[Letterhead of DURA PHARMACEUTICALS, INC.]

 
                                June 5, 1998


To Our Stockholders:

          On May 21, 1998, your Board of Directors declared a dividend 
distribution of Preferred Stock Purchase Rights (the "Rights").  The Rights 
will be issued on June 5, 1998 to stockholders of record on that date and 
will expire in ten years.  This letter and its attachment summarize certain 
key features of the Stockholder Rights Plan and the Board of Directors' 
reasons for adopting it. These documents should be kept with your Common 
Stock Certificates.

          The Rights contain provisions that should, along with certain 
charter and by-law provisions and certain provisions of the Delaware General 
Corporation Law, help protect the stockholders of the Company in the event of 
an unsolicited attempt to acquire the Company, including a gradual 
accumulation of shares in the open market, a partial or two-tier tender offer 
that does not treat all stockholders equally, a squeeze-out merger and/or 
other coercive or unfair takeover tactics.  These tactics can unfairly 
pressure stockholders, squeeze them out of their investment without giving 
them any real choice and deprive them of the full value of their shares, and 
the Board of Directors does not believe they are in the best interests of the 
Company's stockholders.

          Over 1,700 companies, including approximately half the Fortune 500
companies and two-thirds of the Fortune 200 companies, have issued similar
rights to protect their stockholders against these tactics.  We consider the
Rights to be very valuable in protecting both your right to retain your equity
investment in the Company and the full value of that investment, while not
foreclosing a fair acquisition bid for the Company.

          Your Board of Directors was aware when it acted that some people 
have advanced arguments that securities of the sort we are issuing deter 
legitimate acquisition proposals.  We carefully considered these views and 
concluded that the arguments are speculative and do not justify leaving 
stockholders without any protection provided by the distribution of the 
Rights.  Your Board of Directors believes that these Rights represent a sound 
and reasonable means of addressing the complex issues of corporate policy.



To Our Stockholders                                                       Page 2
June 5, 1998


          The Rights are not intended to prevent an acquisition of the Company
and will not do so.  However, they should deter any attempt to acquire the
Company in a manner or on terms not approved by the Board of Directors.  The
Rights may be redeemed by the Board of Directors at a price of $.01 per Right
prior to the first public announcement of the accumulation, through open-market
purchases, a tender offer or otherwise, of 15% or more of the combined number of
the Company's shares of Common Stock by a single acquiror or group, and
thereafter in certain circumstances.  Thus, the Rights should not interfere with
any merger or business combination approved by the Board of Directors prior to
that time.

          Issuance of the Rights does not in any way weaken the financial
strength of the Company or interfere with its business plans.  The issuance of
the Rights has no dilutive effect, will not affect reported earnings per share
and will not change the way in which you can presently trade the Company's
shares.

          The Rights will expire June 5, 2008, which should give the Company
adequate time to determine whether any further protection is required.

          The Board of Directors has been advised by legal counsel for the
Company that the distribution of the Rights will not be taxable to you or to the
Company.  However, stockholders may recognize taxable income upon the occurrence
of certain subsequent taxable events.

          In declaring the Rights dividend, we have expressed our confidence in
the future of the Company and our determination that you, our stockholders, be
given every opportunity to participate in that future.

                                 On behalf of the 
                                 Board of Directors of Dura Pharmaeuticals, Inc.


                                 Cam L. Garner
                                 Chairman, President and 
                                 Chief Executive Officer



                        ATTACHMENT TO LETTER TO STOCKHOLDERS

                              DURA PHARMACEUTICALS, INC.

                            SUMMARY OF RIGHTS TO PURCHASE
                 SHARES OF SERIES A JUNIOR PARTICIPATING PREFERRED STOCK


          On May 21, 1998 the Board of Directors of Dura Pharmaceuticals, 
Inc. (the "Company") declared a dividend of one preferred share purchase 
right (a "Right") for each outstanding share of Common Stock (the "Common 
Stock"), par value $.001 per share, of the Company. The dividend is payable 
on June 5, 1998** (the "Record Date") to the stockholders of record on that 
date.  Each Right entitles the registered holder to purchase from the Company 
one one-thousandth of a share (a "Unit") of Series A Junior Participating 
Preferred Stock, par value $.001 per share (the "Series A Preferred Stock"), 
of the Company at a price of $175.00 per Unit (the "Purchase Price"), subject 
to adjustment. The description and terms of the Rights are set forth in a 
Rights Agreement dated as of May 21, 1998 (the "Rights Agreement") between 
the Company and ChaseMellon Shareholder Services, L.L.C., as Rights Agent 
(the "Rights Agent").

