AMENDMENT NO. 2 TO REVOLVING LOAN AGREEMENT


          This Amendment No. 2 to Revolving Loan Agreement (this "Amendment") is
entered into with reference to the Revolving Loan Agreement dated as of June 2,
1997,  (as heretofore amended, the "Loan Agreement") among Alexandria Real
Estate Equities, Inc., ARE-QRS Corp. and ARE Acquisitions, LLC (collectively,
"Borrowers"), the Banks party thereto, and Bank of America National Trust and
Savings Association, as Managing Agent (the "Loan Agreement).  Capitalized terms
used but not defined herein are used with the meanings set forth for those terms
in the Loan Agreement.

          Borrowers and the Managing Agent, acting with the consent of the
Requisite Banks pursuant to Section 11.2 of the Loan Agreement, agree as
follows:

          1.   AMENDMENT TO SECTION 1.1.  Section 1.1 of the Loan Agreement is
amended by adding the following proviso at the end of the definition of
"Adjusted EBITDA":

               "; PROVIDED, that Adjusted EBITDA for the Interim
               Calculation Period shall be calculated, as of any
               date of determination, by multiplying Adjusted
               EBITDA for the period commencing on July 1, 1997
               through the last day of the then most-recently
               ended Fiscal Quarter by the appropriate factor so
               as to result in annualized Adjusted EBITDA for
               such period."

          2.   AMENDMENT TO SECTION 1.1.  Section 1.1 of the Loan Agreement is
further amended by adding the following proviso at the end of the definition of
"Adjusted NOI":

               "; PROVIDED, that Adjusted NOI for the Interim
               Calculation Period shall be calculated, as of any
               date of determination, by multiplying Adjusted NOI
               for the period commencing on July 1, 1997 through
               the last day of the then most-recently ended
               Fiscal Quarter by the appropriate factor so as to
               result in annualized Adjusted NOI for such
               period."


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           3.   SECTION 1.1.  Section 1.1 of the Loan Agreement is further
  amended by SUBSTITUTING the phrase "for the fiscal period consisting of the
  applicable Calculation Period" for the phrase "for the fiscal period
  consisting of that Fiscal Quarter and the three immediately preceding
  Fiscal Quarters" in each of the following definitions:
  
                "Fixed Charge Coverage"
                "Interest Coverage"
                "Gross Asset Value"
                "Revenue-Producing Property Value"
                "Unencumbered Asset Pool Value"
  
           4.   SECTION 1.1.  Section 1.1 of the Loan Agreement is further
  amended by SUBSTITUTING the phrase "for the applicable Calculation Period" for
  the phrase "for that Fiscal Quarter and the three immediately preceding Fiscal
  Quarters" in the definition of "Mortgage Amount."
  
           5.   SECTION 1.1.  Section 1.1 of the Loan Agreement is further
  amended by SUBSTITUTING the following for the definition of "Consent
  Criteria":
  
                "CONSENT CRITERIA" means, as of any date of
                determination, that as of that date EITHER
                (a) Parent holds a Credit Rating of BBB- (or its
                equivalent) or better or (b) as of the last day of
                the Fiscal Quarter then most recently-ended, the
                RATIO OF (i) Adjusted NOI of all Revenue-Producing
                Properties (PROVIDED, however, in the case of any
                Revenue-Producing Property (a "New Property") that
                within the preceding sixty (60) day period has
                been purchased by a Borrower from a Person that is
                now a tenant occupying 100% of such New Property,
                that Adjusted NOI for such New Property shall be
                the Adjusted NOI for the first year of such lease
                as reflected in a pro-forma income statement for
                this New Property prepared by Parent in good faith
                using reasonable assumptions consistent with all
                facts known to Parent) for the fiscal period
                consisting of the appropriate Calculation Period
                to (ii) the sum of (A) Interest Charges for such
                fiscal period PLUS (B) all scheduled principal
                payments on Indebtedness of Parent (INCLUDING the
                principal portion of rent under Capital Lease
                Obligations)


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                made during such fiscal period, other
                than payments made at the maturity date of such
                Indebtedness, was 3.50 to 1.00 or greater.
  
