Exhibit (10.1)

                            SECURITIES PURCHASE AGREEMENT
                                           


    This SECURITIES PURCHASE AGREEMENT ("Agreement") is entered into as of 
December 12, 1997, by and between Biospherics Incorporated, a Delaware 
corporation (the "Company"), with headquarters located at 12051 Indian Creek 
Court, Beltsville, Maryland, and the Purchaser (the "Purchaser") set forth on 
the execution pages hereof, with regard to the following:

                                       RECITALS
                                           
    A.   The Company and Purchaser are executing and delivering this 
Agreement in reliance upon the exemption from securities registration 
afforded by the provisions of Regulation D ("Regulation D"), as promulgated 
by the United States Securities and Exchange Commission (the "SEC") under the 
Securities Act of 1933, as amended (the "Securities Act").

    B.   Purchaser desires to purchase, upon the terms and conditions stated 
in this Agreement, (i) shares of the Company's Common Stock, par value $.005 
per share (the "Common Stock") and (ii) warrants to purchase shares of Common 
Stock in the forms attached hereto as Exhibits A-1 and A-2.  The shares of 
Common Stock being purchased hereunder are referred to herein as the "Common 
Shares". The warrants being purchased hereunder are referred to herein as the 
"Warrants". The shares of Common Stock issuable upon the exercise of or 
otherwise pursuant to the Warrants are referred to herein as the "Warrant 
Shares".  The Common Shares, Warrants and Warrant Shares are collectively 
referred to herein as the "Securities."

    C.   Contemporaneous with the execution and delivery of this Agreement, 
the parties hereto are executing and delivering a Registration Rights 
Agreement in the form attached hereto as Exhibit B (the "Registration Rights 
Agreement"), pursuant to which the Company has agreed to provide certain 
registration rights under the Securities Act, the rules and regulations 
promulgated thereunder and applicable state securities laws.

                                      AGREEMENTS
                                           
    NOW, THEREFORE, in consideration of their respective promises contained 
herein and other good and valuable consideration, the receipt and sufficiency 
of which are hereby acknowledged, the Company and Purchaser hereby agree as 
follows:

                                      ARTICLE I
                           PURCHASE AND SALE OF SECURITIES
                                           
    1.1  Purchase of Common Stock and Warrants.  Subject to the terms and 
conditions of this Agreement, the Company shall issue and sell, and Purchaser 
shall purchase, Common Stock and Warrants as further contemplated hereby.  
The purchase price for a unit consisting of two (2) shares of Common Stock 
and two (2) Warrants, each Warrant to purchase one (1) share of 

                                       1



Common Stock (subject to adjustment as provided in the Warrant) shall be 
$8.00. Purchaser shall purchase the number of shares of Common Stock set 
forth on the signature page executed by Purchaser.  In addition, Purchaser 
shall purchase Warrants to purchase the number of shares of Common Stock 
(subject to adjustment as provided in the Warrants) set forth on the 
signature page executed by Purchaser.

    1.2  Form of Payment.  Purchaser shall pay the aggregate Purchase Price 
for the Common Shares and Warrants being purchased by Purchaser by wire 
transfer to the Company, in accordance with the Company's written wiring 
instructions, against delivery of duly executed Warrants and stock 
certificates for the Common Shares, and the Company shall deliver such Common 
Shares and Warrants against delivery of such aggregate Purchase Price.

    1.3  Closing Date.  Subject to the satisfaction (or waiver) of the 
conditions set forth in Articles VI and VII below, the closing (the 
"Closing") of the issuance, sale and purchase of the Securities pursuant to 
this Agreement shall occur at 10:00 a.m. on December 12, 1997 (the "Closing 
Date"), at the offices of Ballard, Spahr, Andrews & Ingersoll, 1735 Market 
Street, 51st Floor, Philadelphia, PA 19103-7599.

                                      ARTICLE II
                      PURCHASER'S REPRESENTATIONS AND WARRANTIES
                                           
    Purchaser represents and warrants, solely with respect to itself and its 
purchase hereunder.  No Purchaser makes any other representations or 
warranties, express or implied, to the Company in connection with the 
transactions contemplated hereby and any and all prior representations and 
warranties, if any, which may have been made by Purchaser to the Company in 
connection with the transactions contemplated hereby shall be deemed to have 
been merged in this Agreement and any such prior representations and 
warranties, if any, shall not survive the execution and delivery of this 
Agreement.

    2.1  Investment Purpose.  Purchaser is purchasing the Common Shares and 
Warrants (collectively, the "Purchased Securities") for Purchaser's own 
account for investment only and not with a present view toward or in 
connection with the public sale or distribution thereof.  Purchaser will not 
resell the Purchased Securities or any securities which may be issued upon 
exercise of the Warrants except pursuant to an effective registration 
statement filed under the Securities Act or sales that are exempt from the 
registration requirements of the Securities Act and/or sales registered under 
the Securities Act.  Purchaser understands that Purchaser must bear the 
economic risk of this investment indefinitely, unless the Securities are 
registered pursuant to the Securities Act and any applicable state securities 
laws or an exemption from such Securities Act other than as contemplated by 
the Registration Rights Agreement. By making the representations in this 
Section 2.1, the Purchaser does not agree to hold the Securities for any 
minimum or other specific term and reserves the right to dispose of the 
Securities at any time in accordance with or pursuant to a registration 
statement or an exemption from registration under the Securities Act or 
applicable state securities laws.

    2.2  Accredited Investor Status.  Purchaser is an "accredited investor" 
as that term is defined in Rule 501(a) of Regulation D.

                                          2



    2.3. Reliance on Exemptions.  Purchaser understands that the Purchased 
Securities are being offered and sold to the Purchaser in reliance upon 
specific exemptions from the registration requirements of the United States 
federal and state securities laws and that the Company is relying upon the 
truth and accuracy of, and Purchaser's compliance with, the representations, 
warranties, agreements, acknowledgments and understanding of Purchaser set 
forth herein in order to determine the availability of such exemptions and 
the eligibility of Purchaser to acquire the Purchased Securities.

    2.4  Information.  Purchaser and its counsel have been furnished all 
materials relating to the business, finances and operations of the Company 
and materials relating to the offer and sale of the Purchased Securities 
which have been specifically requested by Purchaser.  Purchaser has been 
afforded the opportunity to ask questions of the Company and has received 
what Purchaser believes to be complete and satisfactory answers to any such 
inquiries.  Neither such inquiries nor any other due diligence investigation 
conducted by Purchaser or any of its representations shall modify, amend or 
affect Purchaser's right to rely on the Company's representations and 
warranties contained in Article III or the Officer's Certificate delivered 
pursuant to Section 3.3.  Purchaser understands that Purchaser's investment 
in the Securities involves a high degree of risk.

    2.5  Governmental Review.  Purchaser understands that no United States 
federal or state agency or any other government agency has passed upon or 
made any recommendation or endorsement of the Securities or an investment 
therein.

    2.6  Transfer or Resale.  Purchaser understands that (i) except as 
provided in the Registration Rights Agreement, the Securities have not been 
and are not being registered under the Securities Act or any state securities 
laws, and may not be transferred unless subsequently registered thereunder, 
an exemption from such registration is available (which exemption the Company 
expressly agrees may be established as contemplated in clauses (b) and (c) of 
Section 5.1 hereof) or such Securities are sold or transferred to an 
"affiliate" (as defined in Rule 144 under the Securities Act (or a successor 
rule) ("Rule 144")); (ii) any sale of such Securities made in reliance on Rule 
144 may be made only in accordance with the terms of said Rule and further, 
if said Rule is not applicable, any resale of such Securities without 
registration under the Securities Act under circumstances in which the seller 
may be deemed to be an underwriter (as that term is defined in the Securities 
Act) may require compliance with some other exemption under the Securities 
Act or the rules and regulations of the SEC thereunder; and (iii) neither the 
Company nor any other person is under any obligation to register such 
Securities under the Securities Act or any state securities laws or to comply 
with the terms and conditions of any exemption thereunder (in each case, 
other than pursuant to this Agreement or the Registration Rights Agreement).

