AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 24, 1997
                                                      REGISTRATION NO. 333-
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                           --------------------------
 
                                   FORM SB-2
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------
 
                       CELL ROBOTICS INTERNATIONAL, INC.
                 (Name of small business issuer in its Charter)
 

                                                          
           COLORADO                        5049-05                 84-1153295
 (State or other jurisdiction    (Primary Standard Industrial    (IRS Employer
              of                 Classification Code Number)     Identification
incorporation or organization)                                      Number)

 
                          2715 BROADBENT PARKWAY N.E.
                         ALBUQUERQUE, NEW MEXICO 87107
                                 (505) 343-1131
                              (505) 344-8112 (FAX)
    (Address, including zip code, and telephone number, including area code,
                  of Registrant's principal executive offices)
 
                           RONALD K. LOHRDING, PH.D.
                               PRESIDENT AND CEO
                          2715 BROADBENT PARKWAY N.E.
                         ALBUQUERQUE, NEW MEXICO 87107
                                 (505) 343-1131
                              (505) 344-8112 (FAX)
(Name, address, including zip code, and telephone number of agent for service of
                                    process)
                           --------------------------
 
                                   COPIES TO:
 
       CLIFFORD L. NEUMAN, ESQ.                  STEPHEN A. ZELNICK, ESQ.
        NATHAN L. STONE, ESQ.                   JOEL J. GOLDSCHMIDT, ESQ.
        NEUMAN & DRENNEN, LLC               MORSE, ZELNICK, ROSE & LANDER, LLP
           1507 PINE STREET                          450 PARK AVENUE
       BOULDER, COLORADO 80302                   NEW YORK, NEW YORK 10022
            (303) 449-2100                            (212) 838-8269
         (303) 449-1045 (FAX)                      (212) 838-9190 (FAX)
 
                           --------------------------
 
          APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO PUBLIC:
 As soon as practicable after the effective date of the Registration Statement.
                           --------------------------
 
    If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, check the following box. / /
 
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
 
    If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /
 
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
                           --------------------------
 
                        CALCULATION OF REGISTRATION FEE
 


                                                                   PROPOSED MAXIMUM    PROPOSED MAXIMUM
           TITLE OF EACH CLASS OF                 AMOUNT TO         OFFERING PRICE        AGGREGATE           AMOUNT OF
        SECURITIES TO BE REGISTERED             BE REGISTERED         PER SHARE       OFFERING PRICE(1)    REGISTRATION FEE
                                                                                              
Common Stock, $.004 par value(2)............      2,300,000             $5.00            $11,500,000          $3,484.85
Representatives' Warrants...................       200,000               $-0-                $-0-                $-0-
Shares of Common Stock Underlying
  Representatives' Warrants(3)..............       200,000              $6.00             $1,200,000           $363.64
Total:......................................      2,500,000                              $12,700,000           $3848.49

 
(1) Estimated solely for the purpose of calculating the registration fee
    pursuant to Rule 457.
(2) Includes Common Stock offered in the offering and issuable upon exercise of
    Underwriters' Over-Allotment Option.
(3) Consists of Common Stock issuable upon exercise of the Representatives'
    Warrants.
                           --------------------------
 
    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.
 
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- --------------------------------------------------------------------------------

                       CELL ROBOTICS INTERNATIONAL, INC.
                             CROSS-REFERENCE INDEX
 


ITEM NO. AND HEADING IN FORM SB-2 REGISTRATION STATEMENT                         LOCATION IN PROSPECTUS
- ----------------------------------------------------------------  -----------------------------------------------------
                                                            
       1.  Forepart of the Registration Statement and Outside
             Front Cover Page of Prospectus.....................  Forepart of Registration Statement and Outside Front
                                                                    Cover Page of Prospectus
 
       2.  Inside Front and Outside Back Cover Pages of
             Prospectus.........................................  Inside Front and Outside Back Cover Pages of
                                                                    Prospectus
 
       3.  Summary and Risk Factors.............................  Prospectus Summary; Risk Factors
 
       4.  Use of Proceeds......................................  Use of Proceeds; Risk Factors
 
       5.  Determination of Offering Price......................  Front Cover Page; Underwriting
 
       6.  Dilution.............................................  Dilution; Risk Factors
 
       7.  Selling Securityholders..............................                            *
 
       8.  Plan of Distribution.................................  Underwriting
 
       9.  Legal Proceedings....................................  Legal Proceedings
 
      10.  Directors, Executive Officers, Promoters and
             Controlling Persons................................  Management
 
      11.  Security Ownership of Certain Beneficial Owners and
             Management.........................................  Security Ownership of Management and Principal
                                                                    Stockholders
 
      12.  Description of Securities............................  Description of Securities
 
      13.  Interest of Named Experts and Counsel................  Legal Matters; Experts
 
      14.  Disclosure of SEC Position on Indemnification for
             Securities Act Liabilities.........................  Management--Indemnification and Limitation on
                                                                    Liability of Directors
 
      15.  Organization Within Last Five Years..................  The Company; Business--Overview
 
      16.  Description of Business..............................  Prospectus Summary; Risk Factors; Business
 
      17.  Management's Discussion and Analysis or Plan of
             Operation..........................................  Management's Discussion and Analysis of Financial
                                                                    Condition and Results of Operations; Financial
                                                                    Statements; Business
 
      18.  Description of Property..............................  Business
 
      19.  Certain Relationships and Related Transactions.......  Certain Transactions
 
      20.  Market for Common Equity and Related Stockholder
             Matters............................................  Market for Common Stock
 
      21.  Executive Compensation...............................  Management--Executive Compensation
 
      22.  Financial Statements.................................  Financial Statements
 
      23.  Changes in and Disagreements with Accountants on
             Accounting and Financial Disclosure................  Business--Changes in Independent Public Accountants

 
- ------------------------
 
*   Omitted from Prospectus because Item is inapplicable or answer is in the
    negative
 
                                       i

                 SUBJECT TO COMPLETION, DATED NOVEMBER 24, 1997
INFORMATION CONTAINED HEREIN IS SUBJECT TO COMPLETION OR AMENDMENT. A
REGISTRATION STATEMENT RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION. THESE SECURITIES MAY NOT BE SOLD NOR MAY
OFFERS TO BUY BE ACCEPTED PRIOR TO THE TIME THE REGISTRATION STATEMENT BECOMES
EFFECTIVE. THIS PROSPECTUS SHALL NOT CONSTITUTE AN OFFER TO SELL OR THE
SOLICITATION OF AN OFFER TO BUY NOR SHALL THERE BE ANY SALE OF THESE SECURITIES
IN ANY STATE IN WHICH SUCH OFFER, SOLICITATION OR SALE WOULD BE UNLAWFUL PRIOR
TO REGISTRATION OR QUALIFICATION UNDER THE SECURITIES LAWS OF ANY SUCH STATE.

PROSPECTUS
 
                       CELL ROBOTICS INTERNATIONAL, INC.
 
                                2,000,000 SHARES
                                  COMMON STOCK
 
    Cell Robotics International, Inc., a Colorado corporation (the "Company"),
is offering 2,000,000 shares (the "Shares") of its common stock, $.004 par value
(the "Common Stock").
 
    Although the Company is a publicly-held corporation, the present market for
its Common Stock is limited and sporadic. On November   , 1997, the closing bid
and ask prices of the Common Stock on the OTC Electronic Bulletin Board
("Bulletin Board") under the trading symbol CRII were $     and $     ,
respectively. Application has been made to have the Common Stock approved for
quotation on the Nasdaq SmallCap Market under the symbol "CRII", subject to
completion of this offering.
 
    It is currently anticipated that the offering price of the Shares will be
between $4.00 and $5.00 per share. The public offering price of the Shares will
be determined by negotiation between the Company and Paulson Investment Company,
Inc. ("Paulson") and Cohig & Associates, Inc. (together with Paulson, the
"Representatives"), as representatives of the several underwriters
("Underwriters"). For a discussion of the factors considered in determining the
public offering price, see "Underwriting."
                            ------------------------
 
  THIS OFFERING INVOLVES A HIGH DEGREE OF RISK. SEE "RISK FACTORS" AT PAGE 8.
                             ---------------------
 
THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
     EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
       COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE
                ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
               REPRESENTATION TO THE CONTRARY IS A CRIMINAL
                                    OFFENSE.
 


                                                                                   UNDERWRITING
                                                              PRICE TO             DISCOUNTS AND           PROCEEDS TO
                                                               PUBLIC             COMMISSIONS(1)           COMPANY(2)
                                                                                             
Per Share.............................................            $                      $                      $
Total(3)..............................................            $                      $                      $

 
(1) Excludes a non-accountable expense allowance equal to 3% of the gross
    proceeds of this offering, payable to Paulson, and five-year warrants (the
    "Representatives' Warrants") entitling the Representatives to purchase up to
    200,000 shares of Common Stock at an exercise price equal to 120% of the
    public offering price per share. The Company also has agreed to indemnify
    the Underwriters against certain liabilities, including liabilities under
    the Securities Act of 1933, as amended (the "Securities Act"). See
    "Underwriting."
 
(2) Before deducting offering expenses payable by the Company of approximately
    $550,000 including the non-accountable expense allowance to Paulson. See
    "Underwriting."
 
(3) The Company has granted the Underwriters an option, exercisable within 45
    days from the date of this Prospectus to purchase up to an additional
    300,000 shares of Common Stock on the same terms as set forth above solely
    to cover over-allotments, if any (the "Over-Allotment Option"). If the
    Underwriters exercise such option in full, the total Price to Public,
    Underwriting Discount and Proceeds to Company will be $10,350,000,
    $1,035,000 and $9,315,000 respectively, assuming an offering price for the
    Common Stock of $4.50 per share. See "Underwriting."
                            ------------------------
 
    The Shares are being offered by the several Underwriters, subject to prior
sale, when and if delivered to and accepted by the Underwriters, and subject to
their right to reject any order, in whole or in part, and to certain other
conditions. It is expected that delivery of the certificates representing the
Shares will be made against payment therefor in New York, New York on or about
           , 1997.
 
PAULSON INVESTMENT COMPANY, INC.                        COHIG & ASSOCIATES, INC.
 
               THE DATE OF THIS PROSPECTUS IS            , 1997.

                            ------------------------
 
    The Company is subject to the reporting and other requirements of the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the
Company intends to furnish its stockholders with annual reports containing
financial statements audited by independent certified public accountants, as
well as quarterly financial information for each of the first three quarters of
each fiscal year. The Company will also file reports, proxy statements and other
information with the Securities and Exchange Commission ("Commission").
 
    IN CONNECTION WITH THIS OFFERING, THE UNDERWRITERS MAY OVER-ALLOT OR EFFECT
TRANSACTIONS WHICH STABILIZE OR MAINTAIN THE MARKET PRICE OF THE COMMON STOCK OF
THE COMPANY AT A LEVEL ABOVE THAT WHICH MIGHT OTHERWISE PREVAIL IN THE OPEN
MARKET. SUCH TRANSACTIONS MAY BE EFFECTED ON THE NASDAQ SMALLCAP MARKET OR
OTHERWISE. SUCH STABILIZING, IF COMMENCED, MAY BE DISCONTINUED AT ANY TIME.
 
    IN CONNECTION WITH THIS OFFERING, CERTAIN UNDERWRITERS AND SELLING GROUP
MEMBERS (IF ANY) MAY ENGAGE IN PASSIVE MARKET MAKING TRANSACTIONS IN THE COMMON
STOCK ON THE NASDAQ SMALLCAP MARKET IN ACCORDANCE WITH RULE 103 OF REGULATION M
UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. FURTHER, SUCH PERSONS MAY
ENGAGE IN TRANSACTIONS THAT STABILIZE, MAINTAIN OR OTHERWISE AFFECT THE PRICE OF
THE COMMON STOCK, INCLUDING PURCHASES OF THE COMMON STOCK TO STABILIZE THE
MARKET PRICE, PURCHASES OF THE COMMON STOCK TO COVER SOME OR ALL OF A SHORT
POSITION IN THE COMMON STOCK MAINTAINED BY THE UNDERWRITERS AND THE IMPOSITION
OF PENALTY BIDS. FOR A DESCRIPTION OF THESE ACTIVITIES, SEE "UNDERWRITING."
 
                                       2


                                       
                            Medical Laser Products

                                 Lasette-TM-

     One photograph of product, two graphic art depictions of skin 
perforation.

                 In Vitro Fertilization Workstation-TM-

     One photograph of product, two photographs of cells showing 
product functions, with descriptions.


                               PROSPECTUS SUMMARY
 
    THE FOLLOWING SUMMARY IS QUALIFIED IN ITS ENTIRETY BY THE MORE DETAILED
INFORMATION AND FINANCIAL STATEMENTS, INCLUDING THE RELATED NOTES THERETO,
APPEARING ELSEWHERE IN THIS PROSPECTUS. UNLESS OTHERWISE INDICATED, ALL
INFORMATION WITH REGARD TO THE CAPITAL STOCK OF THE COMPANY IN THIS PROSPECTUS,
INCLUDING SHARE AND PER SHARE INFORMATION, ASSUMES (I) NO EXERCISE OF ANY
OUTSTANDING OPTIONS OR WARRANTS OF THE COMPANY PRIOR TO THE OFFERING DESCRIBED
HEREIN AND (II) NO EXERCISE OF THE UNDERWRITERS' OVER-ALLOTMENT OPTION, OR THE
REPRESENTATIVES' WARRANTS. (SEE "DESCRIPTION OF SECURITIES" AND "UNDERWRITING".)
UNLESS OTHERWISE SPECIFIED TO THE CONTRARY OR UNLESS THE CONTEXT IMPLIES
OTHERWISE, ALL REFERENCES HEREIN TO THE "COMPANY" SHALL BE DEEMED TO REFER TO
CELL ROBOTICS INTERNATIONAL, INC., A COLORADO CORPORATION, AND ITS WHOLLY-OWNED
SUBSIDIARY, CELL ROBOTICS, INC., A NEW MEXICO CORPORATION.
 
                                  THE COMPANY
 
    The Company has developed, and is preparing to manufacture, market and sell,
a number of sophisticated medical laser products. The "Lasette-TM-," a compact,
lightweight, portable skin perforator, has been designed to permit nearly
painless sampling of capillary blood in both clinical and home settings. The
"RevitaLase-TM-" is a modularly-designed laser system for dermatological use,
which incorporates the laser in the hand-piece. Its design allows for
interchangeable hand-pieces, each with a laser having a different wavelength
suitable for specific applications, driven by a common base unit containing
computer controls, power supply and cooling system. The initial Erbium:YAG laser
for the RevitaLase-TM- has been designed for cosmetic uses such as skin
resurfacing and wrinkle removal and may find added applications in scar
revisioning and burn debridement. The IN VITRO fertilization workstation ("IVF
Workstation-TM-") utilizes a microscope, computer-controlled stages and a
solid-state laser to enhance human assisted reproduction techniques. Both the
Lasette-TM- and RevitaLase-TM- require a disposable shield or disposable
delivery tip each time the laser is used. These disposables will be manufactured
for and sold by the Company. The new medical laser products utilize core
technologies and management skills developed by the Company in connection with
its Cell Robotics Workstation-TM-, a laser scientific instrument which
transforms a microscope from a viewing device into a tool for physically
manipulating and microdissecting living cells. The Company believes that the
markets for its new medical laser devices are broader than for its scientific
instruments and that its future growth will depend, primarily, on market
acceptance of these medical laser devices.
 
    The Erbium:YAG laser handpiece for the RevitaLase-TM- has received FDA
clearance for use in dermatological and surgical applications. It is undergoing
continuing testing to finalize protocols for clinical use. The Company expects
to begin initial shipments of RevitaLase-TM- units with the Erbium:YAG handpiece
in the first quarter of 1998. The Lasette-TM- is a substitute for the stainless
steel lancet now used for capillary blood sampling. In clinical settings the
Company believes that the Lasette-TM- will lessen the spread of, and the fear
among healthcare workers of contracting, infectious diseases through inadvertent
needle sticks while also reducing the problems of sharps disposal. The
Lasette-TM- has received FDA clearance for capillary blood sampling from all
adults, including diabetics, in clinical settings. However, the Company believes
that another principal market for the Lasette-TM- will be for home use by
diabetics. Diabetics are often required to take multiple blood samples each day
and many diabetics develop permanent finger-tip soreness and calluses from
recurrent blood sampling. The Company is making application for FDA clearance of
Lasette-TM- sales for diabetic home use and for use on children. No assurances
can be given that these additional FDA clearances will be received. The Company
plans to begin shipping the Lasette-TM- for clinical use in the fourth quarter
of 1997.
 
    The IVF Workstation-TM- has three basic applications: first, for measuring,
assessing and storing in computer memory the various properties of a human egg
to assess its suitability for fertilization; second, to mechanically inject
sperm into an egg; and third, to pierce the outer shell of a fertilized egg with
a laser to facilitate "hatching" and promote embryo development and successful
pregnancy. In the United States, FDA clearance is required for sale of the IVF
Workstation-TM-. Clinical trials necessary to obtain the data
 
                                       3

required for application for such clearance have recently begun and the Company
expects they will take approximately one year to complete. However, no assurance
can be given that FDA clearance will ever be obtained for use of the IVF
Workstation-TM- in "hatching." The European Community has cleared the use of the
IVF Workstation-TM- for marketing and the Company is applying for the CE Mark
necessary for sales. The first purchase order for an IVF Workstation-TM- has
been received from an IVF clinic in Tunisia.
 
    The Company's growth plan is to concentrate its resources on the development
of the clinical and home markets for its medical laser products. The Company
intends to market the Lasette-TM- through strategic alliances with major
distributors serving the diabetic and clinical markets, supplemented by
distribution arrangements with regional distributors and direct sales by the
Company. The Company intends to market the RevitaLase-TM- with its Erbium:YAG
laser head by establishing an OEM relationship with a major manufacturer of CO2
and other medical laser systems for the aesthetic market, to be supplemented by
direct distribution by the Company under a different trademark. The IVF
Workstation-TM- will be marketed and sold over the internet and through other
direct selling methods by the Company, except that in the United States the IVF
Workstation-TM- will not be offered for laser-assisted hatching until after FDA
clearance is obtained.
 
    The Company was organized on September 28, 1988 as Intelligent Financial
Corporation ("IFC"). In February 1995, IFC acquired all of the issued and
outstanding shares of Cell Robotics, Inc. ("CRI"), a New Mexico corporation (the
"Acquisition"), which had been formed in 1988 to develop the Cell Robotics
Workstation. In May 1995, IFC changed its name to Cell Robotics International,
Inc.
 
    The Company maintains its principal offices at 2715 Broadbent Parkway, N.E.,
Albuquerque, New Mexico 87107. Its telephone number at that address is (505)
343-1131, its facsimile number is (505) 344-8112, and its Internet Website
address is http://www.cellrobotics.com/cell.
 
                                       4

                                  THE OFFERING
 

                                 
Securities Offered................  2,000,000 shares of $.004 par value Common Stock. See
                                    "Description of Securities."
Common Stock outstanding before
  offering........................  5,222,414 shares(1)
Common Stock outstanding after
  offering........................  7,222,414 shares(1)(2)
Use of proceeds...................  To fund marketing and sales, to acquire fixed assets, to
                                    hire additional marketing and manufacturing personnel,
                                    to fund further research and development and for working
                                    capital and other general corporate purposes. See "Use
                                    of Proceeds."
Proposed NASDAQ symbol:
  Common Stock....................  "CRII"

 
- ------------------------
 
(1) Does not include (i) 1,250,000 shares of Common Stock reserved for issuance
    upon exercise of options which may be granted under the Company's Stock
    Incentive Plan (the "Plan"), 1,032,000 of which are subject to outstanding
    and unexercised options having a weighted average exercise price of $1.99
    per share, and of which 357,724 options are subject to future vesting, (ii)
    450,000 shares of the Common Stock reserved for issuance upon the exercise
    of options held by the Company's President, Dr. Ronald K. Lohrding , at the
    same price per share as Common Stock sold in this offering (the "Lohrding
    Options"), (iii) 345,000 shares of Common Stock reserved for issuance upon
    exercise of the outstanding Placement Agent's Warrant (as hereinafter
    defined) and (iv) 300,000 shares of Common Stock reserved for issuance under
    the Company's Employee Stock Purchase Plan ("ESPP"). See "Management--Stock
    Incentive Plans" and "Description of Securities--Placement Agent's Warrant."
 
(2) Assumes no exercise of (i) the Underwriters' Over-Allotment Option and (ii)
    the Representatives' Warrants.
 
    The information contained in this Prospectus relates solely to the issuance
of up to 2,000,000 shares of Common Stock and additional Common Stock included
in the Over-Allotment Option granted to the Underwriters. The Shares are being
offered and sold to the public through the Underwriters on the terms set forth
in "Underwriting."
 
                                       5

                             SUMMARY FINANCIAL DATA
 
    Set forth below is selected summary financial data with respect to the
Company. Actual financial information for the years ended December 31, 1995 and
1996, and as of September 30, 1997 and for the nine months ended September 30,
1996 and September 30, 1997, is derived from the Consolidated Financial
Statements and Notes thereto included elsewhere in this Prospectus and is
qualified by reference to such Consolidated Financial Statements and the Notes
thereto.
 


                                                                                      NINE MONTHS ENDED SEPTEMBER
                                                          YEARS ENDED DECEMBER 31,                30,
                                                        ----------------------------  ----------------------------
                                                            1995           1996           1996           1997
                                                        -------------  -------------  -------------  -------------
                                                                                         
STATEMENTS OF OPERATIONS DATA
Revenues..............................................  $     942,667  $     663,261  $     592,802  $     828,566
Cost of Sales.........................................        728,719        496,531        400,997        597,299
Operating Expenses....................................      1,192,522      1,771,101      1,306,841      2,091,621
Other Income (Expenses)...............................       (372,576)        60,281         33,379         41,186
Net Loss..............................................     (1,351,150)    (1,544,090)    (1,081,657)    (1,819,168)
Net Loss Per Share(1).................................           (.66)          (.37)          (.28)          (.36)
Average Common Shares Outstanding.....................      2,039,280      4,197,499      3,926,416      5,054,026

 


                                                                                          SEPTEMBER 30, 1997
                                                                                     ----------------------------
                                                                  DECEMBER 31, 1996     ACTUAL     AS ADJUSTED(2)
                                                                  -----------------  ------------  --------------
                                                                                          
BALANCE SHEET DATA
Total Assets....................................................    $   2,570,952    $  1,784,323   $  9,334,323
Working Capital.................................................        1,858,088         771,162      8,321,162
Total Liabilities...............................................          363,722         726,752        726,752
Stockholders' Equity............................................        2,207,230       1,057,571      8,607,571

 
- ------------------------
 
(1) See Note 2 of Notes to Consolidated Financial Statements for a discussion of
    the calculation of net loss per share for the fiscal years ended December
    31, 1995 and 1996, and for the nine-month periods ended September 30, 1996
    and 1997.
 
(2) Adjusted to give effect to the application of the estimated net proceeds of
    this offering based upon an assumed public offering price of $4.50 per
    share. See "Use of Proceeds" and "Management's Discussion and Analysis of
    Financial Condition and Results of Operations."
 
                                       6

                           FORWARD-LOOKING STATEMENTS
 
    Certain statements made in this Prospectus are "forward-looking statements"
(within the meaning of the Private Securities Litigation Reform Act of 1995)
regarding the plans and objectives of management for future operations. Such
statements involve known and unknown risks, uncertainties and other factors that
may cause actual results, performance or achievements of the Company to be
materially different from any future results, performance or achievements
expressed or implied by such forward-looking statements. The forward-looking
statements made in this Prospectus are based on current expectations that
involve numerous risks and uncertainties. The Company's plans and objectives are
based, in part, on assumptions involving the growth and expansion of business.
Assumptions relating to the foregoing involve judgments with respect to, among
other things, future economic, competitive and market conditions and future
business decisions, all of which are difficult or impossible to predict
accurately and many of which are beyond the control of the Company. Although the
Company believes that its assumptions underlying the forward-looking statements
are reasonable, any of the assumptions could prove inaccurate and, therefore,
there can be no assurance that the forward-looking statements made in this
Prospectus will prove to be accurate. In light of the significant uncertainties
inherent in the forward-looking statements made in this Prospectus, particularly
in view of the Company's early stage of operations, the inclusion of such
information should not be regarded as a representation by the Company or any
other person that the objectives and plans of the Company will be achieved.
 
                                       7

                                  RISK FACTORS
 
    THE SECURITIES OFFERED HEREBY ARE SPECULATIVE AND INVOLVE A HIGH DEGREE OF
RISK. PROSPECTIVE INVESTORS SHOULD CAREFULLY CONSIDER THE POSSIBILITY OF THE
LOSS OF THEIR ENTIRE INVESTMENT IN THE COMPANY'S SECURITIES AND, ALONG WITH EACH
OF THE FOLLOWING FACTORS, CONSIDER THE INFORMATION SET FORTH ELSEWHERE IN THIS
PROSPECTUS.
 
    HISTORY OF OPERATING LOSSES; FUTURE PROFITABILITY UNCERTAIN.  From its
inception in 1988 through September 30, 1997, the Company has incurred losses of
approximately $13.0 million, substantially all of which consisted of research
and development and general and administrative expenses. To date, the Company
has been unable to profitably market its products. For the years ended December
31, 1996 and 1995 and for the nine months ended September 30, 1997 and 1996, the
Company's net losses were $1,544,090, $1,351,150, $1,819,168 and $1,081,657,
respectively. In addition, the Company's operations used net cash of $1,315,930
and $1,803,286 for the year ended December 31, 1996 and nine months ended
September 30, 1997, respectively. The Company has yet to sell any of its
products in commercial quantities. Moreover, even if the Company eventually
generates increased revenues from product sales, the Company does not expect to
achieve operating profits before the first quarter of 1999. The Company's
ability to achieve a profitable level of operations in the future will depend in
large part on finalizing development of its medical laser products, obtaining
additional regulatory approval for such products and bringing several of these
products to market. The likelihood of long-term success of the Company must be
considered in light of the expenses, difficulties and delays frequently
encountered in the development and commercialization of new medical laser
products, competitive factors in the marketplace as well as the burdensome
regulatory environment in which the Company operates. There can be no assurance
that the Company will ever achieve significant revenues or profitable
operations. See "Selected Financial Data" and "Management's Discussion and
Analysis of Financial Condition and Results of Operations."
 
    GOING CONCERN UNCERTAINTIES.  The consolidated financial statements included
in this Prospectus have been prepared assuming that the Company will continue as
a going concern. As a result of the Company's continuing operating losses and
negative cash flows from operations, the Independent Auditors' Report issued in
conjunction with the audit of the consolidated financial statements of the
Company for the fiscal year ended December 31, 1996, contained an explanatory
paragraph indicating that the foregoing matters raised substantial doubt about
the Company's ability to continue as a going concern. The Company's continued
operating losses have resulted in an accumulated deficit of $12,959,624 at
September 30, 1997. There can be no assurance that the Company's operations will
be profitable or that the Company will be able to attain its business plan
objectives. See Independent Auditors' Report and Notes to Consolidated Financial
Statements--Note 12.
 
    FUTURE REVENUE GROWTH DEPENDENT ON MEDICAL LASER PRODUCTS.  The Company is
relying heavily upon the success of its medical laser products which are in the
product introduction stage. These medical laser products are subject to all of
the risks of failure inherent in the market introduction of innovative
technologies. Those risks include the possibilities that some or all of the
proposed products may fail to receive additional necessary regulatory
clearances, that the proposed products may have features which render them
uneconomical either to manufacture or market, that there does not exist demand
for the products at levels or prices at which the Company can operate
profitably, or that third parties will market a superior product. As a result,
there can be no assurance that all or any of the Company's medical laser
products will receive all of the required governmental regulatory approvals or
become commercially viable or achieve market acceptance. See "Business."
 
    ADDITIONAL FINANCING REQUIREMENTS.  The Company will require substantial
funds for commercialization of its medical laser products, establishing
manufacturing and testing capabilities and marketing and sales efforts. The
Company's capital requirements depend upon numerous factors, including the
progress of its product commercialization, the requirement for additional
clinical testing, the time and cost involved in obtaining additional regulatory
approvals, the cost of filing, prosecuting, defending and enforcing patent
claims and other intellectual property rights, competing technological and
market developments, the ability
 
                                       8

of the Company to establish collaborative arrangements, the development of
commercialization activities and arrangements, and the purchase of capital
equipment. The Company believes that its existing capital resources, including
the estimated net proceeds of this offering, will be sufficient to satisfy its
current and projected funding requirements for at least 12 months from the date
of this Prospectus. Unless the Company is able to achieve profits from
operations within that time, which the Company does not anticipate, or if the
Company experiences unanticipated cash requirements during the next 12 months,
the Company expects that it may require substantial additional capital. The
Company may seek additional funding through public or private financings or
collaborative or other arrangements with third parties. There can be no
assurance that additional funds will be available on acceptable terms, if at
all. If additional funds are raised by issuing equity securities, further
substantial dilution to existing stockholders, including purchasers of the
Shares offered hereby, may result. If adequate funds are not available, the
Company may be required to delay, scale back or eliminate one or more of its
development programs or to obtain funds by entering into arrangements with
collaborative partners or others that may require the Company to relinquish
rights to certain of its products or technologies that the Company would not
otherwise relinquish. See "Use of Proceeds" and "Management's Discussion and
Analysis of Financial Condition and Results of Operations."
 
    PATENT LITIGATION.  On October 15, 1997, Venisect, Inc. ("Venisect")
commenced a patent infringement action (the "Venisect Litigation") against the
Company in the United States District Court for the Eastern District of Arkansas
alleging that the Lasette-TM- infringes on certain patents and patent rights
owned by Venisect. Venisect seeks injunctive relief and monetary relief,
including treble damages. The Company has filed a response to this Complaint,
moving to dismiss the Complaint for lack of jurisdiction. The Company believes,
and has received an opinion from its patent counsel, that the Lasette-TM- does
not infringe on the patents and patent rights owned by Venisect and will assert
substantive defenses if the action is not dismissed or is refiled in another
jurisdiction. Nevertheless, there can be no assurance that the Company will be
able to successfully defend the patent infringement claims made by Venisect. If
Venisect prevails in this litigation, the Company may be permanently enjoined
from selling the Lasette-TM- and may be obligated to pay significant damages to
the plaintiff. Even if the Company is successful in its defense of the
Litigation, the cost of such defense could be substantial and the Company's
management may be required to devote a substantial amount of time to such
defense. Accordingly, the Venisect Litigation could have a material adverse
impact on the Company's business and financial condition.
 
    PATENTS AND PROPRIETARY TECHNOLOGY.  The Company's medical laser products
currently have no patent protection. The Company intends to file applications
for patents covering some features of the medical laser products; however, there
can be no assurance that patents will be issued or, if issued, the degree of
protection that they will afford. The Company's current scientific research
instruments only have limited patent protection. The Company has licenses to or
assignments of United States patents and certain corresponding foreign patents
that cover certain aspects of some of its products. However, there can be no
assurance as to the degree of protection offered by these patents. These patents
may have limited commercial value or may lack sufficient breadth or scope to
adequately protect the aspects of the Company's technology to which they relate.
 
    Since there is no patent protection currently afforded the Company's medical
laser products, there can be no assurance that other patent holders or other
third parties will not claim infringement by the Company or its licensors with
respect to current and future technology. Because United States patent
applications are held and examined in secrecy, it is also possible that
presently pending United States patent applications will eventually issue with
claims that will be infringed by the Company's products. There can be no
assurance that additional competitors, in the United States and in foreign
countries, many of which have substantially greater resources than the Company
and have made substantial investments in competing technologies, will not apply
for and obtain patents that will prevent, limit or interfere with the Company's
ability to make and sell its products. The Company is aware of several patents
held by third parties that relate to certain aspects of its products. There can
be no assurance that these patents would
 
                                       9

not be used as a basis to challenge the Company's current or future patents, to
limit the scope of its patent rights or to limit its ability to obtain
additional or broader patent rights. A successful challenge to the validity of
any of the Company's existing or future patents and/or patent rights may
adversely affect the Company's competitive position and could limit the
Company's ability to commercialize one or more of its medical laser products and
its scientific products. Further, the Company may in the future be required to
initiate litigation to protect its patent position. There can be no assurance
that the Company will have the resources necessary to pursue such litigation or
otherwise protect its patent rights. The defense and prosecution of patent suits
is costly and time-consuming, even if the outcome is favorable. This is
particularly true in foreign countries where the expense associated with a
proceeding can be prohibitive. An adverse outcome in the defense of a patent or
infringement suit could subject the Company to significant liabilities to third
parties, require the Company and others to cease selling products that infringe
or require disputed rights to be licensed from third parties. Such licenses may
not be available on satisfactory terms or at all. Moreover, if claims of
infringement are asserted against future co-development partners or customers of
the Company, those partners or customers may seek indemnification from the
Company for damages and expenses they incur. There can no be assurance that the
Company would prevail in any such action or that any license required under any
such patent would be made available under acceptable terms, if at all. There has
been, and the Company believes that there will continue to be, significant
litigation in the laser-based biotechnological industry regarding patent and
other intellectual property rights. Any litigation, including the Venisect
Litigation, could consume a substantial portion of the Company's financial and
personnel resources and, regardless of the outcome of such litigation, have a
material adverse impact upon the Company's business, results of operations and
financial condition.
 
