Exhibit (10.4)
       
                                       EXHIBIT B
                            to Securities Purchase Agreement
                                           

                              REGISTRATION RIGHTS AGREEMENT
                                         
    THIS REGISTRATION RIGHTS AGREEMENT (this "Agreement"), is made as of 
December 12, 1997, by and among Biospherics Incorporated, a Delaware 
corporation (the "Company"), with headquarters located at 12051 Indian Creek 
Court, Beltsville, Maryland, and the undersigned (the "Purchaser").

                                       RECITALS
                                           
    A.   In connection with the Securities Purchase Agreement dated of even 
date herewith by and between the Company and Purchaser (the "Securities 
Purchase Agreement"), the Company has agreed, upon the terms and subject to 
the conditions contained therein, to issue and sell to Purchaser (i) shares 
of the Company's Common Stock, par value $.005 per share (the "Common Stock") 
and (ii) warrants to purchase shares of Common Stock in the form attached as 
Exhibits A-1 and A-2 to the Securities Purchase Agreement.  The shares of 
Common Stock being purchased under the Securities Purchase Agreement are 
referred to herein as the "Common Shares".  The warrants being purchased 
under the Securities Purchase Agreement are referred to herein as the 
"Warrants".  The shares of Common Stock issuable upon the exercise of or 
otherwise pursuant to the Warrants are referred to herein as the "Warrant 
Shares".

    B.   To induce Purchaser to execute and deliver the Securities Purchase 
Agreement, the Company has agreed to provide certain registration rights 
under the Securities Act of 1933, as amended, and the rules and regulations 
thereunder, or any similar successor statute (collectively, the "Securities 
Act"), and applicable state securities laws.

                                      AGREEMENTS
                                           
    NOW THEREFORE, in consideration of the premises and the mutual covenants 
contained herein and other good and valuable consideration, the receipt and 
sufficiency of which are hereby acknowledged, the Company, and Purchaser 
hereby agree as follows:

                                      ARTICLE I
                                     DEFINITIONS
                                           
    1.1  Definitions.  As used in this Agreement, the following terms shall 
have the following meanings:

         (a)  "Purchaser" means Purchaser and any transferees or assignees 
who agree to become bound by the provisions of this Agreement in accordance 
with Article IX hereof.

         (b)  "register," "registered," and "registration" refer to a 
registration effected by preparing and filing a Registration Statement or 
Statements in compliance with the Securities 

                                          1


Act and pursuant to Rule 415 under the Securities Act or any successor rule 
providing for offering securities on a continuous basis ("Rule 415"), and the 
declaration or ordering of effectiveness of such Registration Statement by 
the United States Securities and Exchange Commission (the "SEC").

         (c)  "Registrable Securities" means the Common Shares and Warrant 
Shares and any shares of capital stock issued or issuable, from time to time 
(with any adjustments), on or in exchange for or otherwise with respect to 
the Common Stock or any other Registrable Securities.

         (d)  "Registration Statement" means a registration statement of the 
Company under the Securities Act.

    1.2  Capitalized Terms.  Capitalized terms used herein and not otherwise 
defined herein shall have the respective meanings set forth in the Securities 
Purchase Agreement.

                                      ARTICLE II
                                     REGISTRATION
                                           
    2.1  Mandatory Registration.  The Company shall prepare, and, on or prior 
to forty-five (45) days after the date of the Closing (the "Filing Date"), 
file with the SEC a Registration Statement on Form S-3 (or, if Form S-3 is 
not then available, on such form of Registration Statement as is then 
available to effect a registration of all of the Registrable Securities, 
subject to the consent of Purchaser (as determined pursuant to Section 11.10 
hereof)) covering the resale of all of the Registrable Securities, which 
Registration Statement, to the extent allowable under the Securities Act and 
the Rules promulgated thereunder (including Rule 416), shall state that such 
Registration Statement also covers such indeterminate number of additional 
shares of Common Stock as may become issuable upon exercise of the Warrants 
pursuant to the so-called anti-dilution provisions thereof.  The Registrable 
Securities included in the Registration Statement shall be allocated among 
Purchaser as set forth in Section 11.11 hereof.  The Registration Statement 
(and each amendment or supplement thereto, and each request for acceleration 
of effectiveness thereof) shall be provided to (and subject to the approval 
of (which approval shall not be unreasonably withheld or denied)) Purchaser 
and their counsel prior to its filing or other submission.

    2.2  Underwritten 0ffering.  If any offering pursuant to a Registration 
Statement pursuant to Section 2.1 hereof involves an underwritten offering, 
Purchaser who hold a majority in interest of the Registrable Securities 
subject to such underwritten offering shall have the right to select a total 
of one firm of legal counsel to represent Purchaser and an investment banker 
or bankers and manager or managers to administer the offering, which 
investment banker or bankers or manager or managers shall be reasonably 
satisfactory to the Company.

    2.3  Payments by the Company.  The Company shall cause the registration 
statement to become effective as soon as practicable, but in no event later 
than the ninetieth (90th) day following the date of the Closing (the 
"Registration Deadline").  If (i) the registration statement(s) covering the 
Registrable Securities required to be filed by the Company pursuant to 
Section 2.1 hereof is not declared effective by the SEC on or before the 
Registration Deadline, or 

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(ii) after the registration statement has been declared effective by the SEC, 
sales of all the Registrable Securities (including any Registrable Securities 
required to be registered pursuant to Section 3.2 hereof) cannot be made 
pursuant to the registration statement (by reason of a stop order or the 
Company's failure to update the registration statement or any other reason 
outside the control of Purchaser) or (iii) the Common Stock is not listed or 
included or quotation on the NASDAQ National Market, NASDAQ SmallCap Market, 
the New York Stock Exchange or the American Stock Exchange after being so 
listed or included for quotation, then the Company will make payments to 
Purchaser in such amounts and at such times as shall be determined pursuant 
to this Section 2.3 as partial relief for the damages to Purchaser by reason 
of any such delay in or reduction of their ability to sell the Registrable 
Securities (which remedy shall not be exclusive of any other remedies 
available at law or in equity).  In such event, the Company shall pay to 
Purchaser an amount equal to (i) (A) .02 times (B) the aggregate purchase 
price of the Common Shares and Warrants held by Purchaser (including, without 
limitation, Warrants that have been converted into Warrant Shares) times (ii) 
the sum of:  (A) the number of months (prorated per day for partial months) 
following the Registration Deadline prior to the date the Registration 
Statement filed pursuant to Section 2.1 is declared effective by the SEC plus 
(B) the number of months (prorated per day for partial months) following the 
Registration Deadline but prior to the termination of the Registration 
Periods that sales cannot be legally made pursuant to the Registration 
Statement after the Registration Statement has been declared effective plus 
(c) the number of months (prorated per day for partial months) that the 
Common Stock is not listed or included for quotations on the NASDAQ National 
Market, NASDAQ SmallCap Market, New York Stock Exchange, or American Stock 
Exchange or that trading thereon is halted after the Registration Statement 
has been declared effective.  Such amounts shall be paid in cash. Payments of 
cash pursuant hereto shall be made within five (5) days after the end of each 
period that gives rise to such obligation, provided that, if any such period 
extends for more than thirty (30) days, payments shall be made for each such 
thirty (30) day period within five (5) days after the end of such thirty (30) 
day period.

