Exhibit 2.5


                            SHARE PURCHASE AGREEMENT



                                      AMONG



                    PHOENIX INTERNATIONAL LIFE SCIENCES INC.



                                       AND



                             DR. ANDRE VON FROREICH



                                       AND



                                DR. ANDREAS WICKI



                                       AND



                                 CLINSERVE A.G.




                           -------------------------
                          DATED AS OF NOVEMBER 5, 1998
                           -------------------------








         SHARE PURCHASE AGREEMENT dated as of November 5, 1998



AMONG:                              PHOENIX INTERNATIONAL LIFE SCIENCES INC., a
                                    corporation incorporated under the Canada
                                    Business Corporations Act, having its head
                                    office at 2350, Cohen Street, Saint-Laurent,
                                    Quebec, Canada, H4R 2N6, herein acting and
                                    represented by John Hooper, its duly
                                    authorized representative;

                                    (hereinafter "Phoenix")


AND:       

                                    DR. ANDRE VON FROREICH, residing at
                                    Forsthohe 33, 21149 Hamburg, Germany;

                                    (hereinafter "Froreich")


AND:                                DR. ANDREAS WICKI, residing at Hohestrasse
                                    39, 8702 Zollikon, Switzerland;

                                    (hereinafter "Wicki")


                                    (Froreich and Wicki are hereinafter
                                    collectively referred to as the "Vendors")


AND:
                                    CLINSERVE A.G., a Swiss corporation with
                                    capital of SFr600,000, registered in the
                                    Commercial Register of the Canton of
                                    Fribourg under number EHRA-Id. 341 555 and
                                    having its head office at rue St. Pierre 18,
                                    1700 Fribourg, Switzerland, herein acting
                                    and represented by Dr. Andreas Wicki, its
                                    duly authorized representative;

                                    (hereinafter "Clinserve")


         WHEREAS, the Vendors hold, directly or indirectly, as more fully set
out in Schedule A, all of the outstanding shares and voting rights of Clinserve;

         WHEREAS, Clinserve Clinical Trials Services GmbH ("Clinserve GmbH"), a
German corporation, with capital of DM50,000, registered in the Commercial
Register of Amtsgericht Hamburg under number 61 348 and having its head office
at Grossmooreogen 25, 21079 Hamburg, Germany, is a subsidiary of Clinserve, held
as to 100% by Clinserve. The capital structure of Clinserve GmbH is set forth in
Schedule B;

         WHEREAS the Vendors have agreed to sell all of the outstanding shares
of Clinserve to Phoenix in consideration for the issuance to the Vendors of
common shares of Phoenix;

         NOW, THEREFORE, the parties hereto agree as follows:





                                      - 2 -

1.       INTERPRETATION AND DEFINITIONS

         Except as the context otherwise explicitly requires, (a) the
capitalized term "Section" refers to sections of this Agreement; (b) the
capitalized terms "Schedules" and "Exhibit" refer to schedules and exhibits to
this Agreement; (c) references to a particular Section include all subsections
thereof; (d) the word "including" shall be construed as "including without
limitation"; (e) accounting terms not otherwise defined herein have the meaning
provided under GAAP (as defined below); (f) references to a particular law,
statute or regulation include all rules and regulations thereunder and any
successor, law, statute, regulation or rules, in each case as from time to time
in effect; (g) references to a particular Person include such Person's
successors and assigns to the extent not prohibited by this Agreement; (h)
references to dollars or $ in this Agreement are to Canadian dollars. In this
Agreement, unless the context otherwise requires, the following terms shall have
the respective meanings assigned to them:

         1.1      "AFFILIATE" means, with respect to any Person, any Person 
                  which, directly or indirectly through one or more 
                  intermediaries, controls, is controlled by, or is under 
                  common control with such Person. For the purposes of this 
                  Agreement, "Affiliate" also means an affiliate as such term 
                  is defined by the SEC.

         1.2      "ARTICLES" means the original or restated articles of 
                  incorporation, articles of amendment, articles of 
                  amalgamation, articles of continuance, articles of 
                  reorganization and articles of arrangement, including 
                  amendments thereto, as in effect from time to time, of 
                  Clinserve.

         1.3      "CLINSERVE AFFILIATE" means any of  Froreich and Wicki.

         1.4      "COMPENSATION" as applied to any Person means the aggregate of
                  all salaries, compensation, remuneration or bonuses of any
                  character, retirement or pension benefits of any kind, or
                  other payments of any kind whatsoever (other than health and
                  medical benefits made available to employees generally and
                  advances and reimbursements of business expenses) made
                  directly or indirectly by Clinserve, the Subsidiary or other
                  specified Persons to such Person and affiliates of such
                  Person.

         1.5      "COMPLETION DATE" means the date of this Agreement, i.e.
                  November 5, 1998.

         1.6      "Consolidated", when used with reference to any term, means
                  that term as applied to the accounts of Clinserve or other
                  indicated Person and each of its respective subsidiaries,
                  consolidated or combined in accordance with GAAP after
                  eliminating all inter-company operations and with appropriate
                  deductions for minority interests in subsidiaries.

         1.7      "CONTRACTUAL OBLIGATION" means, with respect to any Person,
                  any contracts, agreements, deeds, hypothecs, mortgages,
                  indentures, leases, licenses, other instruments, commitments,
                  undertakings, arrangements or understandings, written or oral,
                  or other documents or instruments, including any provisions of
                  its articles of incorporation or other constituting documents
                  or by-laws and any document or instrument evidencing
                  Indebtedness, to which any such Person is a party or otherwise
                  subject to or bound by or to which any property or asset of
                  any such Person is subject.

         1.8      "DISTRIBUTION" means (a) the declaration or payment of any
                  dividend on or in respect of the shares of any class or series
                  of shares of Clinserve, the Subsidiary or other specified
                  Person, other than dividends payable solely in common shares
                  of the share capital of the payor; (b) the purchase,
                  redemption or other retirement of any shares of any class of
                  Clinserve, the Subsidiary





                                      - 3 -

                  or other specified Person directly, or indirectly through a
                  Subsidiary or otherwise; or (c) any other distribution on or
                  in respect of any shares of any class or series of shares of
                  Clinserve, the Subsidiary or other specified Person.

         1.9      "ESCROW AGENT" means Montreal Trust Company.

         1.10     "ESCROW AGREEMENT" means the escrow agreement entered between
                  the parties hereto and the Escrow Agent a copy of which is
                  attached hereto as Schedule 1.10.

         1.11     "ESCROWED SECURITIES" means the Phoenix Shares escrowed
                  pursuant to Section 2.4 together with all Proceeds (as defined
                  in the Escrow Agreement).

         1.12     "ESCROWED SHARE PRICE" means the amount obtained by adding the
                  opening and closing prices of the common shares of Phoenix on
                  each of the Montreal Exchange and The Toronto Stock Exchange
                  for the ten trading days preceding the date of execution of
                  the present Agreement, divided by 40.

         1.13     "ENVIRONMENTAL LAWS" means all Legal Requirements (including
                  consent decrees, administrative orders and contractual
                  obligations) relating to public health and safety, workers
                  health and safety and pollution or protection of the
                  environment.

         1.14     "GAAP" means generally accepted accounting principles, as in
                  effect from time to time, consistently applied.

         1.15     "GUARANTEE" means (a) any guarantee of the payment or
                  performance of, or any contingent obligation in respect of,
                  any indebtedness or other obligation of any other Person, (b)
                  any other arrangement whereby credit or financial assistance
                  is extended to one obligor on the basis of any promise or
                  undertaking of another Person (i) to pay the Indebtedness of
                  such obligor, (ii) to purchase any obligation owed by such
                  obligor, or (iii) to maintain the capital, working capital,
                  solvency or general financial condition of such obligor,
                  whether or not such arrangement is disclosed in the balance
                  sheet of such other Person or is referred to in a footnote
                  thereto or appears in a "keep well" agreement, "comfort
                  letter" or "take or pay" agreement, and (c) any liability of
                  Clinserve or the Subsidiary as general partner of a
                  partnership or as a venturer in a joint venture in respect of
                  Indebtedness or other obligations of such partnership or
                  venture; provided, however, that in no event shall Guarantees
                  include product warranties given or the endorsement of
                  negotiable instruments for deposit or collection in the
                  ordinary course of business.

         1.16     "INDEBTEDNESS" means (a) all indebtedness, obligations and
                  liabilities for borrowed money and similar monetary
                  obligations evidenced by bonds, notes debentures, evidences of
                  indebtedness, capitalized lease obligations, deferred purchase
                  price of property (other than ordinary trade payables) or
                  otherwise, whether direct or indirect; and (b) all
                  indebtedness, obligations and liabilities secured by any Liens
                  existing on property owned or acquired, whether or not the
                  liability secured thereby shall have been assumed.

         1.17     "LEGAL REQUIREMENT" means any national, provincial, regional,
                  municipal, local or foreign law, statute, standard, ordinance,
                  code, order, rule, regulation, resolution, promulgation,
                  by-law, policy, guideline, directive, standard and any other
                  provision having the force or effect of law or any final
                  order, judgment or decree of any court, arbitrator, tribunal
                  or governmental authority, 



                                      - 4 -

                  or any license, franchise, permit, certificate, authorization,
                  registration or similar right granted under any of the
                  foregoing.

