*TOTAL NUMBER OF PAGES:               AS FILED WITH THE SECURITIES AND EXCHANGE
INDEX TO EXHIBITS AT PAGE:                           COMMISSION ON MAY 27, 1998
                                                   REGISTRATION NO. 333-       
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            ------------------------

                                    FORM S-8


                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                            ------------------------

                          CARDIOTHORACIC SYSTEMS, INC.

             (Exact name of Registrant as specified in its charter)

                            ------------------------

         Delaware                                            94-3228757
   -------------------                                   ------------------
 (State of incorporation)                                 (I.R.S. Employer
                                                         Identification No.)


                            10600 North Tantau Avenue
                           Cupertino, California 95014
   (Address, including zip code, of Registrant's principal executive offices)

                            ------------------------



                       1998 NONSTATUTORY STOCK OPTION PLAN
                              INCENTIVE STOCK PLAN

                           (Full titles of the plans)

                            ------------------------

                           CardioThoracic Systems, Inc. 
                            10600 North Tantau Avenue
                           Cupertino, California 95014
                                 (408) 342-1700
(Name, address, and telephone number, including area code, of agent for service)

                            ------------------------

                                   Copies to:

                           Christopher J. Ozburn, Esq.
                        WILSON SONSINI GOODRICH & ROSATI
                            PROFESSIONAL CORPORATION
                               650 PAGE MILL ROAD
                            PALO ALTO, CA 94304-1050
                                 (415) 493-9300

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                           CALCULATION OF REGISTRATION FEE
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                                                                Proposed       Proposed
                                                                 Maximum        Maximum          Amount of
       Title of Each Class of                Amount to be     Offering Price    Aggregate       Registration
  Securities to be Registered (1)             Registered         Per Share    Offering Price         Fee
- -------------------------------------------------------------------------------------------------------------
                                                                                             
Common Stock, $0.001 par value (1)       150,000 shares (2))      $4.9375(3)     $740,625         $218.4844
Common Stock, $0.001 par value (1)       600,000 shares (4)       $4.9375(3)   $2,962,500         $873.9375 
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TOTAL                                                                                            $ 1,093.00
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(1)  In addition, pursuant to Rule 416(c) under the Securities Act of 1933 (the
     "Act"), this Registration Statement also covers an indeterminate amount of
     interests to be offered or sold pursuant to the employee benefit plans
     described herein.

(2)  This number represents the number of shares being registered pursuant to
     this Registration Statement which are issuable upon exercise of options
     which have not yet been granted under the 1998 Nonstatutory Stock Option
     Plan as of the date of this Registration Statement.

(3)  Calculated in accordance with Rule 457(h) under the Act solely for the
     purpose of calculating the total registration fee. Calculation based on the
     weighted average exercise price (rounded to the nearest cent) at which the
     options outstanding whose exercise will result in the issuance of the
     shares being registered may be exercised. 

(4)  This number represents the shares of Common Stock which have become
     available for issuance under the Registrant's Incentive Stock Plan as a
     result of an amendment approved by the stock holders at the Registrant's
     Annual Meeting held on May 19, 1998 increasing the number of shares for
     issuance thereunder from 2,200,000 to 2,800,000.

                                       2




                                       PART II

                  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.  INFORMATION INCORPORATED BY REFERENCE

     The following documents and information previously filed with the
Securities and Exchange Commission are hereby incorporated by reference:

(a)  The Registrant's Quarterly Report on Form 10-Q for the quarter ended April
     3, 1998, filed pursuant to Section 13 or 15(d) of the Securities Exchange
     Act of 1934, as amended (the "Exchange Act"), on May 13, 1998

(b)  The Registrant's Annual Report on Form 10-K for the year ended January 2,
     1998, filed pursuant to the Exchange Act, on March 31, 1998.

Item 4.  DESCRIPTION OF SECURITIES.

     Not applicable.

Item 5.   INTERESTS OF NAMED EXPERTS AND COUNSEL.

     Certain members of Wilson Sonsini Goodrich and Rosati, Professional
Corporation, and investment partnerships of which such persons are partners
beneficially own 1,389 shares of the Registrant's Common Stock.

Item 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

     Section 145 of the General Corporation Law of Delaware provides for the
indemnification of officers, directors and other corporate agents in terms
sufficiently broad to indemnify such persons, under certain circumstances, for
certain liabilities (including reimbursement of expenses incurred) arising under
the Securities Act of 1933 (the "Securities Act"). 

     The Registrant's Bylaws provide that the Registrant shall indemnify its
directors and executive officers and may indemnify its other officers and
employees and other agents to the fullest extent permitted by law, including
circumstances in which indemnification is otherwise discretionary under Delaware
law.

     The Registrant has adopted provisions in its Certificate of Incorporation
that limits the personal liability of its directors and officers for monetary
damages arising from a breach of their fiduciary duties in certain circumstances
to the fullest extent permitted by law.  Such limitation of liability does not
affect the availability of equitable remedies such as injunctive relief or
rescission.

     The Registrant entered into indemnification agreements with its executive
officers and directors containing provisions which are in some respects broader
that the specific indemnification provisions contained in the General
Corporation Law of Delaware.  The indemnification agreements may require the
Company, among other things, to indemnify such officers and directors against
certain liabilities that may arise by reason of their status or service as
directors or officers (other than liabilities arising from willful misconduct of
a culpable nature).  These agreements also indemnify the directors and executive
officers for certain expenses (including attorney's fees), judgments, fines and
settlement amounts incurred as a result of any proceeding against them as to
which they could be indemnified.

