Exhibit 10.16

                                   PATENT AGREEMENT


This Patent Agreement is between DR. ABRAHAM ROSENBERG ("ROSENBERG"), and
AYURCORE, INC. ("AYURCORE"), and is made with reference to the following
recitals:

RECITALS

A.  ROSENBERG is the owner of the U.S. Patent Application identified below, and
    of the technology and materials described therein, along with rights in
    related technology and materials.

B.  AYURCORE desires to secure, and ROSENBERG is willing to grant, ownership of
    such patent, in accordance with the terms and conditions of this Agreement.

AGREEMENTS

In consideration of the covenants and obligations set forth below, ROSENBERG and
AYURCORE agree as follows:

1.  DEFINITIONS

    1.1  Agreement. "Agreement" means this Patent Agreement.

    1.2  Assigned Rights. "Assigned Rights" means the U.S. Patent Application
         (a draft of which has been prepared) to be filed on the invention
         entitled "COMPOSITIONS FOR MODULATING INTRACELLULAR INOSITOL
         TRISPHOSPHATE CONCENTRATION AND USES THEREOF," and all foreign and
         domestic patents or patent-like rights, continuation and
         continuation-in-part applications, divisional applications, reissue
         patents, extensions, and the like, having a priority date based on
         such U.S. Patent Application.

    1.3  AYURCORE. "AYURCORE" includes any corporation, partnership, or
         organization, whether now existing or hereafter created, which
         directly or indirectly controls, is controlled by, or is under common
         control with, AYURCORE, INC. "Control" means (1) the legal power to
         direct or cause the direction of the general management or partners of
         such entity, whether through the ownership of voting securities or by
         contract, or (2) ownership (directly or
         indirectly) of more than 50% of the outstanding  shares conferring a
         right to vote at general meetings, or (3) the right to elect the
         majority of the Board of Directors or its equivalent.

    1.4  Improvement. "Improvement" means any alteration or modification of any




         Invention, but such that the altered or modified version comes within
         any issued claim of the Assigned Rights.

    1.5  Invention. "Invention" means the structure, materials, design,
         concepts, techniques, and processes embodied in the Assigned Rights.

    1.6  Know-how. "Know-How" means the confidential technical information of
         ROSENBERG relating to the Invention and Products and useful in the
         manufacture, use, or sale of Products, and further includes all
         samples, sources of supply, documentation, and other similar tangible
         and intangible information and property relating to the Products and
         in ROSENBERG's possession or control as of the effective date of this
         Agreement.

    1.7  Legal Action. "Legal Action" means any legal or equitable suit,
         proceeding, action, or arbitration.

    1.8  Manufacture. "Manufacture" means make or have made.

    1.9  Net Receipts. "Net Receipts" means the total amounts of money or other
         consideration received or earned by AYURCORE from all Transfers of
         Products, less any of the following amounts if itemized separately
         from the Transfer price:

         (1)  shipping and insurance charges or allowances,

         (2)  customary trade discount allowed, or any commission paid in lieu
              of a trade discount (other than commissions paid to employees of
              AYURCORE);

         (3)  refunds, credits, or allowances given or made on account of the
              return or rejection of any Products;

         (4)  tax, duty, tariff or other governmental charge on the making,
              having made, use, transportation, or Transfer of the Products;
              and

         (5)  reasonable compensation received by AYURCORE for delivery or
              installation services, or as interest or  finance charges.


    1.10 Net Royalties. '`Net Royalties" means the gross amount of license fees
         and royalties (or payments in lieu of license fees or royalties), net
         of withholding taxes, received or earned from any sublicensee by
         AYURCORE pursuant to a sublicense agreement between AYURCORE and such
         sublicensee.

    1.11 Parties, Party. "Parties" means ROSENBERG and AYURCORE, collectively.
         "Party" means either R0SENBERG or AYURCORE.

    1.12 Patent Jurisdiction. "Patent Jurisdiction" means any country or
         territory where ROSENBERG owns or controls an issued, unexpired, and
         enforceable patent coming under the Assigned Rights.