         1.18     "LIEN" means (a) any hypothec, priority, mortgage, pledge,
                  lien, charge, security interest or other similar encumbrance
                  upon any property or assets of any character, or upon the
                  income or profits therefrom, whether arising by agreement or
                  under law, or otherwise (b) any conditional sale or other
                  title retention agreement or arrangement (including a
                  capitalized lease); (c) any sale, assignment, pledge or other
                  transfer for security of any accounts, general intangibles, or
                  chattel paper, with or without recourse, or (d) any
                  transaction (regardless of form) which is intended to create
                  any charge or encumbrance on property to secure the payment or
                  performance of an obligation.

         1.19     "MANAGEMENT" means each of Froreich and Wicki.

         1.20     "MATERIAL ADVERSE EFFECT" means any (a) material adverse
                  effect whatsoever upon the validity, performance or
                  enforceability of this Agreement, (b) material adverse effect
                  upon the business, assets, financial condition, income or
                  prospects of Clinserve and the Subsidiary on a Consolidated
                  basis, or (c) material adverse effect upon the ability of the
                  Vendors to perform their obligations under this Agreement.

         1.21     "PERMITTED LIEN" means those Liens indicated on Schedule 1.21.

         1.22     "PERSON" means an individual, partnership, corporation,
                  company, association, trust, joint venture, unincorporated
                  organization, business trust, limited liability company and
                  any governmental or administrative department or agency or
                  political subdivision.

         1.23     "PHOENIX AFFILIATES" means John Hooper, Stephane Huguet,
                  Heather Baker, Judy Zilber, Jean-Yves Caloz, Diane Bouchard,
                  Carmen Discenza, Lucien Steru, Dominique Steru, Susan
                  Thornton, Greg Holmes, Claude E. Forget, Bertran Spilker,
                  Robert Raich, David Goldman, Suzanne Peeters, George
                  Engelberg, Wicki and Cornelius P. McCarthy III.

         1.24     "SEC" means the United States Securities and Exchange
                  Commission.

         1.25     "SECURITIES ACT" means the United States Securities Act of
                  1933, as amended, and all rules and regulations promulgated
                  thereunder.

         1.26     "SHARES" means the 6,000 bearer shares with a nominal value of
                  SFr100 each of Clinserve being all of the issued and
                  outstanding shares of Clinserve.

         1.27     "SUBSIDIARY" means Clinserve Clinical Trial Services GmbH.

2.       SALE AND PURCHASE OF SHARES

         2.1      AGREEMENT TO PURCHASE AND SELL SHARES

                  Upon the terms and subject to the conditions hereof and in
         reliance on the representations and warranties of Phoenix set forth in
         Section 4, Froreich and Wicki hereby sell to Phoenix and, upon the
         terms and subject to the conditions hereof and in reliance on the
         representations and warranties of the





                                      - 5 -


         Vendors set forth in Section 3, Phoenix hereby purchases from Froreich
         and Wicki, the Shares, as set forth below:




          VENDOR                                      NUMBER OF SHARES
          ------                                      ----------------
          
                                                           
          Froreich                                          4,800
          Wicki                                             1,200
          TOTAL                                             6,000

          
         2.2      PRICE OF SHARES

                  The purchase price of the Shares is payable by the issuance by
         Phoenix to Froreich and Wicki of an aggregate of 316,805 common shares
         of Phoenix. The aggregate purchase price for the Shares is to be
         allocated among Froreich and Wicki as follows:




             VENDOR              NUMBER OF COMMON SHARES OF PHOENIX
             ------              ----------------------------------
             
                                                
             Froreich                          253,444
             Wicki                             63,361
             TOTAL                             316,805


         (The common shares of Phoenix issued to the Vendors pursuant to this
         Section 2.2 are hereinafter collectively referred to as the "Phoenix
         Shares".)

         2.3      DELIVERY OF SHARES AND PAYMENT OF PURCHASE PRICE

                  2.3.1    Phoenix hereby acknowledges receipt from each of
                           Froreich and Wicki of certificates representing the
                           Shares duly endorsed in blank for transfer by
                           Froreich and Wicki.

                  2.3.2    Froreich and Wicki hereby acknowledge receipt from
                           Phoenix of certificates registered in the names of
                           Froreich and Wicki representing 90% of the purchase
                           price for the Shares.

         2.4      ISSUANCE INTO ESCROW

                  Notwithstanding any provision of this Agreement, upon delivery
         of the Phoenix Shares pursuant to Section 2.3, 10% of the aggregate
         number of the Phoenix Shares shall be delivered immediately to the
         Escrow Agent, on a pro rata basis among the Vendors, to be held and
         released by the Escrow Agent pursuant to the terms of this Agreement
         and the Escrow Agreement. All such Phoenix Shares shall be issued in
         the name of the Escrow Agent, as escrow agent under the Escrow
         Agreement. The Vendors hereby acknowledge receipt of such 10% of the
         purchase price of the Shares on their behalf by the Escrow Agent.

3.       REPRESENTATIONS AND WARRANTIES OF VENDORS

         In order to induce Phoenix to enter into this Agreement and to purchase
the Shares hereunder, the Vendors hereby make the following representations and
warranties to Phoenix. The Vendors' liability for the following representations
and warranties shall be joint, and not solidary i.e. pro rata to the number of
Phoenix Shares received by each Vendor according to Section 2.2, except in the
event of fraud with respect thereto.





                                      - 6 -


         3.1      SHARES

                  The Vendors own the Shares free and clear of all Liens and
         there are no rights or other obstacles of any nature whatsoever to the
         sale of the Shares to Phoenix.

         3.2      ORGANIZATION

                  3.2.1    DUE INCORPORATION, ETC. Each of Clinserve and the
                           Subsidiary is duly incorporated or organized and
                           validly exists under the laws of its jurisdiction of
                           incorporation, and is in good standing under the laws
                           applicable to it and has all necessary corporate
                           capacity and power to own and lease its property and
                           assets and to carry on the businesses now conducted
                           or presently proposed to be conducted by it.

                  3.2.2    SUBSIDIARIES. Clinserve does not own or control,
                           directly or indirectly, or have an interest in, any
                           other corporation, partnership, association or
                           business entity other than the Subsidiary.

                  3.2.3    MANAGEMENT. The Management of Clinserve and the
                           Subsidiary is exclusively comprised of the Persons
                           referred to in Section 1.19.

                  3.2.4    AUTHORIZATIONS AND APPROVALS. All authorizations,
                           approvals, licences, permits, certificates,
                           registrations, consents, exemptions or declarations
                           required in order for each of Clinserve and the
                           Subsidiary to own or lease their property and assets
                           and to carry on their business in all jurisdictions
                           in which such property and assets are located or such
                           business is carried on have been duly obtained or
                           effected and are in full force and effect except for
                           authorizations, approvals, licences, permits,
                           certificates, registrations, consents, exemptions or
                           declarations, the absence of which, individually or
                           in the aggregate, does not and shall not result in a
                           Material Adverse Effect.

                           In particular:

                           (a)      except for permits, certificates, licences,
                                    registrations and other authorizations, the
                                    absence of which, individually or in the
                                    aggregate, does not and shall not result in
                                    a Material Adverse Effect, each of Clinserve
                                    and the Subsidiary hold all permits,
                                    certificates, licenses, registrations and
                                    other authorizations required under
                                    applicable Environmental Laws for their
                                    operations (the "Environmental Permits");
                                    each such Environmental Permit is valid and
                                    in force and the operations of Clinserve and
                                    the Subsidiary are in compliance with the
                                    conditions set out in such Environmental
                                    Permits and their is no ground for
                                    revocation, expiry or annulment of any such
                                    Environmental Permits;

                           (b)      except for permits, certificates, licences,
                                    registrations and other authorizations, the
                                    absence of which, individually or in the
                                    aggregate, does not and shall not result in
                                    a Material Adverse Effect, each of Clinserve
                                    and the Subsidiary hold all permits,
                                    certificates, licenses, registrations and
                                    other authorizations required under
                                    applicable Legal Requirement for clinical
                                    research for the pharmaceutical industry and
                                    pharmaceutical research (the "Research
                                    Permits"); each such Research Permit is
                                    valid and in force, the operations of
                                    Clinserve and the Subsidiary are in
                                    compliance with the conditions set out in
                                    such Research 




                                      - 7 -


                                    Permits and there is no ground for
                                    revocation, expiry or annulment of any such
                                    Research Permits.

                  3.2.5    CORPORATE RECORDS. The Corporate records of Clinserve
                           and the Subsidiary are complete and up to date.

                  3.2.6    OFFICERS AND DIRECTORS. The officers and directors of
                           Clinserve and the Subsidiary have been properly
                           elected or appointed in accordance with applicable
                           laws and the relevant articles of incorporation or
                           other constituting documents.

                  3.2.7    CORPORATE ACTION. All necessary corporate action has
                           been taken by Clinserve, to authorize the execution
                           of this Agreement and the consummation of the
                           transactions contemplated hereby. The Board of
                           directors of Clinserve has agreed to register Phoenix
                           in the share ledger of Clinserve as the owner of the
                           Shares. The Vendors and Clinserve have fulfilled any
                           and all of their obligations under the preemptive
                           rights relating to the sale of the Shares.

         3.3      CAPITALIZATION

                  3.3.1    SHARE CAPITAL OF CLINSERVE. The outstanding share
                           capital of Clinserve is exhaustively set forth in
                           Schedule A, all of which has been validly issued and
                           is fully paid and non-assessable and, subject to no
                           Lien, adverse claim or restriction on transfer,
                           except restrictions on transfer under this Agreement.