    2.7  Legends.  Purchaser understands that, subject to Article V hereof, 
the certificates for the Common Shares and Warrant Shares, and until such 
time as the Common Shares and Warrant Shares have been registered under the 
Securities Act as contemplated by the Registration Rights Agreement or 
otherwise may be sold by Purchaser pursuant to Rule 144, the certificates for 
the Common Shares and Warrant Shares will be a restrictive legend (the 
"Legend") in the following form:

                                          3



    THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
    REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE
    SECURITIES LAWS OF ANY STATE OF THE UNITED STATES.  THE SECURITIES
    REPRESENTED HEREBY MAY NOT BE OFFERED OR SOLD OR OTHERWISE TRANSFERRED
    IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE
    SECURITIES UNDER APPLICABLE SECURITIES LAWS OR UNLESS OFFERED, SOLD OR
    TRANSFERRED PURSUANT TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION
    REQUIRMETNS OF THOSE LAWS.

    2.8  Authorization:  Enforcement.  This Agreement and the Registration 
Rights Agreement have been duly and validly authorized, executed and 
delivered on behalf of Purchaser and are valid and binding agreements of 
Purchaser enforceable against Purchaser in accordance with their terms.

    2.9  Residency.  Purchaser is a resident of the jurisdiction set forth 
under Purchaser's name on the signature page hereto executed by Purchaser.

    2.10 Organization.  Purchaser is duly organized, validity existing and in 
good standing under the laws of the jurisdiction in which it is formed, and has 
the requisite power and authority to own its properties and to carry on its 
business as now being conducted.

                                     ARTICLE III
                    REPRESENTATIONS AND WARRANTIES OF THE COMPANY
                                           
    The Company represents and warrants to the Purchaser that:

    3.1  Organization and Qualification.  The Company and each of its 
subsidiaries is a corporation duly organized, validity existing and in good 
standing under the laws of the jurisdiction in which it is incorporated, and 
has the requisite corporate power and authority to own its properties and to 
carry on its business as now being conducted.  The Company and each of its 
subsidiaries is duly qualified as a foreign corporation to do business and is 
in good standing in every jurisdiction where the failure to so qualify would 
have a Material Adverse Effect.  "Material Adverse Effect"  means any 
material adverse effect on either (i) the business, operations, properties, 
financial condition, operating results or prospects of the Company and its 
subsidiaries, taken as a whole on a consolidated basis or (ii) the 
transactions contemplated hereby.

    3.2  Authorization:  Enforcement.  (a) The Company has the requisite 
corporate power and authority to enter into and perform this Agreement, the 
Warrants and the Registration Rights Agreement, and to issue and sell, 
perform its obligations with respect to, the Purchased Securities in 
accordance with the terms hereof and to issue the Warrant Shares in 
accordance with the terms and conditions of the Warrants; (b) the execution, 
delivery and performance of this Agreement, the Warrants and the Registration 
Rights Agreement by the Company and the consummation by it of the 
transactions contemplated hereby and thereby (including without limitation 
the issuance of the Purchased Securities and the reservation for issuance and 
issuance of the Warrant Shares) 

                                          4



have been duly authorized by all necessary corporate action and, except as 
set forth on Schedule 3.2 hereof, no further consent or authorization of the 
Company, its board of directors, or its stockholders or any other person, 
body or agency is required with respect to any of the transactions 
contemplated hereby or thereby (whether under rules of NASDAQ National Market 
System ("NASDAQ"), the National Association of Securities Dealers or 
otherwise); (c) this Agreement, the Registration Rights Agreement and the 
Purchased Securities have been duly executed and delivered by the Company; 
and (d) this Agreement, the Registration Rights Agreement and the Purchased 
Securities constitute legal, valid and binding obligations of the Company 
enforceable against the Company in accordance with their terms.

    3.3  Capitalization.  The capitalization of the Company as of the date 
hereof, including the authorized capital stock, the number of shares issued 
and outstanding, the number of shares reserved for issuance pursuant to the 
Company's stock option plans, the number of shares reserved for issuance 
pursuant to securities (other than the Warrants) exercisable for, or 
convertible into or exchangeable for any shares of Common Stock and the 
number of shares to be initially reserved for issuance upon exercise of the 
Warrants is set forth on Schedule 3.3.  All of such outstanding shares of 
capital stock have been, or upon issuance will be, validly issued, fully paid 
and nonassessable.  No shares of capital stock of the Company (including the 
Common Shares and the Warrant Shares) are subject to preemptive rights or any 
other similar rights of the stockholders of the Company or any liens or 
encumbrances.  Except as disclosed in Schedule 3.3, as of the date of this 
Agreement, (i) there are no outstanding options, warrants, scrip, rights to 
subscribe for, calls or commitments of any character whatsoever relating to, 
or securities or rights convertible into or exercisable or exchangeable for, 
any shares of capital stock of the Company or any of its subsidiaries or 
contracts, commitments, understandings or arrangements by which the Company 
or any of its subsidiaries is or may become bound to issue additional shares 
of capital stock of the Company or any of its subsidiaries, (ii) there are no 
agreements or arrangements under which the Company or any of its subsidiaries 
is obligated to register the sale of any of its or their securities under the 
Securities Act (except the Registration Rights Agreement), and (iii) there 
are no anti-dilutive or price adjustment provisions contained in any security 
issued by the Company (or any agreement providing rights to security holders) 
that will be triggered by the issuance of the Purchased Securities or Warrant 
Shares.  The Company has furnished to Purchaser true and correct copies of 
the Company's Certificate of Incorporation as currently in effect 
("Certificate of Incorporation"), and the Company's By-laws as currently in 
effect (the "By-laws").  The Company has set forth on Schedule 3.3 all 
instruments and agreements (other than the Certificate of Incorporation and 
By-laws) governing securities convertible into or exercisable for Common 
Stock of the Company (and the Company shall provide to Purchaser copies 
thereof upon the request of Purchaser).  The Company shall provide Purchaser 
with a written update of this representation signed by the Company's Chief 
Executive Officer on behalf of the Company as of the date of the Closing.

    3.4  Issuance of Shares.  The Common Shares and Warrant Shares are duly 
authorized and reserved for issuance, and, upon consummation of the purchase 
contemplated hereby (with respect to the Common Shares) and exercise of the 
Warrants in accordance with the terms thereof (with respect to the Warrant 
Shares), will be validly issued, fully paid and non-assessable, and 

                                          5



free from all taxes, liens, claims and encumbrances and will not be subject 
to the preemptive rights or other similar rights of stockholders of the 
Company. The Common Shares are duly authorized and reserved for issuance, and 
are validly issued, fully paid and nonassessable, and free from all taxes, 
liens claims and encumbrances and are not and will not be subject to 
preemptive rights or other similar rights of stockholders of the Company.  
Accordingly, no further corporate authorization or approval is required under 
the rules of the NASDAQ with respect to the transaction contemplated by this 
Agreement, including, without limitation, the issuance of the Warrant Shares 
and the inclusion thereof on the NASDAQ.  The Company understands and 
acknowledges the potentially dilutive effect to the Common Stock upon the 
issuance of the Common Shares and, upon exercise of the Warrants, the Warrant 
Shares.  The Company further acknowledges that its obligation to issue the 
Common Shares and the Warrant Shares upon the exercise of the Warrants in 
accordance with this Agreement and the Warrants is absolute and unconditional 
regardless of the dilutive effect that such issuance may have on the 
ownership interests of other stockholders of the Company.

