AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 19, 1998
                                             REGISTRATION NO. 333- ___________
- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------
                                          
                         SECURITIES AND EXCHANGE COMMISSION
                              Washington, D.C.  20549
                                     -----------
                                      FORM S-8
                               REGISTRATION STATEMENT
                                       UNDER
                             THE SECURITIES ACT OF 1933
                                     -----------
                                  GENE LOGIC INC.
               (Exact name of Registrant as specified in its charter)
                                     -----------
             Delaware                                          06-1411336
  (State or other jurisdiction                              (I.R.S. Employer
of incorporation or organization)                        Identification Number)

                               708 Quince Orchard Road
                             Gaithersburg, Maryland 20878
                       (Address of principal executive offices)
                                     -----------
                              1997 EQUITY INCENTIVE PLAN
                             EMPLOYEE STOCK PURCHASE PLAN
                    1997 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
                              (Full title of the plans)
                                     -----------

                           MICHAEL J. BRENNAN, M.D., PH.D.
                        President and Chief Executive Officer
                                   GENE LOGIC INC.
                               708 Quince Orchard Road
                             Gaithersburg, Maryland 20878
                                    (301) 987-1700
             (Name, address, including zip code, and telephone number, 
                     including area code, of agent for service)
                                     -----------

                                      Copies to:

                               Frederick T. Muto, Esq.
                                L. Kay Chandler, Esq.
                                  COOLEY GODWARD LLP
                           4365 Executive Drive, Suite 1100
                                 San Diego, CA 92121
                                    (619) 550-6000
                                     -----------



                                  CALCULATION OF REGISTRATION FEE
- -----------------------------------------------------------------------------------------------------
                                                     PROPOSED          PROPOSED 
                                                     MAXIMUM            MAXIMUM           AMOUNT OF
TITLE OF SECURITIES               AMOUNT TO       OFFERING PRICE       AGGREGATE         REGISTRATION
 TO BE REGISTERED               BE REGISTERED      PER SHARE (1)    OFFERING PRICE (1)        FEE
- -----------------------------------------------------------------------------------------------------
                                                                              
Common Stock, $.01 par value      5,843,644         $0.15-8.50       $31,810,802           $9,384.19
- -----------------------------------------------------------------------------------------------------




(1)  Estimated solely for the purpose of calculating the amount of the
     registration fee pursuant to Rule 457.  The price per share and aggregate
     offering price are based upon (a) the actual exercise price for shares
     subject to outstanding stock options previously granted under the
     Registrant's 1997 Equity Incentive Plan; and (b) the average of the high
     and low sales prices of Registrant's Common Stock on May 18, 1998, as
     reported on the Nasdaq National Market, for shares issuable under the
     Registrant's 1997 Equity Incentive Plan, Employee Stock Purchase Plan, and
     Non-Employee Directors' Stock Option Plan.  The following chart shows the
     calculation of the registration fee:



                                                     Number of               Offering Price            Aggregate
             Type of Shares                            Shares                  Per Share             Offering Price
             --------------                          ---------               --------------          --------------
                                                                                            
Common Stock issuable pursuant to outstanding          831,999                   $0.15                $  124,800
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           94,500                   $0.30                $   28,350
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding          435,290                   $1.00                $  435,290
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding          765,633                   $2.50                $1,914,083
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           56,000                   $3.50                $  196,000
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           73,000                   $8.375               $  611,375
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           25,024                   $7.9375              $  198,628
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           17,000                   $8.0625              $  137,063
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           20,000                   $8.50                $  170,000
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           28,500                   $8.25                $  235,125
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           23,000                   $8.438               $  194,074
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding            1,000                   $8.00                $    8,000
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding          160,000                   $7.875               $1,260,000
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding            3,000                   $7.031               $   21,093
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           11,000                   $8.313               $   91,443
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to outstanding           11,000                   $8.1250              $   89,375
options under the 1997 Equity Incentive Plan

Common Stock issuable pursuant to the 1997           2,912,698                   $7.9375              $23,119,540
Equity Incentive Plan

Common Stock issuable pursuant to the Employee         250,000                   $7.9375              $1,984,375
Stock Purchase Plan

Common Stock issuable under the 1997 Non-Employee      125,000                   $7.9375              $  992,188
Directors' Stock Option Plan



