EXHIBIT 32.1

                            SECTION 906 CERTIFICATION

The undersigned officers of Anika Therapeutics, Inc. (the "Company") hereby
certify in their respective capacities that the Company's annual report on Form
10-K to which this certification is attached (the "Report"), as filed with the
Securities and Exchange Commission on the date hereof, fully complies with the
requirements of Section 13(a) or 15(d), as applicable, of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), and that the information
contained in the Report fairly presents, in all material respects, the financial
condition and results of operations of the Company.

Date: March 29, 2004                        /s/ Charles H. Sherwood
                                            -----------------------------------
                                            Charles H. Sherwood, Ph.D.
                                            Chief Executive Officer

                                            /s/ William J. Knight
                                            -----------------------------------
                                            William J. Knight
                                            Chief Financial Officer

This certification shall not be deemed "filed" for any purpose, nor shall it be
deemed to be incorporated by reference into any filing, under the Securities Act
of 1933 or the Exchange Act.