    3.5  No Conflicts.  The execution, delivery and performance of this 
Agreement, the Warrants and the Registration Rights Agreement by the Company, 
and the consummation by the Company of transactions contemplated hereby and 
thereby (including, without limitation, the issuance and reservation for 
issuance, as applicable, of the Common Shares and Warrant Shares) will not 
(a) result in a violation of the Certificate of Incorporation or By-laws, (b) 
violate or conflict with, or constitute a default (or an event which with 
notice or lapse of time or both would become a default) under, or give to 
others any rights of termination, amendment, acceleration, or cancellation 
of, any agreement, indenture or instrument to which the Company or any of its 
subsidiaries is a party (except for such conflicts, defaults, terminations, 
amendments, accelerations, and cancellations as would not, individually or in 
the aggregate, have a Material Adverse Effect), or (c) result in a violation 
of any law, rule, regulation, order, judgment or decree to the Company or any 
of its subsidiaries, or by which any property or asset of the Company or any 
of its subsidiaries, is bound or affected.  Neither the Company nor any of 
its subsidiaries is in violation of its Certificate of Incorporation, By-laws 
or other organizational documents, and neither the Company nor any of its 
subsidiaries is in default (and no event has occurred which, with notice or 
lapse of time or both, would put the Company or any of its subsidiaries in 
default) under, nor has there occurred any event giving others (with notice 
or lapse of time or both) any rights of termination, amendment, acceleration 
or cancellation of, any agreement, indenture or instrument to which the 
Company or any of its subsidiaries is a party, except for possible defaults 
or rights as would not, individually or in the aggregate, have a Material 
Adverse Effect. The business of the Company and its subsidiaries are not 
being conducted, and shall not be conducted so long as Purchaser owns any of 
the Securities, in violation of any law, ordinance, rule, regulation, order, 
judgment or decree of any governmental entity, court or arbitration tribunal 
except for possible violations the sanctions for which either singly or in 
the aggregate would not have a Material Adverse Effect.  Except as set forth 
on Schedule 3.5, the Company is not required to obtain any consent, 
authorization or order of, or make any filing or registration with, any court 
or governmental agency or any regulatory or self-regulatory agency in order 
for it to execute, deliver or perform any of its obligations under this 
Agreement, the Warrants or the Registration Rights Agreement or to perform 
its obligations in accordance with the terms hereof or thereof.  The Company 
is not in violation of the listing requirements of NASDAQ and does not 
reasonably anticipate that the Common Stock will be delisted by NASDAQ for 
the foreseeable future.  The Company and its subsidiaries are unaware of any 
facts which might give rise to any of the foregoing.

                                          6



    3.6  Registration and SEC Documents.  The Common Stock is registered 
under Section 12 of the Securities Exchange Act of 1934, as amended (the 
"Exchange Act") and has been so registered since 1969.  Except as disclosed 
in Schedule 3.6, since January 1, 1995, the Company has timely filed all 
reports, schedules, forms, statements and other documents required to be 
filed by it with the SEC pursuant to the reporting requirements of the 
Exchange Act (all of the foregoing filed after December 31, 1993 and all 
exhibits included therein and financial statements and schedules thereto and 
documents incorporated by reference therein, being referred to herein as the 
"SEC Documents").  The Company has delivered to Purchaser true and complete 
copies of the SEC Documents, except for exhibits, schedules and incorporated 
documents (the SEC documents filed prior to the date hereof being the "Filed 
SEC Documents").  As of their respective dates, the SEC Documents complied in 
all material respects with the requirements of the Exchange Act and the rules 
and regulations of the SEC promulgated thereunder applicable to the SEC 
Documents, and none of the SEC Documents, at the time they were filed with 
the SEC, contained any untrue statements of a material fact or omitted to 
state a material fact required to be stated therein or necessary in order to 
make the statements therein, in light of the circumstances under which they 
were made, not misleading.  None of the statements made in any such SEC 
Documents is required to be updated or amended under applicable law.  The 
financial statements of the Company included in the SEC Documents have been 
prepared in accordance with U.S. generally accepted accounting principles, 
consistently applied, and the rules and regulations of the SEC during the 
periods involved (except (i) as may be otherwise indicated in such financial 
statements or the notes thereto, or (ii) in the case of unaudited interim 
statements, to the extent they do not include footnotes or are condensed or 
summary statements) and present accurately and completely the consolidated 
financial position of the Company and its consolidated subsidiaries as of the 
dates thereof and the consolidated results of their operations and cash flows 
for the periods then ended (subject, in the case of unaudited statements, to 
normal, immaterial year-end audit adjustments).  Except as set forth in the 
financial statements of the Company included in the Filed SEC Documents, the 
Company has no liabilities, contingent or otherwise, other than (i) 
liabilities incurred subsequent to the date of such financial statements in 
the ordinary course of business consistent with the past practice and (ii) 
obligations under contracts and commitments incurred in the ordinary course 
of business and not required under generally accepted accounting principles 
to be reflected in such financial statements, in each case of clause (i) and 
(ii) next above which, individually and in the aggregate, are not material to 
the financial condition, business, operations, properties, operating results 
or prospects of the Company and its subsidiaries taken on a whole.  The Filed 
SEC Documents contain a complete and accurate list of all material 
undischarged written or oral contracts, agreements, leases or other 
instruments to which the Company or any subsidiary is a party or by which the 
Company or any subsidiary is bound or to which any of the properties or 
assets of the Company or any subsidiary is subject (each a "Contract").  None 
of the Company, its subsidiaries or, to the best knowledge of the Company, 
any of the other parties thereto, is in breach or violation of any Contract, 
which breach or violation would have a Material Adverse Effect.  No event, 
occurrence or condition exists which, with the lapse of time, the giving of 
notice, or both, or the happening of any further event or condition, would 
become a breach or default by the Company or its subsidiaries or, to the 
Company's knowledge, by any other party under any Contract which breach or 
default would have a Material Adverse Effect.

    3.7  Absence of Certain Changes.  Since December 31, 1996, there has been 
no material adverse change and no material adverse development in the 
business, properties, 

                                          7



operations, financial condition, results of operations or prospects of the 
Company, except as disclosed in Schedule 3.7.

    3.8  Absence of Litigation.  Except as disclosed in Schedule 3.8, there 
is no action, suit, proceeding, inquiry or investigation before or by any 
court, public board, governmental agency or authority, or self-regulatory 
organization or body pending or, to the knowledge of the Company or any of 
its subsidiaries, threatened against or affecting the Company, any of its 
subsidiaries, or any of their respective directors or officers in their 
capacities as such, wherein an unfavorable decision, ruling or finding would 
have a Material Adverse Effect or would adversely affect the transactions 
contemplated by this Agreement or any of the documents contemplated hereby or 
which would adversely affect the validity or enforceability of, or the 
authority or ability of the Company to perform its obligations under, this 
Agreement or any of such other documents.  There are no facts which, if known 
by a potential claimant or governmental agency or authority, could give rise 
to a claim or proceeding which, if asserted or conducted with results 
unfavorable to the Company or any of its subsidiaries, could have a Material 
Adverse Effect.

    3.9  Disclosure.  No information relating to or concerning the Company 
set forth in this Agreement or provided to Purchaser in connection with the 
transactions contemplated hereby contains an untrue statement of a material 
fact or omits to state a material fact necessary in order to make the 
statements made herein or therein, in light of the circumstances under which 
they were made, not misleading.  Except for the execution and performance of 
this Agreement, no material fact (within the meaning of the federal 
securities laws of the United States) exists with respect to the Company or 
any of its subsidiaries which has not been publicly disclosed.

    3.10 Acknowledgment Regarding Purchaser's Purchase of the Securities.  
The Company acknowledges and agrees that Purchaser is not acting as a 
financial advisor or fiduciary of the Company (or in any similar capacity) 
with respect to this Agreement or the transactions contemplated hereby, that 
this Agreement and the transaction contemplated hereby, and the relationship 
between Purchaser and the Company, are "arms-length", and that any statement 
made by Purchaser, or any of its representatives or agents, in connection 
with the Agreement or the transactions contemplated hereby is not advice or a 
recommendation, is merely incidental to Purchaser's purchase of the 
Securities and has not been relied upon in any way by the Company, its 
officers, directors or other representatives.  The Company further represents 
to Purchaser that the Company's decision to enter into this Agreement and the 
transactions contemplated hereby has been based solely on an independent 
evaluation by the Company and its representatives.

    3.11 Current Public Information.  The Company currently meets the 
"Registrant eligibility requirements" set forth in the general instructions to 
Form S-3 under the Securities Act.

    3.12 No General Solicitation.  Neither the Company nor any person acting 
on behalf of the Company has conducted any "general solicitation," as 
described in Rule 502(c) under Regulation D, with respect to any of the 
Securities being offered hereby.