    2.4  Piggy-Back Registrations.  If at any time prior to the expiration of 
the Registration Period (as hereinafter defined) the Company shall file with 
the SEC a Registration Statement relating to an offering for its own account 
or the account of others under the Securities Act of any of its equity 
securities (other than on Form S-4 or Form S-8 or their then equivalents 
relating to equity securities to be issued solely in connection with any 
acquisition of any entity or business or equity securities issuable in 
connection with stock option or other employee benefit plans), then the 
Company shall send to Purchaser, who has a right to have Registrable 
Securities covered by a Registration Statement pursuant to this Agreement 
written notice of such determination and, if within fifteen (15) days after 
the date of such notice, Purchaser shall so request in writing, the Company 
shall include in such Registration Statement all or any part of the 
Registrable Securities Purchaser requests to be registered, except that if, 
in connection with any underwritten public offering for the account of the 
Company the managing underwriters) thereof shall impose a limitation on the 
number of shares of Common Stock which may be included in the Registration 
Statement because, in such underwriter(s)'judgment, marketing or other 
factors dictate such limitation is necessary to facilitate public 
distribution, then the Company shall be obligated to include in such 
Registration Statement only such limited portion of the Registrable 
Securities with respect to which Purchaser has requested inclusion hereunder 
as the underwriter shall permit.  Any exclusion of Registrable Securities 
shall be made pro rata among Purchaser seeking to include Registrable 
Securities, in proportion to the number of Registrable Securities sought to 

                                          3



be included by Purchaser; provided, however, that the Company shall not 
exclude any Registrable Securities unless the Company has first excluded all 
outstanding securities, the holders of which are not entitled to inclusion of 
such securities in such Registration Statement or are not entitled to pro 
rata inclusion with the Registrable Securities; and provided, further, 
however, that, after giving effect to the immediately preceding proviso, any 
exclusion of Registrable Securities shall be made pro rata with holders of 
other securities having the right to include such securities in the 
Registration Statement.  No right to registration of Registrable Securities 
under this Section 2.4 shall be construed to limit any registration required 
under Section 2.1 or 3.2 hereof. If an offering in connection with which 
Purchaser is entitled to registration under this Section 2.4 is an 
underwritten offering, then Purchaser whose Registrable Securities are 
included in such Registration Statement shall, unless otherwise agreed by the 
Company, offer and sell such Registrable Securities in an underwritten 
offering using the same underwriter or underwriters and, subject to the 
provisions of this Agreement, on the same terms and conditions as other 
shares of Common Stock included in such underwritten offering.

    2.5  Eligibility for Form S-3.  The Company represents and warrants that 
it meets the requirements for the use of Form S-3 for registration of the 
re-sale by Purchaser of the Registrable Securities.  The Company covenants 
and agrees that throughout the Registration Period (as herein defined), the 
Company shall continue to be eligible to use Form S-3 for registration of 
such re-sale and the Company shall file all reports required to be filed by 
the Company with the SEC in a timely manner so as to maintain such 
eligibility for the use of Form S-3.

                                     ARTICLE III
                              OBLIGATIONS OF THE COMPANY
                                           
    In connection with the registration of the Registrable Securities, the 
Company shall have the following obligations:

    3.1  The Company shall prepare promptly and file with the SEC not later 
than the Filing Date the Registration Statement required by Section 2.1, and 
cause such Registration Statement relating to Registrable Securities to 
become effective as soon as practicable after such filing, and keep the 
Registration Statement effective pursuant to Rule 415 at all times until such 
date as is the earlier of (i) the date on which all of the Registrable 
Securities have been sold (and no further Registrable Securities may be 
issued in the future) and (ii) the date on which all of the Registrable 
Securities (in the reasonable opinion of counsel to Purchaser) may be 
immediately sold to the public without registration and without restriction 
as to the number with Registrable Securities to be sold, whether pursuant to 
Rule 144 or otherwise (the "Registration Period").  The Registration 
Statement (including any amendments or supplements thereto and prospectuses 
contained therein and all documents incorporated by reference therein) shall 
not contain any untrue statement of a material fact or omit to state a 
material fact required to be stated therein, or necessary to make the 
statements therein not misleading.

    3.2  The Company shall prepare and file with the SEC such amendments 
(including post- effective amendments) and supplements to a Registration 
Statement and the prospectus used in connection with the Registration 
Statement as may be necessary to keep the Registration Statement effective at 
all times during the Registration Period, and, during such period, comply 

                                          4


with the provisions of the Securities Act with respect to the disposition of 
all Registrable Securities of the Company covered by the Registration 
Statement until the termination of the Registration Period or, if earlier, 
such time as all of such Registrable Securities have been disposed of in 
accordance with the intended methods of disposition by the seller or sellers 
thereof as set forth in the Registration Statement.  In the event the number 
of shares available under a Registration Statement filed pursuant to this 
Agreement is insufficient to cover all of the Registerable Securities issued 
pursuant to the Securities Purchase Agreement and exercise of the Warrants, 
the Company shall amend the Registration Statement or file a new Registration 
Statement (on the short form available therefor, if applicable), or both, so 
as to cover all of the Registerable Securities, in each case, as soon as 
practicable, but in any event within twenty (20) business days after the 
necessity therefore arises.  The Company shall use its best efforts to cause 
such amendment and/or new Registration Statement to become effective as soon 
as practicable following the filing thereof.  The provisions of Section 2.3 
above shall be applicable with respect to such obligations, with the ninety 
(90) days running from the day after the date on which the Company reasonably 
first determines (or reasonably should have determined) the need therefor.