          Until the earlier of (i) the close of business on the first date of a
public announcement that a person or group of affiliated or associated persons
(an "Acquiring Person") have acquired beneficial ownership of 15% or more of the
outstanding Common Stock and (ii) the close of business on the tenth business
day (or such later date as may be determined by a majority of the Continuing
Directors prior to such time as any Person becomes an Acquiring Person)
following the commencement of, or announcement of an intention to make, a tender
offer or exchange offer the consummation of which would result in the beneficial
ownership by a person or group of 15% or more of such outstanding Common Stock
(the earlier of such dates being called the "Distribution Date"), the Rights
will be evidenced, subject to certain conditions, with respect to any of the
Common Stock certificates outstanding as of the Record Date, by such Common
Stock certificate with a copy of this Summary of Rights attached thereto.

          The Rights Agreement provides that, until the Distribution Date, the
Rights will be transferred with and only with the Common Stock.  Until the
Distribution Date (or earlier redemption or expiration of the Rights), new
Common Stock certificates issued after the Record Date, upon transfer or new
issuance of Common Stock will contain a notation incorporating the Rights
Agreement by reference.  Until the Distribution Date (or earlier redemption or
expiration of the Rights), the surrender for transfer of any certificates for
Common Stock, outstanding as of the Record Date, even without such notation or a
copy of this Summary of Rights being attached thereto, will also constitute the
transfer of the Rights associated with the Common Stock represented by such
certificate.  As soon as practicable following the Distribution Date, separate

- ---------------------------
** Pursuant to Rule 10b-17, must be at least 10 days after Declaration Date.





certificates evidencing the Rights ("Rights Certificates") will be mailed to
holders of record of the Common Stock as of the Close of Business on the
Distribution Date and such separate Rights Certificates alone will evidence the
Rights.

          The Rights are not exercisable until the Distribution Date.  The
Rights will expire at the close of business on June 5, 2008 (the "Final
Expiration Date"), unless the Final Expiration Date is extended or unless the
Rights are earlier redeemed or exchanged by the Company, in each case as
described below.

          The Purchase Price payable, and the number of Units of Preferred Stock
or other securities or property issuable, upon exercise of the Rights are
subject to adjustment from time to time to prevent dilution (i) in the event of
a stock dividend on, or a subdivision, combination or reclassification of, the
Preferred Stock, (ii) upon the grant to holders of the Units of Preferred Stock
of certain rights or warrants to subscribe for or purchase Units of Preferred
Stock at a price, or securities convertible into Units of Preferred Stock with a
conversion price, less than the then current market price of the Units of
Preferred Stock or (iii) upon the distribution to holders of the Units of
Preferred Stock of evidences of indebtedness or assets (excluding regular
periodic cash dividends paid out of earnings or retained earnings or dividends
payable in Units of Preferred Stock) or of subscription rights or warrants
(other than those referred to above).

          The number of outstanding Rights and the number of Units of Preferred
Stock issuable upon exercise of each Right are also subject to adjustment in the
event of a stock split of the Common Stock or a stock dividend on the Common
Stock payable in Common Stock or subdivisions, consolidations or combinations of
the Common Stock occurring, in any such case, prior to the Distribution Date.

          Units of Preferred Stock purchasable upon exercise of the Rights will
not be redeemable.  Each Unit of Preferred Stock will be entitled to a dividend
equal to any dividend declared per share of Common Stock.  In the event of
liquidation, each Unit of Preferred Stock will be entitled to a payment equal to
any payment made per share of Common Stock.  Each Unit of Preferred Stock will
have one vote, voting together with the Common Stock.  Finally, in the event of
any merger, consolidation or other transaction in which shares of Common Stock
are exchanged, each Unit of Preferred Stock will be entitled to receive an
amount equal to the amount received per share of Common Stock.  These rights are
protected by customary antidilution provisions.