Item 7.  EXEMPTION FROM REGISTRATION CLAIMED.

     Not applicable.


                                       II-1



Item 8.  EXHIBITS.



 Exhibit
  Number                                 Document
- ----------   --------------------------------------------------------------
          
 10.2        1998 Nonstatutory Stock Option Plan and form of Nonstatutory 
             Stock Option Agreement thereunder.


 10.3        Incentive Stock Plan, as amended

 23.1        Consent of Coopers & Lybrand L.L.P., Independent Accountants.


 23.2        Consent of Wilson Sonsini Goodrich & Rosati, Professional
             Corporation (contained in Exhibit 5.1 hereto).


 24.1        Power of Attorney (see page II-4).


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Item 9.  UNDERTAKINGS.

(a)  The undersigned Registrant hereby undertakes:

     (1)  To file, during any period in which offers or sales are being made,
          post-effective amendment to this Registration Statement to include any
          material information with respect to the plan of distribution not
          previously disclosed in the Registration Statement or any material
          change to such information in the Registration Statement.

     (2)  That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial bona fide offering thereof.

     (3)  To remove from registration by means of a post-effective amendment any
          of the securities being registered which remain unsold at the
          termination of the offering.

(b)  The undersigned Registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
     of the Securities Exchange Act of 1934 (and, where applicable, each filing
     of an employee benefit plan's annual report pursuant to Section 15(d) of
     the Securities Exchange Act of 1934) that is incorporated by reference in
     the Registration Statement shall be deemed to be a new registration
     statement relating to the securities therein, and the offering of such
     securities at that time shall be deemed to be an initial bona fide offering
     thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers and controlling persons of
     the Registrant pursuant to the foregoing provisions, or otherwise, the
     Registrant has been advised that in the opinion of the Securities and
     Exchange Commission such indemnification is against public policy as
     expressed in the Securities Act and is, therefore, unenforceable.  In the
     event that a claim for indemnification against such liabilities (other than
     the payment by the Registrant of expenses incurred or paid by a director,
     officer or controlling person of the Registrant in the successful defense
     of any action, suit or proceeding) is asserted by such director, officer,
     or controlling person in connection with 

                                       II-2



     the securities being registered, the Registrant will, unless in the 
     opinion of its counsel the matter has been settled by controlling 
     precedent, submit to a court of appropriate jurisdiction the question 
     whether such indemnification by it is against public policy as expressed 
     in the Act and will be governed by the final adjudication of such issue.

                                       II-3



                                      SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
Registration Statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of Cupertino, State of California, on 
this 27th day of May, 1998

                                   CardioThoracic Systems, Inc.

                                   By:   /s/ RICHARD M. FERRARI             
                                        ---------------------------------------
                                        Richard M. Ferrari
                                        President and Chief Executive Officer

                                  POWER OF ATTORNEY

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below constitutes and appoints Richard M. Ferrari and Steve M. Van 
Dick, jointly and severally, as his attorney-in-fact, each with the power of 
substitution, for him in any and all capacities, to sign any amendments to 
this Registration Statement on Form S-8, and to file the same, with exhibits 
thereto and other documents in connection therewith, with the Securities and 
Exchange Commission, hereby ratifying and confirming all that the said 
attorneys-in-fact, or his substitute or substitutes, may do or cause to be 
done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in the 
capacities and on the date indicated. 



 SIGNATURE                          TITLE                                      DATE
 ---------                          -----                                      ----
                                                                         

       /s/ RICHARD M. FERRARI       President, Chief Executive Officer and     May 27, 1998
  -----------------------------     Director* (Principal Executive Officer)*
         Richard M. Ferrari    

       /s/ STEVE M. VAN DICK        Vice President of Finance and              May 27, 1998
  -----------------------------     Administration and Chief Financial 
         Steve M. Van Dick          Officer (Principal Financial and   
                                    Accounting Officer)                
                                    

       /s/ CHARLES S. TAYLOR        Vice President, Chief Technical Officer    May 27, 1998
  -----------------------------     and Director*
         Charles S. Taylor          

     /s/ ROBERT C. BELLAS, JR.      Director*                                  May 27, 1998
  -----------------------------
       Robert C. Bellas, Jr.

    /s/ THOMAS J. FOGARTY, M.D.     Director*                                  May 27, 1998
  -----------------------------
      Thomas J. Fogarty, M.D.

       /s/ JACK W. LASERSOHN        Director*                                  May 27, 1998
  -----------------------------
         Jack W. Lasersohn

      /s/ THOMAS C. MCCONNELL       Director*                                  May 27, 1998
  -----------------------------
        Thomas C. McConnell

        /s/ PHILIP M. YOUNG         Director*                                  May 27, 1998
  -----------------------------
          Philip M. Young


*  The Incentive Stock Plan, as amended and the 1998 Nonstatutory Stock 
Option Plan are being registered pursuant to this Registration Statement and 
are subject to administration by the Board of Directors of the Registrant. 

                                       II-4



                                  INDEX TO EXHIBITS




  Exhibit                         Description
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 10.2                             1998 Nonstatutory Stock Option Plan and form
                                  of Nonstatutory Stock Option Agreement
                                  thereunder


 10.3                             Incentive Stock Plan, as amended

 23.1                             Consent of Coopers & Lybrand L.L.P.,
                                  Independent Accountants  


 23.2                             Consent of Wilson Sonsini Goodrich & Rosati,
                                  Professional Corporation (contained in
                                  Exhibit 5.1 hereto) 


 24.1                             Power of Attorney (see Page II-4)

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