    The Company also relies on trade secret protection for its unpatented
proprietary technology. However, trade secrets are difficult to protect. There
can be no assurance that others will not independently develop substantially
equivalent proprietary information and techniques or otherwise gain access to
the Company's trade secrets, that such trade secrets will not be disclosed or
that the Company can effectively protect its rights to unpatented trade secrets.
Despite precautions taken by the Company, unauthorized parties may attempt to
engineer, reverse engineer, copy or obtain and use its products and other
information the Company considers proprietary. The Company pursues a policy of
having its employees and consultants execute non-disclosure agreements upon
commencement of employment or consulting relationships with the Company, which
agreements provide that all confidential information developed or made known to
the individual during the course of the relationship shall be kept confidential
except in specified circumstances. There can be no assurance, however, that
these agreements will provide meaningful protection for the Company's trade
secrets or other proprietary information in the event of unauthorized use or
disclosure of such information.
 
    Further, the Company has developed and relies on the trademarks that it uses
with its products, including the Lasette-TM-, the RevitaLase-TM- and the IVF
Workstation-TM-. The Company has applied for a federal registration for the name
Lasette-TM- and intends to apply for federal registration with respect to the
use of the RevitaLase-TM- and IVF Workstation-TM- trademarks. Where
registrations of trademarks have not been issued, the Company claims common law
trademark rights to those names. Notwithstanding, there can be no assurance that
the Company will obtain additional registrations for any of its trademarks or
that the Company will not be subject to opposition, cancellation or infringement
proceedings based upon the use of such trademarks. The loss of the use of any
one or more of the trademarks could have a material adverse effect upon the
Company's ability to profitably market the associated product. See "Business--
Intellectual Property."
 
    COMPETITION.  The industry in which the Company competes is characterized by
intense competition, extensive research and development efforts and rapid
technological progress. New product developments and enhancements of existing
products are expected to continue and there can be no assurance that discoveries
by others will not render the Company's products non-competitive.
 
                                       10

    There are many companies, both public and private, that are engaged in the
development of products for the same applications being pursued by the Company.
Many of those companies have substantially greater financial, research and
development, manufacturing and marketing experience and resources than the
Company and represent substantial long-term competition for the Company. Such
companies may succeed in developing products that are more effective or less
costly than any products that may currently be owned or which may be developed
by the Company in the future. Specifically, the Company is aware of several
other companies which are developing glucose testing products based on
non-invasive technologies, such as skin patches and diode-pumping laser
products. If these products are approved for sale and become commercially
available in the United States in the future, they could have a material adverse
effect on sales of the Lasette-TM- and on the business and financial condition
of the Company.
 
    Factors affecting competition in the laser-based medical and
biotechnological industry vary depending on the extent to which the competitor
is able to achieve a competitive advantage based upon proprietary technology. If
the Company is able to establish and maintain a significant proprietary position
with respect to its products, competition will likely depend primarily on the
effectiveness of the products and their price competitiveness. In addition, the
Company's competitive position also depends upon its ability to attract and
retain qualified scientific and other personnel, develop effective proprietary
products, acquire technology from third parties, implement development and
marketing plans, obtain patent protection and secure adequate capital resources.
See "Business--Competition."
 
    RISKS ASSOCIATED WITH LICENSES.  The LaserTweezers-Registered Trademark-
application of the Cell Robotics Workstation is based upon an exclusive patent
license from AT&T (the "AT&T License"), which requires the payment of
substantial minimum annual royalties in the future. If future sales of the Cell
Robotics Workstation do not increase substantially over historical levels, it is
likely that future sales of the product will be rendered uneconomical by virtue
of the minimum royalty required under the AT&T License. Under such
circumstances, the Company may elect to allow the AT&T License to terminate and
as a result lose its ability to continue to market the LaserTweezers-Registered
Trademark- module of the Cell Robotics Workstation.
 
    TECHNOLOGICAL CHANGE AND PRODUCT OBSOLESCENCE.  The medical device industry
is characterized by extensive research efforts, rapid technological progress,
evolving industry standards, frequent new product and service introductions and
enhancements and intense competition from numerous organizations, including
pharmaceutical and medical diagnostic equipment companies, academic
institutions, and others. New developments are expected to continue at a rapid
pace. There can be no assurance that research and discoveries by others will not
render any of the Company's products or potential products non-competitive,
obsolete and/or unmarketable. In order to compete successfully, the Company must
continue to improve its current products and develop and market new products
that keep pace with technological developments. Accordingly, even if the
Company's medical laser products achieve market acceptance, its future success
will depend in significant part on its ability to continually improve the
performance, features, and reliability of its products in response to both
evolving demands of the marketplace and competitive product offerings. There can
be no assurance that the Company will be successful in so doing. Any failure by
the Company to anticipate or respond adequately to technological developments
could have a material adverse effect on its operating results and financial
condition. The Company's pursuit of necessary technological advances will
require substantial time and expense, and there can be no assurance that the
Company will succeed in adapting its products to changing technology standards
and customer requirements. There can be no assurance that the announcement or
introductions of new products by the Company or its competitors or any change in
industry standards will not cause customers to defer or cancel purchases of
existing products, which could have a material adverse effect on the Company's
business, financial condition and results of operations. See "Business."
 
    GOVERNMENT REGULATION; NEED FOR ADDITIONAL PRODUCT CLEARANCES AND
APPROVALS.  The testing, manufacture, labeling, distribution, marketing and
advertising of products such as the Company's existing and proposed products and
its ongoing research and development activities are subject to extensive
regulation
 
                                       11

by government regulatory authorities in the United States and other countries.
The FDA and comparable agencies in foreign countries impose substantial
requirements on the introduction of new medical laser products through lengthy
and detailed clinical testing procedures, and other costly and time-consuming
compliance procedures. The Company's products must receive FDA clearance before
they can be commercially marketed in the United States, which in many instances
involves rigorous pre-clinical and clinical testing and an extensive FDA
approval process. The time required for completing such testing and obtaining
such approvals is uncertain, and FDA clearance may never be obtained for some
products or applications. Delays or rejections may be encountered based upon
changes in FDA policy during the period of product development and FDA
regulatory review of the Company's submitted application. Similar delays may
also be encountered in other countries. Failure to receive timely approval from
these agencies could result in the Company's incurring substantial costs and
could also have a material adverse effect upon the Company's operations and
financial condition. In addition, if regulatory clearance of a product is
granted, such clearance may entail limitations on the indicated uses for which
the product may be marketed. Also, modifications may be made to the Company's
products to incorporate enhancements to their functionality and performance
based upon new data and design review. There can be no assurance that the FDA
will not request additional information relating to product improvements, that
any such improvements would not require further regulatory review thereby
delaying testing, approval and commercialization of the Company's products or
that ultimately any such improvements will receive FDA clearance.
 
    While the Lasette-TM- has been cleared by the FDA for clinical use for all
adult glucose/hematocrit testing, including diabetics, the Company believes that
realizing the full commercial potential of the Lasette-TM- will depend upon the
Company receiving FDA clearance to sell the Lasette-TM- to all diabetics (adults
and children) for home use. The Company is applying for FDA clearance to sell
the product for home use by diabetics; however, there can be no assurance that
such clearance will be issued or, if issued, that it will not be subject to
restrictions that could substantially impair its future profitability. In
addition, the laser-assisted hatching module of the IVF Workstation-TM- has only
begun clinical trials, which will consist of at least 600 clinical cycles. It is
estimated that the clinical trials for this product will take at least one year
to complete, with no assurance that once completed the product will receive FDA
clearance for sales in the United States.
 
    FDA regulations also require manufacturers of medical devices to adhere to
certain "Medical Device Quality System Regulation" ("MDQS"), which include
testing, design, quality control and documentation procedures. Compliance with
applicable regulatory requirements is subject to continual review and will be
monitored through periodic inspections by the FDA. Similarly, sales of the
Company's products outside of the United States are also subject to certain
manufacturing standards promulgated by the International Standards Organization
("ISO"). In addition, the Company's manufacturing activities are subject to
regulation and control under the Occupational Safety and Health Act (OSHA) and
regulations promulgated thereunder. Later discovery of previously unknown
problems with a product, manufacturer or facility may result in restrictions on
such product or manufacturer, including fines, delays, or suspensions of
regulatory clearances, seizures, recalls of products, operating restrictions and
criminal prosecution. The failure to comply with regulatory requirements could
subject the Company to regulatory or judicial enforcement actions, including,
but not limited to, product recall or seizures, injunctions, civil penalties,
criminal prosecution, refusals to approve new products and withdrawal of
existing approvals, as well as potentially enhanced product liability exposure.
Sales of the Company's products outside of the United States will be subject to
regulatory requirements governing clinical trials and marketing approval.
 
    In addition, the foreign sale by the Company of at least one of its lasers
is subject to the Export Control Act and can only be exported under a license
held by the Company's supplier. Should that source of supply fail to maintain
such license, the Company's ability to export that laser product would be
suspended until it was able to identify and enter into an arrangement with a new
licensed supplier. These requirements vary widely from country to country and
could delay introduction or continuing sales of the Company's products in
foreign countries. See "Government Regulation."
 
                                       12

    DEPENDENCE UPON SOURCE OF SUPPLY.  The Erbium:YAG lasers used by the Company
in the Lasette-TM- and the Revitalase-TM- are made from crystals which the
Company has manufactured in Russia through a strategic relationship. The
Company's competitive advantage in these products is derived to a degree upon
the significant cost savings which the Company is able to realize by having its
crystals manufactured by its Russian supplier. However, the continuation of the
Company's relationship with this source of supply is in doubt due to current
unresolved disputes, including problems related to crystal quality. If this
source of supply were restricted or eliminated due to factors specifically
affecting such supplier, such as the inadvertent or intentional non-performance
by such source, or events flowing from Russia's political or economic
instability, it is likely that alternative sources of supply would be
substantially more expensive. As a result of the foregoing, and other factors
beyond the control of the Company, the Company could lose its strategically
important source of supply for laser crystals, which would impair its
competitive advantage. See "Business."
 
    UNCERTAINTY OF MARKET ACCEPTANCE.  Achieving market acceptance for the
Company's proprietary products will require substantial marketing efforts and
expense. As with any new technology, there is substantial risk that the
marketplace will not accept the potential benefits of such technology or be
willing to pay for any cost differential with the existing technologies. For
example, the Lasette-TM- will compete directly with stainless steel lancets
which only cost pennies apiece and non-invasive procedures and products are
currently being developed by other companies. Market acceptance of these current
and proposed products will depend, in large part, upon the ability of the
Company to educate potential customers, including third-party distributors, of
the distinctive characteristics and benefits of its products. There can be no
assurance that current or proposed products will be accepted by the end users or
that any of the current or proposed products will be able to compete effectively
against current and alternative products. See "Business."
 
    DEPENDENCE ON MANUFACTURERS.  The Company is relying upon a third party to
manufacture the Lasette-TM-. The Company is dependent on third parties to
produce and manufacture certain components for its other products. Certain key
components used in the manufacturing of the Company's products are currently
obtained from single vendors. There are no written agreements with such third
parties, and no third party is obligated to perform any services for the Company
on which the Company depends in order to meet its business objectives.
Consequently, there can be no assurance that these third parties will commit any
resources to the commercialization of the Company's business. Any supply
interruption in a single-sourced component would have a material adverse effect
on the Company's ability to manufacture products until a new source of supply
were qualified. There can be no assurance that the Company would be successful
in qualifying additional sources on a timely basis, if ever. Failure to do so
would have a material adverse effect on the Company's business, financial
condition, and results of operations. See "Business."
 
    PRODUCT DEFECTS AND WARRANTIES.  Products as complex as those developed by
the Company may contain undetected errors or defects when first introduced or as
new versions are released. In addition, the Company offers on existing products
and plans to offer on future products a one-year warranty against defects in
materials and workmanship. There can be no assurance that, despite testing by
the Company or its customers, errors will not be found in new products resulting
in warranty claims, product redevelopment costs and loss of, or delay in, market
acceptance and additional costs. If a product initially fails to produce
acceptable results, customer acceptance of the Company's products, even those
which have been successfully redesigned or improved, could be materially
adversely affected. See "Business."
 
    MARKETING AND SALES; STRATEGIC RELATIONSHIPS.  In order for the Company to
increase revenues and achieve profitability, the Company's products must achieve
a significant degree of market acceptance. The Company's future success is
dependent upon its ability to establish an effective sales organization for its
proprietary products or to enter into distribution arrangements with other
entities selling to its target markets. No assurances can be given that the
Company will be able to hire and retain its own sales force or
 
                                       13

enter into appropriate distribution arrangements. The Company must attract,
build, train and motivate a marketing and sales force which the Company
currently does not have. Building a successful sales force takes time, and
requires a significant amount of capital. The Company intends to acquire
experienced marketing personnel, and to enter into marketing and distribution
agreements with various strategic partners. There can be no assurance that the
Company will be successful in recruiting marketing personnel with the required
skills or that it will be able to enter into such strategic relationships. In
addition, there can be no assurance that a commercial market for the Company's
products will develop, that the Company will be able to compete effectively on
price or some other basis, if such a market does develop, or that the Company's
products will perform up to market expectations. See "Business."
 
    DEPENDENCE UPON KEY PERSONNEL.  The Company's future success is dependent on
the continued service of its key technical, marketing, sales, and management
personnel and on its ability to continue to attract, motivate, and retain highly
qualified employees. The Company's key employees may voluntarily terminate their
employment with the Company at any time. Competition for such employees is
intense and the process of locating technical and management personnel with the
combination of skills and attributes required to execute the Company's strategy
is often lengthy. Accordingly, the loss of the services of key personnel could
have a material adverse effect upon the Company's operations and on research and
development efforts. Further, the Company does not have key person life
insurance covering its management personnel or other key employees, other than a
$500,000 term policy on Dr. Lohrding. See "Management."
 
    MANAGEMENT OF GROWTH.  The Company's ability to manage its growth, if any,
will require it to continue to improve and expand its management, operational
and financial systems and controls. Any measurable growth in the Company's
business will result in additional demands on its customer support, sales,
marketing, administrative and technical resources and will place significant
strain on the Company's management, administrative, operation, financial and
technical resources and increase demand upon its systems and controls. There can
be no assurance that the Company will be able to successfully address these
additional demands. There also can be no assurance that the Company's operating
and financial control systems will be adequate to support its future operations
and anticipated growth. Failure to manage the Company's growth properly could
have a material adverse effect upon the Company's business, financial condition
and results of operations. The Company may also seek potential acquisitions of
patents, products, technologies and businesses that could complement or expand
the Company's business. In the event the Company were to identify an appropriate
acquisition candidate, there is no assurance that the Company would be able to
successfully negotiate, finance or integrate such acquired patents, products,
technologies or businesses. Furthermore, such an acquisition could cause a
diversion of management's time and resources. There can be no assurance that a
given acquisition, when consummated, would not materially adversely affect the
Company's business and results of operations. See "Risk Factors-- Dependence
Upon Key Personnel."
 
    HEALTH CARE REFORM AND POTENTIAL LIMITATIONS ON THIRD-PARTY REIMBURSEMENT
RELATED MATTERS.  The Company's future success may be affected by the continuing
efforts of government and third-party payors to contain or reduce the costs of
health care through various means. The Company cannot predict the effect health
care reforms may have on its business, and there can be no assurance that any
such reforms will not have a material adverse effect on the Company. Certain of
the medical lasers products that the Company is developing are designed for use
in elective medical procedures, such as cosmetic surgery and in vitro
fertilization. In both the United States and elsewhere, uses of elective medical
procedures are dependent in part on the availability of reimbursement to the
consumer from third-party payors, such as government and private insurance
plans. Third-party payors are increasingly challenging the prices charged for
medical products and services. It is unlikely that the cost of the Lasette-TM-
will qualify as a reimbursable expense under most health insurance programs.
There can be no assurance that the Company's laser medical products will be
considered cost effective and that reimbursement to the consumer will be
available or will be sufficient to allow the Company to sell its products on a
competitive basis. See "Business."
 
                                       14

    LIMITED MARKET FOR SCIENTIFIC INSTRUMENTS.  The principal markets for the
Company's scientific instrumentation products are colleges, universities and
other institutions engaged in scientific research. Most, if not all, of these
potential customers rely upon federal and state funding in order to support
their research activities. The ability of these institutions to purchase the
Company's products is dependent upon receiving adequate funding from the public
sector. A reduction or withdrawal of government support of scientific pursuits
could result in, a diminished demand for the Company's products. See "Business."
 
    RISK OF PRODUCT LIABILITY.  Clinical trials or marketing of any of the
Company's products may expose the Company to liability claims from the use of
such products. The Company currently carries product liability insurance;
however, there can be no assurance that the Company will be able to obtain or
maintain insurance on acceptable terms for its clinical and commercial
activities or that such insurance would be sufficient to cover any potential
product liability claim or recall. Failure to have sufficient coverage could
have a material adverse effect on the Company's business and results of
operations. See "Business."
 
    BROAD DISCRETION AND APPLICATION OF PROCEEDS.  The Company expects that the
proceeds of this offering will be used principally for product research and
development and to launch its medical laser products, with approximately 20% to
be reserved for use as working capital. The Company is not currently able to
estimate precisely the allocation of the proceeds among such uses, and the time
and amount of expenditures will vary depending upon numerous factors. The
Company's Board of Directors will have broad discretion to allocate the proceeds
of this offering and to determine the timing of expenditures. See "Use of
Proceeds."
 
    SUBSTANTIAL DILUTION.  Investors acquiring Shares offered hereby will incur
immediate and substantial dilution of their investment of approximately $3.32
per share, or 73.8% of the offering price, based upon the Company's adjusted net
tangible book value as of September 30, 1997. To the extent that currently
outstanding options and warrants to purchase the Company's Common Stock are
exercised, there will be further dilution to investors acquiring Shares. See
"Dilution."
 
    OFFERING PRICE ARBITRARILY DETERMINED.  The offering price of the Shares
being offered hereby were determined by negotiation between the Company and the
Representatives and is not necessarily related to the Company's assets, book
value or financial condition, and may not be indicative of the actual value of
the Company. See "Underwriting."
 
    POTENTIAL ADVERSE EFFECTS OF SHARES ELIGIBLE FOR FUTURE SALE.  Sales of
Common Stock (including Common Stock issued upon the exercise of outstanding
options and warrants) in the public market after this offering could materially
adversely affect the market price of the Common Stock. Such sales also might
make it more difficult for the Company to sell equity securities or
equity-related securities in the future at a time and price that the Company
deems acceptable, or at all. As of November 15, 1997, 5,222,414 shares of the
Company's $.004 par value Common Stock, were issued and outstanding, of which
2,749,708 are unrestricted and freely tradeable at the discretion of their
owners and 2,472,706 are "restricted securities" and under certain circumstances
may, in the future, be sold in compliance with Rule 144 adopted under the
Securities Act. In general, under Rule 144, subject to the satisfaction of
certain other conditions, a person, including an affiliate of the Company, who
beneficially owned restricted shares of Common Stock for at least one (1) year
is entitled to sell, within any three (3) month period, a number of shares that
does not exceed the greater of one percent (1%) of the total number of
outstanding shares of the same class, or if the Common Stock is quoted on NASDAQ
or a stock exchange, the average weekly trading volume during the four (4)
calendar weeks immediately preceding the sale. A person who presently is not,
and who has not been an affiliate of the Company for at least three (3) months
immediately preceding the sale, and who has beneficially owned the shares of
Common Stock for at least two (2) years is entitled to sell such shares under
Rule 144 without regard to the volume limitations described above. Of these
restricted shares, approximately 1,415,106 shares of Common Stock are eligible
for sale in the public market without restriction in reliance upon Rule 144(k)
under the Securities Act. Of the 2,472,706 restricted shares outstanding,
1,040,100 are beneficially owned by officers, directors and affiliates of the
Company, who
 
                                       15

have agreed, pursuant to lock-up agreements, that they will not offer, sell,
contract to sell, grant any option to sell or otherwise dispose of, directly or
indirectly, any shares of Common Stock owned by them or that could be purchased
by them to the exercise of options or warrants to purchase Common Stock of the
Company through a period of 90 days after the date of this Prospectus without
the prior written consent of the Underwriters. Upon the expiration of the
lock-up agreements, the 840,100 shares of Common Stock held by the officers,
directors and affiliates will be immediately eligible for resale subject to the
volume limitations of Rule 144 and approximately 217,500 other restricted shares
will become eligible for resale under Rule 144 from time to time thereafter. In
addition, the Company currently has issued and outstanding options and warrants
to purchase an aggregate of 1,827,000 shares of Common Stock, of which 1,032,000
underlying shares of Common Stock may be freely tradeable upon exercise due to
the registration statement covering the Plan. The Company may also grant options
to purchase an additional 300,000 shares of Common Stock under the ESPP. No
prediction can be made as to the effect, if any, that sales of shares of Common
Stock or the availability of such shares for sale will have on the market prices
prevailing from time-to-time. Nevertheless, the possibility that substantial
amounts of Common Stock may be sold in the public market may adversely affect
prevailing market prices for the Common Stock and could impair the Company's
ability to raise capital in the future through the sale of equity securities.
Actual sales or the prospect of future sales of shares of Common Stock under
Rule 144 may have a depressive effect upon the price of the Common Stock and the
market therefor. See "Shares Eligible For Future Sale."
 
    POSSIBLE DILUTION FROM FUTURE SALES OF COMMON STOCK.  The Company's Board of
Directors has the authority to issue up to 12,500,000 shares of Common Stock and
to issue options and warrants to purchase shares of the Company's Common Stock
without stockholder approval. Future issuance of Common Stock could be at values
substantially below the offering price in this offering and therefore could
represent further substantial dilution to investors in this offering. In
addition, the Board could issue large blocks of common stock to fend off
unwanted tender offers or hostile takeovers without further stockholder
approval. See "Description Of Securities" and "Shares Eligible For Future Sale."
 
    POTENTIAL ADVERSE EFFECTS OF FUTURE SALES OF PREFERRED STOCK.  The Company's
Articles of Incorporation, as amended, authorize the issuance of up to 2,500,000
shares of $.04 par value preferred stock, none of which are outstanding. The
Board of Directors has been granted the authority to fix and determine the
relative rights and preferences of preferred shares, as well as the authority to
issue such shares, without further stockholder approval. As a result, the Board
of Directors could authorize the issuance of a series of preferred stock which
would grant to holders preferred rights to the assets of the Company upon
liquidation, the right to receive dividend coupons before dividends would be
declared to common stockholders, and the right to the redemption of such shares,
together with a premium, prior to the redemption of Common Stock. Common
stockholders have no redemption rights. In addition, the Board could issue large
blocks of preferred stock to fend against unwanted tender offers or hostile
takeovers without further stockholder approval. See "Description Of Securities"
and "Shares Eligible For Future Sale."
 
    MANAGEMENT'S LACK OF VOTING INFLUENCE.  Upon consummation of this offering,
the Company's President, Ronald K. Lohrding, will own 300,000 shares of Common
Stock, and vested options exercisable to acquire an additional 325,000 shares of
Common Stock, together representing 8.7% of the total issued and outstanding
shares following completion of this offering. All of the Company's officers and
directors as a group own only 420,800 shares of Common Stock, and vested options
exercisable to acquire an additional 496,000 shares of Common Stock. Even giving
effect to the exercise of their outstanding and vested options, the Company's
officers and directors as a group would exercise voting control over only 11.9%
of the Company's outstanding shares of Common Stock following completion of this
offering. As a result of this lack of voting influence as stockholders, there
can be no assurance that the Company's officers and directors will be able to
implement the plans and strategies described in this Prospectus. Further, it is
possible that stockholders with greater voting influence could initiate actions
which could be adverse to
 
                                       16

those plans or hostile to current management. See "Security Ownership of
Management and Principal Stockholders."
 
    LIMITED PUBLIC TRADING MARKET FOR THE COMPANY'S COMMON STOCK.  While there
currently exists in the over-the-counter market a limited and sporadic public
trading market for the Common Stock, there can be no assurance that such a
market will improve in the future, even if the Common Stock is approved for
listing on NASDAQ. There can be no assurances that an investor will be able to
liquidate his investment without considerable delay, if at all. If a more active
market does develop, the price may be highly volatile. Factors discussed herein
may have a significant impact on the market price of the Shares. Moreover due to
the relatively low price of the Common Stock, many brokerage firms may not
effect transactions in the Common Stock. See "Description Of Securities."
 
    RISKS OF PRICE AND VOLUME FLUCTUATIONS.  The over-the-counter markets for
securities such as the Common Stock historically have experienced extreme price
and volume fluctuations during certain periods. These broad market fluctuations
and other factors, such as new product developments and trends in the Company's
industry and the investment markets generally, as well as economic conditions
and quarterly variations in the Company's results of operations, may adversely
affect the market price of the Common Stock. See "Certain Market Information."
 
    POSSIBLE LOSS OF NASDAQ LISTING.  The Company has applied to NASDAQ to have
its shares quoted on the SmallCap Market. Even if such application is granted,
in order to continue to be listed on NASDAQ, the Company must satisfy certain
maintenance standards which relate to the Company's net tangible assets and
public trading price of its securities. Currently, NASDAQ rules require that a
listed company maintain certain minimum net tangible assets and a minimum public
trading price of $1.00 per share. As a result, there can be no assurance that
the Company's securities will continue to be listed on NASDAQ. If the Common
Stock is delisted from NASDAQ, trading, if any, in those securities would
thereafter be conducted in the over-the-counter market on an electronic bulletin
board established for securities that do not meet NASDAQ listing requirements,
or in what are commonly referred to as the "pink sheets." As a result, an
investor would find it substantially more difficult to dispose of, or to obtain
accurate quotations as to the price of the Common Stock, and depending upon
several factors including future market price of the Common Stock, the Company's
securities could become subject to the "penny stock" rules. See "Risk
Factors--The Securities Enforcement and Penny Stock Reform Act of 1990."
 
    THE SECURITIES ENFORCEMENT AND PENNY STOCK REFORM ACT OF 1990.  The
Securities Enforcement and Penny Stock Reform Act of 1990 requires additional
disclosure, relating to the market for penny stocks, in connection with trades
in any stock defined as a penny stock. The Commission recently adopted
regulations that generally define a penny stock to be any equity security that
has a market price of less than $5.00 per share, subject to certain exceptions.
Such exceptions include any equity security listed on NASDAQ and any equity
security issued by an issuer that has (i) net tangible assets of at least
$2,000,000, if such issuer has been in continuous operation for three years,
(ii) net tangible assets of at least $5,000,000, if such issuer has been in
continuous operation for less than three years, or (iii) average annual revenue
of at least $6,000,000, if such issuer has been in continuous operation for less
than three years. Unless an exception is available, the regulations require the
delivery, prior to any transaction involving a penny stock, of a disclosure
schedule explaining the penny stock market and the risks associated therewith.
See "Certain Market Information."
 
    Although application has been made to have the Common Stock approved for
quotation on the NASDAQ SmallCap Market, there can be no assurance that they
will be approved or if approved will remain eligible to be included on NASDAQ.
In the event that the Common Stock were no longer eligible for quotation on
NASDAQ and as a result is delisted, the Common Stock could become subject to
rules adopted by the Commission regulating broker-dealer practices in connection
with transactions in "penny stocks." Those disclosure rules applicable to penny
stocks require a broker-dealer, prior to a transaction in a penny stock not
otherwise exempt from the rules, to deliver a standardized list disclosure
document
 
                                       17

prepared by the Commission. That disclosure document advises an investor that
investments in penny stocks can be very risky and that the investor's
salesperson or broker is not an impartial advisor but rather paid to sell the
shares. It contains an explanation and disclosure of the bid and offer prices of
the security, any retail charges added by the dealer to those prices ("markup"
or "markdown"), and the amount of compensation or profit to be paid to or
received by the salesperson in connection with the transaction. The disclosure
contains further admonitions for the investor to exercise caution in connection
with an investment in penny stocks, to independently investigate the security as
well as the salesperson with whom the investor is working, and to understand the
risky nature of an investment in the security. Further, the disclosure includes
information regarding the market for penny stocks, explanations regarding the
influence that marketmakers may have upon the market for penny stocks and the
risk that one or two dealers may exercise domination over the market for such
security and therefore control and set prices for the security not based upon
competitive forces. The broker-dealer must also provide the customer with
certain other information and must make a special written determination that the
penny stock is a suitable investment for the purchaser and receive the
purchaser's written agreement to the transaction. Further, the rules require
that following the proposed transaction the broker provide the customer with
monthly account statements containing market information about the prices of the
securities. These disclosure requirements may have the effect of reducing the
level of trading activity in the secondary market for a stock that becomes
subject to the penny stock rules. If the Common Stock became subject to the
penny stock rules, many brokers may be unwilling to engage in transactions in
the Common Stock because of the added disclosure requirements, thereby making it
more difficult for purchasers of Common Stock in this offering to dispose of
their securities.
 
    POTENTIAL ADVERSE EFFECTS OF MARKET OVERHANG FROM WARRANTS AND OUTSTANDING
OPTIONS.  The Company has outstanding options and warrants exercisable to
acquire 795,000 shares of Common Stock, 450,000 of which are subject to future
vesting. In addition, the Company has 1,250,000, shares of Common Stock reserved
for issuance under the Plan and has granted 1,032,000 options with respect to
such shares, all of which are immediately exercisable. In addition, the Company
has reserved 300,000 shares for issuance under the ESPP. To the extent that such
stock options or warrants are exercised, dilution to the interests of the
Company's stockholders may occur. Exercise of these options or warrants, or even
the potential of their exercise may have an adverse effect on the trading price
and market for the Common Stock. The holders of the options or warrants are
likely to exercise them at times when the market price of the Common Stock
exceeds the exercise price of the options or warrants. Accordingly, the issuance
of shares of Common Stock upon exercise of the options or warrants may result in
dilution of the equity represented by the then outstanding shares of Common
Stock held by other stockholders. Holders of the options or warrants can be
expected to exercise them at a time when the Company would, in all likelihood,
be able to obtain any needed capital on terms which are more favorable to the
Company than the exercise terms provided by such options or warrants. See
"Description of Securities."
 
    UNDERWRITERS' INFLUENCE ON THE MARKET.  A significant number of the Shares
may be sold to customers of the Underwriters. Such customers may subsequently
engage in transactions for the sale or purchase of such securities through or
with the Underwriters. Although they have no legal obligation to do so, the
Underwriters from time to time in the future may make a market in and otherwise
effect transactions in the Common Stock. To the extent the Underwriters do so,
they may be a dominating influence in any market that might develop and the
degree of participation by the Underwriters may significantly affect the price
and liquidity of the Common Stock. Such market making activities, if commenced,
may be discontinued at any time or from time to time by the Underwriters without
obligation or prior notice. Depending on the nature and extent of the
Underwriters' market making activities and retail support of the Common Stock at
such time, the Underwriters' discontinuance could adversely affect the price and
liquidity of the Common Stock. See "Underwriting."
 
                                       18

                                USE OF PROCEEDS
 
    The net proceeds to the Company from the sale of the Shares offered hereby,
assuming an offering price of $4.50 per share, are estimated to be approximately
$7,550,000 ($8,765,000 if the Over-Allotment Option is exercised in full) after
deducting the underwriting discount and offering expenses.
 


USE                                                                                             AMOUNT       PERCENT
- -------------------------------------------------------------------------------------------  ------------  -----------
                                                                                                     
Marketing and Sales(1).....................................................................  $  3,200,000        42.4%
Manufacturing Equipment and Personnel(2)...................................................     1,400,000        18.5%
Product Development(3).....................................................................       725,000         9.6%
Future Research and Development(4).........................................................       700,000         9.3%
Working Capital(5).........................................................................     1,525,000        20.2%
                                                                                             ------------         ---
                                                                                             $  7,550,000         100%

 
- ------------------------
 
(1) Consists primarily of salaries to hire additional marketing and sales staff
    and expenses for negotiating distribution agreements and developing
    marketing material, including advertising brochures and attending trade
    shows.
 
(2) Reflects purchase of machinery, equipment and other fixed assets to be used
    for manufacturing and testing, and hiring and training additional
    manufacturing personnel.
 
(3) Includes funds needed to complete engineering, commercial development and
    validation of the medical laser products.
 
(4) Consists of research and development principally for additional dermatology
    lasers, a dental laser and a smaller version of the Lasette-TM-.
 
(5) The Company continually evaluates potential acquisitions of patents,
    products or technologies owned by third parties that could complement the
    Company's current product portfolio. Funds allocated to working capital
    could be used to complete one or more product or technology acquisitions,
    although there are currently no understandings, agreements or commitments
    with respect to any such material acquisition.
 
    The amounts set forth above represent the Company's best estimate for the
use of the net proceeds of this offering in light of current circumstances.
However, actual expenditures could vary considerably depending upon many
factors, including, without limitation, changes in the economic conditions,
unanticipated complications, delays and expenses, or problems relating to the
development of additional products and/or market acceptance for the Company's
products. Any reallocation of the net proceeds of the offering will be made at
the discretion of the Board of Directors but will be in furtherance of the
Company's strategy to achieve growth and profitable operations through the
development of additional products and augmentation of the Company's marketing
efforts. The Company's working capital requirements are a function of its future
sales growth and expansion, neither of which can be predicted with any
reasonable degree of certainty. As a result, the Company is unable to precisely
forecast the period of time for which net proceeds of this offering will meet
its working capital requirements although it expects it to be at least 12 months
from the date of this Prospectus. The Company may need to seek funds through
loans or other financing arrangements in the future, and there can be no
assurance that the Company will be able to make such arrangements in the future
should the need arise.
 