    1.13 Products. "Products" means any method, machine, manufacture, or
         composition of matter (1) made or practiced in accordance with or
         incorporating the teachings of any Invention and covered in whole or
         in part by any of the now pending or issued claims of the Assigned
         Rights, or (2) incorporating any Knowhow provided by ROSENBERG to
         AYURCORE.

    1.14 Territory. "Territory" means the entire world.

    1.15 Transfer. "Transfer" means any sale, lease, rental, or other
         commercial disposition, with or without consideration.

2.  ASSIGNMENT

    2.1  Grant. ROSENBERG hereby assigns to AYURCORE, and AYURCORE accepts,
         all of ROSENBERG's right, title, and interest in and to the Assigned
         Rights and Know-how, subject to all of the rights and obligations set
         forth in this Agreement.

    2.2  Permits. AYURCORE shall be responsible for obtaining any permits,
         licenses, authorizations, or approvals required or necessary by any
         government or other entity to Manufacture, use, offer to sell, or
         Transfer any Products.


    2.3  Marking Requirement. AYURCORE agrees to mark Products made by or on
         behalf of AYURCORE with the patent number or  numbers of the Assigned
         Rights. The notice shall be directly applied to the Products, or when,
         from the character of the Products this cannot be done, by fixing to
         the Products or their packaging a label containing a like notice.

    2.4  Patent Filings & Maintenance. AYURCORE shall file and prosecute such
         U. S. patent applications as are reasonably required to protect the
         Assigned Rights. AYURCORE, in its discretion, may file and prosecute
         related foreign patent applications as it deems appropriate. AYURCORE
         shall use reasonable diligence, under the circumstances, to prosecute
         and maintain in force any resulting patent rights.

    2.5  Assistance by ROSENBERG. ROSENBERG agrees to assist AYURCORE with
         respect to any Legal Action brought by AYURCORE relating to the
         enforcement of the Assigned Rights. ROSENBERG shall be entitled to
         receive reimbursement of any reasonable out-of-pocket expenses
         incurred by it in rendering such assistance.

3.  COMPENSATION AND ROYALTIES

    3.1  Agreement for Royalties. AYURCORE agrees to pay ROSENBERG a royalty at
         the following rates:




         (1)  A rate of [***] of all Net Receipts from Transfers of Products to
              be used in, or which are imported into, any Patent Jurisdiction 
              by or on behalf of AYURCORE.

         (2)  A rate of [***] of all Net Royalties received or earned by 
              AYURCORE from sublicensees.

    3.2  Payment. The royalty on the Transfer of each Product is earned on the
         earlier of (l) the day on which the Product is shipped to a
         distributor or customer, or (2) the day on which an invoice issues for
         the Product. Each royalty payment to ROSENBERG must be paid within 30
         days after the end of the calendar quarter in which the royalty is
         earned. Royalties earned on Products for which refunds, credits, or
         allowances are given or made by AYURCORE or its sublicensees shall be
         credited against future royalties due to ROSENBERG, Royalties shall be
         paid in U S dollars. For those Transfers of Products made by AYURCORE
         in other currencies, the Net Receipts shall be  converted to U.S.
         dollars in accordance with the exchange rates published in the Wall
         Street Journal at the end of the respective royalty period.

    3.3  Statements. With each royalty payment, AYURCORE must submit to
         ROSENBERG a statement of. (1) the number of Transfers of Products from
         all sources during the applicable period, (2) the total of the Net
         Receipts during the applicable period, and (3) a clear computation of
         the royalty payment.

    3.4  Inspection. AYURCORE agrees to keep or have kept separate and 
         adequately detailed accounting records of all Transfers of Products.
         Such accounting records shall be kept for a minimum of 2 years. During
         the term of this Agreement and for one year thereafter, ROSENBERG or
         its agents have the right to inspect the relevant accounting records
         of AYURCORE to verify the accuracy of the royalties paid or payable to
         ROSENBERG. All inspected information shall be kept in confidence from
         third parties. ROSENBERG must give at least 10 days' written notice to
         AYURCORE before any inspection, and may not inspect more than once in
         any 12 month period. All inspections must be during ordinary business
         hours, and shall be conducted so as to not unreasonably interfere with
         AYURCORE's normal business activities. If any inspection discloses
         that the amount of royalties paid by AYURCORE is incorrect in either
         ROSENBERG's or AYURCORE's favor, then any amount due to either Party
         must be paid within 30 days by the other Party. If ROSENBERG's
         inspection demonstrates that the royalties paid for the period in
         question are less than 95% of the correct amount owing, AYURCORE shall
         be liable for ROSENBERG's cost of inspection. Otherwise, ROSENBERG
         must pay all of ROSENBERG's costs for any inspection.