           6.   SECTION 1.1.  Section 1.1 of the Loan Agreement is further
  amended by adding the following new definitions at the appropriate
  alphabetical places:
  
                "CALCULATION PERIOD" means (a) with respect to the
                last day of each Fiscal Quarter ending before
                June 30, 1998, the related Interim Calculation
                Period and (b) with respect to the last day of
                each Fiscal Quarter ending on or after June 30,
                1998, the period consisting of that Fiscal Quarter
                and the three immediately preceding Fiscal
                Quarters.
  
                "INTERIM CALCULATION PERIOD" means, with respect
                to the last day of each Fiscal Quarter ending
                before June 30, 1998, the period commencing on
                July 1, 1997 and ending on such last day of the
                Fiscal Quarter.
  
           7.   COMPLIANCE CERTIFICATE .  Exhibit E to the Loan Agreement is
  amended to read as set forth in Attachment I to this Amendment.
  
           8.   PRIOR COMPLIANCE CERTIFICATES.  The Banks recognize that the
  Compliance Certificates submitted by Borrower for the Fiscal Quarters ended
  June 30, 1997 and September 30, 1997 utilized a different annualization
  calculation method for Fixed Charge Coverage and Interest Coverage from that
  which is implemented by this Amendment, and agree that such Compliance
  Certificates were and are acceptable to the Banks to evidence Borrower's
  compliance with the Loan Agreement as of the dates thereof.
  
           9.   CONDITIONS PRECEDENT.  The effectiveness of this Amendment shall
  be conditioned upon the receipt by the Managing Agent of all of the following,
  each properly executed by a Responsible Official of each party thereto and
  dated as of the date hereof:
  
                     (a)  Counterparts of this Amendment executed by all
                          parties hereto; and


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                     (b)  Written consent of the Requisite Banks as required
                          under Section 11.2 of the Loan Agreement in the
                          form of Exhibit A to this Amendment.
  
           10.  REPRESENTATION AND WARRANTY.  Borrowers represent and warrant to
  the Managing Agent and the Banks that no Default or Event of Default has
  occurred and remains continuing.
  
           11.  CONFIRMATION.  In all other respects, the terms of the Loan
  Agreement and the other Loan Documents are hereby confirmed.
  
           IN WITNESS WHEREOF, Borrowers and the Managing Agent have executed
  this Amendment as of January 28, 1998 by their duly authorized
  representatives.
  
  
                                       ALEXANDRIA REAL ESTATE EQUITIES, INC.
                                       ARE-QRS CORP.
                                       ARE ACQUISITIONS, LLC
  
  
                                       By:       /s/ Joel S. Marcus
                                           ---------------------------------
                                                   Joel S. Marcus
                                                   Chief Executive Officer
  
                                       BANK OF AMERICA NATIONAL TRUST AND
                                       SAVINGS ASSOCIATION, as Managing Agent
  
  
  
                                       By         /s/ William Rothman
                                           ---------------------------------
                                           William Rothman
                                           Regional Vice President


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                            Exhibit A to Amendment
   
                                CONSENT OF BANK
  
           Reference is hereby made to that certain Revolving Loan Agreement
dated as of June 2, 1997 (as heretofore amended, the "Loan Agreement") among
Alexandria Real Estate Equities, Inc., ARE-QRS Corp. and ARE Acquisitions, LLC
(collectively, "Borrowers"), the Banks party thereto, and Bank of America
National Trust and Savings Association, as Managing Agent (the "Loan Agreement).
Capitalized terms used but not defined herein are used with the meanings set
forth for those terms in the Loan Agreement.
  
           The undersigned Bank hereby consents to the execution and delivery of
Amendment No. 2 to Revolving Loan Agreement by the Managing Agent on its behalf,
substantially in the form of a draft dated on or about January __, 1998
presented to the undersigned Bank.
  
  
           Date: January __, 1998
  
                                         
                                         -----------------------------------
                                         [Name of Institution]
  
  
                                       By: 
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                                           [Printed Name and Title]