    3.3  The Company shall furnish to Purchaser whose Registrable Securities 
are included in the Registration Statement and its legal counsel (a) promptly 
after the same is prepared and publicly distributed, filed with the SEC, or 
received by the Company, one copy of the Registration Statement and any 
amendment thereto, each preliminary prospectus and prospectus and each 
amendment or supplement thereto, and, in the case of the Registration 
Statement referred to in Section 2.1, each letter written by or on behalf of 
the Company to the SEC or the staff of the SEC, and each item of 
correspondence from the SEC or the staff of the SEC, in each case relating to 
such Registration Statement (other than any portion, if any, thereof which 
contains information for which the Company has sought confidential 
treatment), and (b) such number of copies of a prospectus, including a 
preliminary prospectus, and all amendments and supplements thereto and such 
other documents as Purchaser may reasonably request in order to facilitate 
the disposition of the Registrable Securities owned (or to be owned) by 
Purchaser.

    3.4  The Company shall use reasonable efforts to (a) register and qualify 
the Registrable Securities covered by the Registration Statement under 
securities laws of such jurisdictions in the United States as Purchaser who 
holds (or has the right to hold) Registrable Securities being offered 
reasonably requests, (b) prepare and file in those jurisdictions such 
amendments (including post-effective amendments) and supplements to such 
registrations and qualifications as may be necessary to maintain the 
effectiveness thereof during the Registration Period, (c) take such other 
actions as may be necessary to maintain such registrations and qualifications 
in effect at all times during the Registration Period, and (d) take all other 
actions reasonably necessary or advisable to qualify the Registrable 
Securities for sale in such jurisdictions; provided, however, that the 
Company shall not be required in connection therewith or as a condition 
thereto to (i) qualify to do business in any jurisdiction where it would not 
otherwise be required to qualify but for this Section 3.4, (ii) subject 
itself to general taxation in any such jurisdiction, (iii) file a general 
consent to service of process in any such jurisdiction, (iv) provide any 
undertakings that cause the Company material expense or burden, or (v) make 
any change in its charter or by-laws, which in each case the board of 
directors of the Company determines to be contrary to the best interests of 
the Company and its stockholders.

                                          5


    3.5  In the event Purchaser who hold a majority in interest of the 
Registrable Securities being offered in an offering pursuant to a 
Registration Statement or any amendment or supplement thereto under Section 
2.1 or 3.2 hereof select underwriters for the offering, the, Company shall 
enter into and perform its obligations under an underwriting agreement, in 
usual and customary form, including, without limitation, customary 
indemnification and contribution obligations. with the underwriters of such 
offering.

    3.6  As soon as practicable after becoming aware of such event, the 
Company shall notify (by telephone and also by facsimile and reputable 
overnight courier) Purchaser of the happening of any event, of which the 
Company has knowledge, as a result of which the prospectus included in the 
Registration Statement, as then in effect, includes an untrue statement of a 
material fact or omission to state a material fact required to be stated 
therein or necessary to make the statements therein not misleading, and use 
its best efforts promptly (but in any event within five (5) days) to prepare 
a supplement or amendment to the Registration Statement to correct such 
untrue statement or omission, and deliver such number of copies of such 
supplement or amendment to Purchaser as Purchaser may reasonably request.

    3.7  The Company shall use its best efforts to prevent the issuance of 
any stop order or other suspension of effectiveness of a Registration 
Statement, and, if such an order is issued, to obtain the withdrawal of such 
order at the earliest practicable time and to notify (by telephone and also 
by facsimile and reputable overnight carrier) Purchaser who holds Registrable 
Securities being sold (or, in the event of an underwritten offering, the 
managing underwriters) of the issuance of such order and the resolution 
thereof.

    3.8  The Company shall permit a single firm of counsel designated by 
Purchaser to review the Registration Statement and all amendments and 
supplements thereto (as well as all requests for acceleration or 
effectiveness thereof) a reasonable period of time prior to their filing with 
the SEC, and not file any document in a form to which such counsel reasonably 
objects and will not request acceleration of the Registration Statement 
without prior notice to such counsel.  The sections of the Registration 
Statement covering information with respect to the Investors, the Investors' 
beneficial ownership of securities of the Company or the Investors' intended 
method of disposition of the Registerable Securities shall conform to the 
information provided to the Company by each of the Investors.

    3.9  The Company shall make generally available to its security holders 
as soon as practical, but not later than ninety (90) days after the close of 
the period covered thereby, an earnings statement (in form complying with the 
provisions of Rule 158 under the Securities Act) covering a twelve-month 
period beginning not later than the first day of the Company's fiscal quarter 
next following the effective date of the Registration Statement.

    3.10 At the request of Purchaser in connection with any underwritten 
offer hereunder, the Company shall furnish, on the date of effectiveness of 
the Registration Statement and thereafter from time to time on such dates as 
Purchaser may reasonably request (a) an opinion, dated as of such applicable 
date, from counsel representing the Company addressed to Purchaser and in 
form, scope and substances as is customarily given in an underwritten public 
offering and (b) a letter, dated as of such applicable date, from the 
Company's independent certified public 

                                          6



accountants addressed to Purchaser and in form, scope and substance as 
customarily given to underwriters in an underwritten public offering.

