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                         Morgan Stanley Strategist Fund
                           1221 Avenue of the Americas
                               New York, NY 10020

November 28, 2005

Securities and Exchange Commission
Judiciary Plaza
100 F Street, NE
Washington, DC 20549

Attention:    Larry Greene, Division of Investment Management
              Mail Stop 0505

RE:      MORGAN STANLEY STRATEGIST FUND
         (FILE NOS. 33-23669 AND 811-5634)


Dear Mr. Greene:

Thank you for your telephonic comments regarding the registration statement on
Form N-1A for Morgan Stanley Strategist Fund (the "Fund") filed with the
Securities and Exchange Commission on September 27, 2005. Below, we describe the
changes made to the registration statement in response to the Staff's comments
and provide any responses to or any supplemental explanations of such comments,
as requested. These changes will be reflected in post-effective amendment number
22 to the Fund's registration statement on Form N-1A, which will be filed via
EDGAR on or about November 28, 2005.

                  GENERAL COMMENTS TO FORM N-1A

COMMENT 1.        PLEASE CONFIRM THAT THE FUND IS COMPLYING WITH THE PRIVACY
                  POLICY NOTIFICATION REQUIREMENTS OF THE GRAMM-LEACH-BLILEY ACT
                  AND DISTRIBUTING ITS PRIVACY POLICY TO INVESTORS.

                              RESPONSE 1. The Fund provides its privacy policy
                              annually in accordance with the requirements of
                              Regulation S-P.

COMMENT 2.        PLEASE  CONFIRM THAT THE  REGISTRATION  STATEMENT  INCLUDES
                  THE  ANTI-MONEY  LAUNDERING AND CUSTOMER VERIFICATION
                  DISCLOSURE REQUIRED BY THE U.S. PATRIOT ACT.

                              RESPONSE 2. The requisite notice of the customer
                              identification verification policy is disclosed in
                              the account application form. Anti-money
                              laundering and customer verification disclosure is
                              also included under the "Shareholder
                              Information-How to Buy Shares" section of the
                              Fund's prospectus.



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                  COMMENTS TO THE PROSPECTUS

COMMENT 3.        CONSIDER ADDING DISCLOSURE REGARDING JUNK PREFERRED STOCKS
                  AND JUNK CONVERTIBLE SECURITIES, TO THE EXTENT THE FUND
                  INVESTS IN THESE SECURITIES, TO THE SECTION "PRINCIPAL
                  INVESTMENT STRATEGIES".

                              RESPONSE 3. We respectfully acknowledge the
                              comment, but believe the current disclosure is
                              sufficient, as the Fund does not invest in junk
                              preferred stocks and junk convertible
                              securities.

COMMENT 4.        CONSIDER ADDING DISCLOSURE REGARDING INVESTMENTS IN
                  EMERGING MARKETS, TO THE EXTENT THE FUND INVESTS IN THESE
                  SECURITIES, TO THE SECTION "PRINCIPAL INVESTMENT STRATEGIES".

                              RESPONSE 4. We respectfully acknowledge the
                              comment, but believe the current disclosure is
                              sufficient. The applicable disclosure is
                              included in the Fund's SAI.

COMMENT 5.        IN THE "FEES AND EXPENSES" SECTION OF THE PROSPECTUS,
                  CONSIDER MOVING THE FOOTNOTES TO AFTER THE EXAMPLE.

                              RESPONSE 5. We respectfully acknowledge the
                              comment, but believe the current placement of the
                              footnote is appropriate. The footnotes refer to
                              the Annual Fund Operating Expenses and although
                              arguably the Annual Fund Operating Expenses and
                              the Example constitute the "Fee Table", we believe
                              that to move the footnotes to below the Example
                              would diminish the impact of the information and
                              could result in a shareholder being unable to
                              locate the footnotes.

COMMENT 6.        IN CONNECTION WITH THE FUND'S USE OF FORWARD FOREIGN
                  CURRENCY EXCHANGE CONTRACTS, PLEASE CONFIRM THE APPROPRIATE
                  USE OF "SEGREGATING ASSETS" AND INCLUSION OF APPLICABLE
                  DISCLOSURE.

                              RESPONSE 6. The applicable disclosure is included
                              in the Fund's SAI.

COMMENT 7.        WITH RESPECT TO THE FUND'S INVESTMENTS IN TARGETED RETURN
                  INDEX SECURITIES ("TRAINS"), IF APPLICABLE, PLEASE INCLUDE
                  DISCLOSURE REGARDING THE RISK OF DUPLICATIVE FEES RELATING TO
                  SUCH TRAINS.

                              RESPONSE 7. Applicable disclosure has been added.

COMMENT 8.        IN THE "FUND MANAGEMENT" SECTION, (1) PLEASE CLARIFY
                  WHETHER THERE ARE MEMBERS OF THE PORTFOLIO MANAGEMENT TEAM
                  THAT ARE INVOLVED WITH THE MANAGEMENT OF THE FUND THAT ARE NOT
                  DISCLOSED IN THE PROSPECTUS, AND (2) EXPLAIN SUPPLEMENTALLY
                  WHETHER THE FOLLOWING SENTENCE IS CONSISTENT WITH ITEM 5(A)(2)
                  AND ITEM 15(A) OF FORM N-1A: "THE COMPOSITION OF THE PORTFOLIO
                  MANAGEMENT TEAM MAY CHANGE WITHOUT NOTICE FROM TIME TO TIME."

                              RESPONSE 8. The Fund has revised the disclosure to
                              clarify the team and its members jointly and
                              primarily responsible for the day-to-day
                              management of the fund. The referenced disclosure
                              states that the

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                              composition of the team may change
                              without notice from time to time. We note
                              supplementally that to the extent that a team
                              member with primary responsibility for the
                              day-to-day management of the Fund's portfolio
                              changes, the Fund intends to supplement its
                              Prospectus and its Statement of Additional
                              Information with the information required by Item
                              5(a)(2) and Item 15(a) for such team member.

                  COMMENTS TO THE SAI

COMMENT 9.        IN THE SECTION ENTITLED "FUND MANAGEMENT - PORTFOLIO
                  MANAGER COMPENSATION STRUCTURE," (1) INCLUDE ONLY THE
                  DISCRETIONARY COMPENSATION RECEIVED BY THE PORTFOLIO MANAGERS
                  OF THE FUND DURING THE LAST YEAR AND (2) CONFIRM THAT YOU ARE
                  PROVIDING THE REQUESTED INFORMATION.

                              RESPONSE 9. We believe the current disclosure is
                              in compliance with SEC Release 2004-89. This
                              Release requires that the SAI include disclosure
                              regarding the structure of, and the method used to
                              determine, the compensation of its portfolio
                              managers. The Release notes that the purpose of
                              this disclosure is to help investors better
                              understand a portfolio manager's incentives in
                              managing a fund and shed light on possible
                              conflicts of interest that could arise when a
                              portfolio manager manages other accounts.
                              Therefore, in order to achieve this purpose, the
                              disclosure, in our view, should include all
                              possible forms of compensation that are available
                              to the portfolio manager in connection with
                              managing the portfolio and other accounts. Please
                              note that we revised the disclosure to clarify
                              that investment performance, upon which a
                              portfolio manager's compensation is linked, is
                              calculated for one-, three-, and five-year periods
                              measured against a fund's/account's primary
                              benchmark, indices and/or peer groups, where
                              applicable.


If you would like to discuss any of these responses in further detail or if you
have any questions, please feel free to contact me at (630) 684-6724. Thank you.

Sincerely,

/s/ Elisa Mitchell

Elisa Mitchell


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