    3.13 No Integrated Offering.  Neither the Company, nor any if its 
affiliates, nor any person acting on its or their behalf, has directly or 
indirectly made any offers or sales of any security or solicited any offers 
to buy any security under circumstances that would prevent the parties hereto 
from consummating the transactions contemplated hereby pursuant to an 

                                          8



exemption from registration under the Securities Act pursuant to the 
provisions of Regulation D.  The transactions contemplated hereby are exempt 
from the registration requirements of the Securities Act, assuming the 
accuracy of the representations and warranties herein contained of Purchaser 
to the extend relevant for such determination.  The issuance of the 
Securities to the Purchaser will not be integrated with any other issuance of 
the Company's Securities (past, present, or future) which requires 
stockholder approval under the rules of the NASDAQ stock market.

    3.14 No Brokers.  The Company has taken no action which would give rise 
to any claim by any person for brokerage commissions, finder's fees or 
similar payments to Purchaser relating to this Agreement or the transactions 
contemplated hereby, except for dealings with Wharton Capital and Coppers & 
Lybrand Securities LLP (the fees of which shall be paid in full by the 
Company). The Company will indemnify Purchaser from and against any fees and 
expenses sought or other claims made by Wharton Capital and Coppers & Lybrand 
Securities LLP.

    3.15 Acknowledgment of Terms and Nature of Securities.  The Company's 
executive officers and directors have studied and fully understand the terms 
and nature of the securities being sold hereunder.  The board of directors of 
the Company has concluded in its good faith business judgment that such 
issuance is in the best interests of the Company.

    3.16 Intellectual Property.  Each of the Company and its subsidiaries 
owns or possesses adequate and enforceable rights to use all patents, patent 
applications, trademarks, trademark applications, trade names, service marks, 
copyrights, copyright applications, licenses, know-how (including trade 
secrets and other unpatented and/or unpatentable proprietary or confidential 
information, systems or procedures) and other similar rights and proprietary 
knowledge (collectively, "Intangibles") used or necessary for the conduct of 
its business as now being conducted and as previously described in the 
Company's Annual Report on Form 10-KSB for its most recently ended fiscal 
year.  Neither the Company nor any subsidiary of the Company infringes on or 
is in conflict with any right or any other person with respect to any 
Intangibles nor is there any claim or infringement made by a third party 
against or involving the Company or any of its subsidiaries, which 
infringement, conflict or claim, individually or in the aggregate, if the 
subject of an unfavorable decision, ruling or finding, would have a Material 
Adverse Effect.

    3.17 Foreign Corrupt Practices.  Neither the Company, nor any of its 
subsidiaries, nor any director, officer, agent, employee or other person 
acting on behalf of the Company or any subsidiary has, in the course of his 
actions for, or on behalf of, the Company, used any corporate funds for any 
unlawful contribution, gift, entertainment or other unlawful expenses 
relating to political activity; made any direct or indirect unlawful payment 
to any foreign or domestic government official or employee from corporate 
funds; violated or is in violation of any provision of the U.S. Foreign 
Corrupt Practices Act of 1977, as amended; or made any bribe, rebate, payoff, 
influence payment, kickback or other unlawful payment to any foreign or 
domestic government official or employee.  Without limiting the generality of 
the foregoing, the Company and its subsidiaries have not directly or 
indirectly made or agreed to make (whether or not said payment is lawful) any 
payment to obtain, or with respect to, sales other than usual and regular 
compensation to its or their employees and sales representatives with respect 
to such sales.

                                          9



    3.18 Key Employees.  Each Key Employee (as defined below) is currently 
serving the Company in the capacity disclosed in Schedule 3.18.  No Key 
Employee, to the best of the knowledge of the Company and its subsidiaries, 
is, or is now expected to be, in violation of any material term of any 
employment contract, confidentiality, disclosure or proprietary information 
agreement, non-competition agreement, or any other contract or agreement or 
any restrictive covenant, and the continued employment of each Key Employee 
does not subject the Company or any of its subsidiaries to any liability with 
respect to any of the foregoing matters.  No Key Employee has, to the best of 
the knowledge of the Company and its subsidiaries, any intention to terminate 
or limit his employment with, or services to, the Company or any of its 
subsidiaries, nor is any such Key Employee subject to any constraints (e.g., 
limitation) which would cause such employee to be unable to devote his full 
time and attention to such employment or services.  "Key Employee" means each 
of individuals listed on Schedule 3.18.

    3.19 Certain Transactions.  Except as set forth on Schedule 3.19 and 
except for arm's length transactions pursuant to which the Company or any of 
its Subsidiaries makes payments in the ordinary course of business upon terms 
no less favorable than the Company or any of its Subsidiaries could obtain 
from third parties and other than the grant of stock options disclosed on 
Schedule 3.3, none of the officers, directors, or employees of the Company is 
presently a party to any transaction with the Company or any of its 
Subsidiaries (other than for services as employees, officers and directors), 
including any contract, agreement or other arrangement providing for the 
furnishing of services to or by, providing for rental of real or personal 
property to or from, or otherwise requiring payments to or from any officer, 
director or such employee or, to the knowledge of the Company, any 
corporation, partnership, trust or other entity in which any officer, 
director, or any such employee has a substantial interest or is an officer, 
director, trustee or partner.

    3.20 Internal Accounting Controls.  The Company and each of its 
Subsidiaries maintain a system of internal accounting controls sufficient, in 
the judgment of the Company's board of directors, to provide reasonable 
assurance that (i) transactions are executed in accordance with management's 
general or specific authorizations, (ii) transactions are recorded as 
necessary to permit preparation of financial statements in conformity with 
generally accepted accounting principles and to maintain asset 
accountability, (iii) access to assets is permitted only in accordance with 
management's general or specific authorization and (iv) the recorded 
accountability for assets is compared with the existing assets at reasonable 
intervals and appropriate action is taken with respect to any differences.

                                      ARTICLE IV
                                      COVENANTS
                                           
    4.1  Best Efforts.  The Company shall use its best efforts timely to 
satisfy each of the conditions described in Articles VI and VII of this 
Agreement.

    4.2  Securities Laws.  The Company agrees to file a Form D with respect 
to the Securities with the SEC as required under Regulation D and to provide 
a copy thereof to Purchaser within five (5) business days following the Date 
of Closing.  The Company agrees to file a Form 8-K disclosing this Agreement 
and the transactions contemplated hereby with the SEC within five business 
(5) days following the date of Closing.  Such Form 8-K shall include 

                                          10



this Agreement and the related transaction documents as exhibits thereto.  
The Company shall, on or prior to the date of Closing, take such action as is 
necessary to sell the Securities to Purchaser in accordance with applicable 
securities laws of states of the United States, and shall provide evidence of 
any such action so taken to Purchaser on or prior to the date of Closing. 
Without limiting any of the Company's obligations under this Agreement, the 
Registration Rights Agreement or the Warrants, from and after the date of 
Closing, neither the Company nor any person acting on its behalf shall take 
any action which would adversely affect any exemptions from registration 
under the Securities Act with respect to the transactions contemplated hereby.

    4.3  Reporting Status.  For so long as the Purchaser owns any of the 
Securities or three (3) years from the Closing Date, whichever is sooner, the 
Company shall timely file all reports required to be filed with the SEC 
pursuant to the Exchange Act, and the Company shall not terminate its status 
as an issuer required to file reports under the Exchange Act even if the 
Exchange Act or the rules and regulations thereunder would permit such 
termination.  The Company will take all action necessary to continue to meet 
the registrant eligibility requirements set forth in the general instruction 
to Form S-3.

    4.4  Use of Proceeds.  The Company shall use the proceeds from the sale 
of the Common Shares and Warrants for general working capital needs, capital 
expenditures including software development for future contracts and expenses 
associated with new health care call center ventures.

