Marsh
c/o AmeriPath, Inc.
7289 Garden Road, Suite 200
Riviera Beach, FL 33404