    3.5  Credit for Expenses. Any expenses incurred by AYURCORE to obtain
         patent protection for the Assigned Rights, from preparation of an
         application through response to the first substantive office action
         (i.e., excluding a restriction 

* Confidential provisions omitted and filed separately with the Commission.




         requirement), shall be credited against future royalties owed by
         AYURCORE to ROSENBERG. In addition, any expenses incurred by AYURCORE
         to obtain regulatory approval of any Product shall be credited against
         future royalties owed by AYURCORE to ROSENBERG.

4.  TERM AND TERMINATION

    4.1  Term. The term of this Agreement shall be from its effective date as
         defined in PARA6.15 to the expiration of the last to expire patent in
         the Assigned Rights (unless this Agreement is sooner terminated in
         accordance with any of the provisions of this Agreement).

    4.2  By Mutual Agreement. The Parties may mutually agree in writing to
         terminate this Agreement, and all rights granted under this Agreement,
         at any time.

    4.3  Option by ROSENBERG. ROSENBERG, at its option, may immediately
         terminate this Agreement and all rights granted under this Agreement
         if AYURCORE defaults in the performance of any material obligation and
         if the default has not been remedied within 30 days after written
         notice to AYURCORE describing the default. The following events shall
         constitute a default in the performance of a material obligation of
         this Agreement.

         (1)  AYURCORE's failure to pay when due any amount payable under this
              Agreement.

         (2)  The liquidation or dissolution of AYURCORE.

         (3)  If AYURCORE ceases to be actively engaged in business or
              financially capable of fulfilling its obligations under this
              Agreement.

    4.4  Accrued Royalties Payable. Within 30 days after any termination of
         this Agreement by ROSENBERG for cause, AYURCORE must pay all royalties
         accrued up to the date of termination, and provide an accounting for
         the final period.

    4.5  Reversion of Rights. If AYURCORE has not cured a material default
         under this Agreement after due notice and expiration of the remedy
         period, all rights, title, and interest in and to the Assigned Rights
         shall be promptly assigned by AYURCORE back to ROSENBERG.

    4.6  Option by AYURCORE. AYURCORE, at its option, may immediately terminate
         this Agreement and all of its obligations under this Agreement if
         ROSENBERG defaults in the performance of any material obligation and
         if the default has not been remedied within 30 days after  written
         notice to ROSENBERG describing the default.





    4.7  Rights re Inventory. Notwithstanding any contrary provision of this
         Agreement, AYURCORE shall have the right, for a period of one year or
         until AYURCORE's inventory of PRODUCTS is exhausted (whichever comes
         first), to dispose of any Products (including in-process Products) in
         its possession or control at the date of termination by ROSENBERG.
         However, AYURCORE must make all royalty payments relating to such
         Products as are otherwise required by this Agreement. Within 30 days
         after any termination, AYURCORE shall provide ROSENBERG with a report
         of AYURCORE's current inventory of Products as of the date of
         termination.

5.  REPRESENTATIONS AND DISCLAIMER OF WARRANTIES

    5.1  Representation re Ownership. ROSENBERG represents that it is the sole
         owner of the Assigned Rights, that ROSENBERG has not granted any other
         entity any right or license under the Assigned Rights, and that
         ROSENBERG has the right to assign the rights granted to AYURCORE by
         this Agreement.

    5.2  No Warranty re Usefulness. ROSENBERG makes no warranty or
         representation that AYURCORE can successfully use the Assigned Rights
         to make Products.