                                       
                                    PART II
                                       
                 INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

     The prospectus contained in the Form S-1 Registration Statement (No. 
333-37317) filed by Gene Logic Inc. (the "Registrant") with the Securities 
and Exchange Commission (the "Commission") on October 7, 1997, as amended 
through the date hereof (the "Form S-1"), is hereby incorporated by reference 
into this Registration Statement.  Registrant also incorporates by reference 
its Annual Report on Form 10-K for the year ended December 31, 1997, filed on 
March 31, 1998 and its Quarterly Report on Form 10-Q for the quarter ended 
March 31, 1998, filed on May 14, 1998 pursuant to Sections 13 or 15(d) of the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"). A 
description of the Registrant's Common Stock which is contained in the Form 
S-1, including any amendment or reports filed for the purpose of updating 
such description, is hereby incorporated by reference into this Registration 
Statement.  All documents filed by the Registrant with the Commission 
pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the 
date of this Registration Statement and prior to the filing of a 
post-effective amendment which indicates that all securities offered have 
been sold or which deregisters all securities then remaining unsold shall be 
deemed to be incorporated by reference into this Registration Statement and 
to be a part hereof from the date of filing of such documents.  Any statement 
contained in a document incorporated by reference herein shall be deemed to 
be modified or superseded for purposes of this Registration Statement to the 
extent that a statement contained herein or in any other subsequently filed 
document which also is or is deemed to be incorporated by reference herein 
modifies or supersedes such statement.  Any statement so modified or 
superseded shall not be deemed, except as so modified or superseded, to 
constitute a part of this Registration Statement.

ITEM 4.  DESCRIPTION OF SECURITIES.

     Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

     The validity of the shares of Common Stock offered hereby will be passed 
upon for the Company by Cooley Godward LLP, San Diego, California.
       
ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.
       
     Under Section 145 of the Delaware General Corporation Law, the 
Registrant has broad powers to indemnify its Directors and officers against 
liabilities they may incur in such capacities, including liabilities under 
the Securities Act.

     The Registrant's Restated Certificate of Incorporation and Amended and 
Restated By-laws include provisions to (i) eliminate the personal liability 
of its Directors for monetary damages resulting from breaches of their 
fiduciary duty to the extent permitted by Section 102(b)(7) of the General 
Corporation Law of Delaware (the "Delaware Law") and (ii) require the 
Registrant to indemnify its Directors and officers to the fullest extent 
permitted by Section 145 of the Delaware Law, including circumstances in 
which indemnification is otherwise discretionary.  Pursuant to Section 145 of 
the Delaware Law, a corporation generally has the power to indemnify its 
present and former directors, officers, employees and agents against expenses 
incurred by them in connection with any suit to which they are or are 
threatened to be made a party by reason of their serving in such positions so 
long as they acted in good faith and in a manner they reasonably believed to 
be in or not opposed to, the best interests 


                                       1



of the corporation and with respect to any criminal action, they had no 
reasonable cause to believe their conduct was unlawful.  The Registrant 
believes that these provisions are necessary to attract and retain qualified 
persons as Directors and officers.  These provisions do not eliminate the 
Directors' duty of care, and, in appropriate circumstances, equitable 
remedies such as injunctive or other forms of non-monetary relief will remain 
available under Delaware Law.  In addition, each Director will continue to be 
subject to liability for breach of the Director's duty of loyalty to the 
Registrant, for acts or omissions not in good faith or involving intentional 
misconduct, for knowing violations of law, for acts or omissions that the 
Director believes to be contrary to the best interests of the Registrant or 
its stockholders, for any transaction from which the Director derived an 
improper personal benefit, for acts or omissions involving a reckless 
disregard for the Director's duty to the Registrant or its stockholders when 
the Director was aware or should have been aware of a risk of serious injury 
to the Registrant or its stockholders, for acts or omissions that constitute 
an unexcused pattern of inattention that amounts to an abdication of the 
Director's duty to the Registrant or its stockholders, for improper 
transactions between the Director and the Registrant and for improper 
distributions to stockholders and loans to Directors and officers.  The 
provision also does not affect a Director's responsibilities under any other 
law, such as the federal securities law or state or federal environmental 
laws.

     The Registrant has entered into indemnity agreements with each of its 
Directors and executive officers that require the Registrant to indemnify 
such persons against expenses, judgments, fines, settlements and other 
amounts incurred (including expenses of a derivative action) in connection 
with any proceeding, whether actual or threatened, to which any such person 
may be made a party by reason of the fact that such person is or was Director 
or an executive officer of the Registrant or any of its affiliated 
enterprises, provided that such person acted in good faith and in a manner 
such person reasonably believed to be in or not opposed to the best interests 
of the Registrant and, with respect to any criminal proceeding, had no 
reasonable cause to believe his conduct was unlawful.  The indemnification 
agreements also set forth certain procedures that will apply in the event of 
a claim for indemnification thereunder.

