SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

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                                   FORM 8-A/A
                                 AMENDMENT NO. 1


                FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                     PURSUANT TO SECTION 12(b) OR (g) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


                           DURA PHARMACEUTICALS, INC.
               (Exact name of registrant as specified in charter)

        DELAWARE                   000-19809               95-3645543
(State of incorporation           (Commission             (IRS Employer
   or organization)               File Number)          Identification No.)

                7475 Lusk Boulevard, San Diego, California, 92121
                    (Address of principal executive offices)

       Registrant's telephone number, including area code: (619) 457-2553

       Securities to be registered pursuant to Section 12(b) of the Act:

                                      NONE
                                (TITLE OF CLASS)

       Securities to be registered pursuant to Section 12(g) of the Act:


                         PREFERRED STOCK PURCHASE RIGHTS
                                (Title of Class)




Item 1. DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED.

                  On December 10, 1998, Dura Pharmaceuticals, Inc. (the
"Company") amended its Rights Agreement, dated May 21, 1998 (the "Rights Plan"),
to eliminate those provisions that require that certain actions may only be
taken by "Continuing Directors." This Amendment to the Rights Plan was made in
response to the Delaware Court of Chancery's recent decision in CARMODY V. TOLL
BROTHERS, INC. In the view of the Company's Board of Directors, based on advice
of counsel, the TOLL BROTHERS decision has cast doubt on the legality under
Delaware law of "Continuing Directors" provisions, also referred to as
"dead-hand" provisions, in many existing shareholder rights plans. Although the
opinion related to the denial of a motion to dismiss an action challenging the
"Continuing Directors" provision and not an opinion addressing the actual
validity of the provision under Delaware law, the Delaware court stated that a
"Continuing Directors" provision was open to challenge under Delaware law on
both statutory and fiduciary grounds. A "Continuing Directors" provision
provides that outstanding rights can only be redeemed by "continuing directors,"
which is generally defined to mean directors who were members of the board at
the time the Rights Agreement was adopted and any other person who subsequently
becomes a member of the board if such person's nomination for election to the
board was recommended or approved by a majority of the continuing directors.
While the Company's Rights Plan differs in significant respects from the plan
considered in the TOLL BROTHERS case, particularly as regards to the "Continuing
Directors" provisions thereof, the Board of Directors believes the disputed
validity of these provisions under the TOLL BROTHERS opinion warrants action to
amend the Rights Plan. The Form of First Amendment to the Rights Agreement is
attached hereto as Exhibit 1 and is incorporated by reference herein.

Item 2.  EXHIBITS.

1.       Form of First Amendment to the Company's Rights Plan.

                                    SIGNATURE

         Pursuant to the requirements of Section 12 of the Securities Exchange
Act of 1934, the registrant has duly caused this registration statement to be
signed on its behalf by the undersigned, thereto duly authorized.

                               DURA PHARMACEUTICALS, INC.

DATE:  December 10, 1998       By:     /s/ Cam L. Garner
                                      ------------------
                               Name:  Cam L. Garner

                               Title: Chairman, President and Chief Executive
                                      Officer


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                                  EXHIBIT INDEX




EXHIBIT
NUMBER                                  DOCUMENT DESCRIPTION
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  1.           Form of First Amendment to the Company's Rights Plan.