    5.3  No Warranty re Infringement. AYURCORE acknowledges that ROSENBERG
         makes no representations that any Product will not infringe the
         intellectual property rights of any third party. However, ROSENBERG
         represents that, to the best of his knowledge, he is not aware of any
         such infringement as of the execution date of this Agreement.

    5.4  No Assistance to Competitors. During the term of this Agreement,
         ROSENBERG shall not create and/or provide products directly
         competitive with any of the Products to any other entity without
         giving AYURCORE the right of first refusal to acquire or license such
         competitive products. If ROSENBERG patents any Improvement to any
         Invention within 10 years after the effective date of this Agreement,
         ROSENBERG shall promptly disclose any issued patent  covering the
         Improvement to AYURCORE, and AYURCORE shall have the right of first
         refusal to acquire or license such patent.

    5.5  No Minimum Sales. AYURCORE makes no representations to ROSENBERG
         regarding minimum sales and/or royalties relating to Products.

    5.6  Exclusion and Limitation of Liability. In no event shall ROSENBERG be
         liable to AYURCORE or any third party for direct, indirect,
         consequential, incidental, or punitive damages, lost profits or lost
         savings, resulting from any defect in or use of any Product. In no
         event shall ROSENBERG be liable to AYURCORE for indirect,
         consequential, incidental, or punitive damages, lost profits or lost
         savings, for any breach of this Agreement.




    5.7  Indemnification by AYURCORE. AYURCORE agrees to indemnify, defend, and
         hold harmless ROSENBERG from and against any and all liabilities,
         costs, expenses, damages, losses, actions, causes of action, and the
         like arising from or relating to (directly or indirectly) any
         determination that ROSENBERG is liable for any direct, indirect,
         consequential, incidental, or punitive damages, or lost profits or
         lost savings, resulting from any Manufacture, marketing, Transfers, or
         use of, or defect in, any Products. The indemnification required by
         this Paragraph shall include the payment of all attorneys' fees and
         other expenses (not limited to taxable costs) incurred in settling or
         defending any threatened or actual Legal Action.

6.  GENERAL TERMS AND CONDITIONS

    6.1  Arbitration. All disputes between the Parties concerning (l) the terms
         and conditions of this Agreement and involving less than $50,000, or
         (2) enforcement of the Assigned Rights against third parties (but
         excluding any issue about the validity of the Assigned Rights), shall
         be subject to expedited binding arbitration outside of the American
         Arbitration Association ("AAA") before an attorney or expert who is
         knowledgeable and experienced in the patent field, and who is selected
         by mutual agreement of the Parties. A Party shall commence arbitration
         by delivering written notice to the other Party. If the Parties fail
         to agree on an arbitrator within  30 days after notice of a
         commencement of arbitration is delivered, arbitration shall be by the
         AAA, subject to the rules of the AAA then in effect, except that, in
         any case, the arbitrator shall provide for discovery in accordance
         with the Federal Rules of Civil Procedure and Federal Rules of
         Evidence for a period of 120 days following the selection of the
         arbitrator. Questions relating to such discovery shall be determined
         by the arbitrator. Until a determination is made in the arbitration,
         each Party shall share equally in the payment of the expenses of the
         arbitrator, and AYURCORE shall continue to pay to ROSENBERG all
         royalties required by this Agreement. Judgment upon the award rendered
         in any arbitration may be entered in any court having jurisdiction of
         the matter.

    6.2  Attorneys' Fees. If any arbitration, litigation, or other legal
         proceeding occurs between the Parties relating to this Agreement, the
         prevailing Party shall be entitled to recover (in addition to any
         other relief awarded or granted) its reasonable costs and expenses,
         including attorneys' fees, incurred in the proceeding.

    6.3  Relationship of the Parties. This Agreement does not constitute a
         partnership agreement, nor does it create a joint venture or agency
         relationship between the Parties. Neither Party shall hold itself out
         contrary to the terms of this Paragraph. It is specifically understood
         that each Party is an independent contractor and shall not be
         considered an employee, agent, or consultant of the other Party.
         Neither 



         Party shall be liable for the representations, acts, or omissions of
         the other Party contrary to the terms of this Agreement.