     At present, there is no pending litigation or proceeding involving a 
Director, officer or key employee of the Registrant as to which 
indemnification is being sought nor is the Registrant aware of any threatened 
litigation that may result in claims for indemnification by any officer or 
Director.

     The Registrant has an insurance policy covering the officers and 
Directors of the Registrant with respect to certain liabilities, including 
liabilities arising under the Securities Act or otherwise.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.
     
     Not applicable.

ITEM 8.  EXHIBITS.



EXHIBIT NO.    DESCRIPTION
            
     4.1       Amended and Restated Certificate of Incorporation. (1)

     4.2       By-laws, as amended and restated. (1)

     4.3       Specimen Stock Certificate. (1)

     5.1       Opinion of Cooley Godward LLP.

     23.1      Consent of Arthur Andersen LLP, Independent Auditors.

     23.2      Consent of Cooley Godward LLP.  Reference is made to Exhibit 5.1.


                                       2





EXHIBIT NO.    DESCRIPTION
            
     24.1      Power of Attorney.  Reference is made to page 5.

     99.1      Registrant's 1997 Equity Incentive Plan (the "1997 Plan"). (1)

     99.2      Form of Stock Option Agreement under the 1997 Plan. (1)

     99.3      Form of Stock Option Grant Notice under the 1997 Plan. (1)

     99.4      Registrant's Employee Stock Purchase Plan and related offering
               document. (1)

     99.5      Registrant's 1997 Non-Employee Directors' Stock Option Plan. (1)

     99.6      Form of Nonstatutory Stock Option under Registrant's 1997 
               Non-Employee Directors' Stock Option Plan. (1)

- ---------------
(1)  Filed as an exhibit to Registration Statement on Form S-1 (No. 333-37317)
     originally filed on October 7, 1997, as amended through the date hereof,
     and incorporated herein by reference.

ITEM 9.  UNDERTAKINGS.


1.   The undersigned Registrant hereby undertakes:

     (a)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement:

          (i)  To include any prospectus required by Section 10(a)(3) of the
Securities Act;

          (ii) To reflect in the prospectus any facts or events arising after 
the effective date of the Registration Statement (or the most recent 
post-effective amendment thereof) which, individually or in the aggregate, 
represent a fundamental change in the information set forth in the 
Registration Statement. Notwithstanding the foregoing, any increase or 
decrease in volume of securities offered (if the total dollar value of 
securities offered would not exceed that which was registered) and any 
deviation from the low or high end of the estimated maximum offering range 
may be reflected in the form of prospectus filed with the Commission pursuant 
to Rule 424(b) if, in the aggregate, the changes in volume and price 
represent no more than a 20% change in the maximum aggregate offering price 
set forth in the "Calculation of Registration Fee" table in the effective 
Registration Statement;

          (iii) To include any material information with respect to the plan 
of distribution not previously disclosed in the Registration Statement or any 
material change to such information in the Registration Statement;

     PROVIDED, HOWEVER, that paragraphs (1)(a)(i) and (1)(a)(ii) above do not 
apply if the information required to be included in a post-effective 
amendment by those paragraphs is contained in periodic reports filed with or 
furnished to the Commission by the Registrant pursuant to Section 13 or 
Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by 
reference in this Registration Statement;

     (b)  That, for the purpose of determining any liability under the 
Securities Act, each such post-effective amendment shall be deemed to be a 
new registration statement relating to the securities offered therein, and 
the offering of such securities at that time shall be deemed to be the 
initial BONA FIDE offering thereof.

     (c)  To remove from registration by means of a post-effective amendment 
any of the securities being registered which remain unsold at the termination 
of the offering.

                                       3



2.   The undersigned Registrant hereby undertakes that, for purposes of 
determining any liability under the Securities Act, each filing of the 
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the 
Exchange Act of 1934 (and, where applicable, each filing of an employee 
benefit plan's annual report pursuant to Section 15(d) of the Exchange Act of 
1934) that is incorporated by reference in the Registration Statement shall 
be deemed to be a new registration statement relating to the securities 
offered therein, and the offering of such securities at that time shall be 
deemed to be the initial BONA FIDE offering thereof.