                  3.3.2    OPTIONS, ETC. Other than as set forth in Schedule A
                           and Schedule 3.3.5, Clinserve does not have
                           outstanding (a) any rights (either preemptive or
                           otherwise) or options to subscribe for or purchase,
                           or any warrants or other agreements providing for or
                           requiring the issuance of, any shares or any
                           securities convertible into or exchangeable for its
                           shares, (b) any obligation to redeem, purchase or
                           otherwise acquire or retire any of its shares, any
                           securities convertible into or exchangeable for its
                           shares or any rights, options or warrants with
                           respect thereto, (c) any rights to require Clinserve
                           to qualify for distribution for securities laws
                           purposes, or (d) any restrictions on voting.

                  3.3.3    CAPITAL STOCK OF THE SUBSIDIARY. The issued and
                           outstanding shares of the Subsidiary are as set forth
                           in Schedules B. The issued and outstanding shares of
                           the Subsidiary are validly issued, and paid and
                           non-assessable and subject to no Lien, adverse claim
                           or restriction on transfer, other than as set forth
                           in Schedule 3.3.3 and the shares of the Subsidiary
                           were purchased by Clinserve from Wicki and Froreich
                           on May 26, 1998 at their fair market value.

                  3.3.4    SUBSIDIARY OPTIONS, ETC. Other than as set forth in
                           Schedule 3.3.4, the Subsidiary does not have
                           outstanding (a) any rights (either preemptive or
                           otherwise) or options to subscribe for or purchase,
                           or any warrants or other agreements providing for or
                           requiring the issuance of, any shares or any
                           securities convertible into or exchangeable for its
                           shares, (b) any obligation to redeem, purchase or
                           otherwise acquire or retire any of its shares, any
                           securities convertible into or exchangeable for its
                           shares or any rights, options or warrants with
                           respect thereto, (c) any rights to require the
                           Subsidiary to qualify for distribution for securities
                           laws purposes, or (d) any restrictions on voting.





                                      - 8 -


                  3.3.5    NO COMMITMENTS AFFECTING SHARES, ETC. Other than as
                           set forth in Schedule 3.3.5, neither Clinserve nor
                           the Subsidiary is a party to or bound by any
                           agreement, commitment or understanding, whether
                           verbal or written, affecting its shares or the
                           participating or voting rights attached thereto.

         3.4      REPORTS, FINANCIAL STATEMENTS AND OTHER DOCUMENTS

                  Phoenix has been provided with complete and correct copies of
         audited financial statements of Clinserve for the years ended August
         31, 1995, 1996 and 1997 and unaudited financial statements for the year
         ended August 31, 1998 and consolidated financial statements of
         Clinserve for the year ended August 31, 1998, and with complete and
         correct copies of financial statements of the Subsidiary sealed by a
         German auditor according to the German law on limited liability
         companies for the years ended December 31, 1996 and 1997, copies of
         which are attached hereto as Schedule 3.4A.

                  The financial statements of Clinserve and the Subsidiary
         referred to above have been prepared in accordance with Swiss GAAP and
         German GAAP, as applicable, and all such financial statements fairly
         present the financial condition of Clinserve and the Subsidiary at the
         dates thereof and the results of their operations for the periods
         covered thereby. Other than as set forth in Schedule 3.5, neither
         Clinserve nor the Subsidiary has material liabilities, contingent or
         otherwise, which are not referred to in the financial statements.

                  The audited financial statements for the years ended August
         31, 1995, 1996 and 1997, copies of which are attached hereto as
         Schedule 3.4A have been properly approved by the annual general
         meetings of shareholders of the relevant entities in due form without
         reservation.

                  For purposes of financial presentation, Clinserve and the
         Subsidiary recognize net revenue from their contracts on a percentage
         of completion basis as work is performed. The percentage of completion,
         and consequently the revenue to be recorded, of each individual
         contract is determined through detailed analysis and discussion between
         all appropriate operational and financial department management.
         Although Clinserve and the Subsidiary do not require collateral for
         unpaid balances, credit losses have consistently been within
         Management's expectations. Certain contracts contain provisions for
         price adjustment for cost overruns. Such adjusted amounts are included
         in service revenue when realization is assured and the amounts can be
         reasonably determined. In the period in which it is determined that a
         loss will result from the performance of a contract, the entire amount
         of the estimated ultimate loss is charged against income.

                  Since September 1, 1998, the business of Clinserve and the
         Subsidiary has been operated in the customary fashion and no revenues
         that would have been earned by Clinserve or the Subsidiary have been
         earned by any Person who is an Affiliate of any of the Vendors.

                  Notwithstanding anything else in this Agreement, including,
         without limitation, the provisions of this Section 3.4, the Vendors
         make no representation or warranty of any kind whatsoever with respect
         to future business, financial performance or future profitability of
         Clinserve.

         3.5      OFF BALANCE SHEET OBLIGATIONS

                  Schedule 3.5 contains a complete list of the off-balance sheet
         obligations of Clinserve and the Subsidiary, including all guarantees
         and obligations to the benefit of the Vendors, members of their
         families or third parties.


                                      -9-


         3.6      CHANGES IN CONDITION

                  Since September 1, 1998:

                  3.6.1    MATERIAL ADVERSE EFFECT. No event having a Material
                           Adverse Effect has occurred.

                  3.6.2    EXTRAORDINARY TRANSACTIONS, ETC. Other than as set
                           forth in Schedule 3.4A, neither Clinserve nor the
                           Subsidiary has (a) made any Distribution, (b) other
                           than as set forth in Schedule 3.6.2, made any payment
                           (other than Compensation of its directors, officers
                           and employees in amounts in effect prior to September
                           1, 1998 or for bonuses accrued in accordance with
                           normal practice prior to September 1, 1998) to any of
                           the Vendors, (c) other than as set forth in Schedule
                           3.6.2, increased the Compensation, including bonuses,
                           payable or to be payable to any of its directors,
                           officers or employees by more than 5%, or (d) entered
                           into any Contractual Obligation, or entered into or
                           performed any other transaction, not in the ordinary
                           and usual course of business and consistent with past
                           practice.

                  3.6.3    INVENTORY AND WORK-IN-PROGRESS. The value of
                           inventory and work-in-progress reflected in the
                           financial statements of Clinserve and the Subsidiary
                           has been established in accordance with Swiss and
                           German GAAP, respectively, and there has been no
                           material change in the period subsequent to August
                           31, 1998, other than in the ordinary and usual
                           courses of business.

                  3.6.4    REVENUES. The business of Clinserve and the
                           Subsidiary has been operated in the customary fashion
                           and no revenues that would have been earned by
                           Clinserve or the Subsidiary have been earned by any
                           Person which is an Affiliate of any of the Vendors.

         3.7      CONTRACTUAL OBLIGATIONS, ETC.

                  3.7.1    CERTAIN CONTRACTS. Schedule 3.7.1 contains, together
                           with a reference to the subparagraph pursuant to
                           which each item is being disclosed, a correct and
                           complete list of all Contractual Obligations of
                           Clinserve and the Subsidiary of the types described
                           below:

                           (a)      All collective bargaining agreements; all
                                    employment agreements, all profit sharing,
                                    profit participation, deferred compensation,
                                    bonus, stock option, stock purchase,
                                    pension, retainer, consulting, retirement,
                                    welfare or incentive plans or agreements;
                                    and all plans, agreements or practices which
                                    constitute Compensation or "fringe benefits"
                                    to any of the employees of Clinserve or the
                                    Subsidiary, including vacation programs,
                                    sick leave programs, group medical
                                    insurance, group life insurance, disability
                                    insurance and related benefits.

                           (b)      All Contractual Obligations under which
                                    Clinserve or the Subsidiary are restricted
                                    from carrying on any business, venture or
                                    other activities anywhere in the world.

                           (c)      All Contractual Obligations (including
                                    options) to sell, lease (as lessor),
                                    exchange or otherwise dispose of or transfer
                                    any of the properties or assets of Clinserve
                                    or the Subsidiary except in the ordinary
                                    course of business.


                                      -10-


                           (d)      All Contractual Obligations pursuant to
                                    which Clinserve or the Subsidiary guarantees
                                    or otherwise assumes any liability of or
                                    gives financial assistance to any Person, or
                                    pursuant to which any Person guarantees or
                                    otherwise assumes any liability of Clinserve
                                    or the Subsidiary.

                           (e)      All Contractual Obligations constituting
                                    license agreements, service agreements,
                                    consulting agreements or other similar
                                    arrangements, the termination of which,
                                    individually or in the aggregate, would
                                    result in a Material Adverse Effect.

                           (f)      All Contractual Obligations under which
                                    Clinserve or the Subsidiary leases immovable
                                    property or is obligated to lease or
                                    purchase immovable property or incur capital
                                    expenditures in excess of SFr50,000
                                    annually.

                           (g)      All Contractual Obligations of Clinserve or
                                    the Subsidiary relating to the borrowing of
                                    money or to the creation of a Lien, other
                                    than a Permitted Lien, on any property or
                                    asset of Clinserve, or the Subsidiary.

                           (h)      All Contractual Obligations of Clinserve or
                                    the Subsidiary requiring a notice exceeding
                                    6 (six) months for termination.