    4.5  Restriction on Below Market Issuance of Securities.  (a) For a 
period of one hundred and eighty (180) days following the date of Closing 
(the "Restricted Period"), the Company shall not issue or agree to issue 
(except (i) to Purchaser pursuant to this Agreement, (ii) pursuant to any 
employee stock option, stock purchase or restricted stock plan of the Company 
in effect on the date hereof up to the aggregate amounts set forth on 
Schedule 4.5 hereto, (iii) pursuant to any existing security, option, 
warrant, scrip, call or commitment or right in each case or disclosed on 
Schedule 3.3 hereof or (iv) pursuant to a strategic joint venture or 
partnership entered into by the Company, undertaken at the reasonable 
discretion of the Board of Directors of the Company, the primary purpose of 
which is not to raise equity capital) any equity securities (including debt 
securities with an equity component) of the Company (or any security 
convertible into or exercisable or exchangeable, directly or indirectly, or 
equity securities of the Company) if such securities are issued at a price 
(or in the case of securities convertible into or exercisable or 
exchangeable, directly or indirectly, for Common Stock such securities 
provide for a conversion, exercise or exchange price) which may be less than 
the then current market price for Common Stock on the date of issuance (in 
the case of Common Stock) or the date of conversion, exercise or exchange (in 
the case of securities convertible into or exercisable or exchangeable, 
directly or indirectly, for Common Stock).

    4.6  Right of First Offer.  For a period of one year after the expiration 
of the Restricted Period, the Company shall not issue or sell, or agree to 
issue or sell any equity or debt securities of the Company (or any security 
convertible into or exercisable or exchangeable, directly or indirectly, for 
equity or debt securities of the Company) ("Future Offerings") unless the 
Company shall have first delivered to Purchaser at least fifteen (15) 
business days prior to the closing of such Future Offering, written notice 
describing the proposed Future Offering, 

                                          11



including the terms and conditions thereof, and providing Purchaser and its 
affiliates an option during the ten (10) business days period following 
delivery of such notice to purchase up to the full amount of the securities 
being offered in the Future Offering on the same terms as contemplated by 
such Future Offering (the limitations referred to in this sentence are 
collectively referred to as the "Capital Raising Limitations").  The Capital 
Raising Limitations shall not apply to any transaction involving issuances of 
securities in connection with a bona fide merger or consolidation or exercise 
of options of employees, consultants or directors.  In addition, the Capital 
Raising Limitations also shall not apply to (a) the issuance of securities 
upon exercise of conversion of the Company's options, warrants or other 
convertible securities outstanding as of the date hereof or (b) the grant of 
additional options or warrants, or the issuance of additional securities, 
under any employee stock option, stock purchase or restricted stock plan of 
the Company up to the aggregate amounts set forth on Schedule 4.5 hereto.  
This Section 4.6 shall not limit the Company's obligations under Section 4.5 
above.  The Company shall prohibit any Common Stock or other security issued 
subject to the Capital Raising Limitations but not purchased by Purchaser 
from being converted, exercised or resold until the day following the first 
anniversary of the date of the Closing and shall take all actions necessary 
(including, without limitation, the issuance of a stop transfer order) to 
effect such prohibition.  Notwithstanding anything to the contrary contained 
herein, and without limiting any of the Company's other obligations in this 
Agreement, the Registration Rights Agreement or the Warrants, any securities 
issued in a Future Offering (whether or not to Purchaser) (and any security 
issued upon conversion, exercise or exchange of any of such security) shall 
be ineligible for conversion, exercise, exchange, resale and/or registration 
under Federal or state securities laws for a period of six (6) months 
following the closing of such Future Offering.

    4.7  Expenses.  The Company shall pay to Purchaser, or at its direction, 
at the Closing reimbursement for the expenses reasonably incurred by it and 
its affiliates and advisors in connection with the negotiation, preparation, 
execution, and delivery of this Agreement and the other agreements to be 
executed in connection herewith, including, without limitation, Purchaser's 
and its affiliates' and advisors' due diligence and attorneys' fees and 
expenses (the "Expenses"); provided, however, that the Company shall not be 
obliged under this Section 4.7 to reimburse more than an aggregate of 
$10,000.00 of such attorneys' fees and expenses.  From time to time 
thereafter, upon Purchaser's written request, the Company shall pay to 
Purchaser such Expenses, if any, not so paid at Closing and/or covered by 
such payment, in each case to the extent reasonably incurred by Purchaser up 
to the $10,000.00 maximum amount.

    4.8  Information.  For so long as the Purchaser owns any of the 
Securities or three (3) years from the Closing Date, whichever is sooner, the 
Company agrees to send the following reports to Purchaser until Purchaser 
transfers, assigns or sells all of its Securities:  (a) within three (3) days 
after the filing with SEC, a copy of its Annual Report on Form 10-KSB, its 
Quarterly Reports on Form 10-QSB, any proxy statements and any Current 
Reports on Form 8-KSB; and (b) within one (1) day after release, copies of 
all press releases issued by the Company or any if its subsidiaries.  The 
Company further agrees to promptly provide to Purchaser or assignee thereof 
(a "Holder") any information with respect to the Company, its properties, or 
its business or Holder's investment as such Holder may reasonably request; 
provided, however, that the Company shall not be required to give any Holder 
any material nonpublic information.  If any information requested by a Holder 
from the Company contains material nonpublic information, the Company shall 
inform the Holder in writing that the information requested contains material 

                                          12



nonpublic information and shall in no event provide such information to 
Holder without the express prior written consent of such Holder after being 
so informed.

    4.9  Reservation of Shares.  The Company shall at times have authorized 
and reserved for the purpose of issuance of a sufficient number of shares to 
provide for the full exercise of the outstanding Warrants and issuance of the 
Warrant Shares in connection therewith and as otherwise required by the 
Warrants.  The Company shall not reduce the number of shares reserved for 
issuance upon exercise of the Warrants without the consent of Purchaser 
holding a majority in interest of the Warrants then held by Purchaser (said 
majority in interest to be determined based on the number of Warrant Shares 
issuable upon exercise of said Warrants).

    4.10 Listing. The Company shall promptly secure and maintain listing and 
trading of the Common Shares and Warrant Shares on the NASDAQ and any other 
national securities exchange or quotation system on which the Common Stock is 
then listed and for so long as Purchaser owns any of the Securities or three 
(3) years from the Closing Date, whichever is sooner, and comply in all 
respects with the Company's reporting, filing and other obligations under the 
by-laws or rules of the NASDAQ and any other national securities exchange or 
quotation system on which the Common Stock is then listed.

    4.11 Prospectus Delivery Requirement.  Purchaser understands that the 
Securities Act may require delivery of a prospectus relating to the Common 
Stock in connection with any sale thereof pursuant to a registration 
statement under the Securities Act covering the resale by Purchaser of the 
Common Stock being sold, and Purchaser shall use its reasonable efforts to 
comply with the applicable prospectus delivery requirements of the Securities 
Act, if any, in connection with any such sale.

    4.12 Intentional Acts or Omissions.  The Company shall not intentionally 
perform any act which if performed, or intentionally omit to perform any act 
which, if omitted to be performed, would prevent or excuse the performance of 
this Agreement or any of the transactions contemplated hereby.

    4.13 Corporate Existence.  So long as Purchaser beneficially owns any 
Securities or for three (3) years from the Closing Date, whichever is sooner, 
the Company shall maintain its corporate existence and shall not sell all or 
substantially all of the Company's assets, except in the event of a merger or 
consolidation or sale of all or substantially all of the Company's assets, 
where the surviving or successor entity in such transaction (i) assumes the 
Company's obligations hereunder and under the agreements and instruments 
entered into in connection herewith and (ii) is a publicly traded corporation 
whose Common Stock is listed for trading on NASDAQ, NASDAQ SmallCap, NYSE, or 
AMEX.

    4.14 Hedging Transactions.  The Company hereby expressly agrees that 
Purchaser shall not in any way be prohibited or restricted from any purchases 
or sales of any securities or other instruments of, or related to, the 
Company or any of its securities, including, without limitation, puts, call, 
futures contracts, short sales and hedging and arbitrage transactions as long 
as Purchaser complies with applicable law.