          Because of the nature of the dividend, liquidation and voting rights,
the value of each Unit of Preferred Stock purchasable upon exercise of the
Rights should approximate the value of one share of Common Stock.

          In the event that, after the Rights become exercisable, the Company is
acquired in a merger or other business combination transaction with an Acquiring
Person or an affiliate thereof, or 50% or more of its consolidated assets or
earning power are sold to an Acquiring Person or an affiliate thereof, proper
provision will be made so that each holder of a Right will thereafter have the
right to receive, upon exercise thereof at the then current exercise price of
the





Rights, that number of shares of common stock of the acquiring company which at
the time of such transaction will have a market value of two times the exercise
price of the Rights.

          In the event that any person or group of affiliated or associated
persons becomes the beneficial owner of 15% or more of the outstanding shares of
Common Stock proper provision shall be made so that each holder of a Right,
other than Rights beneficially owned by the Acquiring Person (which will
thereafter be void), will thereafter have the right to receive upon exercise
that number of shares of Common Stock or Units of Preferred Stock (or cash,
other securities or property) having a market value of two times the exercise
price of the Rights.

          At any time after the acquisition by a person or group of affiliated
or associated persons of beneficial ownership of 15% or more of the outstanding
shares of Common Stock and prior to the acquisition by such person or group of
50% or more of the outstanding Common Stock, the Continuing Directors of the
Company may exchange all or part of the Rights (other than Rights owned by such
person or group which have become void) for Units of Preferred Stock at an
exchange ratio of (subject to adjustment) which shall equal, subject to
adjustment to reflect stock splits, stock dividends and similar transactions
occurring after the date hereof, that number obtained by dividing the Purchase
Price by the then current per share market price per Unit of Preferred Stock on
the earlier of (i) the date on which any Person becomes an Acquiring Person and
(ii) the date on which a tender or exchange offer is announced by any Person, if
upon consummation thereof such Person would be the Beneficial Owner of 15% or
more of the shares of Company Common Stock then outstanding.

          With certain exceptions, no adjustment in the Purchase Price will be
required until cumulative adjustments require an adjustment of at least 1% in
such Purchase Price.  No fractional shares of Preferred Stock will be issued
(other than fractions which are integral multiples of one one-thousandth of a
share of Preferred Stock, which may, at the election of the Company, be
evidenced by depositary receipts) and, in lieu thereof, an adjustment in cash
will be made based on the market price of the Units of Preferred Stock on the
last trading day prior to the date of exercise.

          The Company may, at its option, upon approval by a majority of the
Continuing Directors, at any time prior to the earlier of (i) the Shares
Acquisition Date, or (ii) the close of business on the tenth anniversary of the
Rights Agreement redeem the Rights in whole, but not in part, at a price of $.01
per Right (the "Redemption Price").  The redemption of the rights may be made
effective at such time on such basis and with such conditions as the Continuing
Directors in its sole discretion may establish.  Immediately upon any redemption
of the Rights, the right to exercise the Rights will terminate and the only
right of the holders of Rights will be to receive the Redemption Price.  The
Rights are also redeemable under other circumstances as specified in the Rights
Agreement.

          The terms of the Rights may be amended by the Board of Directors of
the Company without the consent of the holders of the Rights upon the approval
of a majority of the Continuing Directors except that from and after a
Distribution Date no such amendment may adversely affect the interests of the
holders of the Rights.

                                         



          Until a Right is exercised, the holder thereof, as such, will have no
rights as a stockholder of the Company, including, without limitation, the right
to vote or to receive dividends.

          The Rights have certain anti-takeover effects.  The Rights will cause
substantial dilution to a person or group that attempts to acquire the Company
on terms not approved by the Company's Board of Directors, except pursuant to an
offer conditioned on a substantial number of rights being acquired.  The Rights
should not interfere with any merger or other business combination approved by
the Board of Directors because the Rights may be redeemed by the Company at the
Redemption Price prior to the occurrence of a Distribution Date.

          A copy of the Rights Agreement has been filed with the Securities and
Exchange Commission as an Exhibit to a Registration Statement on Form 8-A.  A
copy of the Rights Agreement is available free of charge from the Company.  This
summary description of the Rights does not purport to be complete and is
qualified in its entirety by reference to the Rights Agreement, which is hereby
incorporated herein by reference.