    3.11 The Company shall make available for inspection during the 
Registration Period by (i) Purchaser, (ii) any underwriter participating in 
any disposition pursuant to the Registration Statement, (iii) one firm of 
attorneys and one firm of accountants retained by Purchaser, and (iv) one 
firm of attorneys retained by all such underwriters (collectively, the 
"Inspectors") all pertinent financial and other records, and pertinent 
corporate documents and properties of the Company (collectively, the 
"Records"), as shall be reasonably deemed necessary by each Inspector and 
cause the Company's officers, directors and employees to supply all 
information which any Inspector may reasonably request; provided, however, 
that each Inspector shall hold in confidence and shall not make any 
disclosure (except to Purchaser) of any Record or other information which the 
Company determines in good faith to be confidential, and of which 
determination the Inspectors are so notified in writing, unless (a) the 
disclosure of such Records is necessary to avoid or correct a misstatement or 
omission in any Registration Statement, (b) the release of such Records is 
ordered pursuant to a subpoena or other order from a court or government body 
of competent jurisdiction, or is otherwise required by applicable law or 
legal process or (c) the information in such Records has been made generally 
available to the public other than by disclosure in violation of this or any 
other agreement (to the knowledge of Purchaser).  The Company shall not be 
required to disclose any confidential information in such Records to any 
Inspector until and unless such Inspector shall have entered into 
confidentiality agreements (in form and reasonable substance satisfactory to 
the Company) with the Company with respect thereto, substantially in the form 
of this Section 3.11.  Purchaser agrees that it shall, upon learning that 
disclosure of such Records is sought in or by a court or governmental body of 
competent jurisdiction or through other means, give prompt notice to the 
Company and allow the Company, at its expense, to undertake appropriate 
action to prevent disclosure of, or to obtain a protective order for, the 
Records deemed confidential.  Nothing herein (or in any other confidentiality 
agreement between the Company and Purchaser) shall be deemed to limit 
Purchaser's ability to sell Registrable Securities in a manner which is 
consistent with applicable laws and regulations.

    3.12 The Company shall hold in confidence and not make any disclosure of 
information concerning Purchaser provided to the Company unless (a) 
disclosure of such information is necessary to comply with federal or state 
securities laws, (b) the disclosure of such information is necessary to avoid 
or correct a misstatement or omission in any Registration Statement, (c) the 
release of such information is ordered pursuant to a subpoena or other order 
from a court or governmental body of competent jurisdiction or is otherwise 
required by applicable law or legal process, (d) such information has been 
made generally available to the public other than by disclosure in violation 
of this or any other agreement (to the knowledge of the Company), or (e) 
Purchaser consents to the form and content of any such disclosure.  The 
Company agrees that it shall, upon learning that disclosure of such 
information concerning Purchaser is sought in or by a court or governmental 
body of competent jurisdiction or through other means, give prompt notice to 
Purchaser prior to making such disclosure, and allow Purchaser, at its 
expense, to undertake appropriate action to prevent disclosure of, or to 
obtain a protective order for, such information.

                                          7



    3.13 For so long as Purchaser owns any of the Securities or three (3) 
years from the Closing Date, whichever is sooner, the Company shall cause the 
listing and the continuation of listing of all the Registrable Securities 
covered by the Registration Statement on the NASDAQ National Market System 
and cause the Registrable Securities to be quoted or listed on each 
additional national securities exchange or quotation system upon which the 
Common Stock is then listed or quoted.

    3.14 The Company shall provide a transfer agent and registrar, which may 
be a single entity, for the Registrable Securities not later than the 
effective date of the Registration Statement.

    3.15 The Company shall cooperate with Purchaser who hold Registrable 
Securities being offered and the managing underwriter or underwriters, if 
any, to facilitate the timely preparation and delivery of certificates (not 
bearing any restrictive legends) representing Registrable Securities to be 
offered pursuant to the Registration Statement and enable such certificates 
to be in such denominations or amounts, as the case may be, as the managing 
underwriter or underwriters, if any, or Purchaser may reasonably request and 
registered in such names as the managing underwriter or underwriters, if any, 
or Purchaser may request, and, within one (1) business days after a 
Registration Statement which includes Registrable Securities is ordered 
effective by the SEC, the Company shall cause legal counsel selected by the 
Company to deliver, to the transfer agent for the Registrable Securities 
(with copies to Purchaser whose Registrable Securities are included in such 
Registration Statement) an instruction in the form attached hereto as Exhibit 
1 and an opinion of such counsel in the form attached hereto as Exhibit 2.

    3.16 At the request of Purchaser, the Company shall promptly prepare and 
file with the SEC such amendments (including post-effective amendments) and 
supplements to a Registration Statement and the prospectus used in connection 
with the Registration Statement as may be necessary in order to change the 
plan of distribution set forth in such Registration Statement.

    3.17 The Company shall comply with all applicable laws related to a 
Registration Statement and offering and sale of securities and all applicable 
rules and regulations of governmental authorities in connection therewith 
(including, without limitation, the Securities Act and the Securities 
Exchange Act of 1934, as amended, and the rules and regulations promulgated 
by the Commission).

    3.18 The Company shall take all such other actions as Purchaser or the 
underwriters, if any, reasonably request in order to expedite or facilitate 
the disposition of such Registrable Securities.

    3.19 From and after the date of this Agreement, the Company shall not, 
and shall not agree to, allow the holders of any securities of the Company to 
include any of their securities in any Registration Statement or any 
amendment or supplement thereto under Section 2.1 or 3.2 hereof without the 
consent of the holders of a majority of the Registrable Securities.

                                          8


                                      ARTICLE IV
                               OBLIGATIONS OF PURCHASER
                                           
    In connection with the registration of the Registrable Securities, 
Purchaser shall have the following obligations:

    4.1  Purchaser shall furnish to the Company such information regarding 
itself, the Registrable Securities held by it and the intended method of 
disposition of the Registrable Securities held by it as shall be reasonably 
required to effect the registration of such Registrable Securities and shall 
execute such documents in connection with such registration as the Company 
may reasonably request.  At least ten (10) business days prior to the first 
anticipated filing date of the Registration Statement, the Company shall 
notify Purchaser of the information the Company requires from Purchaser.

    4.2  Purchaser, by such Purchaser's acceptance of the Registrable 
Securities, agrees to cooperate with the Company as reasonably requested by 
the Company in connection with the preparation and filing of the Registration 
Statements hereunder, unless Purchaser has notified the Company in writing of 
such Purchaser's election to exclude all of Purchaser's Registrable 
Securities from the Registration Statement.

    4.3  Purchaser whose Registrable Securities are included in a 
Registration Statement understands that the Securities Act may require 
delivery of a prospectus relating thereto in connection with any sale thereof 
pursuant to such Registration Statement, and Purchaser shall use its 
reasonable efforts to comply with the applicable prospectus delivery 
requirements of the Securities Act in connection with any such sale.

    4.4  Purchaser agrees that, upon receipt of written notice from the 
Company of the happening of any event of the kind described in Section 3.6, 
such Purchaser will immediately discontinue disposition of Registrable 
Securities pursuant to the Registration Statement covering such Registrable 
Securities until such Purchaser's receipt of the copies of the supplemented 
or amended prospectus contemplated by Section 3.6 and, if so directed by the 
Company, Purchaser shall deliver to the Company (at the expense of the 
Company) or destroy (and deliver to the Company a certificate of destruction) 
all copies in Purchaser's possession (other than a limited number of 
permanent file copies), of the prospectus covering such Registrable 
Securities current at the time of receipt of such notice.