                  3.7.2    NATURE OF CONTRACTS. All of the Contractual
                           Obligations of Clinserve and the Subsidiary at the
                           Completion Date are enforceable against Clinserve and
                           the Subsidiary, the other parties thereto, in
                           accordance with their terms; except for Contractual
                           Obligations the failure of which to be so enforceable
                           does not and shall not, individually or in the
                           aggregate, result in a Material Adverse Effect.
                           Except for breaches, defaults and liabilities which
                           do not and shall not individually or in the aggregate
                           result in a Material Adverse Effect, neither
                           Clinserve nor the Subsidiary is now in default, and
                           no event has occurred which with notice or lapse of
                           time or both would constitute a default under, nor
                           are there any liabilities arising from any breach or
                           default by any of them or event which with notice or
                           lapse of time or both would constitute a default by
                           any of them prior to the Completion Date of, any
                           provision of any such Contractual Obligation.

                  3.7.3    ARTICLES. Neither Clinserve nor the Subsidiary is in
                           violation of, or in default under, any provision of
                           its articles or constituting documents and Phoenix
                           has been provided with complete and correct copies of
                           such articles or constituting documents.

                  3.7.4    INSURANCE. Each of Clinserve and the Subsidiary
                           carries insurance policies with independent third
                           party insurers which, with respect to their amounts
                           and types of coverage, are adequate to insure against
                           risks to which each of Clinserve and the Subsidiary
                           and their respective property and assets are normally
                           exposed in the operation of their respective
                           businesses, including without limitation professional
                           liability. All policies, the absence of which,
                           individually or in the aggregate, would result in a
                           Material Adverse Effect, are in full force and effect
                           and free from any right of termination on the part of
                           the applicable insurance carriers. There are no
                           outstanding unpaid premiums except in the ordinary
                           course of business, and neither Clinserve nor any
                           Subsidiary has received any notice of cancellation or
                           non-renewal of any such policy. Neither Clinserve nor
                           any Subsidiary is aware of any risks, situations,
                           occurrences or other matters which have been
                           disclosed, or should have been disclosed, to
                           insurance carriers or brokers in connection with any
                           application for such insurance as a result of which
                           an insurance carrier would have a right to cancel the
                           corresponding



                                      -11-


                           insurance policy or deny coverage with respect to any
                           rights under any such policies. There exists no event
                           of default or event, occurrence, condition or act
                           (including the transactions contemplated by this
                           Agreement) which, with the giving of notice, the
                           lapse of time or the happening of any further event
                           or condition, would become a default or occasion a
                           material premium increase under any such policy or
                           give rise to, and neither Clinserve nor any
                           Subsidiary has any anticipation of, any termination
                           or cancellation thereof or material premium increase
                           therefor.

                  3.7.5    INSURANCE CLAIM. Each of the Vendors declares that
                           after thorough internal investigation, there is no
                           known fact, situation or circumstance involving
                           Clinserve or the Subsidiary or their directors or
                           officers, which would reasonably be expected to
                           result in any future claim being made against the
                           Company or the Subsidiary.

                  3.7.6    DISPUTE. Neither Clinserve nor the Subsidiary has
                           received any notice from any supplier, vendor,
                           contractor, customer or client with which Clinserve
                           or such Subsidiary has conducted business during the
                           one-year period ending on the date of this Agreement
                           confirming such Person's intention to reduce the
                           volume under, terminate or otherwise alter any
                           Contractual Obligation with Clinserve or any
                           Subsidiary, the effect of which, individually or in
                           the aggregate, would result in a Material Adverse
                           Effect.

         3.8      OPERATIONS IN CONFORMITY WITH LAW, ETC.

                  The operations of Clinserve and the Subsidiary as now
         conducted, and their properties, assets, equipments, buildings,
         immoveables and leased or occupied properties, are not, and have not
         been, in violation of, nor is Clinserve or the Subsidiary in default
         and no event has occurred which with notice or lapse of time or both
         would constitute a default under, any applicable Legal Requirements
         including, in particular, any applicable Environmental Laws or Legal
         Requirements regarding clinical research and experimentation on animals
         [or humans], except for such violations and defaults as do not and
         shall not, in the aggregate, have a Material Adverse Effect. Neither
         Clinserve nor the Subsidiary has received notice of any such violation
         or default and neither the Vendors nor the Management have knowledge of
         any basis on which the operations of Clinserve or the Subsidiary, when
         conducted as currently proposed to be conducted after the Completion
         Date, would be held so as to violate or to give rise to any such
         violation or default. Clinserve and the Subsidiary have all franchises,
         licenses, permits, certificates, authorizations, registrations or other
         authority presently necessary for the conduct of their business as now
         conducted, except for franchises, licences, permits, certificates,
         authorizations, registrations or other authority, the absence of which,
         individually or in the aggregate, does not and shall not result in a
         Material Adverse Effect. Based on the facts presently known to the
         Vendors and Management, all future expenditures on the part of
         Clinserve and the Subsidiary required to meet the provisions of any
         presently existing applicable Legal Requirements (including Legal
         Requirements relating to employment practices or to occupational or
         health standards or to environmental considerations) shall not, in the
         aggregate, have a Material Adverse Effect. Clinserve and the Subsidiary
         have complied and are in compliance with applicable competition
         regulations and have never infringed fair competition in the markets
         where they operate, either with or towards third companies or between
         themselves. Clinserve and the Subsidiary do not hold separately or
         together a dominant position on the markets involved and their market
         share and net aggregate turnover do not meet the European, Swiss or
         German thresholds which authorizes European or domestic competition
         authorities to control the operation and impede the completion of the
         transaction contemplated hereby.

         3.9      INTELLECTUAL PROPERTY


                                      -12-


                  Schedule 3.9 contains a list of all the trade-marks, trade
         names and patents used by any of Clinserve or the Subsidiary
         (collectively "Used Intellectual Property"). The entity indicated in
         said Schedule as owner of Used Intellectual Property is the registered
         and beneficial owner of such Used Intellectual Property or the
         registration thereof, if applicable, (except as set forth in Schedule
         3.9), with good and marketable title, unencumbered (except for
         Permitted Liens), and with full right to sell, assign or otherwise
         transfer or license to others and subject to no pending challenge,
         refutation, expiry or termination other than as set forth in Schedule
         3.9. To the Vendors' and Management's knowledge, other than as set
         forth in Schedule 3.9, none of Clinserve or the Subsidiary uses any
         intellectual property not owned by it, other than software purchased
         "off the shelf", all of which each entity using said property has the
         right to use (collectively "Licenced Intellectual Property"). (Used
         Intellectual Property and Licensed Intellectual Property are sometimes
         hereinafter referred to collectively as "Intellectual Property"). None
         of Clinserve or the Subsidiary is required to pay royalties, fees or
         other consideration to any other person with respect to the use of any
         of the Intellectual Property or in connection with the conduct of its
         business or otherwise. To the Vendors' and Management's knowledge, none
         of Clinserve or the Subsidiary has infringed the intellectual or
         industrial property rights of any other person, nor has any of them
         used any intellectual or industrial property (including, without
         limitation, trade-marks, trade names, patents, models, designs and
         copyrights) which it does not own or have the right to use other than
         as set forth in Schedule 3.9. There are no outstanding claims asserted
         against any of Clinserve or the Subsidiary alleging the infringement or
         the misappropriation by any of them of any intellectual or industrial
         property. None of Clinserve or the Subsidiary has granted any licences
         or sub-licences to third parties with respect to any of the
         Intellectual Property other than as set forth in Schedule 3.9 and
         neither the Vendors nor Management has any knowledge of any
         infringement or misappropriation by any other Person of any of the
         Intellectual Property. Neither the execution nor delivery of this
         Agreement will constitute a breach of or a default under any agreement
         relating to the Intellectual Property.

         3.10     ENVIRONMENTAL MATTERS

                  3.10.1   Clinserve and the Subsidiary, their employees,
                           agents, shareholders, directors and officers (acting
                           in their capacity of employees, agents, shareholders,
                           directors or officers of Clinserve or of the
                           Subsidiary) have never been declared guilty of
                           committing an offence for a violation of
                           Environmental Laws and have never been fined for such
                           an offence or have otherwise settled such a
                           prosecution in connection with the activities of
                           Clinserve and the Subsidiary;

                  3.10.2   There are no contaminants, waste or pollutants of any
                           kind whatsoever in, on or under the equipment,
                           buildings, immoveables or properties owned, leased or
                           occupied by Clinserve or the Subsidiary and caused by
                           Clinserve, the Subsidiary or their employees, agents,
                           shareholders, directors or officers (acting in their
                           capacity of employees, agents, shareholders,
                           directors or officers of Clinserve or the
                           Subsidiary), the presence of which constitutes a
                           violation of applicable Environmental Laws and the
                           presence of which, individually or in the aggregate,
                           constitutes a Material Adverse Effect;

                  3.10.3   Neither Clinserve nor the Subsidiary has received any
                           written notice or request for information in the
                           context of any national, supra-national, provincial,
                           regional, local or municipal environmental
                           investigation or inspection;

                  3.10.4   There are no PCBs, asbestos or urea formaldehyde
                           insolation in, on or under the equipment, buildings,
                           immoveables or properties owned, leased or occupied
                           by Clinserve or the Subsidiary;

                                      -13-


                  3.10.5   There is no action, suit or proceeding pending in
                           relation to environmental matters against Clinserve
                           or the Subsidiary, its employees, agents,
                           shareholders, directors and officers (acting in their
                           capacity of employees, agents, shareholders,
                           directors or officers of Clinserve or of the
                           Subsidiary), or involving Clinserve or the Subsidiary
                           or its assets, before any judicial body, tribunal,
                           commission, agency or other governmental entity, and
                           to the Vendors' knowledge and to the knowledge of
                           Management, there is no threat of, or event or fact
                           based on which, such action, suit or proceeding may
                           be instituted;

                  3.10.6   To the knowledge of Management and the Vendors,
                           Clinserve and the Subsidiary are in compliance with
                           all applicable Environmental Laws.