3.   Insofar as indemnification for liabilities arising under the Securities 
Act may be permitted to directors, officers and controlling persons of the 
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant 
has been advised that in the opinion of the Securities and Exchange 
Commission such indemnification is against public policy as expressed in the 
Act, and is, therefore, unenforceable.  In the event that a claim for 
indemnification against such liabilities (other than the payment by the 
Registrant of expenses incurred or paid by a director, officer or controlling 
person of the Registrant in the successful defense of any action, suit or 
proceeding) is asserted by such director, officer or controlling person in 
connection with the securities being registered, the Registrant will, unless 
in the opinion of its counsel the matter has been settled by controlling 
precedent, submit to a court of appropriate jurisdiction the question whether 
such indemnification by it is against public policy as expressed in the Act 
and will be governed by the final adjudication of such issue.


                                      4



                                 SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of Gaithersburg, State of Maryland, on 
May 19, 1998.

                                     GENE LOGIC INC.

                                     By: /s/Michael J. Brennan
                                         -------------------------------
                                         Michael J. Brennan, M.D., Ph.D.
                                         President and Chief Executive Officer
                                       
                                 
                                POWER OF ATTORNEY

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below constitutes and appoints Michael J. Brennan, M.D., Ph.D., and 
Mark D. Gessler, and each or any one of them, his true and lawful 
attorney-in-fact and agent, with full power of substitution and 
resubstitution, for him and in his name, place and stead, in any and all 
capacities, to sign any and all amendments (including post-effective 
amendments, exhibits thereto and other documents in connection with) to this 
Registration Statement, and to file the same, with all exhibits thereto, and 
other documents in connection therewith, with the Securities and Exchange 
Commission, granting unto said attorney-in-fact and agent full power and 
authority to do and perform each and every act and thing requisite and 
necessary to be done in connection therewith, as fully to all intents and 
purposes as he or she might or could do in person, hereby ratifying and 
confirming all that said attorney-in-fact and agent, or his substitutes or 
substitute, may lawfully do or cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act, this Registration 
Statement has been signed by the following persons in the capacities and on 
the dates indicated.



SIGNATURE                            TITLE                                          DATE
                                                                              

/s/ Michael J. Brennan               President, Chief Executive Officer and         May 19, 1998
- --------------------------------     Director (PRINCIPAL EXECUTIVE OFFICER)                         
Michael J. Brennan, M.D., Ph.D.

/s/ Mark D. Gessler                  Senior Vice President, Corporate Development   May 19, 1998
- --------------------------------     and Chief Financial Officer (PRINCIPAL                         
Mark D. Gessler                      FINANCIAL AND ACCOUNTING OFFICER)


/s/ Alan G. Walton                   Chairman of the Board of Directors             May 19, 1998
- --------------------------------                    
Alan G. Walton, Ph.D., D.Sc.                                                                        


/s/ Jules Blake                      Director                                       May 19, 1998
- --------------------------------
Jules Blake, Ph.D.                                                                                  


/s/ Charles L. Dimmler III           Director                                       May 19, 1998
- --------------------------------
Charles L. Dimmler III                                                                              


/s/ G. Anthony Gorry                 Director                                       May 19, 1998
- --------------------------------
G. Anthony Gorry, Ph.D.                                                                             


/s/ Jeffrey D. Sollender             Director                                       May 19, 1998
- --------------------------------
Jeffrey D. Sollender                                                                                


                                       5




                                EXHIBIT INDEX




EXHIBIT NO.     DESCRIPTION
             
    4.1         Amended and Restated Certificate of Incorporation. (1)

    4.2         By-laws, as amended and restated. (1)

    4.3         Specimen Stock Certificate. (1)

    5.1         Opinion of Cooley Godward LLP.

   23.1         Consent of Arthur Andersen LLP, Independent Auditors.

   23.2         Consent of Cooley Godward LLP.  Reference is made to 
                Exhibit 5.1.

   24.1         Power of Attorney.  Reference is made to page 5.

   99.1         Registrant's 1997 Equity Incentive Plan (the "1997 Plan"). (1)

   99.2         Form of Stock Option Agreement under the 1997 Plan. (1)

   99.3         Form of Stock Option Grant Notice under the 1997 Plan. (1)

   99.4         Registrant's Employee Stock Purchase Plan and related offering 
                document. (1)

   99.5         Registrant's 1997 Non-Employee Directors' Stock Option Plan. (1)

   99.6         Form of Nonstatutory Stock Option under Registrant's 1997 
                Non-Employee Directors' Stock Option Plan. (1)

- -----------------
(1)  Filed as an exhibit to Registration Statement on Form S-1 (No. 333-37317)
     originally filed on October 7, 1997, as amended through the date hereof,
     and incorporated herein by reference.