    4.5  Without limiting Purchaser's rights under Section 2.1 or 3.2 hereof, 
no Purchaser may participate in any underwritten distribution hereunder 
unless Purchaser (a) agrees to sell Purchaser's Registrable Securities on the 
basis provided in any underwriting arrangements in usual and customary form 
entered into by the Company, (b) completes and executes all questionnaires, 
powers of attorney, indemnities, underwriting agreements and other documents 
reasonably required under the terms of such underwriting arrangements, and 
(c) agrees to pay its pro rata share of all underwriting discounts and 
commissions and any expenses in excess of those payable by the Company 
pursuant to Article V.

                                          9

 
                                      ARTICLE V
                               EXPENSES OF REGISTRATION
                                           
    All expenses, other than underwriting discounts and commissions, incurred 
in connection with registrations, filings or qualifications pursuant to 
Articles II and III, including, without limitation, all registration, listing 
and qualification fees, printers and accounting fees, the fees and 
disbursements of counsel for the Company, and the reasonable fees and 
disbursements of one firm of counsel selected by Purchaser pursuant to 
Section 2.2, hereof shall be borne by the Company.

                                      ARTICLE VI
                                   INDEMNIFICATION
                                           
    In the event any Registrable Securities are included in a Registration 
Statement under this Agreement:

    6.1  To the extent permitted by law, the Company will indemnify, hold 
harmless and defend (a) Purchaser who holds such Registrable Securities, (b) 
each underwriter of Registrable Securities and (c) the directors, officers, 
partners, members, employees, agents and persons who control Purchaser within 
the meaning of Section 15 of the Securities Act or Section 20 of the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"), if any, 
(each, an "Indemnified Person"), against any joint or several losses, claims, 
damages, liabilities or expenses (collectively, together with actions, 
proceedings or inquiries by any regulatory or self-regulatory organization, 
whether commenced or threatened, in respect thereof, "Claims") to which any 
of them may become subject insofar as such Claims arise out of or are based 
upon: (i) any untrue statement or alleged untrue statement of a material fact 
in a Registration Statement or the omission or alleged omission to state 
therein a material fact required to be stated or necessary to make the 
statements therein not misleading, (ii) any untrue statement or alleged 
untrue statement of a material fact contained in any preliminary prospectus 
if used prior to the effective date of such Registration Statement, or 
contained in the final prospectus (as amended or supplemented, if the Company 
files any amendment thereof or supplement thereto with the SEC) or the 
omission or alleged omission to state therein any material fact necessary to 
make the statements made therein, in light of the circumstances under which 
the statements therein were made, not misleading, or (iii) any violation or 
alleged violation by the Company of the Securities Act, the Exchange Act, any 
other law, including, without limitation, any state securities law, or any 
rule or regulation thereunder relating to the offer or sale of the 
Registrable Securities (the matters in the foregoing clauses (i) through 
(iii) being, collectively, "Violations").  Subject to the restrictions set 
forth in Section 6.3 with respect to the number of legal counsel, the Company 
shall reimburse Purchaser, each such underwriter and controlling person, and 
each such other Indemnified Person, promptly as such expenses are incurred 
and are due and payable, for any reasonable legal fees or other reasonable 
expenses incurred by them in connection with investigating or defending any 
such Claim.  Notwithstanding anything to the contrary contained herein, the 
indemnification agreement contained in this Section 6.1: (x) shall not apply 
to an Indemnified Person with respect to a Claim arising out of or based upon 
a Violation which occurs in reliance upon and in conformity with information 
furnished in writing to the Company by such Indemnified Person expressly for 
use in the Registration Statement or any such amendment thereof or supplement 
thereto; (y) shall not apply to amounts paid in settlement of any Claim if 
such settlement is effected without the prior written consent of the Company, 
which consent shall not be unreasonably withheld; and (z) with respect to any 
preliminary prospectus, shall not inure to the benefit of any Indemnified 
Person if the untrue statement or omission of material fact contained in the 
preliminary prospectus was corrected on a timely basis in the prospectus, as 
then amended or supplemented, if such corrected prospectus was timely made 
available by the Company pursuant to Section 3.3 hereof, and the Indemnified 
Person was promptly advised in writing not to use the incorrect prospectus 
prior to the use giving rise to a Violation and such Indemnified 

                                          10


Person, notwithstanding such advice, used it.  Such indemnity shall remain in 
full force and effect regardless of any investigation made by or on behalf of 
the Indemnified Person and shall survive the transfer of the Registrable 
Securities by Purchaser pursuant to Article IX.

    6.2  In connection with any Registration Statement in which Purchaser is 
participating, Purchaser agrees to indemnify, hold harmless and defend, to 
the same extent and in the same manner set forth in Section 6. 1, the 
Company, each of its directors, each of its officers who signs the 
Registration Statement, its employees, agents and persons, if any, who 
control the Company within the meaning of Section 15 of the Securities Act or 
Section 20 of the Exchange Act, and any other stockholder selling securities 
pursuant to the Registration Statement, together with its directors, officers 
and members, and any person who controls such stockholder or underwriter 
within the meaning of the Securities Act or the Exchange Act (such an 
"Indemnified Party"), against any Claim to which any of them may become 
subject, under the Securities Act, the Exchange Act or otherwise, insofar as 
such Claim arises out of or is based upon any Violation, in each case to the 
extent (and only to the extent) that such Violation occurs in reliance upon 
and in conformity with written information furnished to the Company by 
Purchaser expressly for use in connection with such Registration Statement; 
and subject to Section 6.3 Purchaser will reimburse any legal or other 
expenses (promptly as such expenses are incurred and are due and payable) 
reasonably incurred by them in connection with investigating or defending any 
such Claim; provided, however, that the indemnity agreement contained in this 
Section 6.2 shall not apply to amounts paid in settlement of any Claim if 
such settlement is effected without the prior written consent of Purchaser, 
which consent shall not be unreasonably withheld; provided, further, however, 
that Purchaser shall be liable under this Agreement (including this Section 
6.2 and Article VII) for only that amount as does not exceed the net proceeds 
actually received by Purchaser as a result of the sale of Registrable 
Securities pursuant to such Registration Statement.  Such indemnity shall 
remain in full force and effect regardless of any investigation made by or on 
behalf of such Indemnified Party and shall survive the transfer of the 
Registrable Securities by Purchaser pursuant to Article IX.  Notwithstanding 
anything to the contrary contained herein, the indemnification agreement 
contained in this Section 6.2 with respect to any preliminary prospectus 
shall not inure to the benefit of any Indemnified Party if the untrue 
statement or omission of material fact contained in the preliminary 
prospectus was corrected on a timely basis in the prospectus, as then amended 
or supplemented, and the Indemnified Party failed to utilize such corrected 
prospectus.