                                          13



                                      ARTICLE V
                     LEGEND REMOVAL, TRANSFER, AND CERTAIN SALES
                                           
    5.1  Removal of Legend.  The Legend shall be removed and the Company 
shall issue a certificate without any legend to the holder of any Security 
upon which such Legend is stamped, and a certificate for a security shall be 
originally issued without any legend, if, unless otherwise required by 
applicable state securities laws, (a) the sale of such Security is registered 
under the Securities Act, (b) such holder provides the Company with an 
opinion of counsel, in form, substance and scope customary for opinions of 
counsel in comparable transactions (the reasonable cost of which shall be 
borne by the Company), to the effect that a public sale or transfer of such 
Security may be made without registration under the Securities Act or (c) 
such Security can be sold pursuant to Rule 144.  Purchaser agrees to sell all 
Securities, including those represented by a certificate(s) from which the 
Legend has been removed, or which were originally issued without the Legend, 
pursuant to an effective registration statement and, if required, to deliver 
a prospectus in connection with such sale or in compliance with an exemption 
from the registration requirements of the Securities Act.  In the event the 
Legend is removed from any Security or any Security is issued without the 
Legend and thereafter the effectiveness of a registration statement covering 
the resale of such Security is suspended or the Company determines that a 
supplement or amendment thereto is required by applicable securities laws, 
then upon reasonable advance notice to Purchaser holding such Security, the 
Company may require that the Legend be placed on any such Security that 
cannot then be sold pursuant to an effective registration statement or Rule 
144 or with respect to which the opinion referred to in clause (b) next above 
has not been rendered, which Legend shall be removed when such Security may 
be sold pursuant to an effective registration statement or Rule 144 or such 
holder provides the opinion with respect thereto described in clause (b) next 
above.

    5.2  Transfer Agent Instructions.  The Company shall irrevocably instruct 
its transfer agent to issue certificates, registered in the name of Purchaser 
or its nominee, for the Common Shares and Warrant Shares in such amounts as 
specified from time to time by Purchaser to the Company.  Such certificates 
shall bear a legend only in the form of the Legend and only to the extend 
permitted by Section 5.1 above.  The Company warrants that no instruction 
other than such instructions referred to in this Article V, and no stop 
transfer instructions other than stop transfer instructions to give effect to 
Section 2.6 hereof in the case of the Common Shares and Warrant Shares prior 
to registration thereof under the Securities Act, will be given by the 
Company to its transfer agent and that the Securities shall otherwise be 
freely transferable on the books and records of the Company to the extent 
provided in this Agreement and the Registration Rights Agreement.  Nothing in 
this Section shall affect in any way Purchaser's obligations and agreement 
set forth in Section 5.1 hereof to resell the Securities pursuant to an 
effective registration statement and to deliver a prospectus in connection 
with such sale or in compliance with an exemption from the registration 
requirements of applicable securities laws. Without limiting the foregoing, 
if (a) Purchaser provides the Company with an opinion of counsel, which 
opinion of counsel shall be in form, substance and scope customary for 
opinions of counsel in comparable transactions (the reasonable cost of which 
shall be borne by the Company), to the effect that the Securities to be sold 
or transferred may be sold or transferred pursuant to an exemption from 
registration or (b) Purchaser transfers Securities to an affiliate or 
pursuant to Rule 144, the Company shall permit the transfer, and, in the case 
of the Common Shares and Warrant Shares, promptly instruct its transfer agent 
to issue one or more certificates in such name 

                                          14



and in such denomination as specified by Purchaser in order to effect such a 
transfer or sale.  The Company acknowledges that a breach by it of its 
obligations hereunder will cause irreparable harm to Purchaser by vitiating 
the intent and purpose of the transaction contemplated hereby.  Accordingly, 
the Company acknowledges that the remedy at law for a breach of its 
obligations under this Article V will be inadequate and agrees, in the event 
of a breach of threatened breach by the Company of the provisions of this 
Article V, that Purchaser shall be entitled, in addition to all other 
available remedies, to an injunction restraining any breach and requiring 
immediate issuance and transfer, without the necessity of showing economic 
loss and without any bond or other security being required.

                                      ARTICLE VI
                    CONDITIONS TO THE COMPANY'S OBLIGATION TO SELL
                                           
    6.1  Conditions to the Company's Obligation to Sell.  The obligation of 
the Company hereunder to issue and sell the Common Shares and Warrants to 
Purchaser at the Closing is subject to the satisfaction, as of the date of 
the Closing and with respect to Purchaser, of each of the following 
conditions thereto, provided that these conditions are for the Company's sole 
benefit and may be waived by the Company at any time in its sole discretion:

    (a)  Purchaser shall have executed the signature page to this Agreement
         and the Registration Rights Agreement and delivered the same to the
         Company.
    (b)  Purchaser shall deliver the applicable Purchase Price for the Common
         Shares and Warrants purchased at the Closing.
    (c)  The representations and warranties of Purchaser shall be true and
         correct as of the date when made and as of the Closing as though made
         at the that time, and Purchaser shall have performed, satisfied and
         complied in all material respects with the covenants and agreements
         required by this Agreement to be performed or complied with by
         Purchaser at or prior to the Closing.
    (d)  No statute, rule, regulation, executive order, decree, ruling or
         injunction shall have been enacted, entered, promulgated, or endorsed
         by any court or governmental authority of competent jurisdiction or
         any self-regulatory organization having authority over the matters
         contemplated hereby which restricts or prohibits the consummation of
         any of the transactions contemplated by this Agreement.

                                     ARTICLE VII
                CONDITIONS TO EACH PURCHASER'S OBLIGATION TO PURCHASE
                                           
    The obligation of Purchaser hereunder to purchase the Common Shares and 
Warrants to be purchased by it on the date of the Closing is subject to the 
satisfaction of each of the following conditions, provided that these 
conditions are for Purchaser's sole benefit and may be waived by Purchaser 
(with respect to it) at any time in Purchaser's sole discretion:

    (a)  The Company shall have executed the signature page to this Agreement
         and the Registration Rights Agreement and delivered the same to
         Purchaser.
                                          15



    (b)  The Company shall have delivered duly executed Warrants and
         certificates for the Common Shares (in each case in such denominations
         as Purchaser shall request) being so purchased by Purchaser at the
         Closing.

    (c)  The Common Stock shall be listed on the NASDAQ and trading in the
         Common Stock shall not have been suspended and no delisting or
         suspension shall be reasonably likely for the foreseeable future.
    (d)  The representations and warranties of the Company shall be true and
         correct as of the date when made and as of the Closing as though made
         at that time and the Company shall have performed, satisfied and
         complied with the covenants and agreements required by this Agreement
         to be performed or complied with by the Company at or prior to the
         Closing.  Purchaser shall have received a certificate, executed by the
         Chief Executive Officer of the Company, dated as of the Closing to the
         foregoing effect and as to such other matters as may be reasonably
         requested by Purchaser.

    (e)  No statute, rule, regulation, executive order, decree, ruling or
         injunction shall have been enacted, entered, promulgated or endorsed
         by any court or governmental authority of competent jurisdiction or
         any self-regulatory organization having authority over the matters
         contemplated hereby which prohibits the consummation of any of the
         transactions contemplated by this Agreement.

    (f)  Purchaser shall have received the officer's certificate described in
         Section 3.3 as of the Closing.

    (g)  Purchaser shall have received opinions of the Company's counsel, dated
         as of the Closing, in the form attached hereto as Exhibit C.

    (h)  The Company's transfer agent has agreed to act in accordance with
         irrevocable instructions in the form attached hereto as Exhibit D.

    (i)  The Company shall have entered into agreements with each of Gilbert V.
         Levin and M. Karen Levin restricting dispositions of Common Stock
         beneficially owned by such persons and in the form attached hereto as
         Exhibit E.