    Pending use of the net proceeds of the offering, the funds will be invested
temporarily in certificates of deposit, short-term government securities or
similar investments. Any income from these short-term investments will be used
for working capital.
 
                                       19

                                DIVIDEND POLICY
 
    The Company has not declared or paid cash dividends on its Common Stock in
the preceding two fiscal years. The Company currently intends to retain all
future earnings, if any, to fund the operation of its business, and, therefore,
does not anticipate paying dividends in the foreseeable future. Future cash
dividends, if any, will be determined by the Board of Directors.
 
                                       20

                                 CAPITALIZATION
 
    The following table sets forth the capitalization of the Company as of
September 30, 1997 (i) on an actual basis and (ii) as adjusted to give effect to
the estimated net proceeds from the sale of the Shares offered hereby, based
upon an assumed public offering price of $4.50 per share. This section should be
read in conjunction with the Consolidated Financial Statements and Notes thereto
contained elsewhere in this Prospectus.
 


                                                                                          SEPTEMBER 30, 1997
                                                                                    ------------------------------
                                                                                                          AS
                                                                                                       ADJUSTED
                                                                                        ACTUAL          (1)(2)
                                                                                    --------------  --------------
                                                                                              
Long term debt....................................................................  $          -0-  $          -0-
Stockholders' equity..............................................................
  Preferred Stock, $.04 par value, 2,500,000 shares authorized; no shares
    outstanding...................................................................             -0-             -0-
  Common Stock, $.004 par value, 12,500,000 shares authorized; 5,222,414 shares
    issued and outstanding actual; and 7,222,414 shares issued and outstanding as
    adjusted(2)...................................................................          20,890          28,890
  Additional paid-in capital......................................................      13,996,305      21,538,305
Accumulated (deficit).............................................................     (12,959,624)    (12,959,624)
Total stockholders' equity........................................................       1,057,571       8,607,571
                                                                                    --------------  --------------
Total capitalization..............................................................  $    1,057,571  $    8,607,571
                                                                                    --------------  --------------
                                                                                    --------------  --------------

 
- ------------------------
 
(1) Does not include (i) 1,250,000 shares of Common Stock reserved for issuance
    upon exercise of options which may be granted under the Plan, 1,032,000 of
    which are subject to outstanding and unexercised options having a weighted
    average exercise price of $1.99 per share, and of which 357,724 options are
    subject to future vesting, (ii) 450,000 shares of the Common Stock reserved
    for issuance upon the exercise of the Lohrding Options, (iii) 345,000 shares
    of Common Stock reserved for issuance upon exercise of the outstanding
    Placement Agent's Warrant, and (iv) 300,000 shares of Common Stock reserved
    for issuance under the ESPP. See "Management--Stock Incentive Plans" and
    "Description of Securities--Placement Agent Warrants."
 
(2) Assumes no exercise of the Underwriters' Over-Allotment Option or the
    Representatives' Warrants.
 
                                       21

                                    DILUTION
 
    At September 30, 1997, the Company had a net tangible book value of $986,057
or $.19 per share based upon 5,222,414 shares of Common Stock outstanding. Net
tangible book value per share is determined by dividing the number of
outstanding shares of Common Stock into the net tangible book value of the
Company (total assets less total liabilities and intangible assets). After
giving effect to the sale of the Shares offered hereby and receipt of the
estimated net proceeds therefrom (after deducting the estimated underwriting
discount and offering expenses), the adjusted net tangible book value at
September 30, 1997 would have been $8,536,057 or $1.18 per share of Common
Stock. This represents an immediate increase in net tangible book value of $.99
per share to current stockholders and an immediate dilution of $3.32 per share,
or 73.8%, to the investors in this offering. The following table illustrates the
per share dilution, assuming all 2,000,000 Shares are sold in this offering:(1)
 


                                                                                                        
Assumed public offering price per share of Common Stock..........................................             $    4.50
  Net tangible book value per share of Common Stock before offering..............................  $     .19
  Increase per share of Common Stock attributable to new investors...............................  $     .99
Adjusted net tangible book value per share of Common Stock after offering........................             $    1.18
Dilution of net tangible book value per share of Common Stock to new investors...................             $    3.32
                                                                                                              ---------
                                                                                                              ---------
Dilution per share of Common Stock as a percentage of offering price.............................                  73.8%
                                                                                                              ---------
                                                                                                              ---------

 
- ------------------------
 
(1) Does not include (i) 1,250,000 shares of Common Stock reserved for issuance
    upon exercise of options which may be granted under the Plan, 1,032,000 of
    which are subject to outstanding and unexercised options having a weighted
    average exercise price of $1.99 per share, and of which 357,724 options are
    subject to future vesting, (ii) 450,000 shares of the Common Stock reserved
    for issuance upon the exercise of the Lohrding Options, (iii) 345,000 shares
    of Common Stock reserved for issuance upon exercise of the outstanding
    Placement Agent's Warrant, and (iv) 300,000 shares of the Common Stock
    reserved for issuance under the ESPP. "Management--Stock Incentive Plans"
    and "Description of Securities--Placement Agent Warrant."
 
    The following table sets forth, as of November 1, 1997, the number of shares
of Common Stock purchased, the percentage of total cash consideration paid, and
the average price per share paid by (i) the existing stockholders and (ii)
investors purchasing Shares in this offering, before deducting estimated
underwriting discounts and offering expenses payable by the Company.
 


                                                                                    AVERAGE
                                                                            TOTAL CASH CONSIDERATION
                                                     SHARES PURCHASED                                    AVERAGE
                                                  -----------------------  --------------------------   PRICE PER
                                                    NUMBER      PERCENT       AMOUNT        PERCENT       SHARE
                                                  ----------  -----------  -------------  -----------  -----------
                                                                                        
Existing Stockholders...........................   5,222,414        72.3%  $  14,017,195        60.9%   $    2.68
New Investors...................................   2,000,000        27.7%(1) $   9,000,000       39.1%(1)  $    4.50(1)
                                                  ----------         ---   -------------         ---
Total...........................................   7,222,414         100%  $  23,017,195         100%

 
- ------------------------
 
(1) Estimated
 
                                       22

                           CERTAIN MARKET INFORMATION
 
PRICE RANGE OF COMMON STOCK
 
    The Common Stock is traded over-the-counter and quoted on the Bulletin Board
on a limited and sporadic basis under the symbol "CRII." The reported high and
low bid and asked prices for the Common Stock are shown below for the period
through November 20, 1997. The prices presented are bid and asked prices which
represent prices between broker-dealers and do not include retail mark-ups and
mark-downs or any commission to the broker-dealer. The prices do not necessarily
reflect actual transactions.
 


                                                            BID                   ASK
                                                    --------------------  --------------------
                                                       LOW       HIGH        LOW       HIGH
                                                    ---------  ---------  ---------  ---------
                                                                         
1995
First Quarter.....................................  $  2.75    $  3.625   $  3.25    $  4.00
Second Quarter....................................     2.25       3.00       3.00       3.75
Third Quarter.....................................     1.00       3.125      2.25       3.50
Fourth Quarter....................................     1.75       2.875      2.00       3.25
 
1996
First Quarter.....................................  $  1.375   $  2.75    $  1.625   $  3.25
Second Quarter....................................     1.875      3.875      2.125      4.125
Third Quarter.....................................     1.375      3.00       1.625      3.125
Fourth Quarter....................................     1.375      2.875      1.563      1.938
 
1997
First Quarter.....................................  $  1.875   $  2.8125  $  2.00    $  3.00
Second Quarter....................................     1.9375     3.375      2.00       3.50
Third Quarter.....................................     2.9375     4.00       3.0625     4.0625
Fourth Quarter (Through Nov. 20, 1997)............     3.375      3.625      3.4375     3.875

 
    The bid and ask prices of the Common Stock on November 20, 1997 were $3.38
and $3.63, respectively, as quoted on the Bulletin Board. As of November 20,
1997 there were approximately 176 stockholders of record of the Common Stock.
 
                                       23

                            SELECTED FINANCIAL DATA
 
    Set forth below is selected financial data with respect to the Company.
Financial information for the years ended December 31, 1995 and 1996, and as of
September 30, 1997 and for the nine months ended September 30, 1996 and
September 30, 1997, is derived from the Consolidated Financial Statements and
Notes thereto included elsewhere in this Prospectus and is qualified by
reference to such Consolidated Financial Statements and the Notes thereto.
 


                                                                                          NINE MONTHS ENDED
                                                             YEARS ENDED DECEMBER 31,       SEPTEMBER 30,
                                                             ------------------------  ------------------------
                                                                1995         1996         1996         1997
                                                             -----------  -----------  -----------  -----------
                                                                                        
STATEMENTS OF OPERATIONS DATA
Revenues...................................................  $   942,667  $   663,261  $   592,802  $   828,566
Cost of Goods Sold.........................................      728,719      496,531      400,997      597,299
Gross Profit...............................................      213,948      166,730      191,805      231,267
Operating Expenses.........................................    1,192,522    1,771,101    1,306,841    2,091,621
Operating Loss.............................................     (978,574)  (1,604,371)  (1,115,036)  (1,860,354)
Other Income (Expenses)....................................     (372,576)      60,281       33,379       41,186
Net Income (Loss)..........................................   (1,351,150)  (1,544,090)  (1,081,657)  (1,819,168)
Net (Loss) Per Share(1)....................................         (.66)        (.37)        (.28)        (.36)
Average Common Shares
  Outstanding(1)...........................................    2,039,280    4,197,499    3,926,416    5,054,026

 


                                                                             DECEMBER 31, 1996  SEPTEMBER 30, 1997
                                                                             -----------------  ------------------
                                                                                          
BALANCE SHEET DATA
  Total Assets.............................................................    $   2,570,952      $    1,784,323
  Working Capital..........................................................        1,858,088             771,162
  Total Liabilities........................................................          363,722             726,752
  Accumulated Deficit......................................................      (11,140,456)        (12,959,624)
  Stockholders' Equity.....................................................        2,207,230           1,057,571

 
- ------------------------
 
(1) See Note 2 of Notes to Consolidated Financial Statements for a discussion of
    the calculation of net loss per share for the fiscal years ended December
    31, 1995 and 1996, and for the nine-month periods ended September 30, 1996
    and 1997.
 
                                       24

          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                           AND RESULTS OF OPERATIONS
 
    The following discussion and analysis should be read in conjunction with the
Financial Statements and Notes thereto appearing elsewhere in this Prospectus.
 
PLAN OF OPERATION--OVERVIEW
 
    In 1995, the Company introduced its laser-based scientific research
instruments, which in 1996 were refined and redesigned into the modularized Cell
Robotics Workstation. Sales of these scientific instruments during 1995 and 1996
were disappointing, resulting in significant operating losses in both periods.
Given the limited market for the scientific research instruments, the Company
acquired certain technology in January 1996, (see Business--"Intellectual
Property") which it has used to develop medical laser products for the clinical
and consumer markets. Having now completed the development of the Lasette-TM-
(skin perforator), the RevitaLase-TM- (skin resurfacer) and the IVF
Workstation-TM-, and having obtained initial regulatory clearances for limited
domestic sales of the Lasette-TM- and RevitaLase-TM-, the Company intends to use
the net proceeds of this offering principally to stimulate both domestic and
international sales of its medical laser products and concurrently complete the
processes necessary for additional domestic and international regulatory
clearances for those products.
 
RESULTS OF OPERATIONS--NINE MONTHS ENDED SEPTEMBER 30, 1997 COMPARED TO THE NINE
  MONTHS ENDED SEPTEMBER 30, 1996
 
    During the nine month period ended September 30, 1997, the Company's
operating activities were limited to continuing efforts to complete the
development of its medical laser products. Product sales for the period were
generated only from sales of its scientific research instruments. Total revenues
from product sales and grant revenue increased from $592,802 for the nine month
period ended September 30, 1996 to $828,566 for the nine month period ended
September 30, 1997, an increase of 39.8%. Research and development grant revenue
increased, from $69,190 during the nine months ended September 30, 1996 to
$105,720 during the nine month period ended September 30, 1997, an increase of
52.8%. The Company's gross profit for the nine months ended September 30, 1997
increased by 20.6%, from gross profit of $191,805 for the period ended September
30, 1996 to $231,267 for the period ended September 30, 1997.
 
    The Company believes that its increased product sales reflect, in part, the
fact that during the fourth quarter of fiscal 1996, the Company converted its
exclusive distribution agreement with Carl Zeiss, Inc. covering its scientific
research instruments to a non-exclusive marketing arrangement. Management
believes this has allowed the Company to more aggressively market and sell its
research based instruments through its own internal efforts, as well as through
other microscope companies. However, the Company's ability to substantially
increase future revenue is heavily dependent upon the successful introduction
and subsequent market acceptance of its new medical laser products.
 
    Total operating expenses for the nine month period increased from $1,306,841
for the period ended September 30, 1996 to $2,091,621 for the period ended
September 30, 1997, an increase of $784,780, or 60.1%. This increase was
principally attributable to costs related to the continuing design and
development of the Company's medical laser products. Salaries increased by
$184,399, or 46.1%, due to the addition of personnel and increased wage rates.
Professional fees increased by $301,992, or 175.3%, principally as a result of
professional design and engineering consulting fees related to the development
of the Company's medical laser products. Other operating expenses, consisting of
overhead, general and administrative expenses, consulting and professional fees,
and other costs associated with the conduct of the Company's business also
increased, from $457,667 during the nine months ended September 30, 1996 to
$666,696 for the comparable period ended September 30, 1997, an increase of
$209,029, or 45.7%. This increase is also related to the Company's accelerated
product development activities during the most recent nine months.
 
                                       25

    During the nine month period ended September 30, 1997, other income and
expenses also increased from a $33,379 net contribution to income for the nine
month period ended September 30, 1996 to a $41,186 net contribution to income
during the period ended September 30, 1997. This increase was due almost
exclusively to an increase in interest income of $12,034, or 66.7%, realized
from the Company's short term investment of the remaining proceeds from the
exercise of warrants during the third quarter of 1996.
 
    As a result of the foregoing, the Company's net loss for the nine month
period ended September 30, 1997 increased by $737,511, or 68.2%, from a net loss
of $1,081,657 for the nine month period ended September 30, 1996 to a net loss
of $1,819,168 for the comparable period ended September 30, 1997. This resulted
in a net loss of $.36 per share on 5,054,026 weighted average shares outstanding
for the nine months ended September 30, 1997 compared to a net loss of $.28 per
share on 3,926,416 weighted average shares outstanding for the comparable period
ended September 30, 1996.
 
RESULTS OF OPERATIONS--YEAR ENDED DECEMBER 31, 1996 COMPARED TO YEAR ENDED
  DECEMBER 31, 1995.
 
    The Company's total revenues for the year ended December 31, 1996 were
$663,261, a decrease of $279,406, or 29.6%, over revenues for the comparable
period in 1995. The gross profit realized by the Company on revenues generated
during fiscal 1996 was $166,730, or 25.1%, compared to a gross profit of
$213,948, or 22.7%, realized during fiscal 1995.
 
    Operating expenses incurred during fiscal 1996 were $1,771,101, an increase
of $578,579, or 48.5%, over fiscal 1995 operating expenses of $1,192,522. This
increase was due primarily to a 117.0% increase in other operating expenses, to
$647,617 in fiscal 1996 from $298,397 in fiscal 1995, This increase reflects
expenses associated with the re-design of the Cell Robotics Workstation, as well
as the efforts to develop its new medical laser products. Also contributing to
the increase in operating expenses was a $98,138, or 23.8%, increase in salaries
and a $142,622, or 153.2%, increase in professional fees. The increase in
salaries was driven by the hiring of additional personnel, and an increase in
the compensation of existing employees. Payroll taxes and benefits increased
correspondingly. Expenses related to the testing of the Company's research
instrument line to ensure compliance with certain federal and international
regulations contributed to the increase in professional fees, as did fees
related to the filing of international patents on the Company's recently
acquired proprietary technology and the new products incorporating that
technology. Slight decreases in rent and utilities, travel, and depreciation and
amortization served to partially offset the overall increase in operating
expenses.
 
    Other income and expenses increased to $60,281 for the year ended December
31, 1996, from a negative $372,576 for the year ended December 31, 1995, arising
from a reduction in interest expense of $344,364. This resulted from the
conversion of a stockholder's note payable to equity, thereby reducing the
Company's outstanding debt.
 
    The foregoing resulted in the Company experiencing a net loss for the year
ended December 31, 1996 of $1,544,090, or $0.37 per weighted average share. This
compares to a net loss of $1,351,150, or $0.66 per weighted average share for
fiscal 1995. As a result of the exercise of Class A Common Stock Purchase
Warrants, the weighted average shares outstanding increased to 4,197,499 for the
year ended December 31, 1996 from 2,039,280 for the year ended December 31,
1995.
 
LIQUIDITY AND CAPITAL RESOURCES
 
    Since its inception, the Company has relied principally upon the proceeds of
both debt and equity financings to provide working capital for its product
development and marketing activities and, to a lesser extent, the proceeds of
two small SBIR grants. The Company has not been able to generate sufficient cash
from operations and, as a consequence, additional financings have been required
to fund ongoing operations. Initially, the Company relied upon one investor,
Mitsui Engineering & Shipbuilding Company ("Mitsui"), a Japanese corporation,
which provided, through a series of loans and stock purchases, in
 
                                       26

excess of $7 million in working capital. In 1995, the Company completed a
private offering of equity in which it raised approximately $2.875 million. As
part of that private offering, the Company issued a series of warrants, whose
exercise during the third quarter of 1996 resulted in an additional capital
infusion of approximately $2 million. Finally, in connection with that private
offering, the Company issued to Paulson, who served as placement agent, warrants
exercisable for a period of five years to purchase 11.5 units at a price of
$25,000 per unit, each unit consisting of 20,000 shares of Common Stock and
10,000 Class A Warrants (the "Placement Agent's Warrants"). As of the date of
this Prospectus, none of the Placement Agent's Warrants have been exercised.
Most recently, the Company completed a private sale of 200,000 shares for gross
proceeds of $650,000.
 
    Cash used in operations for the years ended in December 31, 1995 and 1996
and nine months ended September 30, 1997 were $1,267,920, $1,315,930, and
$1,803,286, respectively. The primary reason for the increase in the negative
cash flow from operations in the nine months ended September 30, 1997 as
compared to prior periods is the increase in product development and operating
expenses during that period.
 
    At its present level of research, development and product introduction, the
Company requires approximately $200,000 per month to cover operating expenses,
in excess of cash flow currently generated from operations. In August, 1997, the
Company sold in a private transaction to one investor 200,000 shares of Common
Stock at a price of $3.25 per share. The proceeds of that private sale are being
used to satisfy the Company's working capital requirements pending completion of
this offering. The Company does not have any available commercial lines of
credit or other sources of capital to satisfy its cash requirements until
revenues from operations can be realized through future product introduction and
sales. Accordingly, the Company will rely exclusively upon the proceeds of this
offering to satisfy its working capital requirements for the foreseeable future.
 
    Cash provided by financing activities for the years ended December 31, 1995
and 1996 and nine months ended September 30, 1997 were $1,953,778, $2,444,812,
and $669,509, respectively. These figures reflect the equity financings
discussed above.
 
    The Company's liquidity and capital resources continued to decrease during
the nine month period ended September 30, 1997, due primarily to the Company's
ongoing operating losses.
 
    The Company's current ratio at September 30, 1997 was 2.1:1, compared to a
current ratio of 6.1:1 on December 31, 1996. This decrease in liquidity is
primarily due to a reduction of the Company's current assets, principally cash.
Total assets decreased from $2,570,952 at December 31, 1996 to $1,784,323 at
September 30, 1997, a decrease of $786,629, or 30.6%. Of this decrease, current
assets accounted for $723,896, or 92%.
 
    The decrease in the Company's current assets of $723,896, or 32.6%, was the
result of a large decrease in cash and cash equivalents which fell from
$1,724,671 at December 31, 1996, to $559,060 at September 30, 1997, a decrease
of $1,165,611 or 67.6%. This decrease in cash and cash equivalents was primarily
the result of continuing operating losses. Slightly offsetting the decrease in
cash and cash equivalents was an increase in accounts receivable of $282,179,
from $69,845 at the end of fiscal 1996, to $352,024 at September 30, 1997. The
increase in accounts receivable was primarily due to increased sales during the
first nine months of fiscal 1997 of the Cell Robotics Workstation. Inventory
increased in the amount of $114,837, or 28.1% to support the increased sales.
Finally, as a result of the pre-payment of a purchase commitment made to a
supplier of a particular inventory component, other current assets increased
from $19,121 to $63,820, an increase of 234%.
 
    During the nine month period ended Septembere 30, 1997, the Company's total
liabilities increased $363,030, from $363,722 at December 31, 1996 to $726,752
at September 30, 1997. Increases in accounts payable of $264,590, or 164.5%, and
royalties payable of $110,914, or 263.9%, and a smaller increase in
 
                                       27

payroll related liabilities were slightly offset by a small decrease in other
current liabilities of $4,561, or 14.3%. The Company did not have any long term
liabilities on December 31, 1996 or September 30, 1997.
 
    As a result of the foregoing, the Company's working capital decreased from
$1,858,088 at December 31, 1996 to $771,162 at September 30, 1997, a decrease of
$1,086,926. This decrease was due almost exclusively to the Company's operating
loss incurred during the nine month period.
 
    The Company will be required to expend resources and working capital in the
defense of the Venisect Litigation. The defense of this action, even if the
Company is successful, could have a material adverse effect on the Company's
future liquidity. See "Risk Factors--Patent Litigation."
 
    The Company expects that its cash used in operating activities will increase
in the near future. The timing of the Company's future capital requirements,
however, cannot accurately be predicted. The Company's capital requirements
depend upon numerous factors, principally the market acceptance of its new
medical laser products. If capital requirements vary materially from those
currently planned, the Company may require additional financing, including but
not limited to, the sale of equity or debt securities. The Company has no
commitments for any additional financing and there can be no assurance that such
commitments can be obtained. Any additional equity financing may be dilutive to
the Company's existing stockholders, and debt financing, if available, may
involve pledging some or all of the Company's assets and may contain restrictive
covenants with respect to raising future capital and other financial and
operational matters. If the Company is unable to obtain additional financing as
needed, the Company may be required to reduce the scope of its operations, which
would have a material adverse effect upon the Company's business, financial
condition and results of operation. The Company believes that the net proceeds
from this offering will be sufficient to meet the Company's working capital
requirements for at least the next 12 months, although there can be no assurance
in this regard. See "Risk Factors--Additional Financing Requirements."
 
NET OPERATING LOSS CARRYFORWARDS
 
    At December 31, 1996, the Company had a net operating loss carryforward for
income tax purposes of approximately $10,000,000, which expires beginning in
2006. Under the Tax Reform Act of 1986, the amounts of and the benefits from net
operating loss carryforwards are subject to certain limitations in the amount of
net operating losses that the Company may utilize to offset future taxable
income. It is likely that the ownership changes in 1995 in connection with the
Acquisition (as hereafter defined) will limit the use of this net operating loss
carryforward under applicable Internal Revenue Service regulations.
 
EARNINGS PER SHARE
 
    In February 1997, the Financial Accounting Standards Board issued SFAS 128,
"Earnings Per Share." SFAS 128 establishes new standards for computing and
presenting earnings per share ("EPS"). Specifically, SFAS 128 replaces the
currently required presentation of primary EPS with a presentation of basic EPS,
requires dual presentation of basic and diluted EPS on the face of the income
statement for all entities with complex capital structures, and requires a
reconciliation of the numerator and denominator of the basic and diluted EPS
computations to the financial statements issued for periods ending after
December 15, 1997, and early application is not permitted. Upon adoption, SFAS
128 requires restatement of prior period EPS presented to conform to the
requirements of SFAS 128. Management believes the adoption of SFAS 128 will not
have a material effect on the Company's previously-issued financial statements.
 
COMPREHENSIVE INCOME
 
    In June 1997, the Financial Accounting Standards Board issued SFAS 130,
"Reporting Comprehensive Income." SFAS 130 establishes standards for reporting
and display of comprehensive income and its components (revenues, expense,
gains, and losses) in a full set of general purposes financial statements.
 
                                       28

Specifically, SFAS 130 requires that all items that meet the definition of
components of comprehensive income be reported in a financial statement that is
displayed with the same prominence as other financial statements. However, SFAS
130 does not specify when to recognize or how to measure the items that make up
comprehensive income. SFAS 130 is effective for fiscal years beginning after
December 15, 1997, and early application is permitted. SFAS 130 requires
reclassification of financial statements for all periods presented for
comparative purposes. Management believes the adoption of SFAS 130 will not have
a material effect on the Company's future financial statements.
 
REPORTING FOR SEGMENTS
 
    In June 1997, the Financial Accounting Standards Board issued SFAS 131,
"Financial Reporting for Segments of a Business Enterprise." SFAS 131 supersedes
the "industry segment" concept of SFAS 14 with a "management approach" concept
as the basis for identifying reportable segments. SFAS 131 is effective for
fiscal years beginning after December 15, 1997, and early application is
permitted. Management believes the adoption of SFAS 131 will not have a material
effect on the Company's future financial statements.
 
                                       29

                                    BUSINESS
 
OVERVIEW
 
    The Company has developed, and is preparing to manufacture, market and sell,
a number of sophisticated medical laser products. The Lasette-TM-, a compact,
lightweight, portable skin perforator, has been designed to permit nearly
painless sampling of capillary blood in both clinical and home settings. The
RevitaLase-TM- is a modularly-designed laser system for dermatological use which
incorporates the laser in the hand-piece. Its design allows for interchangeable,
hand-pieces each with a laser having a different wavelength suitable for
specific applications to be driven by a common base unit containing computer
controls, power supply and cooling system. The initial Erbium:YAG laser for the
RevitaLase-TM- has been designed for cosmetic uses such as skin resurfacing and
wrinkle removal and may find added applications in scar revisioning and burn
debridement. The IVF Workstation-TM-" utilizes a microscope, computer-controlled
stages and a solid-state laser to enhance human assisted reproduction
techniques. Both the Lasette-TM- and RevitaLase-TM- will require a disposable
shield or disposable delivery tip each time the laser is used. These disposables
will be manufactured for and sold by the Company. The new medical laser products
utilize core technologies and management skills developed by the Company in
connection with its Cell Robotics Workstation, a laser scientific instrument
which transforms a microscope from a viewing device into a tool for physically
manipulating and microdissecting living cells. The Company believes that the
markets for its new medical laser devices are broader than for its scientific
instruments and that its future growth will depend, primarily, on market
acceptance of these medical laser devices.
 
    The Erbium:YAG laser handpiece for the RevitaLase-TM- has received FDA
clearance for use in dermatological and surgical applications. It is undergoing
continuing testing to finalize protocols for clinical use. The Company expects
to begin initial shipments of RevitaLase-TM- units with the Erbium:YAG handpiece
in the first quarter of 1998. The Lasette-TM- is a substitute for the stainless
steel lancet now used for such capillary blood sampling. In clinical settings
the Company believes that the Lasette-TM- will lessen the spread of, and the
fear among healthcare workers of contracting, infectious diseases through
inadvertent needle sticks while also reducing the problems of sharps disposal.
The Lasette-TM- has received FDA clearance for capillary blood sampling from all
adults, including diabetics, in clinical settings. However, the Company believes
that another principal market for the Lasette-TM- will be for home use by
diabetics. Diabetics are often required to take multiple blood samples each day
and many diabetics develop permanent finger-tip soreness and calluses from
recurrent blood sampling. The Company is making application for FDA clearance
of, Lasette-TM- sales for diabetic home use and for use on children. No
assurances can be given that these additional FDA clearances will be received.
The Company plans to begin shipping the Lasette-TM- for clinical use before the
end of 1997.
 
    The IVF Workstation-TM- has three basic applications: first, for measuring,
assessing and storing in computer memory the various properties of a human egg
to assess its suitability for fertilization; second, to mechanically inject
sperm into an egg; and third, to pierce the outer shell of a fertilized egg with
a laser to facilitate "hatching" and promote embryo development and successful
pregnancy. In the United States, FDA clearance is required for sale of the IVF
Workstation-TM-. Clinical trials necessary to obtain the data required for
application for such clearance have recently begun and the Company expects they
will take approximately one year to complete. However, no assurance can be given
that FDA clearance will ever be obtained for use of the IVF Workstation-TM- in
"hatching." The European Community has cleared for marketing the IVF
Workstation-TM- and the Company is applying for the CE Mark necessary for sales.
The first purchase order for an IVF Workstation-TM- has been received from an
IVF clinic in Tunisia.
 
    The Company's growth plan is to concentrate its resources on the development
of the clinical and home markets for its medical laser products. The Company
intends to market the Lasette-TM- through strategic alliances with major
distributors serving the diabetic and clinical markets, supplemented by
distribution arrangements with regional distributors and direct sales by the
Company. The Company intends to market the RevitaLase-TM- with its Erbium:YAG
laser head by establishing an OEM relationship
 
                                       30

with a major manufacturer of CO(2) and other medical laser systems for the
aesthetic market, to be supplemented by direct distribution by the Company under
a different trademark. The IVF Workstation-TM- will be marketed and sold over
the internet and through other direct selling methods by the Company, except
that in the United States the IVF Workstation-TM- will not be offered for
laser-assisted hatching until after FDA clearance is obtained.
 
HISTORY
 
    CRI was organized in 1988 under the laws of the State of New Mexico to
develop and commercialize the discoveries embodied in the AT&T Patent (defined
below) as well as related technologies. See "Intellectual Property--Patents and
Licenses." In 1991, it obtained a non-exclusive license covering the AT&T Patent
and, using funding provided by Mitsui, began developing instruments using those
technologies. In 1994, the license with AT&T was converted from non-exclusive to
exclusive. In February 1995, IFC, the shares of which were publicly traded,
acquired 100% of the issued and outstanding shares of Common Stock of CRI in a
transaction treated as a reverse merger (the Acquisition), and subsequently
changed its name to "Cell Robotics International, Inc."
 
BUSINESS STRATEGY
 
    The Company has developed a business strategy to provide a line of
technologically-advanced proprietary medical laser products for both clinical
and consumer markets. The Company's goal is to provide advanced medical laser
products that provide superior safety, efficacy and comfort at competitive
prices. The key components of this business strategy include:
 
    EXPLOIT PROPRIETARY TECHNOLOGY.  Through its patents, licenses and know-how,
the Company has developed and plans to continue to improve sophisticated laser
technology for medical applications.
 
    DEVELOP MARKET RECOGNITION.  The Company plans to position its medical laser
products as the preferred technological solution to clearly-defined medical
needs.
 
    ESTABLISH EXCLUSIVE DISTRIBUTION CHANNELS.  The Company plans to enter into
exclusive distribution agreements with large, well-established manufacturers and
distributors of medical products to take advantage of existing distribution
channels and name recognition.
 
    RAPIDLY EXPAND CAPACITY TO ASSEMBLE PRODUCTS.  The Company is committed to
rapidly expand its manufacturing capacity to assemble some of its medical laser
products. Through a combination of outsourcing for components, OEM (Original
Equipment Manufacturers) relationships and internal assembly capacity, the
Company plans to be prepared to respond efficiently to market demand for its new
products.
 
    Through the implementation of the foregoing, the Company hopes to become a
leader in the development and sale of technologically sophisticated medical
laser products that respond to the rapidly increasing market demand for products
that offer more effective, safer and less painful solutions than conventional
procedures.
 
PRODUCTS
 
                                  LASETTE-TM-
 
    DESCRIPTION.  The Lasette-TM- is a compact, lightweight, portable skin
perforator that uses a laser to pierce the skin on a fingertip to permit the
taking of capillary blood samples . The Lassette-TM- is designed to reduce
patient discomfort, and the Company believes it is a safer and cleaner process
than the lancet or pinprick method now in use... As a result, the Company
believes the Lasette-TM- can replace stainless steel
 
                                       31

lancets in certain applications which contribute to large quantities of medical
sharps, blood-infected medical waste and pose the risk of infection to both the
clinician as well as the patient.
 
    The present generation of the Lasette-TM- is approximately the size of a
video cassette and consists of a battery-driven primary perforator unit, a
recharger and wall mount. The next generation Lasette-TM- is currently under
design and development and, when completed (projected sometime in the fourth
quarter of 1998), will be the approximate size of a handheld cellular telephone.
To protect the laser, enhance its safety and reduce the risk of inadvertent
transmission of disease, the Lasette-TM- requires the use of a disposable
plastic shield for each perforation, which the Company has manufactured on an
OEM basis. The Company expects to initially sell the Lasette-TM- for $2,000 and
the shields for $3.00 for a box of 25.
 
    MARKETS.  The Lasette-TM- is a product that addresses the collection of
capillary blood from fingertips, which according to industry data is a procedure
that is performed approximately one billion times a year in homes, hospitals,
clinics and doctors' offices. Capillary blood sampling is performed in virtually
all clinical settings, including hospitals, dialysis clinics, blood banks,
nursing facilities, home health agencies and physicians' offices. Data indicates
that in the United States alone, there are 9,500 hospitals and 21,000 other
clinical sites performing routine daily capillary blood sampling. Currently the
most commonly used device for capillary blood sampling is the stainless steel
lancet. In the hospital setting, inadvertent transmission of disease from
accidental lancet sticks is a recognized problem. The Company believes that the
Lasette-TM- can substantially reduce the trauma involved in this procedure and
the risk of inadvertent infection for both the clinician and the patient.
 