    6.3  Promptly after receipt by an Indemnified Person or Indemnified Party 
under this Article VI of notice of the commencement of any action (including 
any governmental action), such Indemnified Person or Indemnified Party shall, 
if a Claim in respect thereof is to made against any indemnifying party under 
this Article VI, deliver to the indemnifying party a written notice of the 
commencement thereof, and the indemnifying party shall have the right to 
participate in, and, to the extent the indemnifying party so desires, jointly 
with any other indemnifying party similarly noticed, to assume control of the 
defense thereof with counsel mutually satisfactory to the indemnifying party 
and the Indemnified Person or the Indemnified Party, as the case may be; 
provided, however, that such indemnifying party shall diligently pursue such 
defense and that such indemnifying party shall not be entitled to assume such 
defense and an Indemnified Person or Indemnified Party shall have the right 
to retain its own counsel with the fees and expenses to be paid by the 
indemnifying party, if the representation by such counsel of the Indemnified 
Person or Indemnified Party and the indemnifying party would 

                                          11


be inappropriate due to actual or potential conflicts of interest between 
such Indemnified Person or Indemnified Party and any other party represented 
by such counsel in such proceeding or the actual or potential defendants in, 
or targets of, any such action include both the Indemnified Person or the 
Indemnified Party and any such Indemnified Person or Indemnified Party 
reasonably determines that there may be legal defenses available to such 
Indemnified Person or Indemnified Party which are different from or in 
addition to those available to such indemnifvin2 party.  The indemnifying 
party shall pay for only one separate firm of legal counsel for the 
Indemnified Persons or the Indemnified Parties, as applicable, and such legal 
counsel shall be selected by Purchaser holding a majority-in-interest of the 
Registrable Securities included in the Registration Statement to which the 
Claim relates (with the approval of Purchaser if they hold Registrable 
Securities included in such Registration Statement), if Purchaser are 
entitled to indemnification hereunder, or by the Company, if the Company is 
entitled to indemnification hereunder, as applicable.  The failure to deliver 
written notice to the indemnifying party within a reasonable time of the 
commencement of any such action shall not relieve such indemnifying party of 
any liability to the Indemnified Person or Indemnified Party under this 
Article VI, except to the extent that the indemnifying party is actually 
prejudiced in its ability to defend such action.  The indemnification 
required by this Article VI shall be made by periodic payments of the amount 
thereof during the course of the investigation or defense, as such expense, 
loss, damage or liability is incurred and is due and payable.

                                     ARTICLE VII
                                     CONTRIBUTION
                                           
    To the extent any indemnification by an indemnifying party is prohibited 
or limited by law, the indemnifying party agrees to make the maximum 
contribution with respect to any amounts for which it would otherwise be 
liable under Article VI to the fullest extent permitted by law; provided, 
however, that (i) no contribution shall be made under circumstances where the 
maker would not have been liable for indemnification under the fault 
standards set forth in Article VI, (ii) no person guilty of fraudulent 
misrepresentation (within the meaning of Section 11(f) of the Securities Act) 
shall be entitled to contribution from any person of Registrable Securities 
who was not guilty of such fraudulent misrepresentation, and (iii) 
contribution (together with any indemnification or other obligations under 
this Agreement) by any seller of Registrable Securities shall be limited in 
amount to the net amount of proceeds received by such seller from the sale of 
such Registrable Securities.

                                     ARTICLE VIII
                            REPORTS UNDER THE EXCHANGE ACT
                                           
    With a view to making available to Purchaser the benefits of Rule 144 
promulgated under the Securities Act or any other similar rule or regulation 
of the SEC that may at any time permit Purchaser to sell securities of the 
Company to the public without registration ("Rule 144"), the Company agrees, 
during the Registration Period and for one year thereafter, to:
    
    8.1  Make and keep public information available, as those terms are 
understood and defined in Rule 144;

                                          12



    8.2  File with the SEC in a timely manner and make and keep available all 
reports and other documents required of the Company under the Securities Act 
and the Exchange Act so long as the Company remains subject to such 
requirements (it being understood that nothing herein shall limit the 
Company's obligations under Section 4.3 of the Securities Purchase Agreement) 
and the filing and availability of such reports and other documents is 
required for the applicable provisions of Rule 144; and

    8.3  Furnish to Purchaser so long as Purchaser holds Warrants or 
Registrable Securities, promptly upon request, (i) a written statement by the 
Company that it has complied with the reporting requirements of Rule 144, the 
Securities Act and the Exchange Act, (ii) a copy of the most recent annual or 
quarterly report of the Company and such other reports and documents so filed 
by the Company, and (iii) such other information as may be reasonably 
requested to permit Purchaser to sell such securities pursuant to Rule 144 
without registration.

                                      ARTICLE IX
                          ASSIGNMENT OF REGISTRATION RIGHTS
                                           
    The rights of Purchaser hereunder, including the right to have the 
Company register Registrable Securities pursuant to this Agreement, shall be 
automatically assignable by Purchaser to any transferee of all or any portion 
of the Warrants or the Registrable Securities if:  (a) Purchaser agrees in 
writing with the transferee or assignee to assign such rights, and a copy of 
such agreement is furnished to the Company within a reasonable time after 
such assignment, (b) the Company is, within a reasonable time after such 
transfer or assignment, furnished with written notice of (i) the name and 
address of such transferee or assignee, and (ii) the securities with respect 
to which such registration rights are being transferred or assigned, (c) 
following such transfer or assignment, the further disposition of such 
securities by the transferee or assignee is restricted under the Securities 
Act or applicable state securities laws, (d) at or before the time the 
Company receives the written notice contemplated by clause (ii) of this 
sentence, the transferee or assignee agrees in writing for the benefit of the 
Company to be bound by all of the provisions contained herein, and (e) such 
transfer shall have been made in accordance with the applicable requirements 
of the Securities Purchase Agreement.  Notwithstanding any provision to the 
contrary herein, Purchaser shall have the right to pledge the Registrable 
Securities and in the event that the pledgee forecloses on the pledged 
Registrable Securities, then the pledgee shall be entitled to exercise the 
rights of the Purchaser hereunder.