         3.11     LABOUR AND EMPLOYMENT MATTERS

                  3.11.1   Without limiting the generality of Section 3.8, each
                           of Clinserve and the Subsidiary has complied with all
                           applicable laws relating to the employment of labour,
                           including provisions thereof relating to wages, hours
                           and collective bargaining rights.


                  3.11.2   There is no collective agreement by which Clinserve
                           or the Subsidiary is bound which relates to the
                           employees of Clinserve or the Subsidiary. To the
                           knowledge of the Vendors and to the knowledge of
                           Management, there are no threatened or pending
                           attempts to organize or establish any labour union or
                           employee association in connection with the business
                           of Clinserve or the Subsidiary. To the knowledge of
                           the Vendors and to the knowledge of Management, there
                           is no pending or threatened labour dispute,
                           grievance, strike, or work stoppage materially
                           affecting the business of any of Clinserve or the
                           Subsidiary. Neither Clinserve nor the Subsidiary is a
                           party to any other written employment agreement,
                           contract, arrangement, management contract or service
                           contract affecting employees other than as set forth
                           in Schedule 3.7.1, nor are any such contracts,
                           agreements, arrangements, management contracts or
                           service contracts being currently negotiated or
                           proposed other than in the ordinary course of
                           business.

                  3.11.3   There exist no retirement plans, profit sharing,
                           option or incentive plans, or other employee benefit
                           plans for employees of Clinserve or the Subsidiary
                           other than as set forth in Schedule 3.7.1 for which
                           adequate arrangements have been made since September
                           1, 1998 to set aside the requisite amounts in the
                           prescribed fashion, and neither Clinserve nor the
                           Subsidiary has promised or intends to implement other
                           such plans.

                  3.11.4   Neither Clinserve nor the Subsidiary has any employee
                           who cannot be dismissed without further liability
                           upon such notice period not exceeding what it is
                           required by the applicable Legal Requirement.

                  3.11.5   Each of Clinserve's or any of the Subsidiary's
                           employees who is practising as a physician, nurse or
                           pharmacist is identified in Schedule 3.11.5, and each
                           such employee is duly licensed and in good standing
                           to practice as a physician, nurse or pharmacist, as
                           the case may be, in each jurisdiction in which such
                           employee renders services for or on behalf of
                           Clinserve or any Subsidiary. None of the employees
                           listed on Schedule 3.11.5 is or has been subject to
                           any claim in connection with his or her practice as
                           physician, nurse or pharmacist while employed by
                           Clinserve or the Subsidiary, as the case may be, and
                           no fact or occurrence is known to the Management to
                           exist which is likely to give rise to the revocation
                           of any such licence.

                                      -14-


                  3.11.6   None of Clinserve's or any of the Subsidiary's
                           employees has signed non-compete covenants in favour
                           of Clinserve or the Subsidiary.

         3.12     TAXES

                  Other than as set forth in Schedule 3.12, all tax returns
         required to be filed by Clinserve and the Subsidiary in any
         jurisdiction have been filed and all taxes, assessments, levies and
         other governmental charges upon Clinserve and the Subsidiary or upon
         any of their properties or income, including any tax in respect of
         value added, have been paid if and when due unless such payment is
         being contested in good faith and by appropriate proceedings and
         adequate reserves with respect thereto determined in accordance with
         applicable policies have been established by Clinserve and the
         Subsidiary. There is no tax revision threatened in writing against
         Clinserve and the Subsidiary and there is no basis for such assessment.

         3.13     WITHHOLDINGS

                  Each of Clinserve and the Subsidiary has withheld from each
         payment made to any of its shareholders, officers, directors,
         non-resident creditors and employees the amount of all taxes and other
         deductions required to be withheld and has remitted all such amounts to
         the appropriate authorities within the prescribed times, and has
         otherwise fulfilled all requirements of all Legal Requirements
         governing such deductions and withholdings. Each of Clinserve and the
         Subsidiary has remitted to the proper authorities all employer
         contributions due and payable under all social security, occupational
         health and safety and pension plans.

         3.14     GOOD TITLE

                  Other than as set forth in Schedule 3.14 each of Clinserve and
         the Subsidiary has good and marketable title to all assets in the
         balance sheets as per August 31, 1998 free and clear of Liens and other
         adverse claims.

         3.15     LITIGATION

                  Other than as set forth in Schedule 3.15, no litigation or
         proceeding before, or investigation by, any foreign, national,
         supra-national or municipal, judicial, tax or customs tribunal or board
         or other governmental or administrative agency or any arbitrator, is
         pending or threatened (or does any basis exist therefor), against
         Clinserve or the Subsidiary or, to the Vendors' knowledge or to the
         knowledge of Management, any director or officer of Clinserve or the
         Subsidiary, which individually or in the aggregate could result in a
         Material Adverse Effect, or which seeks rescission of, seeks to enjoin
         the consummation of, or which questions the validity of, this Agreement
         or any of the transactions contemplated hereby. Neither Clinserve nor
         the Subsidiary has been charged, nor to the Vendors' knowledge or to
         the knowledge of Management, is it threatened to be charged, with
         infringement of any trademark, trade name, service mark, copyright,
         patent, patent right or other proprietary right of any Person.

         3.16     PRESS COVERAGE

                  Neither Clinserve nor the Subsidiary has been the object of
         any demonstrations, press campaigns or other attacks due to the nature
         of its activities.

                                      -15-


         3.17     VIOLATION OF OTHER INSTRUMENTS

                  Neither the execution and delivery of this Agreement by the
         Vendors, the consummation of any of the transactions contemplated
         hereby or in Schedule 3.17, shall (a) constitute a breach of or a
         default or an event which with notice or lapse of time or both would
         constitute a default under any Contractual Obligation of Clinserve or
         the Subsidiary, (b) result in acceleration in the time for performance
         of any obligation of Clinserve or the Subsidiary under any such
         Contractual Obligation, (c) result in the creation of any Lien upon any
         property or asset of Clinserve or the Subsidiary, (d) require any
         consent, waiver or amendment to any such Contractual Obligation that
         has not been obtained and remains in full force and effect, (e) give
         rise to any severance payment, right of termination, securities
         purchase or redemption right or other right under any such Contractual
         Obligation, or (f) violate or give rise to a default or an event which
         with notice or lapse of time or both could constitute a default under
         any Legal Requirements, except for events or conditions described in
         clauses (a) through (f) above which shall not, individually or in the
         aggregate, have any Material Adverse Effect or (g) result in any state
         of facts which could have a Material Adverse Effect.

         3.18     APPROVALS, CONSENTS, ETC.

                  Other than as set forth in Schedule 3.18, no approval,
         consent, authorization or other order of, and no declaration, filing,
         registration, qualification or recording with, any governmental
         authority or any other Person is required to be made by or on behalf of
         the Vendors, Clinserve or the Subsidiary in connection with the
         execution, delivery or performance of this Agreement or any of the
         transactions contemplated hereby.

         3.19     INVESTMENT OR DIVESTITURE

                  Schedule 3.19 contains a complete list of all investments and
         divestitures in process which are not mentioned in the financial
         statements of Clinserve and the Subsidiary (balance sheet, statement of
         earnings and schedules) for the period ended August 31, 1998.

         3.20     FULL DISCLOSURE

                  Disclosure made by the Vendors in respect of one of the
         representations contained in this Section 3 is considered being made in
         respect of all other representations. There is no fact that the
         Vendors, to the best of their knowledge, have not disclosed to Phoenix
         which could have a Material Adverse Effect on the properties, business,
         prospects or condition (financial or otherwise) of Clinserve or the
         Subsidiary. Neither the reports, financial statements and other
         documents referred to in Section 3.4, nor any certificate, statement or
         document delivered by the Vendors to Phoenix in connection with this
         Agreement contains any untrue statement of a fact or omits to state any
         fact necessary to keep the statements contained herein or therein from
         being misleading in a manner that would constitute a Material Adverse
         Effect.

4.       REPRESENTATIONS AND WARRANTIES OF PHOENIX

         Phoenix represents and warrants to the Vendors that:

         4.1      DUE INCORPORATION, ETC.


                                      -16-


                  Phoenix is duly incorporated, validly exists and is in good
         standing under the Canada Business Corporations Act and has all
         necessary corporate capacity and power to own and lease its property
         and assets and to carry on the business now conducted by it.

         4.2      SHARE CAPITAL OF PHOENIX

                  The authorized share capital of Phoenix is composed of an
         unlimited number of common shares and an unlimited number of preferred
         shares issuable in series of which, as at November 4, 1998, there were
         24,857,059 common shares issued and outstanding.

         4.3      OPTIONS

                  Other than the options to acquire common shares of Phoenix
         granted pursuant to Phoenix's Key Employee Share Option Plan, shares to
         be issued to Dorn Cook under an earn-out formula which has been
         disclosed to the Vendors, an approximate number of 2,405,000 common
         shares of Phoenix to be issued in payment of the purchase prices for
         certain proposed acquisitions, Phoenix does not have any rights or
         options to subscribe for, or any warrants or other agreements providing
         for or requiring the issuance of common shares or preferred shares.