                                     ARTICLE VIII
                            GOVERNING LAW:  MISCELLANEOUS
                                           
    8.1  Governing Law:  Jurisdiction.  This Agreement shall be governed by 
and construed in accordance with the laws of the State of Delaware applicable 
to contracts made and to be performed in the State of Delaware.  The parties 
hereto irrevocably consent to the jurisdiction of the United States federal 
courts located in the State of Delaware and the state courts located in the 
County of New Castle in the State of Delaware in any suit or proceeding based 
on or arising under this Agreement or the transactions contemplated hereby 
and irrevocably agree that all claims in respect of such suit or proceeding 
may be determined in such courts.  The Company irrevocably waives the defense 
of an inconvenient forum to the maintenance of such suit or proceeding.  The 
Company further agrees that service of process upon the Company mailed by the 
first class mail shall be deemed in every respect effective service of 
process upon the Company in any suite or proceeding arising hereunder.  
Nothing 

                                          16



herein shall affect Purchaser's right to serve process in any other manner 
permitted by law.  The parties hereto agree that a final non-appealable 
judgment in any such suit or proceeding shall be conclusive and may be 
enforced in other jurisdictions by suit on such judgment or in any other 
lawful manner.

    8.2  Counterparts.  This Agreement may be executed in two or more 
counterparts, including, without limitation, by facsimile transmission, all 
of which counterparts shall be considered one and the same agreement and 
shall become effective when counterparts have been signed by each party and 
delivered to the other party.  In the event any signature page is delivered 
by facsimile transmission, the party using such means of delivery shall cause 
additional original executed signature pages to be delivered to the other 
parties.

    8.3  Headings.  The headings of this Agreement are for convenience of 
reference and shall not form part of, or affect the interpretation of, this 
Agreement.

    8.4  Severability.  If any provision of this Agreement shall be invalid 
or unenforceable in any jurisdiction, such invalidity or unenforceability 
shall not affect the validity or enforceability of the remainder of this 
Agreement or the validity or enforceability of this Agreement in any other 
jurisdiction.

    8.5  Entire Agreement:  Amendments.  This Agreement and the instruments 
referenced herein contain the entire understanding of the parties with 
respect to the matters covered herein and therein and, except as specifically 
set forth herein or therein, neither the Company nor Purchaser makes any 
representation, warranty, covenant or undertaking with respect to such 
matters.  No provision of this Agreement may be waived other than by an 
instrument in writing signed by the party to be charged with enforcement and 
no provision of this Agreement may be amended other than by an instrument in 
writing signed by the Company and Purchaser.

    8.6  Notice.  Any notice herein required or permitted to be given shall 
be in writing and may be personally served or delivered by courier or by 
facsimile-machine confirmed telecopy, and shall be deemed delivered at the 
time and date of receipt (which shall include telephone line facsimile 
transmission). The addresses for such communications shall be:

              If to the Company:
              
              Biospherics Incorporated
              12051 Indian Creek Court
              Beltsville, MD  20705
              Telecopy:  301-210-4908/09
              Attention:  Dr. Gilbert V. Levin
              
                   with a copy to:
              
              Smith, Somerville & Case, L.L.C.
              Attorneys At Law
              100 Light Street
              Baltimore, MD  21202

                                          17



              Telecopy:  410-385-8060
              Attention:  James Baker, Esq.
              
              If to RGC International Investors, LDC:
              
              c/o Rose Glen Capital Management, L.P.
              251 St. Asaphs Road
              Suite 200
              3 Bala Plaza East
              Bala Cynwyd, PA  19004
              Telecopy:  610-617-0570
              Attention:  Wayne D. Bloch
              
                   with a copy to:
              
              Ballard, Spahr, Andrews & Ingersoll
              1735 Market Street
              51st Floor
              Philadelphia, PA  19103
              Telecopy:  215-864-8999
              Attention:  Gerald J. Guarcini, Esq.

If to any other Purchaser, to such address set forth under Purchaser's name 
on the signature page hereto executed by Purchaser.  Each party shall provide 
notice to the other parties of any change in address.

    8.7  Successors and Assigns.  This Agreement shall be binding upon and 
inure to the benefit of the parties and their successors and assigns.  
Neither the Company nor Purchaser shall assign this Agreement or any rights 
or obligations hereunder without any prior written consent of the other. 
Notwithstanding the foregoing, Purchaser may assign its rights and 
obligations hereunder to any of its "affiliates," as that term is defined 
under the Exchange Act, without the consent of the Company so long as such 
affiliate is an accredited investor.  This provision shall not limit 
Purchaser's right to transfer the Securities pursuant to the terms of this 
Agreement or to assign Purchasers' rights hereunder to any such transferee 
(and all such rights may in fact be so assigned to any such transferee).  
Notwithstanding anything to the contrary contained in this Agreement, 
Purchaser may pledge the Securities in connection with a bona fide margin 
arrangement.

    8.8  Third Party Beneficiaries.  This Agreement is intended for the 
benefit of the parties hereto and their respective permitted successors and 
assigns and is not for the benefit of, nor may any provision hereof be 
enforced by, any other person.

    8.9  Survival.  The representations and warranties of the Company and the 
agreements and covenants set forth in Articles III, IV, V and VIII shall 
survive the closing hereunder notwithstanding any due diligence investigation 
conducted by or on behalf of Purchaser.  The Company agrees to indemnify and 
hold harmless Purchaser and each of Purchaser's officers, directors, 
employees, partners, agents and affiliates for loss or damage arising as a 
result of or 

                                          18



related to any breach by the Company of any of its representations or 
covenants set forth herein, including advancement of expenses as they are 
incurred.

    8.10 Public Filings:  Publicity.  Immediately following execution on this 
Agreement, the Company shall issue a press release with respect to the 
transactions contemplated hereby.  The Company and Purchaser shall have the 
right to approve before issuance any press releases (including the foregoing 
press release), SEC or other filings, or any other public statements, with 
respect to the transactions contemplated hereby; provided, however, that the 
Company shall be entitled, without the prior approval of Purchaser, to make 
any press release or SEC, NASDAQ, NASD or exchange filings with respect to 
such transactions as is required by applicable law and regulations (although 
Purchaser shall (to the extent time permits) be consulted by the Company in 
connection with any such press release prior to its release and shall be 
provided with a copy thereof.

    8.11 Further Assurances.  Each party shall do and perform, or cause to be 
done and performed, all such further acts and things, and shall execute and 
deliver all such other agreements, certificates, instruments and documents, 
as the other party may reasonably request in order to carry out the intent 
and accomplish the purposes of this Agreement and the consummation of the 
transactions contemplated hereby.

    8.12 Remedies.  No provision of this Agreement providing for any remedy 
to Purchaser shall limit any remedy which would otherwise be available to 
Purchaser at law or in equity.  Nothing in this Agreement shall limit any 
rights Purchaser may have with any applicable federal or state securities 
laws with respect to the investment contemplated hereby.

    8.13 Termination.  In the event that the Closing shall not have occurred 
on or before December 12, 1997, unless the parties agree otherwise, this 
Agreement shall terminate at the close of business on such date.

    8.14 No Strict Construction.  The language used in this Agreement will be 
deemed to be the language chosen by the parties to express their mutual 
intent, and no rules of strict construction will be applied against any party.

                                      * * * * *

                                      19


    IN WITNESS WHEREOF, the undersigned Purchasers and the Company have 
caused this Agreement to be duly executed as of the date first above written.

PURCHASER:

RGC INTERNATIONAL INVESTORS, LDC

By: Rose Glen Capital Management, L.P.
    Investment Manager
    By: RGC General Partner Corp., as General Partner

By:  _____________________________

Its: _____________________________

RESIDENCE:  Cayman Islands

ADDRESS:

c/o Rose Glen Capital Management, L.P.
3 Bala Plaza East, Suite 200
251 St. Asaphs Road
Bala Cynwyd, PA  19004
Facsimile:   (610) 617-0570
Telephone:  (610) 617-5900

AGGREGATE NUMBER OF COMMON SHARES:  750,000

WARRANTS FOR AGGREGATE NUMBER OF WARRANT SHARES: 750,000


COMPANY:

BIOSPHERICS INCORPORATED

By:  _____________________________

Its: _____________________________

                                       20





                                                                  Exhibit (10.1)

                                           
                                           
                                           
                               SCHEDULES TO SECURITIES
                                  PURCHASE AGREEMENT
                                           
                                           
                                           
                                           
                                           
                                           
                                           
                                           
                                           
                                           
                                           
    These Schedules are being provided in connection with the Securities
    Purchase Agreement dated as of December 12, 1997.  All undefined
    capitalized terms contained herein shall have the same meaning as set forth
    in the Securities Purchase Agreement.  It is understood and agreed that
    disclosure of any item on any one of the following Schedules shall
    constitute appropriate disclosure on all appropriate Schedules.