    While the Company believes that the potential clinical market for the
Lasette-TM- is significant, a substantially greater opportunity lies in the
worldwide consumer market of persons afflicted with diabetes. Diabetics
throughout the world are required to take capillary blood samples in order to
monitor their blood sugar levels on average four times per day. The recurring
fingersticks become painful and annoying when performed on a daily basis,
causing many patients to test less frequently than prescribed by their
physicians. The Company believes that, if it can obtain the necessary regulatory
clearances for home use by diabetics, of which there can be no assurance, the
Lasette-TM- can reduce the trauma involved in this procedure and provide
valuable assistance to such patients.
 
    MARKETING AND DISTRIBUTION.  Initial marketing targets will be hospitals,
clinics, and physicians' offices, where sales of multiple units will be
possible. The Company has designed a sales, marketing and distribution program
for the Lasette-TM- which includes (i) strategic alliances with worldwide
distributors already serving the worldwide diabetic and other clinical markets,
(ii) direct sales by the Company and (iii) arrangements with smaller regional
distributors in specific world market segments. The Company is engaged in
negotiations with large companies that already have a presence in the worldwide
diabetic products market. Finalizing those arrangements will depend upon the
satisfactory delivery and testing of pre-production Lasettes-TM- to permit the
distributor to verify product performance and regulatory clearances for diabetic
use. In addition to the Company's efforts to establish major distribution
arrangements, the Company has existing distributorships in South Korea,
Singapore, Thailand and Malaysia, with sales beginning in these locations in the
fourth quarter of 1997. Direct sales by the Company will be accomplished both
through mail order and through the Company's own sales staff and sales
representatives.
 
    MANUFACTURING.  In August 1996, the Company established a strategic
development and production alliance with Big Sky Laser Technologies, Inc., an
OEM manufacturer and developer of medical laser products in Montana. Big Sky
Laser Technologies, Inc. is a recognized laser OEM manufacturer that has agreed
to comply with FDA, MDQS and other regulatory requirements. Big Sky Laser
Technologies, Inc. began the commercial manufacture of the Lasette-TM- for the
Company in the third quarter of 1997.
 
    COMPETITION.  The Lasette-TM- represents a technological alternative to the
traditional stainless steel lancet for routine capillary blood sampling. It
eliminates the risk of cross-contamination and attendant
 
                                       32

indirect costs, and has been designed to reduce the pain, fear and anxiety
associated with blood sampling. It also eliminates the cost and risk of lancet
waste disposal.
 
    While each stainless steel lancet costs only pennies, the Company believes
that by eliminating the associated indirect costs of their use described above,
the Lasette-TM- can be successfully marketed at an initial end price of $2,000
per unit. The Company expects to price the second generation Lasette-TM- below
$1,000 per unit.
 
    The only other commercialized approach to laser-based capillary blood
sampling that has come to the attention of the Company is a laser skin
perforator developed by Venisect. The Company is aware from industry sources,
however, that the Venisect laser is substantially larger than the Lasette-TM- ,
more expensive and, most significantly, has been determined by the FDA to be
unsuitable for use by diabetics. In October 1997, Venisect commenced the
Venisect Litigation in which it claims the Lasette-TM- infringes the U.S. patent
underlying its competitive skin perforator. The Company has investigated the
Venisect patent with its advisors, including patent counsel, and believes that
no basis for any infringement claim exists. Nevertheless, there can be no
assurance that the ultimate outcome of the Venisect Litigation will not have a
material adverse effect upon the Company's ability to market and sell the
Lasette-TM- or the competitive position of this product. See "Legal
Proceedings."
 
    The development of new advanced technologies for determining and/or
controlling glucose levels in diabetic patients is a focus of many corporate
research and development efforts throughout the world. Several companies are
developing glucose testing products based on non-invasive technologies, using
skin patches and diode-pumping lasers. To the Company's knowledge, none of these
products has received FDA clearance for sales in the United States. However, if
these products are approved for sale and become commercially available in the
United States in the future, they could have a material adverse effect on sales
of the Lasette-TM- and, as a result, on the business and financial condition of
the Company.
 
    REGULATORY STATUS.  The Lasette-TM- obtained FDA clearance for clinical use
for all adult glucose/ hematocrit testing, including diabetics, in October 1997.
In addition, the Company will soon begin clinical studies for additional
applications for clearance for children in clinical settings and home use for
all ages. These studies are scheduled to be completed by the end of 1997, and
the FDA is required to respond within 90 days. See "Risk Factors--Government
Regulation" and "Business--Government Regulation--Product Approval Process."
 
                                 REVITALASE-TM-
 
    DESCRIPTION.  Aesthetic procedures are performed worldwide to remove
wrinkles and other cosmetic blemishes. The Company's newly-developed
RevitaLase-TM- is a sophisticated skin resurfacing laser that introduces a new
modular design and concept to clinicians performing aesthetic surgery. The unit
is small, portable and operates on standard 110 volt wall current so that the
clinicians and their staff can easily move the system within a facility or from
office to office. The Company's solid state laser system will consist of a
portable, Erbium:YAG laser with a variable power supply, cooling system and
disposable delivery tip. The most distinguishing feature of the system will be
the location of the laser in the handpiece, which will eliminate the need for
the expensive delivery systems, such as wave guides, optical fibers or
articulated arms, that make competing systems heavy and expensive. This design
offers numerous advantages to the clinician, including a substantial cost
savings from other products currently available, as well as the use of
interchangeable laser heads using different crystals that permit the same unit
to be used for multiple dermatological applications such as wrinkle removal,
scar revision, hair removal and tatoo removal.
 
    The Company has completed manufacture of prototype RevitaLase-TM- systems
which is currently being made available to potential distributors for
evaluation.
 
                                       33

    MARKETS.  In January 1995, CO(2) laser technology was introduced that could
remove wrinkles much more effectively than the topical treatments then available
and at substantially less cost than surgery. CO(2) lasers quickly emerged as the
predominant new treatment for wrinkles and over 20 companies began selling
lasers for this application. According to Medical Laser Insight, through 1996
over 4,000 units have been sold worldwide, generating over $200 million in
revenue.
 
    Market expansion for CO(2) lasers has been hampered by the extended healing
times, high cost, inability to treat skin colors other than Caucasian, and other
product limitations. In March 1997, new Erbium lasers were introduced. The use
of Erbium:YAG lasers has been shown to shorten the healing times and be safe to
treat most skin colors. Since the introduction of Erbium:YAG lasers, more than
100 such lasers have been sold, with worldwide sales rapidly expanding.
 
    Skin resurfacing is one of the fastest growing fields in dermatology, with
approximately 25,000 dermatologists, plastic surgeons and general physicians
qualified to do skin resurfacing procedures in the United States. Industry data
suggests that there are over 70,000 licensed physicians in the United States
practicing in areas of dermatology, plastic surgery, otolaryngology (ENT),
ocular plastic surgery and general practice who collectively performed more that
46,000 laser resurfacings during 1996. In addition, because the Erbium:YAG laser
has been proven effective on all skin colors, the Company believes that the
RevitaLase-TM- can be marketed successfully in many heretofore unserved areas,
such as Asia, South America and the Middle East. The Company believes that the
advantages of the Erbium laser plus the low price of the Company's laser system
will allow it to capture greater market share in international markets.
 
    Traditionally, cosmetic removal of wrinkles and other skin treatments have
been administered by dermatologists, plastic surgeons and other physicians.
Sales of skin resurfacing lasers have in the past been primarily to hospitals
and clinics that could afford the high cost of the lasers. Because of their
cost, single physician or group practice sales have been limited in most
instances to high volume practices or to physicians who are willing to invest in
new technology. The Company believes that at the RevitaLase-TM-'s expected price
point of $35,000 to $40,000 per unit, the RevitaLase-TM- will be attractive to
single physician and small group practices.
 
    MARKETING AND DISTRIBUTION.  The Company's primary distribution strategy for
the RevitaLase-TM- involves the establishment of an OEM relationship with a
major manufacturer and distributor of medical laser systems in the aesthetic
market. Under this arrangement, a strategic partner would use its existing
presence in the market to promote and sell the RevitaLase-TM- under its own
brand name. The Company is currently engaged in negotiations with a major
distributor of medical laser systems; however, as of the date of this
Prospectus, no definitive agreements, commitments or understandings exist with
any third party, and there can be no assurance that the Company will be
successful in these efforts. The Company will also establish its own worldwide
distribution network to sell a similar product under its own trademark.
 
    MANUFACTURING.  The Company will outsource the manufacture of certain
components of the Revitalase-TM- and then complete the final assembly and
delivery of the finished product. The Company is remodeling a portion of its
existing facility and will purchase the fixed assets necessary to assemble the
RevitaLase-TM- internally, with a projected capacity of 30 units per month. All
manufacturing must be in conformity with the requirements of the FDA, GMP, the
European Community's ISO 9001 and other applicable requirements. The Company
expects the first units to be ready for initial shipments in February 1998.
 
    COMPETITION.  The worldwide market for laser skin resurfacers is
characterized by the dominance of several large, well-established competitors,
including Coherent, Inc., LaserScope, Inc., Sharplan Lasers, Inc., Laser
Industries, Ltd., ESC Medical Systems, Ltd., and Continuum Biomedical, Inc.
These manufacturers already have achieved varying degrees of market penetration
with the first generation of CO(2) lasers and are in a position to offer their
existing and expanding markets significant advantages by upgrading to the
technology offered by the RevitaLase-TM-.
 
                                       34

    Erbium:YAG lasers have recognized advantages over the CO(2) lasers
previously marketed to clinicians performing aesthetic surgery. Healing times of
patients treated with Erbium lasers are four to 14 days while CO(2) lasers can
take as long as six weeks to three months. In addition, clinical trials suggest
that the Erbium wavelength of the laser may enhance healing and reduce thermal
damage.
 
    Because of their clinical and aesthetic advantages, Erbium:YAG laser systems
currently are the best selling lasers in the skin resurfacing market. The
Erbium:YAG skin resurfacers which are currently available range in price from
$61,000 to $90,000 per unit. The Company believes that it can profitably
manufacture and market a RevitaLase-TM- for $35,000 to $40,000 per unit, giving
it a significant price advantage over existing competition. Further, the
interchangeable heads offering expanded applications will be offered at
approximately $10,000 to $15,000 each, which is substantially below the cost to
the clinician of buying an entire unit to service a new application. The Company
believes that this significant price advantage as well as its versatility,
reduced size and portability will open new markets beyond the high performance,
high-priced user to include the single physician's office and additional
international markets.
 
    REGULATORY STATUS.  In July 1997, the Company received all necessary FDA
clearances for marketing and sales of the RevitaLase-TM- for dermatological and
surgical applications. It will be tested on additional patients to develop
protocols for clinical use.
 
                       IN VITRO FERTILIZATION WORKSTATION
 
    DESCRIPTION.  The IVF Workstation-TM- is a computer-controlled
multi-functional workstation that combines for the first time a technological
solution to both the functional and informational requirements of clinicians
working in the IVF environment. Utilizing a microscope, computer-controlled
motorized stage, video camera, sophisticated laser technology and data storage
and retrieval systems, the IVF Workstation-TM- permits standardized evaluation,
measurement and diagnosis of eggs and embryos, sperm injection and
laser-assisted embryo hatching in one integrated system. With its computer
hardware and software, the IVF Workstation-TM- also permits the detailed
cataloguing and documentation of each IVF procedure and the organization and
retrieval of data and other information.
 
    The Company plans to offer the IVF Workstation-TM- in various
configurations, including a standard platform plus optional laser modules and a
pair of micromanipulators and/or micro syringe pumps for sperm injection. The
computer controls the pumps used for sperm injection, positions and fires the
laser and documents each step with a video image in a Microsoft Word document.
 
    IVF is a rapidly-growing area of human fertility treatment. However, success
rates with current procedures vary significantly from clinic to clinic. While
sperm injection is a technique commonly used by IVF clinics, it has been found
that problems encountered in embryo hatching often contribute to infertility and
poor success rates. The Company believes the IVF Workstation-TM- is the only
product currently available that offers laser-assisted hatching technology,
while providing more accurate diagnosis of the embryo and documentation of the
procedure for improved future outcomes. An IVF clinic's reputation is dependent
upon the number of successful pregnancies it is able to achieve. The IVF
Workstation-TM- is designed to improve success rates for clinics and IVF
patients. Initial animal trials have demonstrated improved success rates
utilizing the IVF Workstation-TM- with its laser-assisted hatching. Using
laser-assisted hatching, the Company believes that IVF clinics will have the
ability to provide substantially improved success rates with fewer IVF cycles,
thereby also reducing costs. The complete IVF Workstation-TM- can currently be
sold in most of the world, excluding the United States and Japan. The European
Community allows the Company to market and sell the product and much of the rest
of the world follows the European Community guidance. The Company has received
its first purchase order from an IVF clinic in Tunisia.
 
    MARKETS.  The market for the IVF Workstation-TM- consists of the more than
1,300 clinics worldwide that treat infertility, approximately 300 of which are
located in the United States. Worldwide these clinics conduct approximately
100,000 IVF treatment cycles a year. At an average cost of $5,000 per treatment
 
                                       35

cycle, it is estimated that over $500 million is spent annually at these
clinics. It is believed that the IVF Workstation-TM- will substantially increase
success rates and reduce the time and cost required to successfully complete a
fertility treatment cycle, thereby increasing profits and revenue to the
clinician.
 
    MARKETING AND DISTRIBUTION.  The IVF Workstation-TM- has received all
necessary clearances within the European Community and most foreign markets.
Clinical trials for FDA clearance for marketing in the United States have begun
in Europe, Australia, Israel and, more recently in the United States. The
Company hopes that the improved success rate experienced by foreign clinics will
have the effect of stimulating interest in the product in domestic markets.
 
    Sales, service and installation of the IVF Workstation-TM- will be handled
directly by the Company's staff. The Company is also using its Internet Website
as a sales medium. In addition, the Company is entering into arrangements with
distributors in foreign markets. Currently, distribution agreements are in place
covering South Korea and Brazil.
 
    The complete IVF Workstation-TM- will be offered with two pricing
structures. Wherever permitted, the Company will promote the pricing strategy of
a reduced purchase price with ongoing revenues based upon each laser shot. Under
this scenario, the Company will maintain ownership of the laser and will provide
annual calibration and maintenance of the laser module. This will ensure that
the system is performing as it was designed and the Company expects that
customers will increase their use of the laser as they experience a reduction in
time and expense and improve their success rates. In the United States, clinics
will be able to pass along the fees for laser-assisted hatching to their
patients since most procedures are direct patient-pay procedures. This will
allow the clinic to purchase the equipment initially at a much lower price. In
many countries outside of the United States, however, the Company expects the
IVF Workstation-TM- will be sold for a single, higher flat fee.
 
    MANUFACTURING.  The Company plans to outsource the manufacture of certain
components and then assemble the IVF Workstation-TM- at its facility. The
Company expects to use a portion of the proceeds of this offering to purchase
equipment and hire personnel required for the assembly of the IVF
Workstation-TM- at its own facility. The Company anticipates that it will be
able to assemble and ship sufficient units to satisfy demand for the product, if
any.
 
    COMPETITION.  The Company is not aware of any other product that combines
all of the features and performance specifications of the IVF Workstation-TM-.
Once operational, the IVF Workstation-TM- will offer IVF clinics a tool that
integrates the latest in technological advances together with needed
documentation for better outcomes.
 
    REGULATORY STATUS.  The IVF Workstation-TM- has been approved for marketing
and sale in Europe and international sales efforts have been initiated. The only
functional component of the IVF Workstation-TM- that requires FDA clearance is
the laser module used for laser-assisted hatching. An Investigational Device
Exemption (IDE) application for clinical trials of the IVF Workstation-TM- has
been approved by the FDA. Clinical trials started in October 1997 at two sites
in the United States and are scheduled to begin in Belgium, Israel, and
Australia. It is expected that FDA clinical trials of the IVF Workstation-TM-
will be completed no earlier than late 1998. There can be no assurance when, if
ever, FDA clearance for sales in the United States will be obtained.
 
                        SCIENTIFIC RESEARCH INSTRUMENTS
 
    APPLICATIONS OF THE RESEARCH INSTRUMENTS.  The Company's microrobotic
technology allows scientists to manipulate objects in microspace, upgrading the
microscope from simply an instrument for observation to an interactive
micro-laboratory. The scientific research instruments are designed to enhance
the usefulness and importance of the conventional laboratory microscope as a
tool in medical, biological and genetic applications in the life sciences. The
technology can be used for cell separation, cell-cell interaction,
microdissection, and intercellular manipulation of living cells. The Company has
either demonstrated itself
 
                                       36

that its products can be used for, or is aware of others using its products in,
cancer research and immunology, neurobiology, assisted reproductive techniques
and genome research.
 
    DESCRIPTION.  In 1996, the Company introduced the computer-controlled Cell
Robotics Workstations for optical trapping, micromanipulation and microsurgery.
These workstations are based on the Company's core LaserTweezers-Registered
Trademark-, LaserScissors-Registered Trademark-, CellSelector-Registered
Trademark- and SmartStage-Registered Trademark- technologies. The functionality
of the Cell Robotics Workstations has been improved through the addition of
computer control, providing more powerful and user-friendly features such as
interactive software with mouse or keyboard control, unique motorized stage and
motorized focus drive providing motion in three directions. The Cell Robotics
Workstation integrates the Company's research instruments into a complete
computer-controlled optical trapping and ablation workstation. The Cell Robotics
Workstation provides and improves upon functions that are routinely used in
research microscopy, but offers advanced laser-mediated micromanipulation. With
the Cell Robotics Workstation, instruments are controlled via an easy-to-use
software program. Performance and observation of experiments are entirely on
screen. Video and image capture capabilities allow the storage of images while
experiments are in progress for use in papers, reports, and presentations. A
fully-equipped Cell Robotics Workstation includes the SmartStage-Registered
Trademark-, LaserTweezers-Registered Trademark-, LaserScissors-Registered
Trademark-, and CellSelector-Registered Trademark- modules, an electronic
controller, a motorized stage, computer, motorized focus drive, instrument
control software, and video camera. A fully-equipped Cell Robotics Workstation
sells for a retail price of $80,940 in the United States. The modules included
in the complete Cell Robotics Workstation are also offered separately, with the
basic microscope Workstation offered at a retail price of $25,000, the
LaserTweezers-Registered Trademark- Workstation for a retail price of $52,250
and the LaserScissors-Registered Trademark- Workstation at a retail price of
$52,440.
 
    MARKETS.  The initial market for the Company's research workstations has
been the national and international biology research community. In the United
States, the research market consists of approximately 108,000 research
biologists working in 2,400 institutions. The Company specifically targets users
of inverted microscopes, for which there were approximately 10,000 existing
users in 1996 and approximately 1,000 new purchases made annually in the United
States and Canada. Worldwide, the installed base of inverted microscopes was
approximately 33,000 in 1996, with 3,000 additional new sales annually. Another
potential market, and a form of competition to the Company's products, is the
mechanical micromanipulator market. A micromanipulator consists of a very thin
needle, or micropipette, that performs many of the same functions as the
Company's CellSelector-Registered Trademark- and SmartStage-Registered
Trademark- but is operated manually and often compromises the sterility of the
specimen. Annual sales of micromanipulators totaled approximately 800 in the
United States in 1996 and 2,000 worldwide.
 
    Principal markets for the Company's research instruments are researchers
using inverted microscopes in universities, research laboratories, biotechnology
and pharmaceutical companies, and commercial laboratories currently conducting
biological research. The Company's marketing strategy is to identify key
scientists who are engaged in specific research applications for which the
Company's instruments are particularly well suited.
 
    MARKETING AND DISTRIBUTION.  While the Company intends to focus its
marketing efforts on the distribution and sale of its medical laser devices, it
will continue to promote and market its scientific instruments through direct
sales, dealers, representatives and distribution arrangements. The Company
previously had an exclusive distribution arrangement with Carl Zeiss, Inc.
("Zeiss"), one of the largest worldwide manufacturers of microscopes and lenses.
However, due to disappointing performance by Zeiss under the agreement, the
Company chose not to renew the arrangement at the end of 1996. The Company has
decided that direct marketing of its scientific instrument products will provide
a more effective and lucrative strategy for this industry segment. The Company
also has a distribution agreement with Mitsui granting Mitsui exclusive
distribution rights for the Company's products in Japan for a term of ten years.
The Company also expanded its domestic and international distribution channels,
and now distributors in 15 countries are starting to sell the research
instruments.
 
                                       37

MANUFACTURING
 
    The Company has entered into an arrangement for the manufacture of the
Lasette-TM- by a third party on an OEM basis. The Company's manufacturing
approach for the RevitaLase-TM- and IVF Workstation-TM- attempts to minimize the
capital outlay by outsourcing parts to machine shops and circuit board
companies, but completing all final assembling and testing on its premises to
ensure the quality of the final products. The Company plans to continue to use
this approach with the new and current products. The Company is instituting the
record keeping, quality control, and production procedures to meet the
requirements of the FDA MDQS , and the European Community's ISO 9001
manufacturing requirements.
 
COMPETITION
 
    The industry in which the Company competes with its medical laser products
is characterized by rapidly evolving technology and intense competition. Many
companies of all sizes, including both large organizations as well as several
specialized medical laser products companies are engaged in activities similar
to that of the Company. In addition, colleges, universities, governmental
agencies and other public and private research institutions will continue to
conduct research and to protect technologies that they have developed, some of
which will be directly competitive with that of the Company. Many of the
Company's competitors have substantially greater financial, research and
development, human and other resources than the Company.
 
    The Company believes it has certain technological advantages in producing
the compact, low-cost laser design in the Lasette-TM- and the RevitaLase-TM-.
However, the Company's cost advantage is dependent in part upon its ability to
maintain its relationship with New Technology Enterprise Center ("NTEC"), its
Russian associate, the supplier of the crystals used in the manufacture of its
lasers, the continuation of which is in doubt due to current unresolved disputes
between the Company and NTEC. In addition, the Company has experienced quality
or supply problems with its Russian supplier, either of which, if not remedied,
could necessitate it changing the source of supply. Alternative sources of
supply for the crystals, while available, would increase the production cost of
the Company's product and reduce its competitive advantage.
 
    The development of new advanced technologies for determining and/or
controlling glucose levels in diabetic patients is a focus of many corporate
research and development efforts throughout the world. Several companies are
developing glucose testing products based on non-invasive technologies, using
skin patches and diode-pumped lasers. To the Company's knowledge, none of the
products has received FDA clearance for sales in the United States. However, if
these products are approved for sale and become commercially available in the
United States in the future, they could have a material adverse effect on sales
of the Lasette-TM-, and, as a result, on the business and financial condition of
the Company.
 
    The Company believes that its success is highly dependent upon its ability
to complete distribution agreements for the sale of its new medical laser
products and create additional internal sales and marketing resources. Although
several distribution agreements are in place, there can be no assurance that the
Company can achieve these goals.
 
    The Company believes that the principal factor affecting its competitive
position is the suitability of its instruments for, and performance in, a
particular application. Because of the highly specialized nature of its markets,
such traditional competitive factors as price, delivery, upgradability and
support are less significant, with the exception of the RevitaLase-TM- which is
in a very cost-competitive market. The Company faces potential competition from
a number of established domestic and international companies, all of which have
vastly greater engineering, manufacturing, marketing and financial capabilities
than the Company. The ability of the Company to compete successfully in existing
and future markets will depend on elements both within and outside its control,
including, but not limited to, its success in market penetration, protection of
its products by effective utilization of intellectual property laws, including
full exercise of its patent rights, improvements in product quality and
reliability, ease of use, price, diversity of
 
                                       38

product line, efficiency of production, the rate at which customers incorporate
the Company's instruments into their products, product introductions by the
Company's competitors and general domestic and international economic
conditions.
 
INTELLECTUAL PROPERTY
 
    The Company relies primarily on a combination of patent, trade secret,
copyright and trademark laws, confidentiality procedures and other intellectual
property protection methods to protect its proprietary technology. The Company's
medical laser products currently have no patent protection and its scientific
research instruments only have limited patent protection. The commercial success
of the Company's medical laser products will depend, in part, upon the Company's
ability to protect and defend its intellectual property rights and the
competitive advantages that those rights offer to its products. There can be no
assurance that the Company will be successful in these efforts.
 
    Both the Lasette-TM- and the RevitaLase-TM- were originally developed under
the MCR Patent (defined and described below). However, the RevitaLase-TM-
currently does not use the MCR Patent and, in fact, does not currently have any
direct patent protection. The Company is, however, in the process of preparing,
and will be submitting, design patents related to the RevitaLase-TM-. Similarly,
the Lasette-TM-, also does not use the MCR Patent design, but uses other
crystals which the Company believes offer certain advantages over crystals made
under the MCR Patent. As a result, the Lasette-TM- also does not currently have
any direct patent protection. The IVF Workstation-TM- does not have any direct
patent protection, although the Company believes that certain features may be
patentable and intends to make patent applications for them in the future.
Finally, the LaserTweezers-Registered Trademark- application of the Cell
Robotics Workstation is being developed and sold under the AT&T License and the
related optical trapping patent (defined and described below).
 
    PATENTS AND LICENSES
 
    AT&T LICENSE--In 1991, the Company entered into a license agreement with
AT&T (the "AT&T" License") pursuant to which the Company was granted a worldwide
exclusive license to manufacture, use and sell products and processes covered by
the claims of one (1) United States patent held by AT&T (the "AT&T Patent")
related to "Optical Traps" which covers all biological optical trapping
applications for wavelengths that are longer than 800nm. The AT&T Patent expires
in 2007. Corresponding patents have also been issued in Canada, Japan,
Australia, Hong Kong and the European Community. The inventions covered by the
AT&T Patent and License apply to the Company's LaserTweezers-Registered
Trademark-. Under the terms of the AT&T License, the Company is required to pay
a royalty equal to five percent (5%) of the value of each product sold utilizing
the patents, subject to minimum annual royalties initially in the amount of
$100,000 at December 31, 1996 and increasing by an additional $50,000 per year
to as high as $500,000 per year, regardless of actual sales. As of the date of
this Prospectus, the Company is current in its minimum royalty payment
obligations under the AT&T License. However, the Company recognizes that the
minimum royalty will escalate to a substantial annual capital commitment, and
there can be no assurance that its future financial condition or results of
operations will be able to support that commitment. The Company is engaged in
efforts to renegotiate the terms of the AT&T License, but there can be no
assurance that these efforts will be successful. If the Company is unable to
renegotiate the AT&T License, it may be forced to abandon the
LaserTweezers-Registered Trademark- product.
 
    TECNAL PATENTS--On January 10, 1996, the Company acquired from Tecnal
Products, Inc., a subsidiary of Lovelace Scientific Resources, Inc., one United
States patent known as the Multifaceted Crystal Resonator patent, ("MCR
Patent"), and one foreign patent application and a strategic license. These
acquisitions comprised a package of technological assets covering two laser
products: a low-cost, high-power solidstate laser that eliminates many of the
delicate optical components required by conventional solidstate lasers, and a
laser perforator. The MCR Patent was originally developed under the license
agreement with NTEC of Russia. The advanced laser design of the MCR Patent and
other related technology developments can
 
                                       39

be used in a variety of laser applications, including skin resurfacing (facial
wrinkle removal), laser dentistry, eye surgery and other medical and industrial
procedures. While these technologies were used in early versions of the
Lasette-TM- and the RevitaLase-TM-, the Company has now developed its own
technology for these products.
 
    The Company acquired the MCR Patent and other technological assets in
consideration of cash payments in the amount of approximately $15,000, the
issuance of an aggregate of 17,500 shares of Common Stock and the grant of a 1%
royalty on future net revenue based upon the technology, with a lifetime maximum
royalty of $20,000.
 
    OTHER PATENTS--The Company has also been issued two (2) United States
patents. One patent covers three dimensional mechanical staging and the other a
specialized chamber for the LaserTweezers-Registered Trademark-, both used in
the Cell Robotics Workstation. In addition, the Company is in the process of
preparing, and will be submitting, applications for design patents related to
the RevitaLase-TM- as well as applications for patents associated with the IVF
Workstation-TM-. However, neither the RevitaLase-TM- nor the IVF Workstation is
currently covered by any of the Company's existing patents.
 
    Because of rapid technological developments in the industries in which the
Company competes and the broad and rapidly developing patent coverage, the
patent position of the Company is subject to certain uncertainties and may
involve complex legal and factual issues. Consequently, although the Company
holds certain patents, is licensed under other patents and is currently
prosecuting additional patent applications, there can be no assurance that
patents will issue from any pending or future applications or that claims
allowed by any existing or future patents issued or licensed to the Company will
not be challenged, invalidated or circumvented, or that any rights granted
thereunder will provide adequate protection to the Company. Moreover, the
Company may be required to participate in interference proceedings to determine
the priority of inventions, which could result in substantial costs to the
Company. Further, while the Company believes, based upon its research and
investigations, as well as those of its advisors, including patent counsel, that
none of its products infringe upon the domestic or foreign patent rights, or
other intellectual property rights, of third parties, there can be no assurance
that the Company will not be required to defend against future infringement
claims of third parties in addition to the Venisect-TM- Litigation. Such
additional litigation could represent a substantial commitment of the Company's
limited capital resources, including both funds and human resources, without any
assurance that the Company will ultimately prevail on the merits. As a result,
the potential of such litigation could represent a material adverse effect upon
the Company's future financial condition and results of operations.
 
    OTHER INTELLECTUAL PROPERTY
 
    In addition to its patent rights, the Company relies upon certain
proprietary know-how in its manufacturing process and has entered into employee
and third party nondisclosure agreements to protect its proprietary technology.
In addition, the Company has developed distinctive trademarks for both its
medical laser devices and its scientific research instruments which it believes
constitute valuable intellectual property rights. The Company has obtained
federal registrations for LaserTweezers-Registered Trademark-,
LaserScissors-Registered Trademark-, CellSelector-Registered Trademark- and
SmartStage-Registered Trademark-, all modules of its Cell Robotics Workstation.
The Company has not obtained federal registrations for Lasette(TM),
Revitalase(TM), and IVF Workstation(TM). While it intends to apply for these
registrations, to date it has made application only for Lasette(TM). However,
there can be no assurance that federal registrations for these trademarks will
be issued or, if issued, the degree of protection that they will afford. In the
absence of Federal registration, the Company relies on common law rights for its
trademarks.
 
RESEARCH AND DEVELOPMENT
 
    The Company's success will depend in large part upon its ability to enhance
existing products and to continue developing new products incorporating the
latest improvements in laser technology. Accordingly, the Company is committed
to investing significant resources in research and development activities.
 
                                       40

    During the year ended December 31, 1996 and in the nine months ended
September 30, 1997, the Company spent approximately $709,000 and $813,000,
respectively, on internal research and development programs. As of September 30,
1997, three of the Company's scientists and engineers were engaged primarily in
research and development activities. The majority of funds expended by the
Company for its internal research and development activities was derived from
sales of capital stock and short-term borrowings from its principal stockholder,
Mitsui, and the sale of securities in 1995, 1996 and 1997. The Company does not
have any research arrangements with outside R&D firms and does not anticipate
entering into development arrangements with third parties in the foreseeable
future. The Company does not currently perform any research and development
under contract to third parties except for Small Business Innovative Research
("SBIR") grants from the federal government. These include a Phase II grant from
the National Cancer Institute (NCI) of the National Institutes of Health (NIH).
The award funds two years of development of a proprietary laser instrument for
semi-automated single cell sorting. The total award over two years is
approximately $749,000, of which approximately $42,600 has been received to
date. The receipt of this award should facilitate the Company's goal of
developing a single cell analysis workstation which could aid in the
understanding of cancer cells and viruses. Proceeds from this award will be used
to expand the current capabilities of the Cell Robotics Workstation and
LaserTweezers-Registered Trademark-technology.
 
    While the Company is actively engaged in the development of potential future
products from its core technology, these products are essentially extensions of
the current product lines. There can be no assurance that any of these programs
will be continued or completed. Even if these products are successful, the
Company does not expect to introduce any resulting new products for at least six
months, and there can be no assurance that any such products will be
commercially successful.
 
GOVERNMENT REGULATION--PRODUCT APPROVAL PROCESS
 
    The Company is subject to a variety of government regulations pertaining to
various aspects of its marketing, sales and manufacturing processes. The Company
has been successful in obtaining many of the regulatory clearances that are
required to market and sell its products, however additional clearance for
broader markets will be required, of which there can be no assurance.
 
    For research applications, the Company's products are subject only to safety
regulations by the FDA. However, the European Community ("EC") has recently
required that the research instruments receive their CE mark before they can be
exported to the EC. The Company received the CE mark for its Cell Robotics
Workstation and all of its modules in September 1997. However, the Company's
medical device products require more extensive regulatory approval.
 