                                      ARTICLE X
                           AMENDMENT OF REGISTRATION RIGHTS
                                           
    Provisions of this Agreement may be amended and the observance thereof 
may be waived (either generally or in a particular instance and either 
retroactively or prospectively), only with written consent of the Company and 
Purchaser who hold a majority interest of the Registrable Securities 
(determined as if all Warrants then outstanding had been exercised for 
Warrant Shares).  Any amendment or waiver effected in accordance with this 
Article X shall be binding upon Purchaser and the Company.  Notwithstanding 
the foregoing, no amendment or waiver shall retroactively affect Purchaser 
without its consent or prospectively adversely affect Purchaser who no longer 
owns any Warrants or Registrable Securities without its consent.  

                                          13



Neither Article VI nor Article VII hereof may be amended or waived in a 
manner adverse to Purchaser without its consent.

                                      ARTICLE XI
                                    MISCELLANEOUS
                                           
    11.1 A person or entity is deemed to be a holder of Registrable 
Securities whenever such person or entity owns of record such Registrable 
Securities.  If the Company receives conflicting instructions, notices or 
elections from two or more persons or entities with respect to the same 
Registrable Securities, the Company shall act upon the basis of instructions, 
notice or election received from the registered owner of such Registrable 
Securities.

    11.2 Any notices herein required or permitted to be given shall be in 
writing and may be personally served or delivered by courier (including a 
recognized overnight delivery service) or by confirmed telecopy, and shall be 
deemed delivered at the time and date of receipt (which shall include 
telephone line facsimile transmission).  The addresses for such 
communications shall be:

              If to the Company:
              
              Biospherics Incorporated
              12051 Indian Creek Court
              Beltsville, MD  20705
              Telecopy:  301-210-4908/09
              Attention:  Dr. Gilbert V. Levin
              
                   with a copy to:
              
              Smith, Somerville & Case, L.L.C.
              Attorneys At Law
              100 Light Street
              Baltimore, MD  21202
              Telecopy:  410-385-8060
              Attention:  James Baker, Esq.
              
              If to RGC International Investors, LDC:
              
              c/o Rose Glen Capital Management, L.P.
              251 St. Asaphs Road
              Suite 200
              3 Bala Plaza East
              Bala Cynwyd, PA  19004
              Telecopy:  610-617-0570
              Attention:  Wayne D. Bloch
              
                   with a copy to:
              


                                          14


              Ballard, Spahr, Andrews & Ingersoll
              1735 Market Street
              51st Floor
              Philadelphia, PA  19103
              Telecopy:  215-864-8999
              Attention:  Gerald J. Guarcini, Esq.

and if to Purchaser, at such address as Purchaser shall have provided in 
writing to the Company, or at such other address as each such party furnishes 
by notice given in accordance with this Section 11.2.

    11.3 Failure of any party to exercise any right or remedy under this 
Agreement or otherwise, or delay by a party in exercising such right or 
remedy, shall not operate as a waiver thereof.

    11.4 This Agreement shall be governed by and construed in accordance with 
the laws of the State of Delaware applicable to contracts made and to be 
performed in the State of Delaware.  The Company irrevocably consents to the 
jurisdiction of the federal courts located in the state of Delaware and the 
state courts of the State of Delaware located in the County of New Castle in 
the State of Delaware in any suit or proceeding based on or arising under 
this Agreement and irrevocably agrees that all claims in respect of such suit 
or proceeding may be determined in such courts.  The Company irrevocably 
waives the defense of an inconvenient forum to the maintenance of such suit 
or proceeding. The parties hereto further agree that service of process upon 
the parties hereto mailed by first class mail shall be deemed in every 
respect effective service of process upon each such party in any such suit or 
proceeding.  Nothing herein shall affect either party's right to serve 
process in any other manner permitted by law.  The parties hereto agree that 
a final non-appealable judgment, in any such suit or proceeding shall be 
conclusive and may be enforced in other jurisdictions by suit on such 
judgment or in any other lawful manner.

    11.5 This Agreement, the Warrants and the Securities Purchase Agreement 
(including all schedules and exhibits thereto and all certificates and 
opinions required thereby) constitute the entire agreement among the parties 
hereto with respect to the subject matter hereof and thereof.  There are no 
restrictions, promises, warranties or undertakings, other than those set 
forth or referred to herein and therein.  This Agreement, the Warrants and 
the Securities Purchase Agreement supersede all prior agreements and 
understandings among the parties hereto with respect to the subject matter 
hereof and thereof.

    11.6 Subject to the requirements of Article IX hereof, this Agreement 
shall inure to the benefit of and be binding upon the successors and 
permitted assigns of each of the parties hereto.

    11.7 The headings in this Agreement are for convenience of reference only 
and shall not limit or otherwise affect the meaning hereof.

    11.8 This Agreement may be executed in two or more counterparts, each of 
which shall be deemed an original but all of which shall constitute one and 
the same agreement.  This Agreement, once executed by a party, may be 
delivered to the other party hereto, by facsimile 

                                          15


transmission of a copy of this Agreement bearing the signature of the party 
so delivering this Agreement.

    11.9 Each party shall do and perform, or cause to be done and performed, 
all such further acts and things, and shall execute and deliver all such 
other agreements, certificates, instruments and documents, as the other party 
may reasonably request in order to carry out the intent and accomplish the 
purposes of this Agreement and the consummation of the transactions 
contemplated hereby.

    11.10     All consents and other determinations to be made by Purchaser 
pursuant to this Agreement shall be made by Purchaser holding a majority of 
the Registrable Securities (determined as if all Warrants then outstanding 
had been exercised for Warrant Shares) held by Purchaser.