         4.4      DUE AUTHORIZATION

                  All necessary corporate action has been taken by Phoenix to
         authorize the execution of this Agreement and the consummation of the
         transactions contemplated hereby, including the issuance of the Phoenix
         Shares as fully paid and non-assessable in consideration for the
         purchase of the Shares.

         4.5      CONFORMITY WITH APPLICABLE SECURITIES LAWS

                  All documents have been filed, all requisite proceedings have
         been taken and all approvals, exemptions, consents, orders and
         authorizations required under applicable securities laws have been
         obtained in order to validly and lawfully issue and deliver the Phoenix
         Shares issued hereunder. The execution of this Agreement and the
         issuance of the Phoenix Shares by Phoenix to the Vendors will be exempt
         from the prospectus and registration requirements of the applicable
         Canadian securities legislation.

         4.6      STOCK EXCHANGE APPROVALS

                  The listing of the Phoenix Shares on The Montreal Exchange and
         the Toronto Stock Exchange has been approved by such exchanges, subject
         to Phoenix fulfilling all of the standard requirements of such
         exchanges.

         4.7      REPORTING ISSUER

                  Phoenix is a reporting issuer under the laws of the provinces
         of Ontario and Quebec and is not in default of any requirements of the
         securities legislation of such provinces.

         4.8      PHOENIX SHARES

                  The Phoenix Shares will at the time of issuance be duly
         authorized, validly issued, fully paid and non-assessable.

                                      -17-


         4.9      HOLD PERIOD

                  The Phoenix Shares are not subject to any statutory hold
         period or any resale restrictions under the SECURITIES ACT (Quebec).

         4.10     PUBLIC INFORMATION

                  No material change (as defined in the Securities Act (Quebec))
         has occurred in the affairs of Phoenix which had not been generally
         disclosed to the public, nor has Phoenix any knowledge of any other
         material adverse information in regard to the current and prospective
         operations of Phoenix which have not been generally disclosed to the
         public.

         4.11     UNDERTAKING

                  Phoenix undertakes to refer to Clinserve all clinical
         laboratory tests derived from Phoenix's European Phase II-IV studies,
         to the extent allowed by Phoenix's clients.

5.       POOLING OF INTERESTS

         5.1      ACCOUNTING TREATMENT

                  Phoenix, Clinserve and the Vendors intend and desire for the
         transactions contemplated by this Agreement to qualify for "pooling of
         interests" treatment for US GAAP purposes in accordance with Accounting
         Principles Board Opinion No. 16.

         5.2      POOLING LETTERS

                  On or prior to the Completion Date, Clinserve shall cause to
         be executed and delivered to Ernst & Young, auditors to Phoenix, and to
         Phoenix a letter or letters, dated the Completion Date, from
         Clinserve's shareholders in form and substance reasonably satisfactory
         to Phoenix and its auditors relating to "pooling of interests"
         accounting (the "Clinserve Pooling Letter"). On or prior to the
         Completion Date, Phoenix shall deliver to Ernst & Young, auditors to
         Phoenix, a letter or letters, dated the Completion Date, from Phoenix's
         management in form and substance reasonably satisfactory to its
         auditors relating to "pooling of interests" accounting.

         5.3      PLACEMENT AND STOCK TRANSFER RESTRICTIONS AND RELATED MATTERS

                  Each party to this Agreement agrees that from and after the
         date of this Agreement, such party shall not knowingly take any action,
         or knowingly fail to take any action, which action or failure is
         reasonably likely to disqualify the transactions contemplated by this
         Agreement from pooling of interests accounting treatment by Phoenix,
         and that such party shall take all reasonable actions necessary to
         cause the transactions contemplated by this Agreement to qualify as a
         pooling of interest, if such characterization shall be jeopardized by
         action taken by such party. Without limiting the foregoing, each Vendor
         who is a Pooling Affiliate of Clinserve agrees that such Vendor shall
         not sell, transfer, pledge, or otherwise dispose of such Vendor's
         interests in or reduce such Vendor's risk relative to any of the
         Phoenix Shares until Phoenix shall have published financial results
         (including combined sales and net income) covering at least thirty (30)
         days of combined operations of Phoenix and Clinserve after the
         Completion Date. No later than April 30, 1999, Phoenix shall prepare
         and publish such financial results for the first full month of
         operations following the Completion Date. Each of the Vendors and
         Clinserve acknowledge and agree with Phoenix that none of the Vendors
         or Clinserve



                                      -18-


         is a party to any agreement or arrangement among themselves or with
         third parties regarding the transactions contemplated by this Agreement
         or the subject matter hereof.

                  Prior to the Completion Date, Phoenix shall deliver to
         Clinserve a list of names and addresses of those persons who are or may
         be, in Phoenix's reasonable judgement, Affiliates of Phoenix within the
         meaning of Rule 145 of the rules and regulations promulgated under the
         Securities Act or applicable SEC accounting releases with respect to
         pooling of interests accounting treatment (each such persons, a
         "Pooling Affiliate"). Phoenix also shall provide Clinserve with such
         information and documents as Clinserve shall reasonably request for
         purposes of reviewing such list. Prior to the Completion Date, Phoenix
         shall deliver to Clinserve an affiliate letter, in form and substance
         reasonably satisfactory to Clinserve, executed by each of the Pooling
         Affiliates identified in the foregoing list.

                  Prior to the Completion Date, Clinserve shall deliver to
         Phoenix an affiliate letter, in form and substance reasonably
         satisfactory to Phoenix, executed by each of the Pooling Affiliate of
         Clinserve. Clinserve represents to Phoenix that Froreich and Wicki are
         the only Pooling Affiliates of Clinserve.

6.       EMPLOYMENT AGREEMENT AND COOPERATION AGREEMENT

         6.1      EMPLOYMENT AGREEMENT WITH CEMAL KUYAS

                  Cemal Kuyas and Clinserve GmbH shall execute an employment
         agreement satisfactory in form and content to Phoenix and Clinserve.

7.       SURVIVAL OF REPRESENTATIONS; INDEMNITY

         7.1      SURVIVAL OF REPRESENTATIONS

                  The respective representations and warranties of the Vendors
         contained in this Agreement or in any schedule attached hereto shall
         survive the consummation of the transactions contemplated hereby and
         shall remain in full force and effect notwithstanding any investigation
         or examination of, or knowledge with respect to, the subject matter
         thereof by or on behalf of Phoenix until the earlier of November 5,
         1999 or the date of completion of the audit of the combined financial
         statements of Phoenix and Clinserve (the period ending on such date
         being referred to herein as the "Representations Period"), except that
         such representations and warranties shall survive indefinitely in the
         event of fraud with respect thereto. No claim for indemnification
         pursuant to Section 7.2.1 below may be brought after the expiration of
         the Representations Period, except for claims made in good faith in
         writing prior to such expiration and setting forth in reasonable detail
         the claim, regardless of whether any action or demand has been
         commenced against Phoenix (it being understood without limitation, that
         any and all Losses (as defined below) arising after the expiration of
         the Representations Period shall be recoverable upon notice properly
         given prior to the expiration of the Representations Period in
         accordance with this Section 7.1). The representations and warranties
         of Phoenix contained in this Agreement or in any schedule attached
         hereto shall terminate upon and not survive the Completion Date, except
         in the event of fraud by Phoenix with respect thereto, in which case
         they shall survive indefinitely.

                                      -19-


         7.2      INDEMNIFICATION

                  7.2.1    From and after the Completion Date, Phoenix and its
                           Affiliates (including Clinserve and the Subsidiary)
                           and all of their respective officers, directors,
                           employees, agents and shareholders (each, an
                           "Indemnitee") shall be defended, indemnified and held
                           harmless by the Vendors pursuant to this Agreement
                           and the Escrow Agreement to the full extent permitted
                           by law, from and against any and all losses, claims,
                           actions, damages, liabilities, costs and expenses
                           (including attorneys' fees and expenses)
                           (collectively, "Losses") relating to or arising from
                           or in connection with (i) any misrepresentation or
                           any non-fulfilment of any representation, warranty,
                           covenant, obligation or agreement by any Vendor
                           contained in or made pursuant to this Agreement or
                           any other document, agreement, officer's certificate
                           or other certificate delivered to Phoenix in
                           connection with this Agreement, and (ii) the
                           enforcement by Phoenix of its rights pursuant to this
                           Section 7.2, or any litigation, proceeding or
                           investigation relating to any of the foregoing. The
                           indemnification obligations of the Vendors pursuant
                           hereto shall be joint and not solidary, i.e. prorata
                           to the number of Phoenix Shares received by each
                           Vendor in accordance with Section 2.2.

                  7.2.2    Notwithstanding the foregoing provisions of this
                           Section 7.2, but except with respect to any Losses
                           resulting from or arising out of fraud or other
                           intentional or knowing misconduct or
                           misrepresentation, (i) the maximum aggregate recourse
                           by the Indemnitees pursuant to Section 7.2.1 above
                           shall not exceed the aggregate value (calculated by
                           adding together the opening and closing prices of the
                           common shares of Phoenix on each of the Toronto Stock
                           Exchange and The Montreal Exchange for each of the
                           ten trading days preceding the Completion Date, and
                           dividing this sum by 40) of the Escrowed Securities
                           (the "Indemnity Cap"), and (ii) the sole recourse of
                           any Indemnitee in respect of Losses (but not in
                           respect of fraud or other intentional or knowing
                           misconduct or misrepresentation) shall be from, out
                           of, and to the extent of the Escrowed Securities. Any
                           indemnification shall be payable by the return of
                           Escrowed Securities to Phoenix in accordance with the
                           provisions of the Escrow Agreement. In particular,
                           the number of Escrowed Shares to be remitted to
                           Phoenix in payment of any indemnification obligation
                           shall be calculated on the basis of the average price
                           of the Escrowed Shares obtained by adding together
                           the opening and closing prices of the common shares
                           of Phoenix on each of the Toronto Stock Exchange and
                           The Montreal Exchange for each of the ten trading
                           days preceding the Completion Date, and dividing this
                           sum by 40. All dividends or other distributions
                           received by a Vendor in respect of common shares of
                           Phoenix which are remitted to Phoenix in satisfaction
                           of an indemnification obligation under this Section
                           7, shall also be repaid to Phoenix at the time of
                           payment of indemnification.