    In the United States, the Company's medical instruments are subject to
rigorous regulation under federal and state statutes and regulations governing
the testing, manufacture, safety and efficacy, labeling, recordkeeping,
approval, advertising and promotion of the Company's products. Product
development and approval within this regulatory framework may take many months
and may involve the expenditure of substantial resources. In addition to
obtaining FDA clearances for each product, each manufacturing establishment must
be registered with, and approved by the FDA and meet ISO 9001 requirements.
 
    The FDA has separate review processes for medical devices that must be
followed before such products can be commercially marketed in the United States.
There are two basic review procedures for medical devices in the United States.
Certain products may qualify for a Section 510(k) procedure, under which the
manufacturer gives the FDA a Pre-Market Notification ("510(k) Notification") of
the manufacturer's intention to commence marketing of the product at least 90
days before the product will be introduced for clinical use. Among other things,
the manufacturer must establish in the 510(k) Notification that the product to
be marketed is "substantially equivalent" to another legally-marketed,
previously existing product. If a device does not qualify for the 510(k)
procedure, the manufacturer must file a Pre-Market Approval Application ("PMA").
The PMA requires more extensive pre-filing testing than the 510(k) procedure and
involves a significantly longer FDA review process.
 
    As Class II devices, both RevitaLase-TM- and Lasette-TM- were eligible to
qualify under the Section 510(k) procedure. The RevitaLase-TM- received FDA
clearance within a few months without clinical trials. The
 
                                       41

Lasette-TM-, on the other hand, required approximately one year to obtain its
first FDA clearance, limited to clinical use with healthy adults, due to the
required extensive clinical trials. FDA clearance for use of the Lasette-TM- for
adult diabetics in clinical settings was issued in October 1997, and the Company
has begun clinical studies for additional applications for clearance for
children in clinical settings and home use for all ages. Until such clearances
are obtained, the Company will not be able to market or sell the Lasette-TM- in
the United States for home use by diabetics, a principal market for the product.
The IVF Workstation-TM-, as a Class III device insofar as laser-assisted
hatching is concerned, was not eligible for the Section 510(k) procedure and
requires complete Pre-Market Approval. The IVF Workstation-TM- was granted an
IDE and is in the process of completing detailed clinical trials, which may take
more than two years in their entirety. However, while marketing in the United
States must await FDA clearance which is likely not to occur before the fourth
quarter of 1998, the Company has the right to market and sell the IVF
Workstation-TM- in Europe and most foreign countries, since it is not deemed a
medical device in those jurisdictions. Nevertheless, as an electronic laser
product, actual shipments of the IVF Workstation-TM- to the EC requires a CE
Mark which the Company expects to receive by the end of 1997.
 
    For marketing outside of the United States, the Company or its prospective
licensees will be subject to foreign regulatory requirements governing clinical
trials and marketing approval for the products. The requirements governing the
conduct of clinical trials, product licensing, pricing, and reimbursement vary
widely from country to country. Although the Company does have employees
experienced in the EC and other regulatory procedures, it does not currently
have any facilities or employees outside of the United States. In some cases the
Company will rely on its strategic partners in foreign markets to satisfy the
regulatory requirements imposed by those jurisdictions.
 
EMPLOYEES
 
    At September 1, 1997, the Company had 15 full-time employees and two
part-time employees. Of the full-time employees, 4 were principally engaged in
product development, 4 in manufacturing, 5 in marketing and sales and the
balance in administration and finance. None of the Company's employees is
represented by a labor union or covered by a collective bargaining agreement.
The Company has experienced no work stoppages and believes that its employee
relations are good. The Company believes that its success will depend, in part,
on its continuing ability to attract and retain qualified technical, marketing
and management personnel.
 
FACILITIES
 
    The Company's facilities are located in approximately 12,000 square feet in
Albuquerque, New Mexico. This facility contains the Company's executive and
administrative offices, as well as its assembly, production, testing, storage
and inventory functions. The lease covering the facility requires monthly
payments of $7,986, subject to a 3% annual increase, and has recently been
renegotiated to terminate in 2002. The Company believes that this facility is
adequate for its present and near-term requirements. The equipment, fixtures and
other assets of the Company located within the facility are adequately insured
against loss.
 
LEGAL PROCEEDINGS
 
    In October 1997, a civil action was brought by Venisect, Inc. against the
Company in the United States District Court of the Eastern District of Arkansas,
Case No. LR-C-97-877 (the "Venisect Litigation") in which Venisect claims that
the Lasette-TM- infringes a U.S. patent, underlying its competitive laser skin
perforator. The Company and its advisors, including patent counsel, have
conducted a comprehensive investigation of the basis of the claims underlying
the Venisect Litigation and believe that the Lasette-TM- does not infringe upon
the Venisect U.S. patent or any of its related foreign patents. The Company
intends to vigorously defend the claims being asserted in the Venisect
Litigation. See "Risk Factors--Patent Litigation."
 
                                       42

                                   MANAGEMENT
 
DIRECTORS, EXECUTIVE OFFICERS AND KEY EMPLOYEES
 
    The name, position with the Company, age of each Director, executive officer
and key employee of the Company is as follows:
 


NAME                            AGE                      POSITION(1)
- ------------------------------  ---   -------------------------------------------------
                                
Dr. Ronald K. Lohrding........  56    President, Chief Executive Officer and Chairman
                                      of the Board
Craig T. Rogers...............  35    Vice-President of Investor Relations, Secretary,
                                        Treasurer and Director
Jean Scharf...................  35    Chief Financial Officer and Controller
Travis Lee....................  38    Vice-President of Sales and Marketing
Richard Zigweid...............  49    Manufacturing Manager
Connie White..................  43    Regulatory Affairs and Quality Manager
Michael Wolf..................  55    Chief Engineer
Dr. Larry Keenan..............  50    Product Manager, CR Workstation
Dr. Jerome Conia..............  37    Product Manager, IVF Workstation-TM-
David Costello................  42    Product Manager, Lasette-TM-
Mark T. Waller................  46    Director
Dr. Raymond Radosevich........  59    Director
Dr. Debra Bryant..............  46    Director

 
- ------------------------
 
(1) There exists no family relationship between any officer or director.
 
    DR. RONALD K. LOHRDING, has served as the Company's Chief Executive Officer,
President and Chairman of the Board since February 23, 1995. He co-founded the
wholly-owned subsidiary, Cell Robotics, Inc., in 1988 and has served as the
Chairman, President and CEO since incorporation. He has over 20 years of
management experience. He received his Ph.D. in mathematical statistics from
Kansas State University in 1969, and then spent from 1968 to 1988 at LANL as an
R&D manager and as a scientist. He served as LANL 's Assistant Director for
Industrial and International Initiatives, Deputy Associate Director for
Environment and Biosystems, as well as Program Director for Energy, Environment
and Technology, among other senior management positions. Concurrently, he has
been a general partner in seven real estate partnerships, two of which are still
currently active.
 
    CRAIG T. ROGERS has served as the Company's Vice President for Investor
Relations, Secretary, Treasurer and as a Director since 1995. From 1991 until
1995, he served as the Chief Executive Officer, President and a Director of IFC.
As a result of the Acquisition, Mr. Rogers resigned as the Chief Executive
Officer and President of IFC and, in February 1995, concurrently was appointed
Chief Financial Officer, Secretary and Treasurer of the Company. Mr. Rogers
served as Chief Financial Officer until January 8, 1997 Mr. Rogers served as
Chief Operating Officer of The Rockies Fund, Inc. from July 1993 to October 1,
1996. Mr. Rogers also currently serves as an officer and director of Discovery
Technologies, Inc., a Colorado-based publicly-held holding company. From April
1988 to June 1991, he also served as Chief Financial Officer for DMA Computer
Solutions, a general partnership operating four Connecting Point franchise
stores. Mr. Rogers received a Bachelor of Arts Degree in Business/Economics from
Colorado College in 1984.
 
    JEAN SCHARF was appointed Chief Financial Officer and Controller of the
Company in August 1997. From April 1995 to August 1997, she served as, the
Controller for TPL, Inc., a $7 million defense and private sector contractor.
From April 1984 to September 1994, she was employed by with Applied Technology
Associates and with SAIC. She has also owned her own financial software
consulting business since 1994. She has a BA degree in business with an
accounting specialty from the University of New Mexico and is currently working
on a M.B.A. degree.
 
                                       43

    TRAVIS LEE was appointed Vice-President of Sales and Marketing in January,
1997. During 1996, Mr. Lee, was responsible for International Marketing and
Business Development at LaserScope Surgical Systems, San Jose, CA, a $70 million
manufacturer of surgical laser systems. From February 1994 to September 1996, he
was Vice President for Marketing at Heraeus Surgical Inc., a $30 million
manufacturer of surgical lasers and other medical products. He held senior
management, marketing and sales positions with Medasonics, Inc. and Xintec
Corporation from 1991 to 1994. Mr. Lee received his B.S. degree from San Jose
State University in Graphic Design.
 
    RICHARD ZIGWEID, Manufacturing Manager, joined the Company in August, 1996.
Mr. Zigweid was Manufacturing Manager at Olympus America from May 1994 to August
1996. He served as engineering manager at Bausch & Lomb and as engineering
manager and manufacturing engineer at Baxter Healthcare from December 1988 to
February 1994. He received his B.S. degree from the University of Wyoming in
Mechanical Engineering.
 
    CONNIE WHITE, Regulatory Affairs and Quality Assurance Manager, joined the
Company in January, 1997. She, served as Compliance Officer for Tissue
Technologies, Inc., a skin resurfacing laser manufacturer and wholly-owned
subsidiary of Palomar Medical Technologies, Inc. during 1995 and 1996, where she
achieved FDA Medical Device Quality System compliance, European market
permission, and ISO 9000 registration for Tissue Technologies' skin resurfacing
laser systems. From 1986 to 1995, was responsible for regulatory affairs at the
"O" Company, a dental implant company. Ms. White received her B.A. degree from
the University of New Mexico.
 
    MICHAEL WOLF, Chief Engineer, joined the Company in June 1991, and has been
principally responsible for designing the Company's flagship products. He served
as Senior Engineer at Amtech Systems Corp. and spent 24 years at LANL in various
technical positions beginning in 1967. He has authored over 30 technical papers,
holds 10 United States patents, and has been the lead designer on three projects
that were awarded the R&D 100 Award, signifying one of the 100 most significant
technological advances of the year.
 
    DR. LARRY KEENAN, Sales Representative, joined the Company in January 1993
and has been Product Manager for the Cell Robotics Workstation since July, 1997.
Dr. Keenan was the Regional Sales Manager of BioRad for the confocal microscope
product line of BioRad from 1991 through 1992. He received his Ph.D. in
Biological Sciences at the University of California at Irvine and was an
Associate Research Scientist in Neurobiology at Yale University.
 
    DR. JEROME CONIA joined the Company in May 1992 as a Scientist and has been
the IN VITRO Fertilization Workstation Product Manager since May 1996. He has
authored several scientific papers on optical trapping and scissoring and is the
principal investigator on several SBIR grants. He received his M.S. in
Embryology, Cellular Biology, and Physiology from the University of Paris, and
his Ph.D. in Specialty Life Science from the University of Orsay, Paris, France.
He also was a post-doctoral fellow in the Genetics Group at the LANL from March
1989 until May 1992.
 
    DAVID COSTELLO, Product Manager of the Lasette-TM-, joined the Company in
August 1996. From February 1994 to September 1995, he was founder and Executive
Vice-President of Technal Products, Inc. From May 1992 to February 1994, he was
Technology Development Program Manager at Lovelace Scientific Resources. His
qualifications include five patents in medical optics, experience in regulatory
development of new clinical products, and a master's degree in Biomedical
Engineering from Texas A&M University.
 
    MARK WALLER, DIRECTOR, was elected to the Board in February 1995. Since
1990, Mr. Waller has been President and founder of BridgeWorks Capital, a sole
proprietorship which arranges public and private financing for and provides
public relations services to client companies. Mr. Waller was Interim President
and Director of Totem Health Sciences, Inc., a Canadian medical products and
research company, from 1988 to 1990.
 
    DR. RAYMOND RADOSEVICH, Director, was elected to the Board in 1992. From
1985 to 1989, he was Dean of the Anderson School of Management at the University
of New Mexico, where he is currently a Professor
 
                                       44

of Management, specializing in business strategy and the management of
technology. In addition, he teaches a course in Technology Entrepreneurship and
lectures on the subject nationally and internationally. Dr. Radosevich earned
his Ph.D. from Carnegie-Mellon University, a B.S. in Mechanical Engineering and
an M.S. in Industrial Engineering from the University of Minnesota.
 
    DR. DEBRA BRYANT, Director, was elected to the Board in July 1997. She is
President, CEO and majority stockholder of Humagen Fertility Diagnostics, Inc.,
which is the largest manufacturer of micropipets for the worldwide IN VITRO
fertilization market. In 1984, Dr. Bryant joined Humagen, Inc. as a Senior
Scientist. In 1991, Dr. Bryant purchased the fertility diagnostics division of
Humagen, Inc. and founded Humagen Fertility Diagnostics, Inc. Dr. Bryant
received her Ph.D. in Medical Microbiology from Bowman Gray School of Medicine,
Wake Forest University and completed a NIH postdoctoral fellowship in molecular
biology at the University of Virginia.
 
    Each director is elected to serve for a term of one year until a successor
is duly elected and qualified.
 
    The executive officers of the Company are elected annually at the first
meeting of the Company's Board of Directors held after each annual meeting of
stockholders. Each executive officer will hold office until his successor is
duly elected and qualified, until his resignation or until he shall be removed
in the manner provided by the Company's By-Laws.
 
    During the fiscal year ended December 31, 1996, the Company had a standing
Audit Committee of the Board of Directors, but did not have a Compensation or
Nominating Committee of the Board. The members of the Audit Committee were Dr.
Raymond Radosevich and Dr. Denis Burger. Dr. Burger has since resigned as a
director and was succeeded on the Audit Committee by Mr. Waller. No member of
the Audit Committee receives any additional compensation for his service as a
member of that Committee. The Audit Committee is responsible for providing
assurance that financial disclosures made by management reasonably portray the
Company's financial condition, results of operations, plan and long-term
commitments. To accomplish this, the Audit Committee oversees the external audit
coverage, including the annual nomination of the independent public accountants,
reviews accounting policies and policy decisions, reviews the financial
statements, including interim financial statements and annual financial
statements, together with auditor's opinions, inquires about the existence and
substance of any significant accounting accruals, reserves or estimates made by
management, reviews with management the Management's Discussion and Analysis
section of the Annual Report, reviews the letter of management Representations
given to the independent public accountants, meets privately with the
independent public accountants to discuss all pertinent matters, and reports
regularly to the Board of Directors regarding its activities.
 
    The Company plans to form a Compensation Committee during fiscal 1997. No
member of the Compensation Committee will receive any additional compensation
for his service as a member of that Committee. The Compensation Committee will
be responsible for reviewing pertinent data and making recommendations with
respect to compensation standards for the executive officers, including the
President and Chief Executive Officer, establishing guidelines and making
recommendations for the implementation of management incentive compensation
plans, reviewing the performance of the President and CEO, establishing
guidelines and standards for the grant of incentive stock options to key
employees under the Company's Incentive Stock Option Plan, and reporting
regularly to the Board of Directors with respect to its recommendations.
 
    There are no family relationships among Directors or persons nominated or
chosen by the Company to become a Director, nor any arrangements or
understandings between any Director and any other person pursuant to which any
Director was elected as such. The present term of office of each Director will
expire at the next annual meeting of stockholders.
 
TECHNICAL ADVISORY BOARD
 
    The Company has voluntarily formed a Technical Advisory Board (the "Advisory
Board ") whose members are chosen by the Board of Directors based upon their
individual technical and scientific expertise in areas related to the Company's
business. In consideration of their services as members of the Advisory Board,
each member has been granted non-qualified stock options exercisable to purchase
6,000
 
                                       45

shares of Common Stock at exercise prices ranging from $1.75 per share to $2.50
per share. Members of the Advisory Board receive no other compensation for their
services, which consist of approximately one day per year devoted to the
business of the Company. The following persons currently serve as members of the
Advisory Board:
 
    DR. MICHAEL BERNS is President, Beckman Laser Institute and Professor of
Cell Biology at the University of California.
 
    DR. STEVEN CHU is Chairman of the Physics Department, Stanford University.
 
    DR. STEVEN BLOCK is Associate Professor of Molecular Biology at Princeton
University.
 
    DR. PAUL JACKSON is a Molecular and Plant Biologist at a national
laboratory.
 
    DR. WILFRIED FEICHTINGER is at the Institute for Fertility in Vienna,
Austria and was the recent chairman of the IXth World Congress on IN VITRO
Fertilization and Assisted Reproduction.
 
    DR. CHARLES BRACKER is the G. B. Cummins Distinguished Professor, Department
of Botany and Plant Pathology, Purdue University.
 
    DR. ROBERT STEVENSON is a biotech consultant in marketing and acquisitions.
 
    DR. OTIS PETERSON is a laser expert and an inventor of the Alexandrite
Laser.
 
DIRECTOR COMPENSATION
 
    During the fiscal year ended December 31, 1996, outside Directors received
no cash compensation or other remuneration for their services as such, however
they were reimbursed their expenses associated with attendance at meetings or
otherwise incurred in connection with the discharge of their duties as Directors
of the Company.
 
    Directors who are also executive officers of the Company receive no
additional compensation for their services as Directors.
 
EXECUTIVE COMPENSATION
 
    The following table and discussion set forth information with respect to all
compensation earned by or paid to the Company's Chief Executive Officer ("CEO"),
and its most highly compensated executive officers other than the CEO, for all
services rendered in all capacities to the Company and its subsidiaries for each
of the Company's last three fiscal years; provided, however, that no disclosure
has been made for any executive officer, other than the CEO, whose total annual
salary and bonus does not exceed $100,000.
 
                                       46

                                    TABLE 1
                           SUMMARY COMPENSATION TABLE


                                                                                              LONG TERM COMPENSATION
                                                                                           ----------------------------
                                               ANNUAL COMPENSATION                                    AWARDS
                                                                                           ----------------------------
                                            --------------------------    OTHER ANNUAL       RESTRICTED      OPTIONS/
NAME AND PRINCIPAL POSITION        YEAR      SALARY($)     BONUS($)      COMPENSATION($)   STOCK AWARD(S)      SARS
- -------------------------------  ---------  -----------  -------------  -----------------  ---------------  -----------
                                                                                          
Dr. Ronald K. Lohrding(1)......       1996   $ 115,500           -0-        $   3,623               -0-         25,000
  President and CEO                   1995   $  96,821           -0-        $   3,220               -0-        150,000
Craig T. Rogers(2).............       1995   $  24,525           -0-           -0-                  -0-         50,000
  President, CEO and Treasurer
  of IFC                              1994   $  27,000           -0-           -0-                  -0-         -0-
 

 
                                     PAYOUTS
                                 ---------------        ALL OTHER
NAME AND PRINCIPAL POSITION      LTIP PAYOUTS($)     COMPENSATION($)
- -------------------------------  ---------------  ---------------------
                                            
Dr. Ronald K. Lohrding(1)......           -0-                 -0-
  President and CEO                       -0-                 -0-
Craig T. Rogers(2).............           -0-                 -0-
  President, CEO and Treasurer
  of IFC                                  -0-

 
- ------------------------------
 
(1) Dr. Lohrding replaced Mr. Rogers as President and CEO of the Company in
    February 1995, following consummation of the Acquisition.
 
(2) Mr. Rogers served as President and CEO of the predecessor company, IFC,
    until the Acquisition in February 1995. Mr. Rogers served as the Company's
    Chief Financial Officer through January 8, 1997, and currently serves as the
    Company's Vice-President of Investors Relations, Secretary and Treasurer.
 
EMPLOYMENT AGREEMENTS
 
    The Company has entered into written Employment Agreements, having terms of
five years each, with Dr. Lohrding and Mr. Rogers. The Employment Agreement with
Dr. Lohrding provides for Dr. Lohrding to serve the Company as its Chairman,
President and CEO, on a full-time basis, for a minimum base salary of $100,000
per year. During fiscal 1996, Dr. Lohrding was paid a base salary of $115,500.
The Employment Agreement with Mr. Rogers provides for his serving as Chief
Financial Officer, Secretary and Treasurer, on a part-time basis, for a minimum
base salary of $27,000 per year. Mr. Rogers was paid a base salary of $40,000
during fiscal 1996. Effective January 9, 1997, Mr. Rogers resigned as Chief
Financial Officer; however, he remains as the Company's Vice-President of
Investor Relations, Secretary and Treasurer. The Company also has a written
employment agreement with Mr. Travis Lee, Vice President of Marketing and Sales.
Under Mr. Lee's agreement, he receives a base salary of $110,000 per year;
provided, however, that either the Company or Mr. Lee may terminate the
employment relationship upon thirty days' prior written notice.
 
STOCK INCENTIVE PLAN
 
    During fiscal 1992, the Company adopted the Plan. Pursuant to the Plan,
stock options granted to eligible participants may take the form of Incentive
Stock Options ("ISO's") under Section 422 of the Internal Revenue Code of 1986,
as amended (the "Code") or options which do not qualify as ISO's (Non-Qualified
Stock Options or "NQSO's"). As required by Section 422 of the Code, the
aggregate fair market value of the Company's Common Stock with respect to its
ISO's granted to an employee exercisable for the first time in any calendar year
may not exceed $100,000. The foregoing limitation does not apply to NQSO's. The
exercise price of an ISO may not be less than 100% of the fair market value of
the shares of the Company's Common Stock on the date of grant. The exercise
price of an NQSO may be set by the administrator. An option is not transferable,
except by will or the laws of descent and distribution. If the employment of an
optionee terminates for any reason (other than for cause, or by reason of death,
disability, or retirement), the optionee may exercise his options within a
ninety day period following such termination to the extent he was entitled to
exercise such options at the date of termination. Either the Board of Directors
(provided that a majority of directors are "disinterested") can administer the
Plan, or the Board of Directors may designate a committee comprised of directors
meeting certain requirements to administer the Plan. The Administrator will
decide when and to whom to make grants, the number of shares to be covered by
the grants, the vesting schedule, the type of award and the terms and provisions
relating to the exercise of the awards. An aggregate of 1,250,000 shares of the
Company's Common Stock is reserved for issuance under the Plan.
 
                                       47

    At September 30, 1997, the Company had granted a total of 1,032,000 Stock
Options under the Plan consisting of 694,000 Incentive Stock Options exercisable
at prices ranging from $1.75 per share to $1.875 per share, and 338,000
Non-Qualified Stock Options (NQSO's), which NQSO's have been issued to members
of the Advisory Board and other Company advisors, and to certain members of the
Board of Directors, and are exercisable at prices ranging from $1.75 per share
to $2.81 per share. All options have been issued with exercise prices at or
above market value on the date of issuance.
 
    The following tables set forth certain information concerning the granting
and exercise of incentive stock options during the last completed fiscal year by
each of the named executive officers and the fiscal year-end value of
unexercised options on an aggregated basis:
 
                                    TABLE 2
                           OPTION/SAR GRANTS FOR LAST
                         FISCAL YEAR--INDIVIDUAL GRANTS
 


                                               NUMBER OF        % OF TOTAL OPTIONS/
                                              SECURITIES          SARS GRANTED TO       EXERCISE
                                          UNDERLYING OPTIONS/   EMPLOYEES IN FISCAL       PRICE
NAME                                        SARS GRANTED(#)            YEAR              ($/SH)      EXPIRATION DATE
- ----------------------------------------  -------------------  ---------------------  -------------  ---------------
                                                                                         
Ronald K. Lohrding......................          25,000                  14.3%         $   1.875         12/13/01
Craig T. Rogers.........................          10,000                   5.7%         $   1.875         12/13/01

 
                                    TABLE 3
              AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR
                          AND FY-END OPTION/SAR VALUES
 


                                                                                                             VALUE OF
                                                                                             NUMBER OF      UNEXERCISED
                                                                                            UNEXERCISED    IN-THE-MONEY
                                                                                           OPTIONS/SARS   OPTIONS/SARS AT
                                                                                           AT FY-END(#)    FY-END($)(2)
                                               SHARES ACQUIRED ON     VALUE REALIZED(1)    -------------  ---------------
NAME                                               EXERCISE(#)               ($)            EXERCISABLE     EXERCISABLE
- ---------------------------------------------  -------------------  ---------------------  -------------  ---------------
                                                                                              
Ronald K. Lohrding(3)........................             -0-                   -0-            175,000     $   40,625.00
Craig T. Rogers..............................             -0-                   -0-             60,000     $   13,750.00

 
- ------------------------
 
(1) Value Realized is determined by calculating the difference between the
    aggregate exercise price of the options and the aggregate fair market value
    of the Common Stock on the date the options are exercised.
 
(2) The value of unexercised options is determined by calculating the difference
    between the fair market value of the securities underlying the options at
    fiscal year end and the exercise price of the options. The fair market value
    of the securities underlying the options, based on the closing bid price of
    the Company's Common Stock at December 31, 1996, as quoted on OTC Electronic
    Bulletin Board, was $2.00 per share.
 
(3) Does not reflect the Lohrding Options issued in anticipation of this
    offering exercisable to purchase, in the aggregate, 450,000 shares of the
    Company's Common Stock at an exercise price equal to the initial price per
    share of the Shares sold in this offering, or $4.50 per share, whichever is
    greater. The Lohrding Options are subject to vesting. Specifically, 150,000
    Lohrding Options will vest and become exercisable on the closing of this
    offering and the balance will vest on November 30, 2002; provided, however,
    (i) 150,000 Lohrding Options will vest and become exercisable thirty days
    after the end of any quarter in which the Company reports pre-tax income of
    at least $50,000; and (ii) 150,000 Lohrding Options shall vest and become
    exercisable upon the Company reporting its first fiscal year with net income
    of at least $500,000. The Lohrding Options are exercisable for a period of
    36 months from each respective vesting date, but in no event later than
    December 31, 2002.
 
                                       48

EMPLOYEE STOCK PURCHASE PLAN
 
    The Board of Directors and stockholders have approved the ESPP which has
been adopted pursuant to Section 423 of the Code. The ESPP has an initial term
of three years at which time it will terminate except as to any options
outstanding on the termination date. The ESPP is available to all employees of
the Company and its subsidiaries, except those employees of less than six
months, those employed on a part-time basis (20 hours per week or less), those
customarily employed for not more than five months in any calendar year, and
those persons who are officers, supervisors, or highly-compensated employees. In
addition, no persons owning five percent (5%) or more of the Company's Common
Stock may participate in the ESPP. No employee may purchase any more than
$25,000 worth of stock in any calendar year. The plan is limited to 100,000
shares per year over the three-year term with a maximum aggregate number of
shares which may be purchased by the Company's employees pursuant to the ESPP
being 300,000.
 
    Under the plan, the year is divided into two enrollment periods of six
months each. At the commencement of each six month enrollment period, an
employee is given the ability to subscribe for and purchase shares of the
Company's Common Stock at the end of the six month enrollment at a price equal
to 85% of the fair market value of the Company's Common Stock on the
commencement date or the termination date of such enrollment, whichever price
per share is lower. The shares are purchased pursuant to a payroll deduction
program pursuant to which an employee may elect to have up to 10% of that
employee's compensation withheld during each pay period for the purposes of
covering subscriptions made under the plan.
 
    As of the date of this Prospectus, no shares of Common Stock have been
issued under the ESPP and there have been no subscriptions of employees to
participate in the plan. The Company expects to begin implementing the ESPP
during fiscal 1998.
 
    No officer of the Company receives any additional compensation for his
services as a director. The Company does not contribute to any retirement,
pensions, or profit sharing plans covering its directors who are not also
employees of the Company. The Company does, however, maintain a group health
insurance plan for its employees.
 
INDEMNIFICATION AND LIMITATION ON LIABILITY OF DIRECTORS
 
    The Company's Articles of Incorporation provide that the Company shall
indemnify, to the fullest extent permitted by Colorado law, any director,
officer, employee or agent of the corporation made or threatened to be made a
party to a proceeding, by reason of the former or present official of the
person, against judgments, penalties, fines, settlements and reasonable expenses
incurred by the person in connection with the proceeding if certain standards
are met. At present, there is no pending litigation or proceeding involving any
director, officer, employee or agent of the Company where indemnification will
be required or permitted. Insofar as indemnification for liabilities arising
under the Securities Act of 1933 may be permitted to directors, officers and
controlling persons of the Company pursuant to the foregoing provisions, or
otherwise, the Company has been advised that in the opinion of the Commission
such indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable.
 
    The Company's Articles of Incorporation limit the liability of its directors
to the fullest extent permitted by the Colorado Business Corporation Act.
Specifically, directors of the Company will not be personally liable for
monetary damages for breach of fiduciary duty as directors, except for (i) any
breach of the duty of loyalty to the Company or its stockholders, (ii) acts or
omissions not in good faith or that involved intentional misconduct or a knowing
violation of law, (iii) dividends or other distributions of corporate assets
that are in contravention of certain statutory or contractual restrictions, (iv)
violations of certain laws, or (v) any transaction from which the director
derives an improper personal benefit. Liability under federal securities law is
not limited by the Articles.
 
                                       49

                              CERTAIN TRANSACTIONS
 
ACQUISITION
 
    Effective February 23, 1995, IFC and CRI consummated the Acquisition
pursuant to which IFC acquired 100% of the issued and outstanding shares of
common stock and equity rights of CRI in exchange for which IFC issued to the
stockholders of CRI, PRO RATA, 668,019 shares of IFC Common Stock, Incentive
Stock Options exercisable to purchase 66,594 shares of Common Stock at an
exercise price of $2.39 per share, and non-qualified stock options exercisable
to purchase 36,000 shares of Common Stock at an exercise price of $2.39 per
share, the latter of which were issued in exchange for non-qualified stock
options of CRI held by members of its Board of Technical Advisors and Board of
Directors. As a result, CRI became a wholly-owned subsidiary of IFC. IFC
subsequently changed its name to "Cell Robotics International, Inc." The shares
of Common Stock issued to the stockholders of CRI, PRO RATA, represented
immediately following the Acquisition, 62.3% of the total issued and outstanding
shares of the Company's Common Stock. The Acquisition was accounted for as a
reverse purchase of all of the assets and liabilities of IFC by CRI.
 
    In connection with the Acquisition, Mitsui voluntarily surrendered to CRI
for cancellation a total of 491,499 shares of common stock of CRI. As a result
of this surrender and cancellation, Mitsui retained 231,519 shares of CRI common
stock which were exchanged for an equal number of shares of Company Common Stock
in the Acquisition. The number of shares that Mitsui retained after the
voluntary surrender was subject to adjustment based upon the completion of a
subsequent financing. See "Financing and Capital Contribution Agreement." In
addition, Mitsui executed a Forbearance Agreement pursuant to which it agreed to
forebear from exercising or enforcing any rights it had by virtue of a series of
promissory notes having an outstanding principal balance of $5,758,338,
including unpaid interest, penalty interest and expenses due and owing of
$358,338, pending performance by the Company of its agreements under the
Financing Agreement described below.
 
FINANCING AND CAPITAL CONTRIBUTION AGREEMENT
 
    Concurrently with the Acquisition, IFC, CRI, Mitsui and BridgeWorks
Investors I, L.L.C., an Oregon limited liability company ("BW") entered into a
Financing and Capital Contribution Agreement ("Financing Agreement"). Pursuant
to the terms of the Financing Agreement, BW executed a Subscription Agreement to
subscribe for and purchase 380,000 shares of the Company's Common Stock at an
exercise price of $1.00 per share, 50,000 of which were subsequently assigned
to, and purchased by R.O.I., Inc., controlled by Craig T. Rogers, Vice President
of Investor Relations of the Company. As of the date of this Prospectus, all
380,000 shares have been purchased in accordance with the Subscription
Agreement.
 
    Further, under the terms of the Financing Agreement, BW agreed to obtain on
behalf of the Company a financing commitment which would result, when
consummated, in the infusion of a minimum of $1,400,000 of additional equity
into the Company (the "Financing"). Following consummation of the Acquisition,
the Company completed a $12.875 million private placement of its securities
through Paulson, a Representative in this offering, which served as placement
agent (the "Private Offering"). The Private Offering was designed, in part, to
meet the requirements of the Financing and the Financing Agreement.
 
    In accordance with and fulfilling the terms of the Financing Agreement,
following the first closing of the private offering which occurred on August 31,
1995, the Company and Mitsui consummated the following transactions:
 
    (1) The Company paid to Mitsui the sum of $250,000;
 
    (2) The Company issued to Mitsui an additional 177,887 shares of Common
       Stock;
 
                                       50

    (3) The Company and Mitsui executed and delivered a Royalty Agreement
       pursuant to which the Company agreed to pay to Mitsui a royalty equal to
       one percent (1%) of the aggregate net sales of certain products for a
       term of ten years; and
 
    (4) Mitsui executed and delivered to the Company a Capital Contribution
       Agreement pursuant to which it agreed to contribute to the capital and
       equity of the Company $5,400,000 in aggregate principal debt obligation
       of Cell Robotics, Inc. to Mitsui, together with all accrued and unpaid
       interest in the aggregate amount of $358,338.
 
TRANSACTIONS WITH DIRECTOR
 
    Mark Waller, a director of the Company, is also the managing member of BW.
In addition, Mr. Waller provided services to the Company in connection with
structuring the Private Offering and arranging on the Company's behalf for
Paulson to serve as placement agent, therefor. In consideration of his services
in connection with the Private Offering, Mr. Waller was granted non-qualified
stock options exercisable to purchase, in the aggregate, 200,000 shares of the
Company's Common Stock at an exercise price of $1.75 per share.
 