    6.4  Notices. Unless otherwise provided for in this Agreement, all notices
         or other communications required or permitted under this Agreement
         must be in writing and either personally delivered or sent in any
         fashion that provides written proof of actual delivery by a third
         party. The effective date of delivery shall be considered to be the
         next business day after actual delivery. Until written notice to the
         contrary is given, the addresses of the Parties are as shown on the
         signature page of this Agreement.

    6.5  Waiver and Amendment. No waiver, amendment, or modification of any
         provision of this Agreement shall be effective unless in writing and
         signed by the Party against whom the waiver, amendment, or
         modification is sought to be enforced. No failure or delay by either
         Party in exercising any right, power, or remedy under this Agreement
         shall operate as a waiver of the right, power, or remedy. No waiver of
         any provision, condition, or breach of this Agreement shall be
         construed as a waiver of any other provision, condition, or breach.

    6.6  Assignment. This Agreement is binding upon and inures to the benefit
         of the successors and assigns of the Parties. However, no right or
         interest in this Agreement shall be assigned by either Party without
         the written permission of the other Party, except that either Party
         may assign its rights in this Agreement without the permission of the
         other Party to any majority owned subsidiary, or in the event of a
         merger, consolidation, or sale of substantially all of the assets of
         the assigning Party.

    6.7  No Third Party Rights. This Agreement is not for the benefit of any
         third party, and shall not be deemed to grant any right or remedy to
         any third party, whether or not referred to in this Agreement.

    6.8  Interpretation. The section and paragraph headings of this Agreement
         are intended as a convenience only, and shall not be used to interpret
         its provisions. Where the context of this Agreement requires, singular
         terms shall be considered plural, and plural terms shall be considered
         singular.

    6.9  Ambiguities. The Parties have reviewed this Agreement, and have either
         had this Agreement reviewed by legal counsel or declined to do so.
         Accordingly, no rule of preferential interpretation for the
         non-drafting party shall be applied to this Agreement.

    6.10 Severability. If any provision of this Agreement is finally held by a
         court or arbitration panel of competent jurisdiction to be unlawful,
         the remaining provisions 



         of this Agreement shall remain in full force and effect to the extent
         that the intent of the Parties can be enforced.

    6.11 Governing Law and Forum. The validity, construction, and performance
         of this Agreement is governed by the laws of California. Suit or
         arbitration with respect to this Agreement may be brought only in
         California. The Parties agree to submit to personal jurisdiction in
         California.

    6.12 Further Assurances. The Parties agree to execute any and all
         agreements and documents in connection with this Agreement in order to
         complete and fulfill the terms of this Agreement. Where this Agreement
         provides that documents are to be signed and/or filed, such shall be
         done within a reasonable time after the signing of this Agreement.

    6.13 Signature Authority. The persons executing this Agreement warrant that
         they have the right, power, legal capacity, and appropriate authority
         to enter into this Agreement on behalf of the Party for which they
         have signed below.

    6.14 Publicity. The Parties shall be free to publicize the existence of
         this Agreement after the effective date. However, each Party shall use
         its best efforts not to disclose specific clauses (particularly those
         clauses relating to payment of fees or royalties) to any third party
         during the term of this Agreement, except as required by law, or by
         governmental regulation, requirement or order, or as may be required
         to establish its rights under this Agreement.

    6.15 Counterparts. This Agreement may be executed in counterparts. Each
         executed counterpart shall be considered an original of one and the
         same document if each Party has executed at least one counterpart.
         Each Party's signature to a counterpart may be appended to any other
         Counterpart. Each Party shall deliver to every other Party a duplicate
         original of the counterpart executed by such Party. This Agreement
         shall be effective on the date that all Parties have signed at least
         one counterpart.

    6.16 Entire Agreement. This Agreement constitutes the complete and final
         agreement etween the Parties, and supersedes all prior negotiations,
         agreements, and understandings between the Parties concerning its
         subject  matter.



AGREED:

    ABRAHAM ROSENBERG             AYURCORE, INC.

    By: s/Abraham Rosenberg       By: s/Barry Wald 




    Date: 12/9/95                 Name: Barry Wald         
                                  Title: President              
                                  Date: 12/15/95