                  7.2.3    Notwithstanding any other provision of this
                           Agreement, as of and after the Completion Date,
                           Clinserve shall not have any liability under this
                           Agreement, and no Vendor shall threaten or bring any
                           claim or action whatsoever against Clinserve for
                           contribution to any amounts payable under this
                           Section 7.2 by such Vendor.

                                      -20-




8.       NOTICES

         Any demand, notice or other communication to be given in connection
with this Agreement shall be given in writing and shall be given by personal
delivery, by registered mail or by electronic means of communication addressed
to the recipient as follows:

         8.1      To Phoenix:

                  Phoenix International Life Sciences Inc.
                  2350, Cohen Street
                  Saint-Laurent, Quebec
                  H4R 2N6 Canada

                  Telecopier No.: (514) 333-7306

                  ATTENTION: JEAN-YVES CALOZ

         8.2      To Froreich:

                  Dr. Andre von Froreich
                  Forsthohe 33
                  21149 Hamburg, Germany

         8.3      To Wicki:

                  Dr. Andreas Wicki
                  Hohestrasse 39
                  8702 Zollikon, Switzerland

         8.4      To Clinserve:

                  Clinserve A.G.
                  Rue St. Pierre 18
                  1700 Fribourg, Switzerland

                  ATTENTION: DR. VON FROREICH


9.       MODIFICATION

         All modifications or amendments of any provision of this Agreement
shall be effective only if the same shall be in writing and then shall be
effective only in the specific instance and for the purpose for which given.

10.      WAIVER

         No failure to exercise, and no delay in exercising, on the part of a
party hereto, any right hereunder shall operate as a waiver thereof, nor shall
any single or partial exercise thereof preclude any other or further exercise
thereof or the exercise of any other right. No waiver of any provision of this
Agreement shall beeffective unless in writing. No notice or demand given in any
case shall constitute a waiver of the right to take other action in the same,
similar or other instances without such notice or demand.



                                      -21-



11.      CONFIDENTIALITY

         The parties agree to treat this Agreement as confidential and not to
disclose its contents to third parties other than their advisers, except to the
extent necessary to enforce performance of obligations hereunder, or as is
required to comply with applicable laws or regulations, including regulations of
any stock exchange on which the securities of Phoenix are listed following
consultations with Froreich and Wicki.

12.      FURTHER ASSURANCES

         The parties shall, with all reasonable diligence, do all such things
and provide all such reasonable assurances as may be required to consummate the
transactions contemplated hereby, and each party shall provide such further
documents or instruments required by another party as may be reasonably
necessary or desirable to give effect to the purpose of this Agreement and to
carry out its provisions.

13.      GOVERNING LAWS

         This Agreement shall be governed by the laws of the Province of Quebec
and the laws of Canada applicable therein.

14.      ARBITRATION

         All disputes arising out of or in connection with the present Agreement
shall be finally settled under the Rules of Arbitration of the International
Chamber of Commerce by one or more arbitrators appointed in accordance with the
said Rules.

         The place of arbitration shall be Montreal.

         The language of the arbitration shall be English.

15.      GENERAL

         The invalidity or unenforceability of any term or provision hereof
shall not affect the validity or enforceability of any other term or provision
hereof. The headings in this Agreement are for convenience of reference only and
shall not alter or otherwise affect the meaning hereof. This Agreement and the
other documents and instruments referred to herein constitute the entire
understanding of the parties hereto with respect to the subject matter hereof
and thereof and supersede all present and prior agreements, whether written or
oral. No investigation made by or on behalf of a party hereto shall mitigate,
diminish or affect the representations and warranties made herein by the
Vendors. This Agreement may be executed in any number of counterparts which
together shall constitute one instrument and shall be governed by and construed
in accordance with the laws of the Province of Quebec and the laws of Canada
applicable therein, and shall bind and inure to the benefit of the parties
hereto and their respective heirs, executors, administrators, personal
representatives, successors and assigns. The parties hereto have expressly
required that this Agreement and all documents and notices related hereto be
drafted in English. LES PARTIES AUX PRESENTES ONT EXPRESSEMENT EXIGE QUE LE
PRESENT CONTRAT ET TOUS LES DOCUMENTS ET AVIS Y AFFERENTS SOIENT REDIGES EN
ANGLAIS.

         IN WITNESS WHEREOF, the parties hereto caused this Agreement to be duly
executed as of the Completion Date.


                                      -22-


                                 PHOENIX INTERNATIONAL LIFE SCIENCES INC.


                                 By:           /s/ John W. Hooper 
                                          -------------------------------------
                                          John Hooper, Ph.D.
                                 Title:   Chairman and Chief Executive Officer


                                               /s/ Andre Von Froreich
                                          -------------------------------------
                                          DR. ANDRE VON FROREICH

                                                /s/ Andreas Wicki
                                          -------------------------------------
                                          DR. ANDREAS WICKI

                                          CLINSERVE A.G.

                                 By:            /s/ Andreas Wicki
                                          -------------------------------------
                                          Andreas Wicki
                                 Title:   Chairman of the board of directors







                                LIST OF SCHEDULES

Schedule A        Outstanding shares and voting rights of Clinserve

Schedule B        The capital structure of Clinserve

Schedule C        The capital structure of Clinserve GmbH

Schedule 1.10     Escrow Agreement

Schedule 1.21     Permitted Lien

Schedule 3.3.3    Capital Stock of the Subsidiary

Schedule 3.3.4    Subsidiary Options

Schedule 3.3.5    Commitments affecting shares or voting rights of Clinserve 
                  or the Subsidiary

Schedule 3.4A     Financial Statements

Schedule 3.5      Material liabilities, contingent or otherwise of Clinserve 
                  or the Subsidiary

Schedule 3.6.2    Extraordinary Transactions after August 31, 1998

Schedule 3.7.1    Contractual Obligations

Schedule 3.9      Intellectual Property

Schedule 3.11.5   Physicians, nurses or pharmacists employed by Clinserve and 
                  the Subsidiary

Schedule 3.12     Taxes

Schedule 3.14     Title to assets

Schedule 3.15     Litigation

Schedule 3.17     Violation of Other Instruments

Schedule 3.18     Approvals, Consents, etc.

Schedule 3.19     Investment or Divestiture




                                                                  Schedule 1.10


ESCROW AGREEMENT dated as of November 5, 1998.



AMONG:                              PHOENIX INTERNATIONAL LIFE SCIENCES INC., a
                                    corporation incorporated under the Canada
                                    Business Corporations Act, having its head
                                    office at 2350, Cohen Street, Saint-Laurent,
                                    Quebec, Canada, H4R 2N6, herein acting and
                                    represented by John Hooper, Ph.D., its duly
                                    authorized representative;

                                    (hereinafter "Phoenix")


AND:                                DR. ANDRE VON FROREICH, residing at 
                                    Forsthohe 33, 21149 Hamburg, Germany;

                                    (hereinafter "Froreich")


AND:                                DR. ANDREAS WICKI, residing at Hohestrasse
                                    39, 8702 Zollikon, Switzerland;

                                    (hereinafter "Wicki")


AND:                                MONTREAL TRUST COMPANY, 1800 McGill College
                                    Avenue, Montreal, Quebec, H3A 3K9, as escrow
                                    agent, herein represented by its duly
                                    authorized representatives Rose Marie Labbe
                                    and Guy L'Esperance;

                                    (hereinafter the "Escrow Agent")



         WHEREAS Phoenix and the Vendors are parties to a share purchase
agreement dated November 5, 1998 (the "Purchase Agreement");

         WHEREAS the Purchase Agreement provides that certain shares of Phoenix
issued to the Vendors pursuant thereto are to be held in escrow for the purposes
described therein;

         NOW THEREFORE the parties hereby agree as follows:

1.       INTERPRETATION AND DEFINITIONS

         1.1      Whenever used in this Agreement:

                  1.1.1    "AFFILIATE" means any of Froreich and Wicki and
                           "Affiliates" means more than one of them;



                                      -2-



                  1.1.2    "CLAIM" means any claim by Phoenix against and the
                           Vendors under Section 7.2 of the Purchase Agreement;

                  1.1.3    "DISTRIBUTIONS" has the meaning ascribed thereto in
                           Section 2.3 hereof;

                  1.1.4    "ESCROWED SHARES" has the meaning ascribed thereto in
                           Section 2.1 hereof;

                  1.1.5    "ESCROWED SHARE PRICE" means the amount obtained by
                           adding the opening and closing prices of the common
                           shares of Phoenix on each of the Montreal Exchange
                           and The Toronto Stock Exchange for the ten trading
                           days preceding the date of execution of the Purchase
                           Agreement, divided by 40;

                  1.1.6    "NOTICE OF CLAIM" means a written notice of any Claim
                           given by Phoenix setting forth the details of each
                           Claim referred to therein including the amount
                           thereof, if known to Phoenix, or Phoenix's reasonable
                           estimate thereof, as well as the provisions of the
                           Purchase Agreement upon which such Claim is based;

                  1.1.7    "OBJECTION" means, in respect of any Claim, any
                           objection raised in the Response by any of the
                           Vendors to such Claim;

                  1.1.8    "PROCEEDS" has the meaning ascribed thereto in
                           Section 3.1 hereof;

                  1.1.9    "PURCHASE AGREEMENT" has the meaning ascribed thereto
                           in the preamble to this Agreement;

                  1.1.10   "RELEASED SHARES" has the meaning ascribed thereto in
                           Section 3.3.1.1 hereof;

                  1.1.11   "RESPONSE" means, in respect of any Claim, the joint
                           written response of the representatives of the
                           Vendors duly appointed in the manner set forth in
                           Section 3.3 hereof indicating whether they accept or
                           dispute such Claim;

                  1.1.12   "VENDORS" means Froreich and Wicki.