    Any transactions between the Company and its officers, directors, principal
stockholders, or other affiliates have been, and will be, on terms no less
favorable to the Company than could be obtained from unaffiliated third parties
on an arms-length basis and will be approved by a majority of the Company's
independent, disinterested directors.
 
                                       51

                             PRINCIPAL STOCKHOLDERS
 
    The following table sets forth, as of the date of this Prospectus, the stock
ownership of each person known by the Company to be the beneficial owner of five
(5%) percent or more of the Company's Common Stock, all executive officers of
the Company and directors individually and all directors and executive officers
of the Company as a group. Each person has sole voting and investment power with
respect to the shares shown, except as noted.
 


                                                                                          PERCENT OF CLASS(1)
                                                         AMOUNT AND NATURE OF   ----------------------------------------
NAME AND ADDRESS OF BENEFICIAL OWNER                     BENEFICIAL OWNERSHIP   BEFORE OFFERING(2)    AFTER OFFERING(2)
- ------------------------------------------------------  ----------------------  -------------------  -------------------
                                                                                            
Ronald K. Lohrding (3) ...............................           475,000                   8.8%                 6.4%
c/o Cell Robotics, Inc.
2715 Broadbent Parkway, NE
Albuquerque, NM 87107
 
Mitsui Engineering & (4) .............................           409,406                   7.8%                 5.7%
Shipbuilding Co., Ltd.
405 Park Avenue, Suite 501
New York, NY 10022
 
Mark T. Waller (5) ...................................           220,000                   4.0%                 3.0%
1820 North Shore Road
Lake Oswego, OR 97304
 
Craig T. Rogers (6) ..................................           180,800                   3.4%                 2.3%
c/o Rockies Fund, Inc.
4465 Northpark Drive
Colorado Springs, CO 80907
 
Raymond Radosevich (7) ...............................            26,000                   0.5%                 0.4%
c/o Cell Robotics, Inc.
2715 Broadbent Parkway, NE
Albuquerque, NM 87107
 
Debra Bryant (8) .....................................            15,000                   0.3%                 0.2%
c/o Cell Robotics, Inc.
2715 Broadbent Parkway, NE
Albuquerque, NM 87107
 
Richard S. Hall (9) ..................................           619,300                  11.9%                 8.6%
280 Estrellita Drive
Ft. Myers Beach, FL 33931
 
Travis Lee (10) ......................................           -0-                    -0-                  -0-
c/o Cell Robotics, Inc.
2715 Broadbent Parkway, NE
Albuquerque, NM 87107
 
Jean Scharf (11) .....................................           -0-                    -0-                  -0-
c/o Cell Robotics, Inc.
2715 Broadbent Parkway, NE
Albuquerque, NM 87107

 
                                       52



                                                                                          PERCENT OF CLASS(1)
                                                         AMOUNT AND NATURE OF   ----------------------------------------
NAME AND ADDRESS OF BENEFICIAL OWNER                     BENEFICIAL OWNERSHIP   BEFORE OFFERING(2)    AFTER OFFERING(2)
- ------------------------------------------------------  ----------------------  -------------------  -------------------
                                                                                            
All Officers and Directors as a Group (7 persons).....           916,800                  16.0%                11.9%

 
- ------------------------
 
(1) Shares not outstanding but deemed beneficially owned by the virtue of the
    individual's right to acquire them within sixty days of the date of this
    Prospectus are treated as outstanding when determining the percent of the
    class owned by such individual and when determining the percent owned by the
    group.
 
(2) Assumes no exercise by Paulson of the Placement Agent's Warrant to purchase
    230,000 shares of Common Stock and 115,000 Class A Warrants issued to
    Paulson in conjunction with the Company's Private Placement of securities in
    September, 1995, and no subsequent exercise of the Class A Warrants by
    Paulson. Also assumes no exercise by the Representatives of the
    Representatives' Warrants.
 
(3) Includes Incentive Stock Options exercisable to purchase 150,000 shares of
    Common Stock at an exercise price of $1.75 per share, and Incentive Stock
    Options exercisable to purchase 25,000 shares of Common stock at an exercise
    price of $1.875 per share, issued under the Plan. Does not include
    additional Lohrding Options exercisable to purchase 450,000 shares of the
    Company's Common Stock subject to future vesting. Of the Lohrding Options,
    150,000 will vest and become exercisable upon completion of this offering,
    resulting in Dr. Lohrding being the beneficial owner (as defined herein) of
    an aggregate of 625,000 shares or 8.7%, of the total issued and outstanding
    shares immediately after the offering.
 
(4) Mitsui Engineering & Shipbuilding Co., Ltd., a Japanese corporation, is the
    record owner and exercises the sole power to vote and invest 409,406 shares
    of the Company's Common Stock.
 
(5) Represents non-qualified stock options exercisable to purchase, in the
    aggregate, 200,000 shares of Common Stock at $1.75 per share, and
    Non-Qualified Stock Options exercisable to purchase 20,000 shares of Common
    Stock at an exercise price of $2.81 per share.
 
(6) Mr. Rogers exercises the sole voting and investment power with respect to
    40,800 shares of Common Stock. Also includes 10,000 shares of Common Stock
    owned of record by Leslie Rogers, Mr. Roger's wife, and 70,000 shares of
    Common Stock owned of record by R.O.I, Inc., a Colorado corporation, of
    which Mr. Rogers is an officer, director and fifty percent stockholder, and
    as a result would be deemed to exercise the shared voting and investment
    power with respect to the securities. Mr. Rogers disclaims beneficial
    ownership of 35,000 shares of Common Stock owned of record by R.O.I., Inc.
    for purposes of Section 16 of the Exchange Act Also includes Incentive Stock
    Options exercisable to purchase 50,000 shares of Common Stock at an exercise
    price of $1.75 per share, and Incentive Stock Options exercisable to
    purchase 10,000 shares of Common Stock at an exercise price of $1.875 per
    share, granted pursuant to the Company's 1992 Stock Incentive Plan.
 
(7) Reflects Non-Qualified Stock Options exercisable to purchase 6,000 shares of
    Common Stock at an exercise price of $1.75 per share, and Non-Qualified
    Stock Options exercisable to purchase 20,000 shares of Common Stock at an
    exercise price of $2.81 per share.
 
(8) Represents nonqualified stock options exercisable to purchase 15,000 shares
    of Common Stock at $3.56 per share.
 
(9) Includes 320,500 shares of Common Stock owned by Mr. Hall individually
    and/or by the R.S. Hall IRA; 6,000 shares of Common Stock owned collectively
    by the Hall Grantor Retained Annuity Trust and the R.S. Hall Gift Trust,
    both of which were created and are controlled by Mr. Hall; 2,500 shares of
    Common Stock owned by the Wildwood Foundation, Inc., a non-profit private
    foundation founded by Mr. Hall, and for whom Mr. Hall serves as President of
    the Board of Trustees and supervises investment decisions; and 1,000 shares
    of Common Stock owned by the Hall Scholarship Trust which
 
                                       53

    was created and supervised by Mr. Hall. Also includes 139,000 shares of
    Common Stock owned by Richard S. Hall, Jr., and 148,000 shares of Common
    Stock owned by Mr. Hall's son, William R. Hall, with whom Mr. Hall shares
    voting and dispositive power. Finally, includes 2,300 shares of Common Stock
    owned by Tayloreel Corporation South, Inc., a controlled corporation of Mr.
    Hall. Mr. Hall disclaims beneficial ownership of all shares of Common Stock
    owned by Messrs. Richard S. Hall, Jr. and William R. Hall, the Hall
    Scholarship Trust, and the Wildwood Foundation, Inc. for purposes of Section
    16 of the Exchange Act.
 
(10) Does not reflect incentive stock options exercisable to purchase 74,174
    shares of Common Stock at a price of $2.25 per share which are subject to
    future vesting.
 
(11) Does not reflect incentive stock options exercisable to purchase 20,000
    shares of Common Stock at a price of $3.50 per share which are subject to
    future vesting.
 
                                       54

                           DESCRIPTION OF SECURITIES
 
    The Company is authorized to issue up to 12,500,000 shares of $.004 par
value Common Stock and 2,500,000 shares of $.04 par value Preferred Stock. As of
November 15, 1997, 5,222,414 shares of Common Stock and no shares of Preferred
Stock were issued and outstanding, and there were 176 stockholders of record.
 
COMMON STOCK
 
    Each holder of Common Stock is entitled to one vote for each share held of
record. There is no right to cumulative voting of shares for the election of
directors. The shares of Common Stock are not entitled to pre-emptive rights and
are not subject to redemption or assessment. Each share of Common Stock is
entitled to share ratably in distributions to stockholders and to receive
ratably such dividends as may be declared by the Board of Directors out of funds
legally available therefor. Upon liquidation, dissolution or winding up of the
Company, the holders of Common Stock are entitled to receive, pro-rata, the
assets of the Company which are legally available for distribution to
stockholders. The issued and outstanding shares of Common Stock are validly
issued, fully paid and non-assessable.
 
PREFERRED STOCK
 
    The Company is authorized to issue up to 2,500,000 shares of $.04 par value
Preferred Stock. The preferred stock of the corporation can be issued in one or
more series as may be determined from time-to-time by the Board of Directors. In
establishing a series the Board of Directors shall give to it a distinctive
designation so as to distinguish it from the shares of all other series and
classes, shall fix the number of shares in such series, and the preferences,
rights and restrictions thereof. All shares of any one series shall be alike in
every particular. The Board of Directors has the authority, without stockholder
approval, to fix the rights, preferences, privileges and restrictions of any
series of preferred stock including, without limitation: (1) the rate of
distribution, (2) the price at and the terms and conditions on which shares
shall be redeemed, (3) the amount payable upon shares for distributions of any
kind, (4) sinking fund provisions for the redemption of shares, and (5) the
terms and conditions on which shares may be converted if the shares of any
series are issued with the privilege of conversion, and (6) voting rights except
as limited by law.
 
    Although the Company currently does not have any plans to issue shares of
Preferred Stock or to designate any series of Preferred Stock, there can be no
assurance that the Company will not do so in the future. As a result, the
Company could authorize the issuance of a series of Preferred Stock which would
grant to holders preferred rights to the assets of the Company upon liquidation,
the right to receive dividend coupons before dividends would be declared to
common stockholders, and the right to the redemption of such shares, together
with a premium, prior to the redemption to Common Stock. The common stockholders
of the Company have no redemption rights. In addition, the Board could issue
large blocks of voting stock to fend off unwanted tender offers or hostile
takeovers without further stockholder approval.
 
PLACEMENT AGENT'S WARRANT
 
    In connection with a private placement undertaken by the Company in 1995,
the Company issued to Paulson, a Representative in this offering, a warrant (the
"Placement Agent's Warrant") to purchase 11.5 units at a price of $25,000 per
unit, each unit consisting of 20,000 shares of Common Stock and 10,000 Class A
Warrants. The Placement Agent's Warrant is exercisable until September 30, 2000.
Each Class A Warrant included in the units gives to the holder the right to
purchase one additional share of the Company's Common Stock at an exercise price
of $1.75 share. The Class A Warrants are exercisable until December 31, 2000.
 
                                       55

TRANSFER AGENT, WARRANT AGENT AND REGISTRAR
 
    The transfer agent, registrar and Warrant Agent for the Company's Common
Stock is Corporate Stock Transfer, Inc., Denver, Colorado.
 
REPORTS TO STOCKHOLDERS
 
    The Company intends to furnish annual reports to stockholders which will
include audited financial statements reported on by its certified public
accountants. In addition, the Company will issue unaudited quarterly or other
interim reports to stockholders as it deems appropriate.
 
                                       56

                        SHARES ELIGIBLE FOR FUTURE SALE
 
    Prior to this offering, there has been only a limited public market for the
Common Stock. No prediction can be made of the effect, if any, that future
market sales of shares of Common Stock or the availability of such shares for
sale will have on the prevailing market price of the Common Stock following this
offering. Nevertheless, sales of substantial amounts of such shares in the open
market following this offering could adversely affect the prevailing market
price of the Common Stock.
 
    Upon completion of this offering, and assuming no exercise of outstanding
options and warrants to purchase Shares, the Company will have 7,222,414,
outstanding shares of Common Stock. Of those, 2,749,708 shares of Common Stock
that are currently outstanding, together with the 2,000,000 Shares sold in this
offering (plus any shares sold as a result of any exercise of the Over Allotment
Option) by the Company and, commencing approximately three months after the date
of this Prospectus, up to 200,000 shares of Common Stock that are issuable upon
exercise of the Representatives' Warrants, will, subject to any applicable state
law restrictions on secondary trading, be freely tradeable without restriction
under the Securities Act, except that any shares purchased by an "affiliate" of
the Company (as that term is defined in Rule 144 under the Securities Act) will
be subject to the resale limitations of Rule 144.
 
    The remaining 2,472,706 shares of Common Stock are "restricted" within the
meaning of Rule 144 under the Securities Act (the "Restricted Shares"). Of this
number, 1,415,106 shares are eligible for immediate sale in the public market
without restriction under Rule 144k. Beginning 90 days after the date of this
Prospectus (or earlier with the consent of the Underwriters), 840,100 additional
shares of Common Stock will become eligible for sale upon the expiration of a
lock-up agreement between the Underwriters and certain stockholders not to sell
such shares, subject to the volume limitation, set forth in Rule 144.
 
    In general, under Rule 144, as currently in effect, any person (or persons
whose shares are aggregated) who has beneficially owned Restricted Shares for at
least one year, is entitled to sell, within any three-month period, a number of
shares that does not exceed the greater of (i) 1% of the then outstanding shares
of the Company's Common Stock (approximately 72,224 shares immediately after the
offering) or (ii) the average weekly trading volume of the Company's Common
Stock in the Nasdaq Small Cap Market during the four calendar weeks immediately
preceding the date on which notice of the sale is filed with the Commission.
Sales pursuant to Rule 144 are also subject to certain requirements relating to
manner of sale, notice and availability of current public information about the
Company. A person who is not deemed to have been an affiliate of the Company at
any time during the 90 days immediately preceding the sale and whose Restricted
Shares have been fully-paid for two years since the later of the date they were
acquired from the Company or the date they were acquired from an affiliate of
the Company may sell such Restricted Shares under Rule 144(k) without regard to
the limitations and requirements described above. Under Rule 701, shares
privately issued under certain compensatory stock-based plans, such as the Plan
or the ESPP, may be resold under Rule 144 by non-affiliates, subject only to the
manner of sale requirements, and by affiliates without regard to the two-year
holding period requirement.
 
    The Company has filed a registration statement under the Securities Act
covering shares of Common Stock reserved for issuance under the Company's
outstanding stock options and stock option plans, which registration statement
was declared effective on June 14, 1996. Based on the number of options
outstanding and options and shares reserved for issuance, said registration
statement currently covers 1,250,000 shares.
 
    Prior to the offering, there has been only a limited and sporadic public
market for the Common Stock. No prediction can be made of the effect, if any,
that sales of shares under Rule 144 or the availability of shares for sale will
have on the market price of the Common Stock prevailing from time to time after
the offering. The Company is unable to estimate the number of shares that may be
sold in the public market under Rule 144, because such amount will depend on the
trading volume in, and market price for, the Common Stock and other factors.
Nevertheless, sales of substantial amounts of shares in the public market, or
the perception that such sales could occur, could adversely affect the market
price of the Common Stock of the Company. See "Underwriting."
 
                                       57

                                  UNDERWRITING
 
    The underwriters named below (the "Underwriters"), acting through the
Representatives, have agreed, severally and not jointly, subject to the terms
and conditions contained in the Underwriting Agreement between the Company and
the several Underwriters (the "Underwriting Agreement"), to purchase from the
Company the Shares offered by this Prospectus in the amounts set forth below.
 


                                                                                   NUMBER OF
UNDERWRITER                                                                          SHARES
- ---------------------------------------------------------------------------------  ----------
                                                                                
Paulson Investment Company, Inc..................................................
Cohig & Associates, Inc..........................................................
 
                                                                                   ----------
    Total........................................................................   2,000,000
                                                                                   ----------
                                                                                   ----------

 
    The Underwriting Agreement provides that the Underwriters are obligated to
purchase all of the Shares offered by this Prospectus if any shares are
purchased. The Company has been advised that the Underwriters propose to offer
the Shares offered by this Prospectus to the public, initially at the offering
price set forth on the cover page of this Prospectus and to selected dealers,
including Underwriters, at that price less a concession to be determined by the
Representatives. After the initial offering of the Shares offered by this
Prospectus, the public offering price and other offering terms may be changed.
 
    The Company has granted the Underwriters an option, exercisable by the
Representatives, during the 45-day period after the date of this Prospectus to
purchase up to 300,000 additional shares of Common Stock on the same terms as
the Shares being purchased by the Underwriters from the Company. The
Representatives may exercise this option only to cover over-allotments, if any,
incurred in the sale of the Shares.
 
    The Underwriters will purchase the Shares offered hereby (including the
shares subject to the Over-Allotment Option) at a discount equal to 10% of the
public offering price, or $4.05 per share, assuming an initial offering price of
$4.50 per share.
 
    As one of the Representatives, Paulson will also receive at the closing a
non-accountable expense allowance equal to 3% of the aggregate initial offering
price of the Shares sold in the offering, of which $25,000 has already been
paid.
 
    The Company has agreed to issue to the Representatives the Representatives'
Warrants giving the Representatives the right to purchase up to 200,000 shares
of Common Stock. The Representatives' Warrants are exercisable for a period of
four years beginning one year from the date of this Prospectus at a price equal
to 120% of the public offering price, or $5.40 per share, assuming a public
offering price of $4.50 per share. The Representatives' Warrants are not
transferrable for a period of one year from the date of this Prospectus except
(i) to any of the Representatives or to individuals who are either a partner or
an officer of a Representative, or (ii) by will or by the laws descent and
distribution. The holders of the Representatives' Warrants will have, in that
capacity, no voting, dividend or other shareholder rights. Any profits realized
by the Representatives on the sale of the Common Stock issuable upon exercise of
the Representatives' Warrants may be deemed to be additional underwriting
compensation.
 
    The shares of Common Stock underlying the Representatives' Warrants are
being registered on the Registration Statement of which this Prospectus is a
part. The Company has agreed to maintain an effective Registration Statement
with respect to such shares to permit their resale at all times during the
period in which the Representatives' Warrants are exercisable. The sale of the
shares issuable upon exercise of the Representatives' Warrants could dilute the
interest of other holders of Common Stock and
 
                                       58

the existence of the Representatives' Warrants may make the raising of
additional capital by the Company more difficult. At any time at which exercise
of Representatives' Warrants might be expected, it is likely that the Company
could raise additional capital on terms more favorable than the terms of the
Representatives' Warrants.
 
    The Company has agreed that, for a period of 90 days following the closing
of this offering, it will not, subject to certain exceptions, offer, sell,
contract to sell, grant any option for the sale or otherwise dispose of any
securities of the Company without Paulson's prior written consent. All officers
and directors and 5% stockholders of the Company have agreed that for a period
of 90 days following the closing of this offering, they will not offer, sell,
contract to sell, grant any option for the sale or otherwise dispose of any
securities of the Company pursuant to Rule 144 under the Securities Act or
otherwise without Paulson's prior written consent.
 
    Until the distribution of the Shares is completed, rules of the Commission
may limit the ability of the Underwriters and certain selling group members to
bid for and purchase the securities. As an exception to these rules, the
Underwriters are permitted to engage in certain transactions that stabilize the
price of the Common Stock. Such transactions consist of bids or purchases for
the purpose of pegging, fixing or maintaining the price of the Common Stock. If
the Underwriters create a short position in the Shares in connection with the
offering, i.e., if they sell more Shares than are set forth on the cover page of
this Prospectus, the Underwriters may reduce that short position by purchasing
Common Stock in the open market. The Underwriters may also elect to reduce any
short position by exercising all or part of the Over-Allotment Option described
above.
 
    The Underwriters may also impose a penalty bid on selling group members.
This means that if the Underwriters purchase Common Stock in the open market to
reduce the Underwriters' short position or to stabilize the price of the Common
Stock, it may reclaim the amount of the selling concession from the selling
group members who sold those securities as part of this offering.
 
    In general, purchase of a security for the purpose of stabilization or to
reduce a short position could cause the price of the security to be higher than
it might be in the absence of such purchases. The imposition of a penalty bid
might also have an effect on the price of a security to the extent that it were
to discourage resales of the security. Neither the Company nor the Underwriters
make any representation or predictions as to the direction or magnitude of any
effect that the transactions described above may have on the price of the Common
Stock. In addition, neither the Company nor the Underwriters make any
representation that the Underwriters will engage in such transactions or that
such transactions, once commenced, will not be discontinued without notice.
 
    Prior to this offering, there has been only a limited and sporadic public
market for the shares of Common Stock. Accordingly, the public offering price of
the Shares offered by this Prospectus has been determined by negotiations
between the Company and Paulson. Among the factors considered in determining the
public offering price of the Shares included the Company's net worth and
earnings, the amount of dilution per share of Common Stock to the public
investors, the history and the prospects of the Company and the industry in
which it operates, the status and development prospects for the Company's
proposed products and the trends of such results, the experience and
qualifications of the Company's executive officers and the general condition of
the securities markets at the time of the offering.
 
    The Underwriting Agreement provides for indemnification between the Company
and the Underwriters against certain liabilities, including liabilities under
the Securities Act and for contribution by the Company and the Underwriters to
payments that may be required to be made in respect thereof.
 
                                       59

                                 LEGAL MATTERS
 
    The validity of the issuance of the Shares offered hereby will be passed
upon for the Company by Neuman & Drennen, LLC, Boulder, Colorado. Clifford L.
Neuman, a partner in the firm of Neuman & Drennen, LLC, is the beneficial owner
of 3,100 shares of the Company's Common Stock. Certain legal matters will be
passed upon for the Underwriters by Morse, Zelnick, Rose & Lander, LLP, New
York, New York.
 
                                    EXPERTS
 
    The consolidated financial statements of Cell Robotics International, Inc.
as of December 31, 1996 and 1995 and for the years then ended, have been
included herein and in the registration statement in reliance upon the report of
KPMG Peat Marwick LLP, independent certified public accountants, appearing
elsewhere herein, and upon the authority of said firm as experts in accounting
and auditing.
 
    The report of KPMG Peat Marwick LLP covering the December 31, 1996 financial
statements contains an explanatory paragraph that states that the Company's
recurring losses from operations and negative cash flows from operations raise
substantial doubt about the Company's ability to continue as a going concern.
The consolidated financial statements referred to above do not include any
adjustments that might result from the outcome of that uncertainty.
 
                             AVAILABLE INFORMATION
 
    The Company is subject to the information requirements of the Exchange Act,
and in accordance with the Exchange Act files periodic reports, proxy statements
and other information with the Commission. Reports, proxy statements and other
information concerning the Company can be inspected and copied (at prescribed
rates) at the Commission's Public Reference Section, Room 1024, 450 Fifth
Street, N.W. Judiciary Plaza, Washington, D.C. 20549, as well as at the
following Regional Offices: Northwestern Atrium Center, 500 West Madison Street,
Suite 1400, Chicago, Illinois 60661-2511; and Seven World Trade Center, 13th
Floor, New York, New York 10048. Copies of such material also may be obtained at
prescribed rates from the Public Reference Section of the Commission, 450 Fifth
Street, N.W., Judiciary Plaza, Washington, D.C. 20549, and are publicly
available through the Commission's website at http:\\www.sec.gov.
 
    The Company has filed a Registration Statement on Form SB-2 with the
Commission in Washington, D.C., in accordance with the provisions of the
Securities Act. This Prospectus does not contain all of the information set
forth in the Registration Statement, certain portions of which have been omitted
as permitted by the rules and regulations of the Commission. For further
information pertaining to the Shares offered hereby and the Company, reference
is made to the Registration Statement, including the exhibits and financial
statement schedules filed as a part thereof. Statements herein contained
concerning the provisions of any document are not necessarily complete and, in
each instance, reference is made to the copy of such document filed as an
Exhibit to the Registration Statement. Each such statement is qualified in its
entirety by such reference. The Registration Statement may be obtained from the
Commission upon payment of the fees prescribed therefor and may be examined at
the principal office of the Commission in Washington, D.C.
 
                                       60

                   INDEX TO CONSOLIDATED FINANCIAL STATEMENTS
 
    This index relates to the consolidated financial statements set forth in
this Prospectus of Cell Robotics International, Inc.
 

                                                                                     
Independent Auditors' Report of KPMG Peat Marwick LLP.................................         F-2
 
Consolidated Financial Statements
 
  Consolidated Balance Sheets.........................................................         F-3
 
  Consolidated Statements of Operations...............................................         F-4
 
  Consolidated Statements of Stockholders' Equity (Deficit)...........................         F-5
 
  Consolidated Statements of Cash Flows...............................................         F-6
 
Notes to Consolidated Financial Statements............................................         F-7

 
                                      F-1

                          INDEPENDENT AUDITORS' REPORT
 
The Board of Directors and Shareholders
Cell Robotics International, Inc.:
 
    We have audited the accompanying consolidated balance sheets of Cell
Robotics International, Inc. and subsidiary as of December 31, 1995 and 1996,
and the related consolidated statements of operations, stockholders' equity
(deficit), and cash flows for the years then ended. These consolidated financial
statements are the responsibility of the Company's management. Our
responsibility is to express an opinion on these consolidated financial
statements based on our audits.
 
    We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.
 
    In our opinion, the consolidated financial statements referred to above
present fairly, in all material respects, the financial position of Cell
Robotics International, Inc. and subsidiary as of December 31, 1995 and 1996,
and the consolidated results of its operations and its cash flows for the years
then ended in conformity with generally accepted accounting principles.
 
    The accompanying consolidated financial statements have been prepared
assuming that the Company will continue as a going concern. As discussed in note
12 to the consolidated financial statements, the Company has suffered recurring
losses from operations and negative cash flows from operations. These matters
raise substantial doubt about its ability to continue as a going concern.
Management's plans concerning these matters are also described in note 12. The
consolidated financial statements do not include any adjustments that might
result from the outcome of this uncertainty.
 
                                                  KPMG Peat Marwick LLP
 
February 21, 1997
Albuquerque, New Mexico
 
                                      F-2

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
 
                          CONSOLIDATED BALANCE SHEETS
 
                                     ASSETS
 


                                                              DECEMBER 31,        SEPTEMBER
                                                         ----------------------      30,
                                                            1995        1996        1997
                                                         ----------  ----------  -----------
                                                                                 (UNAUDITED)
                                                                        
Current assets:
  Cash and cash equivalents............................  $  739,952   1,724,671     559,060
  Restricted cash (note 5).............................     425,000      --          --
  Accounts receivable, net of allowance for doubtful
    accounts of $2,500 and $1,841 in December 1995 and
    1996, respectively and $1,841 (unaudited) in
    September 1997.....................................     389,608      69,845     352,024
  Inventory............................................     169,076     408,173     523,010
  Other................................................      29,067      19,121      63,820
                                                         ----------  ----------  -----------
    Total current assets...............................   1,752,703   2,221,810   1,497,914
Property and equipment, net (note 3)...................     213,447     256,635     214,895
Other assets, net (note 4).............................      33,963      92,507      71,514
                                                         ----------  ----------  -----------
                                                         $2,000,113   2,570,952   1,784,323
                                                         ----------  ----------  -----------
                                                         ----------  ----------  -----------
 
                LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
 
Current liabilities:
  Accounts payable.....................................  $  129,483     160,824     425,414
  Payroll related liabilities..........................      99,226     128,932     121,019
  Royalties payable....................................      56,587      42,029     152,943
  Other current liabilities............................      24,871      31,937      27,376
                                                         ----------  ----------  -----------
    Total current liabilities..........................     310,167     363,722     726,752
                                                         ----------  ----------  -----------
Stockholders' equity (note 5):
  Preferred stock, $.04 par value. Authorized 2,500,000
    shares, no shares issued and outstanding...........      --          --          --
  Common stock, $.004 par value. Authorized 12,500,000
    shares, 3,825,914 and 5,003,414 shares issued and
    outstanding in December 1995 and 1996, respectively
    and 5,222,414 (unaudited) in September 1997........      15,304      20,014      20,890
  Additional paid-in capital...........................  11,271,008  13,327,672  13,996,305
  Accumulated deficit..................................  (9,596,366) (11,140,456) (12,959,624)
                                                         ----------  ----------  -----------
    Total stockholders' equity.........................   1,689,946   2,207,230   1,057,571
Commitments and contingencies (notes 9 and 11).........
                                                         ----------  ----------  -----------
                                                         $2,000,113   2,570,952   1,784,323
                                                         ----------  ----------  -----------
                                                         ----------  ----------  -----------

 
          See accompanying notes to consolidated financial statements.
 
                                      F-3

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
 
                     CONSOLIDATED STATEMENTS OF OPERATIONS
 


                                                                                          NINE MONTHS ENDED
                                                            YEARS ENDED DECEMBER 31,        SEPTEMBER 30,
                                                           --------------------------  ------------------------
                                                               1995          1996         1996         1997
                                                           -------------  -----------  -----------  -----------
                                                                                             (UNAUDITED)
                                                                                        
Product sales............................................  $     932,761      594,071      523,612      722,846
Research and development grants..........................          9,906       69,190       69,190      105,720
                                                           -------------  -----------  -----------  -----------
    Total revenues.......................................        942,667      663,261      592,802      828,566
Product cost of goods sold...............................        718,813      427,341      331,807      491,358
SBIR direct expenses.....................................          9,906       69,190       69,190      105,941
                                                           -------------  -----------  -----------  -----------
Total cost of goods sold.................................        728,719      496,531      400,997      597,299
                                                           -------------  -----------  -----------  -----------
    Gross profit.........................................        213,948      166,730      191,805      231,267
                                                           -------------  -----------  -----------  -----------
Operating expenses:
  Salaries...............................................        412,536      510,674      400,409      584,808
  Payroll taxes and benefits.............................         51,086       78,466       56,220       97,259
  Rent and utilities.....................................        122,484      119,371       88,553      108,606
  Travel.................................................        100,211       68,499       51,854       80,793
  Depreciation and amortization..........................        114,708      110,752       79,893       79,222
  Professional fees......................................         93,100      235,722      172,245      474,237
  Other operating expenses...............................        298,397      647,617      457,667      666,696
                                                           -------------  -----------  -----------  -----------
    Total operating expenses.............................      1,192,522    1,771,101    1,306,841    2,091,621
                                                           -------------  -----------  -----------  -----------
    Loss from operations.................................       (978,574)  (1,604,371)  (1,115,036)  (1,860,354)
                                                           -------------  -----------  -----------  -----------
Other income (deductions):
  Interest income........................................         17,160       40,645       18,032       30,066
  Interest expense.......................................       (345,777)      (1,413)      (1,303)        (680)
  Other..................................................        (43,959)      21,049       16,650       11,800
                                                           -------------  -----------  -----------  -----------
    Total other income (deductions)......................       (372,576)      60,281       33,379       41,186
                                                           -------------  -----------  -----------  -----------
    Net loss.............................................  $  (1,351,150)  (1,544,090)  (1,081,657)  (1,819,168)
                                                           -------------  -----------  -----------  -----------
                                                           -------------  -----------  -----------  -----------
Average common shares outstanding........................      2,039,280    4,197,499    3,926,416    5,054,026
                                                           -------------  -----------  -----------  -----------
                                                           -------------  -----------  -----------  -----------
Net loss per common share................................  $        (.66)        (.37)        (.28)        (.36)
                                                           -------------  -----------  -----------  -----------
                                                           -------------  -----------  -----------  -----------

 
          See accompanying notes to consolidated financial statements.
 