    11.11     The initial number of Registrable Securities included on any 
Registration Statement and each increase to the number of Registrable 
Securities included thereon shall be allocated 100% to Purchaser based on the 
number of Registrable Securities held by Purchaser at the time of such 
establishment or increase, as the case may be.  In the event Purchaser shall 
sell or otherwise transfer any of such holder's Registrable Securities, each 
transferee shall be allocated a pro rata portion of the number of Registrable 
Securities included on a Registration Statement for such transferor.  Any 
shares of Common Stock included on a Registration Statement and which remain 
allocated to any person or entity which does not hold any Registrable 
Securities shall be allocated to Purchaser, pro rata based on the number of 
shares of Registrable Securities then held by Purchaser.  Without implication 
that the contrary would otherwise be true, for purposes, of this paragraph, 
all Warrants then outstanding shall be assumed exercised for Warrant Shares.

    11.12     If any provision of this Agreement shall be invalid or 
unenforceable, such invalidity or unenforceability shall not affect the 
validity or enforceability of the remainder of this Agreement.
    
    11.13     The language used in this Agreement will be deemed to be the 
language chosen by the parties to express their mutual intent, and no rules 
of strict construction will be applied against any party.

                                      * * * * *
                                           


                                          16


    IN WITNESS WHEREOF, the parties have caused this Agreement to be duly 
executed as of the date first above written.

COMPANY:

BIOSPHERICS INCORPORATED

By: _______________________________

Name:    _______________________________

Title:   _______________________________


PURCHASER:

RGC INTERNATIONAL INVESTORS, LDC

By: Rose Glen Capital Management, L.P.
    Investment Manager
    By:  RGC General Partner Corp., as General Partner

By:  _____________________________

Its: ______________________________

                                          17



                                                                       EXHIBIT 1
                                                                 to Registration
                                                                Rights Agreement

                                         Date
                                           
American Stock Transfer and Trust Co.
6201 15th Avenue, 3rd Floor
Brooklyn, NY  11219

Ladies and Gentlemen:

    This letter shall serve as our irrevocable authorization and direction to 
you (1) to transfer or re-register (or at the holders request to reissue to 
the holder thereof without any restrictive legend) the certificates for the 
shares of Common Stock, par value $.005 per share (the "Common Stock"), of 
Biospherics Incorporated, a Delaware corporation (the "Company"), represented 
by certificate numbers _____ for an aggregate of _____ shares (the 
"Outstanding Shares") of Common Stock presently registered in the name of 
[Name of Investor] (the "Investor") (which shares were previously issued 
pursuant to the Securities Purchase Agreement dated December 12, 1997 (the 
"Agreement") or exercise of the Warrants (as hereinafter defined)), upon 
surrender of such certificates to you, notwithstanding the legend appearing 
on such certificates, and (2) to issue shares (the "Warrant Shares") of the 
Common Stock to or upon the order of the registered holder from time to time 
of the Warrants of the Company (the "Warrants") upon surrender to you of a 
properly completed and duly executed Exercise Agreement and such Warrants 
notwithstanding the legend appearing on such Warrants.  The transfer or 
re-registration of the certificates for the Outstanding Shares by you should 
be made at such time as you are requested to do so by the record holder of 
the Outstanding Shares.  The certificate issued upon such transfer or 
re-registration should be registered in such name as requested by the holder 
of record of the certificate surrendered to you and should not bear any 
legend which would restrict the transfer of the shares represented thereby.  
In addition, you are hereby directed to remove any stop-transfer instruction 
relating to the Outstanding Shares.  Certificates for the shares issued 
pursuant to the Agreement and Warrant Shares should not bear any restrictive 
legend and should not be subject to any stop-transfer restriction.

    Pursuant to applicable securities laws or certain agreements between the 
Company and the Investor, the Investor may be prohibited during certain 
limited periods of time from selling its Outstanding Shares or other shares 
of Common Stock issued pursuant to the Agreement or issuable upon exercise of 
the Warrants under the Registration Statement; provided, however, that such 
Investor may continue to sell such securities pursuant to an exemption from 
registration under the Securities Act of 1933, as amended (the "1933 Act").  
The Company may, during such periods, deliver a notice to you advising you to 
refrain from transferring any Outstanding Shares pursuant to such 
Registration Statement, provided that such notice shall not prohibit the 
transfer of such shares pursuant to an exemption from registration under the 
1933 Act during such periods.

                                          18


    Contemporaneous with the delivery of this letter, the Company is 
delivering to you a letter of ____________ as to registration of the 
Outstanding Shares and the Conversion Shares under the Securities Act of 
1933, as amended.

    Should you have any questions concerning this matter, please contact me.

                                               Very truly yours,

                                               BIOSPHERICS INCORPORATED



                                               ________________________________
                                               By:
                                               Title:

Enclosures:
cc:  [Name of Investor]


                                          19


                                                                       EXHIBIT 2
                                                                 to Registration
                                                                Rights Agreement

                                         Date
                                           
American Stock Transfer and Trust Co.
6201 15th Avenue, 3rd Floor
Brooklyn, NY  11219

                             RE: Biospherics Incorporated
                                           
Ladies and Gentlemen:

    We are counsel to Biospherics Incorporated, a Delaware corporation (the 
"Company"), and we understand that [Name of Purchaser] (the "Holder") has 
purchased from the Company (i) shares of the Company's common stock, par 
value $.005 per share (the "Common Stock") and (ii) warrants to purchase 
shares of Common Stock.  Such securities were purchased by the Holder 
pursuant to a Securities Purchase Agreement, dated as of December 12, 1997, 
by and among the Company and the signatories thereto (the "Agreement").  
Pursuant to a Registration Rights Agreement, dated as of December 12, 1997, 
by and among the Company and the signatories thereto (the "Registration 
Rights Agreement"), the Company agreed with the Holder, among other things, 
to register the Registrable Securities (as that term is defined in the 
Registration Rights Agreement) under the Securities Act of 1933, as amended 
(the "Securities Act"), upon the terms provided in the Registration Rights 
Agreement.  In connection with the Company's obligations under the 
Registration Rights Agreement, on ________ ___, 1998, the Company filed a 
Registration Statement on Form S-_____ (File No. 333-_____________) (the 
"Registration Statement") with the Securities and Exchange Commission (the 
"SEC") relating to the Registrable Securities, which names the Holder as a 
selling stockholder thereunder.

    
[Other customary introductory and scope of examination language to be inserted]

    Based on the foregoing, we are of the opinion that the Registrable 
Securities have been registered under the Securities Act.

                [Other appropriate customary language to be included.]
                                           
                                  Very truly yours,
                                           
cc: [Name of Purchaser]


                                          20