                                          1



                                     Schedule 3.2
                                           
                              Authorization, Enforcement
                                           

    There are no further consents or authorizations of the Company, its board
of directors, or its stockholders or any other person, body or agency required
with respect to any of the transactions contemplated by the Securities Purchase
Agreement.


                                          2


                                     Schedule 3.3
                                           
                                    Capitalization
                                           

    This schedule includes the authorized capital stock, the number of shares
issued and outstanding, the number of shares reserved for issuance pursuant to
the Company's stock option plans, the number of shares reserved for issuance
pursuant to securities (other than the Warrants) exercisable for, or convertible
into or exchangeable for any shares of Common Stock and the number of shares to
be initially reserved for issuance upon exercise of the Warrants:



                                              At September 30, 1997
                                            -------------------------
                                                       Shares
                                                     ----------
                                                  
Common Stock, $0.005 par value,
18,000,000 shares authorized   

Issued, non-redeemable                               6,518,837
Issued, redeemable                                   1,577,253
                                                     ---------
                                                     8,096,090

Treasury Stock, at cost                                (69,006)
                                                     --------- 

                                                     8,027,084
                                                     ---------
                                                     ---------



Nonqualified Stock Option Plan

    Under the Company's Nonqualified Stock Option Plan dated May 15, 1997 
(the 1987 plan), options may be granted to officers and other key employees 
to purchase up to 4,400,000 shares of common stock in amounts determined by 
the Board of Directors at a price not less than 50% of the fair market value 
of the stock on the date the options are granted, and for a term not to 
exceed five years and one month from the date of grant.

    To date, all options granted, except for those part of an anti-hostile 
takeover plan explained below, have been at the then-publicly quoted price of 
the stock.  The 1987 plan expired on May 14, 1997.  On November 17, 1997, the 
Company's Board of Directors approved the 1997 Stock Option Plan subject to 
stockholders' approval.  The 1997 plan provides 400,000 options for granting 
to officers, directors, and other key employees and contains terms similar to 
the 1987 plan.

                                          3




                                     Schedule 3.3
                                           
                              Capitalization (Continued)
                                           

Outstanding Options Granted Under the 1987 Nonqualified Stock Option Plan

    Options as of September 30, 1997                  2,731,250(1)

    Price Range of Options Outstanding:               $1.4375 to $7.25

    Options Exercisable as of September 30, 1997:     554,750

(1) See attached summary of outstanding stock options.


Stock Redemption Agreement

    The Company has agreements with two officers-stockholders who 
beneficially own 39.7% of the outstanding common stock.  Upon their deaths, 
the Company may be required to redeem from their estates, the number of 
shares of the Company's stock necessary to pay estate taxes and 
administrative expenses of the estate, if any, up to $5,000,000.  Shares 
would be redeemed at the then current market price.  The Company is the 
beneficiary to an insurance policy on the lives of the two 
officers-stockholders, which the Company maintains to provide benefits of 
$5,000,000 for this agreement.

                                          4




                                     Schedule 3.5
                                           
                                     No Conflicts
                                           

                                         None.



                                          5




                                     Schedule 3.6
                                           
                            Registration and SEC Documents
                                           

    Since January 1, 1995, the Company has timely filed all reports, 
schedules, forms, statements and other documents required to be filed by it 
with the SEC pursuant to the reporting requirements of the Exchange Act.

                                          6



                                     Schedule 3.7
                                           
                              Absence of Certain Changes
                                           

    Since December 31, 1996, there has been no material adverse change and no 
material adverse development in the business, properties, operations, 
financial condition, results of operations or prospects of the Company.  The 
Company has filed its quarterly report on Form 10-QSB for the three-month and 
nine-month periods ended September 30, 1997 on November 13, 1997 with the 
Securities and Exchange Commission.  In such filing, the Company reclassified 
deferred revenue of $1,000,000, which represents a non-refundable advance 
against future royalties from the D-tagatose licensing agreement with MD 
Foods Ingredients amba of Denmark from current to non-current.  The advance 
will be recoverable at 50% of such annual royalties.  As commercialization of 
D-tagatose is not anticipated prior to the summer of 1999, the deferred 
revenue has accordingly been reclassified as non-current.

    The Company's government contracts typically have a term of three to five 
years.  Several contracts were rebid in 1997, which represented over 25% of 
consolidated revenues.  The Company was successful in securing new contracts 
for two of three contracts which were rebid.  Both of these contract awards 
are being protested by the unsuccessful bidder(s).  The Company is 
aggressively protesting the award of a contract that it had performed for the 
last two years and was unsuccessful in securing award during the rebid 
process.  The Company believes that it will continue to provide services 
under this contract through at least September 30, 1998, as the protest is 
being resolved.

                                          7



                                     Schedule 3.8
                                           
                                      Litigation
                                           

    Summarized below is a listing of all actions, suits, proceedings, 
inquiries or investigations before or by any court, public board, 
governmental agency or authority, or self-regulatory organization or body 
pending or threatened against or affecting the Company, any of its 
subsidiaries, or any of their respective directors or officers in their 
capacities as such:

    In the fourth quarter of 1997, the Company collected the outstanding 
amount owed to it by Tetra Technologies, Inc. ($100,000) and the Pennsylvania 
Merchant Group.  See Note 7 to the Company's Annual Report on 10-KSB for 
further discussion on this Tetra matter.  The Company has filed a lawsuit 
against Forbes for an article printed about the Company.  There have been 
motions for dismissal of the suit and counter motions against dismissal; a 
decision is pending from the judge on these motions.

    The Company received a notice of potential liability from the U.S. EPA. 
See Note 7 of the Company's Annual Report on Form 10-KSB for background on 
this matter.  There has been no correspondence between the Company and EPA 
regarding this claim during 1997.

    The Company is awaiting a final determination by the Department of Labor 
on the wage rates paid to employees at the Company's Cumberland, Maryland 
facility. The Government Accounting Office must rule/decide if the wage rates 
are applicable to the Company.  A decision is still pending.  If there is an 
unfavorable ruling to the Company, the Company has recourse through an 
equitable adjustment claim under its contract with the GSA/Federal 
Information Center.

                                          8



                                    Schedule 3.18
                                           
                                    Key Employees
                                           

    Summarized below is a listing of Key Employees of Biospherics 
Incorporated and the capacity in which they currently serve.

         Dr. Gilbert Levin        President & CEO; Chairman of the Board
         Karen Levin              VP, Communications & Corporate Secretary
         Jeffrey W. Church        Executive VP & Chief Financial Officer
         Richard Levin            VP, Planning
         Raul Vera                VP, Technology

                                          9





                                    Schedule 3.19
                                           
                                 Certain Transactions
                                           

    Consulting Agreements:  Each of Gilbert V. Levin and M. Karen Levin have 
entered into Consulting Agreements with the Company pursuant to which such 
individuals will provide post-employment consulting services to the Company.

    Retirement Agreements:  Each of Gilbert V. Levin and M. Karen Levin have 
entered into Supplemental Executive Retirement Plan Agreements with the 
Company pursuant to which such individuals would be entitled to certain 
post-employment payments.

    Copies of the above described Agreements have been furnished to Purchaser.


                                          10



                                     Schedule 4.5
                                           
                             Restriction on Below Market
                                Issuance of Securities
                                           

    The Company has an Employees' Nonqualified Stock Option Plan, whereby 
options are granted to officers and key employees.  See Schedule 3.3 
Capitalization for further details regarding this plan.

    The Company has an informal plan with its outside Board directors whereby 
options are granted on an annual basis.  Historically these grants have 
averaged 4,000 options per outside directors.  There are currently six (6) 
outside directors on Biospherics' Board of Directors.

                                          11