                                      F-4

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
 
           CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)
 
                 FOR THE YEARS ENDED DECEMBER 31, 1995 AND 1996
 
            AND THE NINE MONTHS ENDED SEPTEMBER 30, 1997 (UNAUDITED)
 


                                                                CELL ROBOTICS INTERNATIONAL,
                                                                            INC.
                                  CELL ROBOTICS, INC.          -------------------------------
                          ------------------------------------
                                                 COMMON CLASS    PREFERRED
                              COMMON CLASS A           B           STOCK       COMMON STOCK
                          ---------------------- ------------- ------------- -----------------  PAID-IN   ACCUMULATED
                            SHARES     AMOUNT    SHARES AMOUNT SHARES AMOUNT   SHARES   AMOUNT  CAPITAL     DEFICIT
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
                                                                            
Balance at December 31,
  1994...................  1,101,279 $ 1,602,967 58,239 $81,174  --   $--        --     $--    $1,202,665 $(8,245,216)
Forfeiture of shares at
  $.00 per share (note
  5).....................   (491,499)     --       --     --    --     --        --      --        --         --
Issuance of Cell Robotics
  International, Inc.
  shares in substitution
  for the capital stock
  of Cell Robotics, Inc.
  (note 5)...............   (609,780)  (1,602,967) (58,239) (81,174)  --  --    668,019 2,672   1,681,469     --
Issuance of Cell Robotics
  International, Inc.
  shares in substitution
  for the capital stock
  of Intelligent
  Financial Corporation
  (note 5)...............     --         --        --     --    --     --       300,008 1,200     248,800     --
Sale of shares at $1.00
  per share
  (note 5)...............     --         --        --     --    --     --       380,000 1,520     378,480     --
Sale of shares at $1.25
  per share, less costs
  of offering (note 5)...     --         --        --     --    --     --     2,300,000 9,200   2,251,968     --
Payment to a stockholder
  (note 5)...............     --         --        --     --    --     --        --      --      (250,000)     --
Conversion of a
  stockholder's debt to
  equity (note 5)........     --         --        --     --    --     --        --      --     5,758,338     --
Issuance of shares at
  $0.00 per share (note
  5).....................     --         --        --     --    --     --       177,887   712        (712)     --
Net loss for 1995........     --         --        --     --    --     --        --      --        --     (1,351,150 )
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
Balance at December 31,
  1995...................     --         --        --     --    --     --     3,825,914 15,304 11,271,008 (9,596,366 )
Issuance of shares for
  asset acquisition (note
  4).....................     --         --        --     --    --     --        17,500    70      41,492     --
Exercise of warrants.....     --         --        --     --    --     --     1,150,000 4,600   1,997,712     --
Issuance of shares at
  $1.75 per share........     --         --        --     --    --     --        10,000    40      17,460     --
Net loss for 1996........     --         --        --     --    --     --        --      --        --     (1,544,090 )
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
Balance at December 31,
  1996...................     --         --        --     --    --     --     5,003,414 20,014 13,327,672 (11,140,456)
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
Issuance of shares at
  $3.25, less costs of
  offering (unaudited)...     --         --        --     --    --     --       200,000   800     629,700     --
Issuance of shares at
  $2.39 (unaudited)......     --         --        --     --    --     --         9,000    36      21,474     --
Issuance of shares at
  $1.75 (unaudited)......     --         --        --     --    --     --        10,000    40      17,459     --
Net loss (unaudited).....     --         --        --     --    --     --        --      --        --     (1,819,168 )
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
Balance at September 30,
  1997 (unaudited).......     --     $   --        --   $ --    --    $--     5,222,414 $20,890 $13,996,305 $(12,959,624)
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------
                          ---------- ----------- ------ ------ ------ ------ ---------- ------ ---------- -----------

 
          See accompanying notes to consolidated financial statements.
 
                                      F-5

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
                     CONSOLIDATED STATEMENTS OF CASH FLOWS
 


                                                                      YEARS ENDED          NINE MONTHS ENDED
                                                                     DECEMBER 31,            SEPTEMBER 30,
                                                                -----------------------  ----------------------
                                                                   1995         1996        1996        1997
                                                                -----------  ----------  ----------  ----------
                                                                                              (UNAUDITED)
                                                                                         
Cash flows from operating activities:
  Net loss....................................................  $(1,351,150) (1,544,090) (1,081,657) (1,819,168)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
    Depreciation and amortization.............................      114,708     126,096      88,893      94,567
    Decrease (increase) in accounts receivable................     (327,913)    319,763     293,984    (282,179)
    Decrease (increase) in inventory..........................       39,422    (239,097)   (125,074)   (114,837)
    Decrease (increase) in other current assets...............      (21,231)      9,946      (1,737)    (44,699)
    Increase in other long-term assets........................      (11,120)    (42,103)    (62,701)     --
    Increase (decrease) in accounts payable and payroll
      related liabilities.....................................     (104,935)     61,047     (15,546)    256,677
    Increase in accrued interest payable......................      329,508      --          --          --
    Increase (decrease) in other current liabilities and
      royalties payable.......................................       64,791      (7,492)    (14,600)    106,353
                                                                -----------  ----------  ----------  ----------
      Net cash used by operating activities...................   (1,267,920) (1,315,930)   (918,438) (1,803,286)
                                                                -----------  ----------  ----------  ----------
Cash flows from investing activities--Purchase of property and
  equipment...................................................      (84,659)   (144,163)   (115,728)    (31,834)
                                                                -----------  ----------  ----------  ----------
Net cash used by investing activities.........................      (84,659)   (144,163)   (115,728)    (31,834)
Cash flows from financing activities:
  Proceeds from loans.........................................       70,010      --          --          --
  Repayments of loans.........................................     (172,400)     --          --          --
  Payment to stockholder......................................     (250,000)     --          --          --
  Proceeds from issuance of common stock......................    3,345,000   2,030,000   2,012,500     689,009
  Costs of offering common stock..............................     (613,832)    (10,188)    (10,188)    (19,500)
  Restricted proceeds released (received) from issuance of
    common
    stock.....................................................     (425,000)    425,000     425,000      --
                                                                -----------  ----------  ----------  ----------
      Net cash provided by financing activities...............    1,953,778   2,444,812   2,427,312     669,509
                                                                -----------  ----------  ----------  ----------
Net increase (decrease) in cash and cash equivalents..........      601,199     984,719   1,393,146  (1,165,611)
 
Cash and cash equivalents:
  Beginning of period.........................................      138,753     739,952     739,952   1,724,671
                                                                -----------  ----------  ----------  ----------
  End of period...............................................  $   739,952   1,724,671   2,133,098     559,060
                                                                -----------  ----------  ----------  ----------
                                                                -----------  ----------  ----------  ----------
Supplemental information:
  Interest paid...............................................  $    12,659      --           1,303         680
                                                                -----------  ----------  ----------  ----------
                                                                -----------  ----------  ----------  ----------
  Noncash financing activity:
    Note payable to a stockholder and accrued interest
      contributed to paid-in capital (note 5).................  $ 5,758,338      --          --          --
                                                                -----------  ----------  ----------  ----------
                                                                -----------  ----------  ----------  ----------
    Stock issued in exchange for asset acquisition (note 4)...  $   --           41,562      41,562      --
                                                                -----------  ----------  ----------  ----------
                                                                -----------  ----------  ----------  ----------
    Short-term borrowings repaid with common stock............  $   160,000      --          --          --
                                                                -----------  ----------  ----------  ----------
                                                                -----------  ----------  ----------  ----------

 
          See accompanying notes to consolidated financial statements.
 
                                      F-6

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                    (AMOUNTS AND INFORMATION WITH RESPECT TO
                   SEPTEMBER 30, 1996 AND 1997 ARE UNAUDITED)
 
(1) ORGANIZATION AND ACTIVITIES
 
    (A) ORGANIZATION
 
    Cell Robotics International, Inc., a Colorado corporation ("CRII"), was
organized on September 28, 1988 as Intelligent Financial Corporation ("IFC"). As
described in note 5, in 1995 the Company acquired Cell Robotics, Inc. ("CRI"), a
New Mexico corporation, in a transaction which resulted in the stockholders of
CRI owning 62.3 percent of IFC. Accordingly, the transaction was recorded as a
reverse purchase of IFC by CRI. Therefore, the historical financial information
in the accompanying consolidated financial statements is that of CRI adjusted to
reflect the capital structure of IFC. The consolidated financial statements
include the accounts of CRII and CRI (the "Company"). All significant
intercompany accounts and transactions have been eliminated in consolidation.
 
    On May 19, 1995, IFC changed its name to Cell Robotics International, Inc.
 
    (B) BUSINESS
 
    The Company is developing and preparing to manufacture and market a series
of laser-based medical devices with applications in the blood sample collection,
skin resurfacing, and IN VITRO fertilization markets. Currently, the Company
also develops, produces and markets a line of advanced scientific instruments
which increase the usefulness and importance of the conventional laboratory
microscope. The Company markets its scientific instruments in both domestic and
international markets. Currently, approximately two-thirds of the Company's
sales are in the United States, with Japan being the largest international
market.
 
(2) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
 
    (A) FINANCIAL STATEMENT ESTIMATES
 
    The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities, and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.
 
    (B) CASH AND CASH EQUIVALENTS
 
    For purposes of the statements of cash flows, the Company considers all
short-term investments with original maturities of three months or less to be
cash equivalents.
 
    (C) INVENTORY
 
    Inventory is recorded at the lower of cost, determined by the first-in,
first-out method, or market.
 
                                      F-7

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(2) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    Inventory at December 31 consists of the following:
 


                                                                            1995       1996
                                                                         ----------  ---------
                                                                               
Parts and components...................................................  $  161,311    267,273
Sub-assemblies.........................................................       7,765    140,900
                                                                         ----------  ---------
                                                                         $  169,076    408,173
                                                                         ----------  ---------
                                                                         ----------  ---------

 
    (D) PROPERTY AND EQUIPMENT
 
    Property and equipment are stated at cost. Depreciation is calculated on a
straight-line basis over the estimated useful lives of the assets, which range
from five to seven years. Leasehold improvements are amortized over the life of
the lease.
 
    (E) LICENSES
 
    Licenses are recorded at cost and are amortized on a straight-line basis
over the shorter of economic or legal lives of the underlying patents.
 
    (F) OTHER ASSETS
 
    Certain legal fees and other related costs associated with start-up,
organization, license fees, software development costs, patents and noncompete
agreements have been capitalized. Start-up and organization costs are amortized
on a straight-line basis over five years, loan acquisition costs are amortized
over the life of the respective loan, license fees are amortized over the life
of the license, and software development costs are amortized as sales occur
based on the estimated total number of units to be sold.
 
    (G) IMPAIRMENT OF LONG-LIVED ASSETS AND LONG-LIVED ASSETS TO BE DISPOSED OF
 
    The Company adopted the provisions of SFAS No. 121, "ACCOUNTING FOR THE
IMPAIRMENT OF LONG-LIVED ASSETS AND FOR LONG-LIVED ASSETS TO BE DISPOSED OF," on
January 1, 1996. This Statement requires that long-lived assets and certain
identifiable intangibles be reviewed for impairment whenever events or changes
in circumstances indicate that the carrying amount of an asset may not be
recoverable. Recoverability of assets to be held and used is measured by a
comparison of the carrying amount of an asset to future net cash flows expected
to be generated by the asset. If such assets are considered to be impaired, the
impairment to be recognized is measured by the amount by which the carrying
amount of the assets exceed the fair value of the assets. Assets to be disposed
of are reported at the lower of the carrying amount or fair value less costs to
sell. Adoption of this Statement did not have a material impact on the Company's
financial position, results of operations, or liquidity.
 
    (H) FAIR VALUE OF FINANCIAL INSTRUMENTS
 
    Cash and cash equivalents, restricted cash, accounts receivable, accounts
payable, royalties payable and accrued liabilities are reflected in the
consolidated financial statements at fair value because of the short-term
maturity of these instruments.
 
                                      F-8

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(2) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    (I) INCOME TAXES
 
    The Company follows the asset and liability method for accounting for income
taxes whereby deferred income taxes are recognized for the tax consequences of
"temporary differences" by applying enacted statutory tax rates applicable to
future years to differences between the financial statement carrying amounts and
the tax basis of existing assets and liabilities.
 
    (J) REVENUE
 
    The Company recognizes revenue on sales of its products when the products
are shipped from the plant and ownership is transferred to the customer.
 
    Total export sales, primarily in the Far East, were $443,653 and $248,278
for the years ended December 31, 1995 and 1996, respectively. Sales revenues to
individual customers, each of which accounted for 10 percent or more of total
sales, are as follows for the years ended December 31:
 


                                                                            1995       1996
                                                                         ----------  ---------
                                                                               
Mitsui, a related party (note 5).......................................  $  229,043    201,314
Customer A.............................................................     230,200    105,421
Customer B.............................................................     149,494     --
Customer C.............................................................      --         92,821
                                                                         ----------  ---------
                                                                         ----------  ---------

 
    (K) RESEARCH AND DEVELOPMENT
 
    Research and development costs related to both present and future products
are expensed as incurred. Research and development costs consist primarily of
salaries, materials and supplies.
 
    (L) WARRANTIES
 
    The Company warrants their microrobotic laser systems against defects in
materials and workmanship for one year. The warranty reserve is reviewed
periodically and adjusted based upon the Company's historical warranty costs and
its estimate of future costs.
 
    (M) STOCK OPTION PLAN
 
    Prior to January 1, 1996, the Company accounted for its stock option plan in
accordance with the provisions of Accounting Principles Board ("APB") Opinion
No. 25, "ACCOUNTING FOR STOCK ISSUED TO EMPLOYEES," and related interpretations.
As such, compensation expense would be recorded on the date of grant only if the
current market price of the underlying stock exceeded the exercise price. On
January 1, 1996, the Company adopted SFAS No. 123, "ACCOUNTING FOR STOCK BASED
COMPENSATION," which permits entities to recognize as expense over the vesting
period the fair value of all stock-based awards on the date of grant.
Alternatively, SFAS No. 123 also allows entities to continue to apply the
provisions of APB Opinion No. 25 and provide pro forma net income and pro forma
earnings per share disclosures for employee stock option grants made in 1995 and
future years as if the fair-value-based method defined in SFAS No. 123 had been
applied. The Company has elected to continue to apply the provisions of APB
Opinion No. 25 and provide the pro forma disclosure provisions of SFAS No. 123.
 
                                      F-9

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(2) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)
    (N) NET LOSS PER COMMON SHARE
 
    Net loss per common share is based on the weighted average shares of common
stock and, if dilutive, common equivalent shares (options and warrants)
outstanding during the period. None of the common stock equivalents were
dilutive during the periods presented.
 
    (O) PRESENTATION OF UNAUDITED FINANCIAL STATEMENTS
 
    The unaudited consolidated financial statements as of September 30, 1997 and
for the nine months ended September 30, 1996 and 1997 have been prepared in
accordance with the rules of the Securities and Exchange Commission and,
therefore, do not include all information and footnotes otherwise necessary for
a fair presentation of financial position, results of operations and cash flows,
in conformity with generally accepted accounting principles. However, the
information furnished, in the opinion of management, reflects all adjustments
necessary to present fairly the financial position, results of operations and
cash flows on a consistent basis. Such adjustments consisted only of normal
recurring items. The results of operations are not necessarily indicative of
results which may be expected for any other interim period or for the year as a
whole.
 
    (P) RECLASSIFICATION
 
    Certain prior period amounts have been reclassified to conform with the
current presentation.
 
(3) PROPERTY AND EQUIPMENT
 
    Property and equipment consist of the following at December 31:
 


                                                                          1995         1996
                                                                       -----------  ----------
                                                                              
Furniture and fixtures...............................................  $     8,028       8,028
Computers............................................................      250,164     299,894
Equipment............................................................      272,239     366,672
Leasehold improvements...............................................       48,150      48,150
                                                                       -----------  ----------
                                                                           578,581     722,744
Accumulated depreciation.............................................     (365,134)   (466,109)
                                                                       -----------  ----------
  Net property and equipment.........................................  $   213,447     256,635
                                                                       -----------  ----------
                                                                       -----------  ----------

 
                                      F-10

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(4) OTHER ASSETS
 
    Other assets consist of the following at December 31:
 


                                                                          1995         1996
                                                                       -----------  ----------
                                                                              
Software development costs...........................................  $    11,120      59,019
Patents..............................................................      --           48,246
License and prepaid royalties........................................       36,320      --
Start-up and organization costs......................................       33,116      33,116
Noncompete agreements................................................      --            8,116
                                                                       -----------  ----------
                                                                            80,556     148,497
Accumulated amortization.............................................      (46,593)    (55,990)
                                                                       -----------  ----------
  Net other assets...................................................  $    33,963      92,507
                                                                       -----------  ----------
                                                                       -----------  ----------

 
    In January, 1996, the Company acquired certain technological assets and
covenants not to compete from Tecnal Products, Inc. for a consideration of
approximately $15,000 cash, 17,500 shares of the Company's common stock and the
grant of a 1 percent royalty on future sales, with a lifetime maximum of
$20,000.
 
    During 1996, the Company expensed the remaining net costs relating to the
license and prepaid royalty on specific technology. That technology is not
currently incorporated into the Company's product lines and it is not
anticipated that it will be used in future products.
 
    During 1995, the Company expensed the remaining net costs relating to the
acquisition of notes payable since all the principal and interest has been
forgiven and contributed to capital (note 7).
 
    During 1995 and 1996, the Company capitalized $11,120 and $47,899 of
software development costs relating to a project whose technological feasibility
has been established. During 1996, the Company recorded amortization of $15,345
as cost of goods sold.
 
(5) CAPITAL TRANSACTIONS
 
    In February 1995, IFC acquired 100 percent of CRI's issued and outstanding
shares of Class A and B common stock (the "Acquisition"). In connection with the
Acquisition, IFC issued 668,019 shares of IFC common stock to shareholders of
CRI, which represents 62.3 percent of the issued and outstanding IFC common
stock immediately following the transaction. In addition, the options to
purchase CRI's common stock described in note 6 were exchanged for options to
purchase the same number of IFC shares of common stock with identical terms. The
Acquisition was accounted for using the purchase method of accounting, treating
the merger as a reverse purchase of the assets and liabilities of IFC by CRI.
Immediately prior to the Acquisition, all operations, assets and liabilities of
IFC, except $250,000 of receivables from CRI and cash, were transferred to a
separate entity ("IFHC"). The assets, liabilities and results of operation of
IFHC are excluded from the accompanying consolidated financial statements. Pro
forma results of operations of the combined entities are substantially identical
to the results of operations of CRI presented in the accompanying consolidated
statements of operations.
 
    On September 19, 1995, the Company successfully closed a private equity
offering to selected qualified investors at a price of $25,000 per Unit (the
"Private Offering"). Each Unit consisted of
 
                                      F-11

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(5) CAPITAL TRANSACTIONS (CONTINUED)
20,000 shares of Common Stock and Class A Warrants exercisble to purchase an
additional 10,000 shares of common stock at an exercise price of $1.75 per
share. Proceeds of this private offering, net of offering costs, were $2,261,168
of which $425,000 was held in escrow until the Company's SB-2 was declared
effective on February 14, 1996, at which time the funds were released. During
1996, 100 percent of the Class A Warrants were exercised generating net proceeds
of $2,002,312. As part of the Private Offering, the placement agent was issued
warrants to purchase 230,000 shares of common stock at $1.25 per share and, if
these placement agent warrants are exercised, the placement agent will receive
up to 115,000 additional Class A Warrants, exercisable at $1.75 per share.
 
    At December 31, 1994, CRI had outstanding notes payable of $5,400,000 due to
a wholly owned subsidiary of Mitsui Engineering and Shipbuilding Company
("Mitsui"), a Japanese corporation, and majority stockholder of CRI's Class A
common stock at the time. Immediately prior to the Acquisition, Mitsui
voluntarily surrendered to CRI, for cancellation, a total of 491,499 shares of
common stock of CRI. During 1995, in conjunction with the Private Offering and
in accordance with agreements entered into prior to the Acquisition, the Company
paid to Mitsui the sum of $250,000, issued to Mitsui 177,887 shares of CRII
common stock, increasing their ownership to approximately 8 percent, and Mitsui
contributed to the capital of the Company the $5,400,000 of notes payable
together with unpaid interest totaling $358,338.
 
(6) STOCK OPTIONS
 
    The Company has adopted a Stock Incentive Plan ("the Plan") pursuant to
which the Company's Board of Directors may grant to eligible participants
options in the form of Incentive Stock Options ("ISO's") under Section 422 of
the Internal Revenue Code of 1986, as amended, or options which do not qualify
as ISO's (Non-Qualified Stock Options of "NQSO's"). An aggregate of 1,000,000
shares of the Company's Common Stock is reserved for issuance under the Plan.
Generally, stock options granted under the Plan have five-year terms and become
fully exercisable after three or four years from the date of grant.
 
    During 1995, 97,579 options were re-priced to an exercise price of $1.75,
all vesting requirements were eliminated and the expiration date was extended to
December 31, 2003. The exercise price of $1.75 is only effective if the options
are exercised after January 1, 2000. If the options are exercised before that
date, the exercise price reverts back to the original grant with an exercise
price range of $2.39 to $2.50. During 1996, the vesting requirements were
eliminated on 360,000 options having original, and in some cases amended,
exercise prices of $1.75.
 
                                      F-12

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(6) STOCK OPTIONS (CONTINUED)
    The following is a summary of the stock options granted under the Plan:
 


                                                                                     WEIGHTED-
                                                                      NUMBER OF       AVERAGE
                                                                       SHARES     EXERCISE PRICE
                                                                     -----------  ---------------
                                                                            
Options at December 31, 1994.......................................     102,594      $    2.39
  Options expired..................................................     (19,115)          2.39
  Options granted..................................................     672,100           1.85
  Options repriced.................................................     (97,579)          2.41
  Options repriced.................................................      97,579           1.75
                                                                     -----------         -----
Options at December 31, 1995.......................................     755,579           1.83
  Options expired..................................................     (34,753)          1.75
  Options granted..................................................     175,000           2.17
  Options exercised................................................     (10,000)          1.75
                                                                     -----------         -----
Options at December 31, 1996.......................................     885,826      $    1.91
                                                                     -----------         -----
                                                                     -----------         -----

 
    At December 31, 1996, range of exercise prices and weighted-average
remaining contractual life of outstanding options were $1.75--$2.875, and 4.20
years, respectively.
 
    At December 31, 1996, the number of options exercisable was 665,826 and the
weighted-average exercise price of those options was $1.77.
 
    During 1995, the Board of Directors and stockholders approved an Employee
Stock Purchase Plan ("ESPP"). As of December 31, 1995 and 1996, no shares of
Common Stock have been issued under the ESPP and there have been no
subscriptions of employees to participate in the plan.
 
    At December 31, 1996, there were 104,174 additional shares available for
grant under the Plan. The per share weighted-average fair value of stock options
granted and modified during 1995 and 1996 was $908,019 and $239,818,
respectively, on the date of grant or amendment using the Black Scholes option-
pricing model with the following weighted-average assumptions: 1995--expected
dividend yield 0 percent, risk-free interest rate of 6.0 percent, expected life
of 4 years for original grants and 7 years for modified grants, and an expected
volatility of 80 percent; 1996--expected dividend yield 0 percent, risk-free
interest rate of 6.6 percent, expected life of 4 years, and an expected
volatility of 80 percent.
 
    The Company applies APB Opinion No. 25 in accounting for its Plan and,
accordingly, no compensation cost has been recognized for its stock options in
the consolidated financial statements. Had the Company determined compensation
cost based on the fair value at the date of grant for its stock options under
SFAS No. 123, the Company's net loss would have been increased to the pro forma
amounts indicated below:
 


                                                                       1995          1996
                                                                   -------------  -----------
                                                                            
Reported net loss................................................  $  (1,351,150)  (1,544,090)
Pro forma net loss...............................................     (1,751,909)  (1,997,271)
Pro forma net loss per share.....................................           (.86)        (.48)

 
                                      F-13

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(6) STOCK OPTIONS (CONTINUED)
    Pro forma net loss reflects only options granted in 1995 and 1996.
Therefore, the full impact of calculating compensation cost for stock options
under SFAS No. 123 is not reflected in the pro forma net loss amounts presented
above because compensation cost is reflected over the options' vesting period
and compensation cost for options granted prior to January 1, 1995 is not
considered.
 
(7) EMPLOYMENT AGREEMENTS
 
    At the closing of the Acquisition, the Company executed written employment
agreements, having terms of five years each, with two officers of the Company.
The employment agreement with one officer provides that he will serve the
Company as its Chairman, President and CEO, on a full-time basis, for a minimum
base salary of $100,000 per year. The employment agreement with the other
officer provides for his serving as Vice President of Finance, on a part-time
basis, for a minimum base salary of $27,000 per year.
 
    In December 1996, the Company executed a written employment agreement with a
new officer of the Company. The employment period ends upon discharge or
resignation of the employee. The employment agreement provides that the officer
will serve the Company as Vice President of Marketing, on a full-time basis, for
a minimum base salary of $110,000 per year.
 
(8) OPERATING EXPENSES
 
    For the years ended December 31, 1995 and 1996, operating expense consists
of the following:
 


                                                                      1995           1996
                                                                  -------------  -------------
                                                                           
General and administrative......................................  $     488,972        710,330
Marketing.......................................................        262,799        420,976
Research and development........................................        450,657        708,985
                                                                  -------------  -------------
                                                                  $   1,202,428      1,840,291
                                                                  -------------  -------------
                                                                  -------------  -------------

 
(9) ROYALTY AGREEMENTS
 
    The Company is party to four royalty agreements under which it must make
payments to the original holders of patents on components used in its products.
Such royalties are generally due upon sale of products containing patented
components.
 
    The first royalty agreement, with the University of California, pertains to
the Company's exclusive license agreement which continues until February 14,
2007. The royalty is calculated as either (a) $1,000 for each patentable item
included on a product sold for an amount in excess of $75,000, or (b) one
percent of the selling price of a product sold for less than $75,000 which
includes a patentable item. Minimum annual royalty payments required to retain
the license are $15,000 each year. This royalty agreement was renegotiated on
January 5, 1996. Pursuant to the renegotiation, the licensor agreed to accept
$15,000 for full satisfaction of the old license agreement. The new agreement
consists of two underlying patents. The new agreement continues until the
expiration of the last underlying patent which is February 14, 2007. Under the
terms of the new agreement, the Company agrees to pay a royalty equal to 4
percent of the net selling price of products utilizing one patent and two
percent of the net selling price of products utilizing the other patent. Minimum
annual royalty payments required to retain the license are $5,000 per year. The
 
                                      F-14

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(9) ROYALTY AGREEMENTS (CONTINUED)
Company currently feels the technology covered in this license agreement is no
longer needed for future product development and intends to terminate the
license.
 
    The second royalty agreement, with AT&T, requires a royalty payment equal to
5 percent of revenue generated from sales by the Company's products and pertains
to the Company's major, worldwide, exclusive license agreement which continues
until March 31, 2016. Minimum royalty payments required to retain this license
are as follows:
 


                      TWELVE-MONTH PERIOD ENDED MARCH 31
- -------------------------------------------------------------------------------
                                                                              
1998...........................................................................  $     150,000
1999...........................................................................        200,000
2000...........................................................................        250,000
2001...........................................................................        300,000
2002...........................................................................        400,000
Thereafter.....................................................................      4,550,000
                                                                                 -------------
                                                                                 $   5,850,000
                                                                                 -------------
                                                                                 -------------

 
    The third royalty agreement is with Mitsui (note 5). Under the terms of the
agreement, which continues until September 11, 2005, the Company agrees to pay
Mitsui a royalty equal to 1 percent of the aggregate net sales of certain
products.
 
    The fourth royalty agreement, with Tecnal Products, Inc., requires quarterly
royalty payments equal to 1 percent of the net revenues from sales of a certain
product. The royalty agreement stipulates that lifetime maximum royalty payments
will not exceed $20,000. The Company has the option to relieve itself of this
obligation by paying an amount equal to the difference between royalties
previously paid and the lifetime maximum of $20,000.
 
                                      F-15

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(10) INCOME TAXES
 
    No provision for federal or state income tax expense has been recorded due
to the Company's losses. The Company has net operating loss carryforwards and
temporary differences that give rise to the following deferred tax assets and
liabilities:
 


                                                                          DECEMBER 31
                                                                  ----------------------------
                                                                      1995           1996
                                                                  -------------  -------------
                                                                           
Deferred tax assets:
  Net operating loss carryforwards..............................  $   2,800,000      3,400,000
  Inventory capitalization......................................         63,000        104,000
  Obsolete inventory reserve....................................          8,000         15,000
  Vacation and sick leave payable...............................         31,500         27,000
  Allowance for doubtful accounts...............................            625            625
  Legal fees....................................................         11,000          9,000
                                                                  -------------  -------------
                                                                      2,914,125      3,555,625
  Less valuation allowance......................................     (2,897,925)    (3,536,625)
                                                                  -------------  -------------
    Net deferred tax asset......................................         16,200         19,000
Deferred tax liabilities:
  Depreciation..................................................        (16,200)       (19,000)
                                                                  -------------  -------------
    Net deferred income taxes...................................  $    --             --
                                                                  -------------  -------------
                                                                  -------------  -------------

 
    The net deferred taxes have been fully offset by a valuation allowance since
the Company cannot currently conclude that it is more likely than not that the
benefits will be realized. The net operating loss carryforward for income tax
purposes of approximately $10,000,000 expires beginning in 2006. Ownership
changes resulting from the Acquisition (note 5) will limit the use of this net
operating loss under applicable Internal Revenue Service regulations.
 
(11) COMMITMENTS
 
    The Company is obligated under a noncancelable operating lease for building
facilities which require minimum rental payment of $86,196 in 1997. Rent expense
for 1995 and 1996 was $108,054 and $104,336, respectively.
 
    The Company is obligated under a noncancelable purchase agreement to
purchase 1,000 units of a particular inventory component at $125 per unit for a
total commitment of $125,000 during 1997.
 
(12) CAPITAL RESOURCES
 
    Since inception, the Company has incurred operating losses which resulted in
an accumulated deficit of $11,140,456 at December 31, 1996 and operations using
net cash of $1,315,930 in 1996.
 
    The Company's ability to improve cash flow and ultimately achieve
profitability will depend on its ability to significantly increase sales.
Although the Company believes future sales of its scientific instrument line
will improve, it does not expect these products to materially contribute to its
goal of achieving
 
                                      F-16

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(12) CAPITAL RESOURCES (CONTINUED)
future profitability. Accordingly, the Company has begun development on, and is
preparing to manufacture and market a series of laser-based medical devices
which leverage the Company's existing base of patented technology. The Company
believes the markets for these new products are broader than that of the
scientific instrumentation market and, as such, offer a greater opportunity to
significantly increase sales. In addition, the Company is pursuing development
and marketing partners for several of its new medical products. These
partnerships will enhance the Company's ability to rapidly ramp-up its marketing
and distribution strategy, and possibly offset the products' development costs.
 
    Although the Company has refocused its strategy to concentrate on the
development of its laser based medical devices while continuing to market its
scientific instrument line, it does not anticipate achieving profitable
operations during fiscal 1997. As a result, the Company's working capital
surplus at December 31, 1996 is expected to erode over the next twelve months.
Nevertheless, the Company expects that its working capital surplus at December
31, 1996 will be sufficient to cover its expected operational deficits during
fiscal 1997.
 
    The accompanying consolidated financial statements have been prepared in
conformity with generally accepted accounting principles which contemplate
continuation of the Company as a going concern. The ultimate continuation of the
Company is dependent on attaining profitable operations.
 
(13) SUBSEQUENT EVENTS (UNAUDITED)
 
    At its present level of research and development and product introduction,
the Company requires approximately $200,000 per month to cover operating
expenses in excess of cash flow currently generated by operations. The proceeds
of an August 1997 private equity sale, resulting in net proceeds of $630,500,
are being used to satisfy the Company's working capital requirements pending
completion of the proposed offering described below. The Company does not have
any available commercial lines of credit or other sources of capital to satisfy
its cash requirements until revenues from operations can be realized through
future product introduction and sales. Accordingly, the Company will rely
exclusively upon the proceeds of the proposed public offering described below to
satisfy its working capital requirements for the foreseeable future.
 
    The Board of Directors of the Company has authorized management to offer
2,000,000 shares of common stock in a registered offering to the public. If
successful, the net proceeds will be used for product development, future
research and development, manufacturing equipment and personnel, marketing, and
sales and working capital.
 
    In conjunction with this offering, the Company will issue to the President
and CEO, warrants exercisable to purchase in the aggregate, 450,000 shares of
the Company's common stock at an exercise price equal to the initial price per
share of the Company's common stock sold in this offering or $4.50 per share,
whichever is greater. Of the total 450,000 warrants, 150,000 vest at the closing
of the offering. The remaining 300,000 warrants vest on November 30, 2002,
however, earlier vesting occurs if certain pre-tax and net income targets are
met.
 
    In October 1997, a competitor filed a civil suit against the Company
claiming that the Lasette-TM- infringes a U.S. patent, underlying its
competitive laser skin perforator. The Company and its patent counsel have
conducted a comprehensive investigation of the basis of the claims underlying
such litigation, and believe that the Lasette-TM- does not infringe upon such
competitor's U.S. patent or any of its related
 
                                      F-17

                       CELL ROBOTICS INTERNATIONAL, INC.
                                 AND SUBSIDIARY
             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
 
(13) SUBSEQUENT EVENTS (UNAUDITED) (CONTINUED)
foreign patents. The Company intends to vigorously defend the claims being
asserted in such litigation. There has been, and the Company believes that there
will continue to be, significant litigation in the laser-based biotechnological
industry regarding patent and other intellectual property rights. Any
litigation, including the claim described above, could consume a substantial
portion of the Company's financial and personnel resources and, regardless of
the outcome of such litigation, have a material adverse impact on the Company's
business, results of operations and financial condition.
 
                                      F-18

                                       
                      Medical and Research Laser Products

                            Cell Robotics Workstation

     One photograph of Workstation, two photographs of cells with 
description of product and functions.



                                 Revitalase-TM-

     One photograph of product with description.



- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
    NO UNDERWRITER, DEALER, SALESMAN OR ANY OTHER PERSON HAS BEEN AUTHORIZED TO
GIVE ANY INFORMATION OR TO MAKE ANY REPRESENTATIONS OTHER THAN THOSE CONTAINED
IN THIS PROSPECTUS IN CONNECTION WITH THE OFFER MADE BY THIS PROSPECTUS AND IF,
GIVEN OR MADE, SUCH INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS
HAVING BEEN AUTHORIZED BY THE COMPANY OR ANY UNDERWRITER. THIS PROSPECTUS DOES
NOT CONSTITUTE AN OFFER TO SELL OR THE SOLICITATION OF ANY OFFER TO BUY ANY
SECURITY OTHER THAN THE SHARES OF COMMON STOCK OFFERED BY THIS PROSPECTUS, NOR
DOES IT CONSTITUTE AN OFFER TO SELL OR A SOLICITATION OF ANY OFFER TO BUY THE
SHARES OF COMMON STOCK OFFERED BY THIS PROSPECTUS BY ANYONE IN ANY JURISDICTION
IN WHICH SUCH OFFER OR SOLICITATION IS NOT AUTHORIZED, OR IN WHICH THE PERSON
MAKING SUCH OFFER OR SOLICITATION IS NOT QUALIFIED TO DO SO, OR TO ANY PERSON TO
WHOM IT IS UNLAWFUL TO MAKE SUCH OFFER OR SOLICITATION. NEITHER THE DELIVERY OF
THIS PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL, UNDER ANY CIRCUMSTANCES,
CREATE ANY IMPLICATION THAT INFORMATION CONTAINED HEREIN IS CORRECT AS OF ANY
TIME SUBSEQUENT TO THE DATE HEREOF OR THAT THERE HAS BEEN NO CHANGE IN THE
AFFAIRS OF THE COMPANY SINCE THAT DATE.
 
                           --------------------------
 
                               TABLE OF CONTENTS
 


                                                    PAGE
                                                    -----
                                              
Prospectus Summary.............................           3
The Company....................................           3
Risk Factors...................................           8
Use of Proceeds................................          19
Dividend Policy................................          20
Capitalization.................................          21
Dilution.......................................          22
Certain Market Information.....................          23
Selected Financial Data........................          24
Management's Discussion and Analysis of
  Financial Condition and Results of
  Operations...................................          25
Business.......................................          30
Management.....................................          43
Certain Transactions...........................          50
Principal Stockholders.........................          52
Description of Securities......................          55
Underwriting...................................          58
Legal Matters..................................          60
Experts........................................          60
Available Information..........................          60
Financial Statements ........................... F-1 to F-18

 
                           --------------------------
 
    UNTIL             , 19  , ALL DEALERS EFFECTING TRANSACTIONS IN THE
REGISTERED SECURITIES, WHETHER OR NOT PARTICIPATING IN THIS DISTRIBUTION, MAY BE
REQUIRED TO DELIVER A PROSPECTUS. THIS IS IN ADDITION TO THE OBLIGATIONS OF THE
DEALERS TO DELIVER A PROSPECTUS WHEN ACTING AS UNDERWRITERS AND WITH RESPECT TO
THEIR UNSOLD ALLOTMENTS OR SUBSCRIPTIONS.
 
                                2,000,000 SHARES
 
                                  COMMON STOCK
 
                                 CELL ROBOTICS
                              INTERNATIONAL, INC.
 
                             ---------------------
 
                                   PROSPECTUS
 
                             ---------------------
 
                               PAULSON INVESTMENT
                                 COMPANY, INC.
 
                            COHIG & ASSOCIATES, INC.
 
                                          , 1997
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 24.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.
 
    The only statute, charter provision, bylaw, contract, or other arrangement
under which any controlling person, director or officers of the Registrant is
insured or indemnified in any manner against any liability which he may incur in
his capacity as such, is as follows:
 
    Sections 7-109-101 through 7-109-110 of the Colorado Corporation Code
provide as follows:
 
7-109-101. DEFINITIONS. As used in this article:
 
    (1) "Corporation" includes any domestic or foreign entity that is a
predecessor of a corporation by reason of a merger or other transaction in which
the predecessor's existence ceased upon consummation of the transaction.
 
    (2) "Director" means an individual who is or was a director of a corporation
or an individual who, while a director of a corporation, is or was serving at
the corporation's request as a director, officer, partner, trustee, employee,
fiduciary, or agent of another domestic or foreign corporation or other person
or of an employee benefit plan. A director is considered to be serving an
employee benefit plan at the corporation's request if his or her duties to the
corporation also impose duties on, or otherwise involve services by, the
director to the plan or to participants in or beneficiaries of the plan.
"Director" includes, unless the context requires otherwise, the estate or
personal representative of a director.
 
    (3) "Expenses" includes counsel fees.
 
    (4) "Liability" means the obligation incurred with respect to a proceeding
to pay a judgment, settlement, penalty, fine, including an excise tax assessed
with respect to an employee benefit plan, or reasonable expenses.
 
    (5) "Official capacity" means, when used with respect to a director, the
office of director in a corporation and, when used with respect to a person
other than a director as contemplated in section 7-109-107, the office in a
corporation held by the officer or the employment, fiduciary, or agency
relationship undertaken by the employee, fiduciary, or agent on behalf of the
corporation. "Official capacity" does not include service for any other domestic
or foreign corporation or other person or employee benefit plan.
 
    (6) "Party" includes a person who was, is, or is threatened to be made a
named defendant or respondent in a proceeding.
 
    (7) "Proceeding" means any threatened, pending, or completed action, suit,
or proceeding, whether civil, criminal, administrative, or investigative and
whether formal or informal.
 
7-109-102. AUTHORITY TO INDEMNIFY DIRECTORS.
 
    (1) Except as provided in subsection (4) of this section, a corporation may
indemnify a person made a party to a proceeding because the person is or was a
director against liability incurred in the proceeding if:
 
        (a) The person conducted himself or herself in good faith; and
 
        (b) The person reasonable believed:
 
            (I) In the case of conduct in an official capacity with the
       corporation, that his or her conduct was in the corporation's best
       interests; and
 
                                      II-1

           (II) In all other cases, that his or her conduct was at least not
       opposed to the corporation's best interests; and
 
        (c) In the case of any criminal proceeding, the person had no reasonable
    cause to believe his or her conduct was unlawful.
 
    (2) A director's conduct with respect to an employee benefit plan for a
purpose the director reasonably believed to be in the interests of the
participants in or beneficiaries of the plan is conduct that satisfies the
requirement of subparagraph (II) of paragraph (b) of subsection (1) of this
section. A director's conduct with respect to an employee benefit plan for a
purpose that the director did not reasonably believe to be in the interests of
the participants in or beneficiaries of the plan shall be deemed not to satisfy
the requirements of paragraph (a) of subsection (1) of this section.
 
    (3) The termination of a proceeding by judgment, order, settlement,
conviction, or upon a plea of nolo contendere or its equivalent is not, of
itself, determinative that the director did not meet the standard of conduct
described in this section.
 
    (4) A corporation may not indemnify a director under this section:
 
        (a) In connection with a proceeding by or in the right of the
    corporation in which the director was adjudged liable to the corporation; or
 
        (b) In connection with any other proceeding charging that the director
    derived an improper personal benefit, whether or not involving action in an
    official capacity, in which proceeding the director was adjudged liable on
    the basis that he or she derived an improper personal benefit.
 
    (5) Indemnification permitted under this section in connection with a
proceeding by or in the right of the corporation is limited to reasonable
expenses incurred in connection with the proceeding.
 
7-109-103. MANDATORY INDEMNIFICATION OF DIRECTORS.
 
    Unless limited by its articles of incorporation, a corporation shall
indemnify a person who was wholly successful, on the merits or otherwise, in the
defense of any proceeding to which the person was a party because the person is
or was a director, against reasonable expenses incurred by him or her in
connection with the proceeding.
 
7-109-104. ADVANCE OF EXPENSES TO DIRECTORS.
 
    (1) A corporation may pay for or reimburse the reasonable expenses incurred
by a director who is a party to a proceeding in advance of final disposition of
the proceeding if:
 
        (a) The director furnishes to the corporation a written affirmation of
    the director's good faith belief that he or she has met the standard of
    conduct described in section 7-109-102;
 
        (b) The director furnishes to the corporation a written undertaking,
    executed personally or on the director's behalf, to repay the advance if it
    is ultimately determined that he or she did not meet the standard of
    conduct; and
 
        (c) A determination is made that the facts then known to those making
    the determination would not preclude indemnification under this article.
 
    (2) The undertaking required by paragraph (b) of subsection (1) of this
section shall be an unlimited general obligation of the director but need not be
secured and may be accepted without reference to financial ability to make
repayment.
 
    (3) Determinations and authorizations of payments under this section shall
be made in the manner specified in section 7-109-106.
 
                                      II-2

7-109-105. COURT-ORDERED INDEMNIFICATION OF DIRECTORS.
 
    (1) Unless otherwise provided in the articles of incorporation, a director
who is or was a party to a proceeding may apply for indemnification to the court
conducting the proceeding or to another court of competent jurisdiction. On
receipt of an application, the court, after giving any notice the court
considers necessary, may order indemnification in the following manner:
 
        (a) If it determines that the director is entitled to mandatory
    indemnification under section 7-109-103, the court shall order
    indemnification, in which case the court shall also order the corporation to
    pay the director's reasonable expenses incurred to obtain court-ordered
    indemnification.
 
        (b) If it determines that the director is fairly and reasonable entitled
    to indemnification in view of all the relevant circumstances, whether or not
    the director met the standard of conduct set forth in section 7-109-102 (1)
    or was adjudged liable in the circumstances described in section 7-109-102
    (4), the court may order such indemnification as the court deems proper;
    except that the indemnification with respect to any proceeding in which
    liability shall have been adjudged in the circumstances described in section
    7-109-102 (4) is limited to reasonable expenses incurred in connection with
    the proceeding and reasonable expenses incurred to obtain court-ordered
    indemnification.
 
7-109-106. DETERMINATION AND AUTHORIZATION OF INDEMNIFICATION OF DIRECTORS.
 
    (1) A corporation may not indemnify a director under section 7-109-102
unless authorized in the specific case after a determination has been made that
indemnification of the director is permissible in the circumstances because the
director has met the standard of conduct set forth in section 7-109-102. A
corporation shall not advance expenses to a director under section 7-109-104
unless authorized in the specific case after the written affirmation and
undertaking required by section 7-109-104 (1) (a) and (1) (b) are received and
the determination required by section 7-109-104 (1) -C- has been made.
 
    (2) The determinations required by subsection (1) of this section shall be
made:
 
        (a) By the board of directors by a majority vote of those present at a
    meeting at which a quorum is present, and only those directors not parties
    to the proceeding shall be counted in satisfying the quorum; or
 
        (b) If a quorum cannot be obtained, by a majority vote of a committee of
    the board of directors designated by the board of directors, which committee
    shall consist of two or more directors not parties to the proceeding; except
    that directors who are parties to the proceeding may participate in the
    designation of directors for the committee.
 
    (3) If a quorum cannot be obtained as contemplated in paragraph (a) of
subsection (2) of this section, and a committee cannot be established under
paragraph (b) of subsection (2) of this section, or, even if a quorum is
obtained or a committee is designated, if a majority of the directors
constituting such quorum or such committee so directs, the determination
required to be made by subsection (1) of this section shall be made:
 
        (a) By independent legal counsel selected by a vote of the board of
    directors or the committee in the manner specified in paragraph (a) or (b)
    of subsection (2) of this section or, if a quorum of the full board cannot
    be obtained and a committee cannot be established, by independent legal
    counsel selected by a majority vote of the full board of directors; or
 
        (b) By the shareholders.
 
    (4) Authorization of indemnification and advance of expenses shall be made
in the same manner as the determination that indemnification or advance of
expenses is permissible; except that, if the determination that indemnification
or advance of expenses is permissible is made by independent legal counsel,
 
                                      II-3

authorization of indemnification and advance of expenses shall be made by the
body that selected such counsel.
 
7-109-107. INDEMNIFICATION OF OFFICERS, EMPLOYEES, FIDUCIARIES, AND AGENTS.
 
    (1) Unless otherwise provided in the articles of incorporation:
 
        (a) An officer is entitled to mandatory indemnification under section
    7-109-103, and is entitled to apply for court-ordered indemnification under
    section 7-109-105, in each case to the same extent as a director;
 
        (b) A corporation may indemnify and advance expenses to an officer,
    employee, fiduciary, or agent of the corporation to the same extent as to a
    director; and
 
        (c) A corporation may also indemnify and advance expenses to an officer,
    employee, fiduciary, or agent who is not a director to a greater extent, if
    not inconsistent with public policy, and if provided for by its bylaws,
    general or specific action of its board of directors or shareholders, or
    contract.
 
7-109-108. INSURANCE. A corporation may purchase and maintain insurance on
behalf of a person who is or was a director, officer, employee, fiduciary, or
agent of the corporation, or who, while a director, officer, employee,
fiduciary, or agent of the corporation, is or was serving at the request of the
corporation as a director, officer, partner, trustee, employee, fiduciary, or
agent of another domestic or foreign corporation or other person or of an
employee benefit plan, against liability asserted against or incurred by the
person in that capacity or arising from his or her status as a director,
officer, employee, fiduciary, or agent, whether or not the corporation would
have power to indemnify the person against the same liability under section
7-109-102, 7-109-103, or 7-109-107. Any such insurance may be procured from any
insurance company designated by the board of directors, whether such insurance
company is formed under the laws of this state or any other jurisdiction of the
United States or elsewhere, including any insurance company in which the
corporation has an equity or any other interest through stock ownership or
otherwise.
 
7-109-109. LIMITATION OF INDEMNIFICATION OF DIRECTORS.
 
    (1) A provision treating a corporation's indemnification of, or advance of
expenses to, directors that is contained in its articles of incorporation or
bylaws, in a resolution of its shareholders or board of directors, or in a
contract, except an insurance policy, or otherwise, is valid only to the extent
the provision is not inconsistent with sections 7-109-101 to 7-109-108. If the
article of incorporation limit indemnification or advance of expenses,
indemnification and advance of expenses are valid only to the extent not
inconsistent with the articles of incorporation.
 
    (2) Sections 7-109-101 to 7-109-108 do not limit a corporation's power to
pay or reimburse expenses incurred by a director in connection with an
appearance as a witness in a proceeding at a time when he or she has not been
made a named defendant or respondent in the proceeding.
 
7-109-110. NOTICE TO SHAREHOLDER OF INDEMNIFICATION OF DIRECTOR. If a
corporation indemnifies or advances expenses to a director under this article in
connection with a proceeding by or in the right of the corporation, the
corporation shall give written notice of the indemnification or advance to the
shareholders with or before the notice of the next shareholders' meeting. If the
next shareholder action is taken without a meeting at the instigation of the
board of directors, such notice shall be given to the shareholders at or before
the time the first shareholder signs a writing consenting to such action.
 
                                     * * *
 
    b.  Article XII of Registrant's Articles of Incorporation provide that the
corporation may indemnify each director, officer, and any employee or agent of
the corporation, his heirs, executors and administrators, against expenses
reasonably incurred or any amounts paid by him in connection with any action,
suit or proceeding to which he may be made a party by reason of his being or
having been a director, officer,
 
                                      II-4

employee or agent of the corporation to the extent permitted by the law as
recited above in subparagraph (a).
 
    c.  Article XII of Registrant's Articles of Incorporation provides, in part:
 
    "e.  To the maximum extent permitted by law or by public policy, directors
of this Corporation are to have no personal liability for monetary damages for
breach of fiduciary duty as a director."
 
ITEM 25.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.
 
    The estimated expenses of the offering are to be borne by the Company, are
as follows:
 


SEC Filing Fee....................................................  $   3,849
                                                                 
NASD Fee..........................................................      1,770
Nasdaq Fee........................................................     15,000
Printing Expenses.................................................     75,000
Accounting Fees and Expenses......................................     40,000
Legal Fees and Expenses...........................................     60,000
Blue Sky Fees and Expenses........................................     25,000
Registrar and Transfer Agent Fee..................................      5,000
Underwriters' Non-Accountable Expense Allowance...................    270,000
Miscellaneous.....................................................     54,381
                                                                    ---------
  Total...........................................................  $ 550,000

 
ITEM 26.  RECENT SALES OF UNREGISTERED SECURITIES.
 
        1.  In January 1994, the IFC issued an aggregate of 22,500 shares of
    Common Stock valued at $.50 per share to officers and directors for services
    performed in those capacities. The securities were issued to six
    individuals, each of whom represented that he was an "accredited investor"
    within in the meaning of Rule 501(a) of Regulation D. The securities, which
    were taken for investment and were subject to appropriate transfer
    restrictions, were issued without registration under the Securities Act of
    1933, as amended (the "Act") in reliance upon the exemption provided in
    Section 4(2) of the Act.
 
        2.  In February 1995, the Company issued an aggregate of 668,019 shares
    of Common Stock and Incentive Stock Options exercisable to purchase an
    additional 66,594 shares of Common Stock at $1.75 per share and
    Non-Qualified Stock Options exercisable to purchase 36,000 shares of Common
    Stock at $1.75 per share in connection with the Company's acquisition of
    Cell Robotics, Inc., a New Mexico corporation. The shares of Common Stock
    were issued to total of eight (8) former stockholders of Cell Robotics,
    Inc., PRO RATA, each of whom represented that he, she or it satisfied
    certain suitability and qualification requirements. The securities, which
    were taken for investment and were subject to appropriate transfer
    restriction, were issued without registration under the Act in reliance upon
    the exemption provided in Section 4(2) of the Act.
 
        3.  In 1995, the Company sold 380,000 shares of Common Stock to
    BridgeWorks Investors I, L.L.C., an Oregon limited liability company, for
    $1.00 per share. The shares of Common Stock were acquired for investment
    purposes and were subject to appropriate transfer restrictions. The shares
    of Common Stock were not registered under the Act in reliance upon Section
    4(2) thereof.
 
        4.  In 1994, the IFC sold 120,000 shares of Common Stock to six (6)
    investors for $1.00 per share. Each investor represented that they satisfied
    certain suitability requirements. The shares of Common Stock were acquired
    for investment purposes and were subject to appropriate transfer
    restrictions. The shares of Common Stock were not registered under the Act
    in reliance upon Section 4(2) thereof.
 
                                      II-5

        5.  In August 1995, the Company granted Incentive Stock Options
    exercisable to purchase 360,000 shares of the Company's Common Stock at an
    exercise price of $1.75 per share. The Incentive Stock Options were issued
    to executive officers and key employees of the Company pursuant to the
    Company's 1992 Stock Incentive Plan. The Incentive Stock Options were taken
    for investment, were subject to appropriate transfer restrictions, and were
    issued without registration under the Act in reliance upon the exemption
    provided in Section 4(2) of the Act.
 
        6.  In September 1995, the Company sold an aggregate 115 Units, each
    Unit consisting of 20,000 shares of Common Stock and 10,000 Class A
    Warrants. Each Class A Warrant entitles the holder thereof to purchase one
    (1) share of Common Stock at an exercise price of $1.75 per share. The Units
    were sold to an aggregate of 89 investors who represented that they
    qualified as "accredited investors" within the meaning of Rule 501(a) of
    Regulation D, and a total of 4 other investors who satisfied certain other
    suitability requirements. The securities were acquired for investment
    purposes and were subject to appropriate transfer restrictions. The
    securities were not registered under the Act in reliance upon Section 4(2)
    thereof and Rule 506 of Regulation D promulgated thereunder.
 
        7.  In September 1995, the Company issued a warrant to purchase 11.5
    Units of the Company's securities, each Unit consisting of 20,000 shares of
    Common Stock and 10,000 Class A Warrants. Each Class A Warrant entitles the
    holder thereof to purchase one (1) share of Common Stock at an exercise
    price of $1.75 per share. The subject warrant was issued to a registered
    broker-dealer which qualified as a "accredited investor" within the meaning
    of Rule 501(a) of Regulation D. The subject warrant was acquired for
    investment purposes and was subject to appropriate transfer restrictions.
    The subject warrant was not registered under the Act in reliance upon
    Section 4(2) thereof and Rule 506 of Regulation D thereunder.
 
        8.  In September 1995, the Company granted a Non-Qualified Stock Option
    exercisable to purchase 3,000 shares of the Company's Common Stock at an
    exercise price of $2.39 per share. The Non-Qualified Stock Option was
    granted to one (1) individual in addition to cash compensation for public
    relations services performed for the Company. The option was deemed to have
    only nominal value. The Non-Qualified Stock Option was acquired for
    investment purposes and was subject to appropriate transfer restrictions.
    The Non-Qualified Stock Option was not registered under the Act in reliance
    upon Section 4(2) thereof.
 
        9.  In September 1995, the Company granted a Non-Qualified Stock Option
    exercisable to purchase 6,000 shares of the Company's Common Stock at an
    exercise price of $2.39 per share. The Non-Qualified Stock Option was
    granted for services performed as a member of the Company's Technical
    Advisory Board and was deemed to have only nominal value. The Non-Qualified
    Stock Option was acquired for investment purposes and was subject to
    appropriate transfer restrictions. The Non-Qualified Stock Option was not
    registered under the Act in reliance upon Section 4(2) thereof.
 
        10. In December, 1995, the Company granted Non-Qualified Stock Options
    exercisable to purchase 60,000 shares of the Company's Common Stock at an
    exercise price of $2.81 per share. The Non-Qualified Stock Options were
    granted to three (3) directors of the Company. The Non-Qualified Stock
    Options were deemed to have only nominal value. The Non-Qualified Stock
    Options were acquired for investment purposes and were subject to
    appropriate transfer restrictions. The Non-Qualified Stock Options were not
    registered under the Act in reliance upon Section 4(2) thereof.
 
                                      II-6

        11. In January 1996, the Company issued an aggregate of 17,500 shares to
    seven (7) investors as partial consideration for certain United States and
    foreign patent rights. The shares of Common Stock were valued at $2.25 per
    share. The shares of Common Stock were acquired for investment purposes and
    were subject to appropriate transfer restrictions. The shares of Common
    Stock were not registered under the Act in reliance upon Section 4(2)
    thereof.
 
        12. During fiscal 1996, the Company granted Incentive Stock Options
    exercisable to purchase 175,000 shares of the Company's Common Stock at
    exercise prices of $1.875 to $2.875 per share. The Incentive Stock Options
    were issued to executive officers and key employees of the Company pursuant
    to the Company's 1992 Stock Incentive Plan. The Incentive Stock Options were
    taken for investment, were subject to appropriate transfer restrictions, and
    were issued without registration under the Act in reliance upon the
    exemption provided in Section 4(2) of the Act.
 
        13. In August 1997, the Company sold to one (1) accredited investor an
    aggregate of 200,000 shares of Common Stock at a price of $3.25 per share.
    The shares of Common Stock were acquired for investment purposes and subject
    to the appropriate transfer restrictions. The shares of Common Stock were
    not registered under the Act in reliance upon Section 4.2 thereof.
 
ITEM 27.  EXHIBITS.
 
        a.  The following Exhibits are filed as part of this Registration
    Statement pursuant to Item 601 of Regulation S-B:
 


EXHIBIT NO.                                TITLE
- -----------  ------------------------------------------------------------------
          
 *****  1.0  Underwriting Agreement
 
 **     3.2  Amended and Restated Bylaws
 
 ****   3.3(a) Amended and Restated Articles of Incorporation
 
 **     3.3(b) Articles of Amendment to the Articles of Incorporation dated May
               23, 1995
 
 **     4.1  Specimen Certificate of Common Stock
 
 *****  4.2  Representatives' Common Stock Purchase Warrant
 
 *****  4.3  Warrant Agreement
 
 *****  4.4  Lohrding Option Agreement
 
 *****  5.0  Opinion of Neuman & Drennen, LLC regarding the legality of the
               securities being registered
 
 *     10.1  Agreement and Plan of Reorganization between and among Cell
               Robotics, Inc., Intelligent Financial Corporation, MiCel, Inc.,
               BridgeWorks Investors I, L.L.C., and Ronald K. Lohrding.
 
 *     10.2  Employment Agreement of Ronald K. Lohrding.
 
 *     10.3  Employment Agreement of Craig T. Rogers.
 
       10.4  Employment Agreement of Travis Lee
 
 *     10.5  Financing and Capital Contribution Agreement between and among
               Cell Robotics, Inc., Intelligent Financial Corporation, MiCel,
               Inc., and BridgeWorks Investors I, L.L.C.
 
 *     10.6  Irrevocable Appointment of Voting Rights by Dr. Lohrding to MiCel,
               Inc.
 
 *     10.7  Stock Pooling and Voting Agreement

 
                                      II-7



EXHIBIT NO.                                TITLE
- -----------  ------------------------------------------------------------------
          
 **    10.8  Royalty Agreement dated September 11, 1995 between the Registrant,
               Cell Robotics, Inc., and Mitsui Engineering & Shipbuilding Co.,
               Ltd.
 
 **    10.9  Agreement of Contribution and Mutual Comprehensive Release dated
               September 11, 1995 between the Company, Cell Robotics, Inc. and
               Mitsui Engineering & Shipbuilding Co., Ltd.
 
 **   10.10  Distribution Agreement dated April 6, 1995, between Carl Zeiss,
               Inc. and the Registrant
 
 **   10.11  Distribution Agreement dated December 15, 1994, between MiCel,
               Inc. and the Registrant
 
 **   10.12  Revised License Agreement dated January 5, 1996 between the
               Registrant and the Regents of the University of California
 
 **   10.13  Purchase Agreement with Tecnal Products, Inc.
 
 **   10.14  License Agreement with NTEC
 
 **** 10.15  License Agreement dated May 13, 1996, between the Registrant and
               GEM Edwards, Inc.
 
 *****10.16  Termination Agreement and Release dated             , 1997 between
               the Registrant and GEM Edwards, Inc.
 
 ***  16.00  Letter of Schumacher & Associates, Inc., Certified Public
               Accountants, filed pursuant to Item 304(a)(3) of Regulation S-B
 
 **    21.0  Subsidiaries
 
 ***** 23.1  Consent of Neuman & Drennen, LLC
 
 ***** 23.2  Consent of KPMG Peat Marwick LLP, Certified Public Accountants

 
- ------------------------
 
*     Incorporated by reference from the Registrant's Current Report on Form 8-K
      dated February 23, 1995, as filed with the Commission on March 10, 1995,
      SEC File No. 33-26467.
 
**    Incorporated by reference from the Registrant's Pre-Effective Amendment
      No. 1 to Registration Statement on Form SB-2 declared effective by the
      Commission on February 14, 1996, SEC File No. 33-80347.
 
***   Incorporated by reference from the Registrant's Current Report on Form 8-K
      dated May 15, 1995, as filed with the Commission on May 18, 1995, SEC File
      No. 33-26467.
 
****  Incorporated by reference from the Registrant's Post-Effective Amendment
      No. 1 to Registration Statement on Form SB-2 filed with the Commission on
      July 15, 1996, SEC File No. 33-80347.
 
***** Filed herewith.
 
ITEM 28.  UNDERTAKINGS.
 
    The undersigned Registrant hereby undertakes:
 
        1.  To file, during any period in which it offers or sells securities, a
    post-effective amendment to this registration statement to:
 
           a.  Include any prospectus required by Section 10(a)(3) of the
       Securities Act of 1933;
 
           b.  Reflect in the prospectus any facts or events which, individually
       or together, represent a fundamental change in the information in the
       registration statement;
 
                                      II-8

           c.  Include any additional or changed material information on the
       plan of distribution.
 
        2.  That, for determining liability under the Securities Act, to treat
    each post-effective amendment as a new registration statement of the
    securities offered, and the offering of the securities at that time to be
    the initial bona fide offering.
 
        3.  To file a post-effective amendment to remove from registration any
    of the securities that remain unsold at the end of the offering.
 
        4.  Insofar as indemnification for liabilities arising under the
    Securities Act of 1933 (the "Act") may be directors, officers and
    controlling persons of the Registrant pursuant to the foregoing provisions,
    or otherwise, the Registrant has been advised that in the opinion of the
    Securities and Exchange Commission such indemnification is against public
    policy as expressed in the Act and is, therefore, unenforceable.
 
        5.  In the event that a claim for indemnification against such
    liabilities (other than the payment by the Registrant of expenses incurred
    and paid by a director, officer or controlling person of the Registrant in
    the successful defense of any action, suit or proceeding) is asserted by
    such director, officer or controlling person in connection with the
    securities being registered hereby, the Registrant will, unless in the
    opinion of its counsel the matter has been settled by controlling precedent,
    submit to a court of appropriate jurisdiction the question whether such
    indemnification by it is against public policy as expressed in the
    Securities Act and will be governed by the final adjudication of such issue.
 
                                      II-9

                                   SIGNATURES
 
    Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form SB-2 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned thereunto
duly authorized, in the City of Albuquerque, State of New Mexico on the 24th day
of November, 1997.
 

                               
                                CELL ROBOTICS INTERNATIONAL, INC.
 
                                By:            /s/ RONALD K. LOHRDING
                                     -----------------------------------------
                                           Ronald K. Lohrding, PRESIDENT

 
    Pursuant to the requirements of the Securities Act of 1933, as amended, this
Registration Statement has been signed by the following persons in the
capacities with Cell Robotics International, Inc. and on the dates indicated.
 
          SIGNATURE                      POSITION                  DATE
- ------------------------------  --------------------------  -------------------
 
    /s/ RONALD K. LOHRDING      Chairman of the Board,
- ------------------------------    President, Chief           November 24, 1997
      Ronald K. Lohrding          Executive Officer
 
       /s/ JEAN SCHARF          Chief Financial Officer,
- ------------------------------    Chief Accounting Officer   November 24, 1997
         Jean Scharf              and Controller
 
     /s/ CRAIG T. ROGERS
- ------------------------------  Director                     November 24, 1997
       Craig T. Rogers
 
       /s/ MARK WALLER
- ------------------------------  Director                     November 24, 1997
         Mark Waller
 
    /s/ RAYMOND RADOSEVICH
- ------------------------------  Director                     November 24, 1997
      Raymond Radosevich
 
       /s/ DEBRA BRYANT
- ------------------------------  Director                     November 24, 1997
         Debra Bryant
 
                                     II-10

                               INDEX TO EXHIBITS
 


EXHIBIT NO.                                TITLE
- -----------  ------------------------------------------------------------------
          
 *****  1.0  Underwriting Agreement
 
 **     3.2  Amended and Restated Bylaws
 
 ****   3.3(a) Amended and Restated Articles of Incorporation
 
 **     3.3(b) Articles of Amendment to the Articles of Incorporation dated May
               23, 1995
 
 **     4.1  Specimen Certificate of Common Stock
 
 *****  4.2  Representatives' Common Stock Purchase Warrant
 
 *****  4.3  Warrant Agreement
 
 *****  4.4  Lohrding Option Agreement
 
 *****  5.0  Opinion of Neuman & Drennen, LLC regarding the legality of the
               securities being registered
 
 *     10.1  Agreement and Plan of Reorganization between and among Cell
               Robotics, Inc., Intelligent Financial Corporation, MiCel, Inc.,
               BridgeWorks Investors I, L.L.C., and Ronald K. Lohrding.
 
 *     10.2  Employment Agreement of Ronald K. Lohrding.
 
 *     10.3  Employment Agreement of Craig T. Rogers.
 
       10.4  Employment Agreement of Travis Lee
 
 *     10.5  Financing and Capital Contribution Agreement between and among
               Cell Robotics, Inc., Intelligent Financial Corporation, MiCel,
               Inc., and BridgeWorks Investors I, L.L.C.
 
 *     10.6  Irrevocable Appointment of Voting Rights by Dr. Lohrding to MiCel,
               Inc.
 
 *     10.7  Stock Pooling and Voting Agreement
 
 **    10.8  Royalty Agreement dated September 11, 1995 between the Registrant,
               Cell Robotics, Inc., and Mitsui Engineering & Shipbuilding Co.,
               Ltd.
 
 **    10.9  Agreement of Contribution and Mutual Comprehensive Release dated
               September 11, 1995 between the Company, Cell Robotics, Inc. and
               Mitsui Engineering & Shipbuilding Co., Ltd.
 
 **   10.10  Distribution Agreement dated April 6, 1995, between Carl Zeiss,
               Inc. and the Registrant
 
 **   10.11  Distribution Agreement dated December 15, 1994, between MiCel,
               Inc. and the Registrant
 
 **   10.12  Revised License Agreement dated January 5, 1996 between the
               Registrant and the Regents of the University of California
 
 **   10.13  Purchase Agreement with Tecnal Products, Inc.
 
 **   10.14  License Agreement with NTEC
 
 **** 10.15  License Agreement dated May 13, 1996, between the Registrant and
               GEM Edwards, Inc.
 
 ***  16.00  Letter of Schumacher & Associates, Inc., Certified Public
               Accountants, filed pursuant to Item 304(a)(3) of Regulation S-B
 
 **    21.0  Subsidiaries
 
 ***** 23.1  Consent of Neuman & Drennen, LLC




EXHIBIT NO.                                TITLE
- -----------  ------------------------------------------------------------------
          
 ***** 23.2  Consent of KPMG Peat Marwick LLP, Certified Public Accountants

 
- ------------------------
 
*     Incorporated by reference from the Registrant's Current Report on Form 8-K
      dated February 23, 1995, as filed with the Commission on March 10, 1995,
      SEC File No. 33-26467.
 
**    Incorporated by reference from the Registrant's Pre-Effective Amendment
      No. 1 to Registration Statement on Form SB-2 declared effective by the
      Commission on February 14, 1996, SEC File No. 33-80347.
 
***   Incorporated by reference from the Registrant's Current Report on Form 8-K
      dated May 15, 1995, as filed with the Commission on May 18, 1995, SEC File
      No. 33-26467.
 
****  Incorporated by reference from the Registrant's Post-Effective Amendment
      No. 1 to Registration Statement on Form SB-2 filed with the Commission on
      July 15, 1996, SEC File No. 33-80347.
 
***** Filed herewith.