         1.2      Each capitalized term used in this Agreement but not defined
                  herein as the meaning ascribed thereto in the Purchase
                  Agreement.

         1.3      In the event of (i) any subdivision, consolidation or
                  reclassification of the class of shares comprising the
                  Escrowed Shares or (ii) any reorganization of the share
                  capital of Phoenix affecting the Escrowed Shares or (iii) the
                  amalgamation of Phoenix with any other company, the number of
                  Escrowed Shares and Escrowed Share Price shall be adjusted, if
                  required, so that none of the parties hereto shall be in a
                  position less favorable to it than as provided in this
                  Agreement as a result of any of the foregoing actions.

         1.4      For all purposes of this Agreement, the amount of any Claim in
                  a currency other than Canadian dollars shall be converted to
                  Canadian dollars at the exchange rate between Canadian and
                  such currency shall be the "Spot Rate" of the alternate
                  currency on the business day preceding the day as of which the
                  conversion from one currency to the other is to be effected,
                  as reported in the Financial Post of Canada on that day.

                                      -3-


         1.5        In any calculation hereunder of the applicable number of
                    Escrowed Shares results in fractional shares, the result
                    shall be rounded up or down, as the case may be, to the
                    nearest whole number and, if such result represents exactly
                    one-half of a whole number, then such fraction shall be
                    rounded up to the next whole number.

2.       ESTABLISHMENT OF ESCROW

         2.1      Phoenix hereby delivers in escrow to the Escrow Agent
                  certificates representing an aggregate of 31,680 common shares
                  of Phoenix registered in the name of the Escrow Agent, as
                  escrow agent (the "Escrowed Shares"). The Vendors' interests
                  in the Escrowed Shares are as set forth below:




                  VENDOR                       ESCROWED SHARES
                  ------                       ---------------
                                            
                  Froreich                          6,336
                  Wicki                            25,344



         2.2      The Escrow Agent hereby accepts delivery and acknowledges
                  receipt of the Escrowed Shares and agrees to act as escrow
                  agent and to hold, safeguard and release the Escrowed Shares
                  in accordance with the provisions of this Agreement. The
                  Escrowed Shares shall not be assigned, hypothecated,
                  alienated, released from escrow, transferred within escrow or
                  dealt with in any manner whatsoever except as provided in this
                  Agreement.

         2.3      Notwithstanding the registration of the Escrowed Shares in the
                  name of the Escrow Agent, the Vendors shall, subject to the
                  provisions hereof, remain the owners thereof in the proportion
                  contemplated by Section 2.1 hereof and be entitled to the
                  exercise of all voting rights related thereto and to receive
                  all dividends, income and other distributions in respect
                  thereof (collectively, "Distributions"). In the event that any
                  Escrowed Shares are remitted to Phoenix for cancellation
                  pursuant to the provisions of Section 3 hereof, the Vendors
                  shall repay to Phoenix any Distributions received in respect
                  of such Escrowed Shares.

3.       INSTRUCTIONS TO ESCROW AGENT

         3.1      At any time after receipt by the Escrow Agent of written
                  notice by Phoenix of the release, in the format prescribed by
                  the SEC, of at least 30 days of post-combination financial
                  results of Phoenix and Clinserve AG, and provided that the
                  Escrowed Shares are not then subject to any restrictions on
                  transfer imposed by any Regulatory Authority, an Affiliate may
                  instruct the Escrow Agent to sell all or part of their portion
                  of the Escrowed Shares. Upon receipt of such written
                  instruction, the Escrow Agent shall sell such Escrowed Shares
                  on the open market and shall retain the proceeds of sale, less
                  any expenses incurred in realizing such sale (the "Proceeds")
                  as escrowed property for such Affiliate. The Escrow Agent
                  shall invest such Proceeds according to the written
                  instructions of such Affiliate for the duration of the escrow.
                  The Escrow Agent shall keep complete records of any such sales
                  of Escrowed Shares.

                                      -4-


         3.2      Whenever Phoenix has a Claim it shall promptly give a Notice
                  of Claim in respect thereof to the Vendors and the Escrow
                  Agent. Upon receipt of a Notice of Claim, the Escrow Agent
                  shall immediately reserve for distribution in accordance with
                  the provisions of Section 3.3 hereof (but shall not release
                  from escrow except in accordance with the provisions hereof)
                  that number of the Escrowed Shares which is equal in value to
                  the amount provided for in the Notice of Claim, calculated on
                  the basis of the Escrowed Share Price for such Claim.

         3.3      Within 15 days of receipt of a Notice of Claim, the Vendors
                  (or any of them) shall give to Phoenix and the Escrow Agent a
                  response (the "Response") with respect to each Claim set forth
                  therein. If:

                  3.3.1    the Response indicates that the Vendors accept a
                           Claim set forth in the Notice of Claim, or if the
                           Escrow Agent does not receive a Response with respect
                           to a Claim within said 15 day period, the Vendors
                           shall be deemed to have irrevocably consented to each
                           Claim so accepted or in respect of which no Response
                           is so received, as made, and the Escrow Agent shall
                           forthwith give written notice thereof to Phoenix:

                           3.3.1.1  setting forth the total amount of all Claims
                                    which have been consented to and the number
                                    of shares from the Escrowed Shares to be
                                    released from escrow for the benefit of
                                    Phoenix (the "Released Shares"), being that
                                    number of the Escrowed Shares which is equal
                                    in value to the amount of the admitted
                                    Claims set forth in such Notice of Claim,
                                    calculated on the basis of the Escrowed
                                    Share Price for such Claim; and

                           3.3.1.2  surrender for cancellation to Phoenix the
                                    share certificate(s) in its possession
                                    representing the Released Shares, duly
                                    endorsed for transfer, and the Escrow Agent
                                    shall retain in its possession the other
                                    share certificate(s) representing the
                                    balance of the Escrowed Shares, if any, to
                                    be held by it in escrow and dealt with in
                                    accordance with the terms hereof; or

                  3.3.2    the Response indicates that the Vendors (or any of
                           them) dispute a Claim set forth in the Notice of
                           Claim (whether or nor arbitration proceedings have
                           been instituted), the Escrow Agent shall retain in
                           its possession and continue to hold in escrow that
                           number of the Escrowed Shares which is equal in value
                           to the amount provided for in the disputed Claims,
                           calculated on the basis of the Escrowed Share Price
                           for such Claim:

                           3.3.2.1  until the Escrow Agent receives a joint
                                    written notice from Phoenix and the Vendors
                                    directing the Escrow Agent as to the manner
                                    in which such Escrowed Shares and the share
                                    certificate(s) representing same are to be
                                    dealt with, in which case the Escrow Agent
                                    shall deal with same in accordance with such
                                    joint written instructions; or

                           3.3.2.2  in the absence of such a joint written
                                    notice within 10 business days of the Escrow
                                    Agent's receipt of the Response, the Escrow
                                    Agent shall deal with such Escrowed Shares
                                    and the share certificate(s) representing
                                    same in accordance with a final arbitration
                                    order in respect of such 



                                      -5-


                                    disputed Claim(s) pursuant to the
                                    arbitration contemplated by Section 12
                                    hereof. Any arbitration order shall be
                                    accompanied by a legal opinion by counsel
                                    for the presenting party satisfactory to the
                                    Escrow Agent to the effect that the said
                                    order is final and non-appealable.

         3.4      If, at the time of receipt by the Escrow Agent of any Notice
                  of Claim as provided for in Section 3.2 hereof, the Escrowed
                  Shares remaining in escrow for the account of any Vendor
                  calculated on the basis of the Escrowed Share Price is
                  insufficient to meet such Vendor's pro rata portion of the
                  number of Released Shares to be remitted to Phoenix, the
                  balance of such Vendor's pro rata portion of the admitted
                  Claims shall be satisfied by payment in cash from the Proceeds
                  of those Escrowed Shares sold by the Escrow Agent at the
                  direction of such Vendor pursuant to Section 3.1 hereof.

         3.5      On the earlier of (i) November 5, 1999, or (ii) the date at
                  which the Escrow Agent receives a notice from Phoenix
                  confirming that the audit of the combined financial statements
                  of Phoenix and Clinserve AG has been completed, the Escrow
                  Agent will deliver the Escrowed Shares and all Distributions
                  and Proceeds to the Vendors, pro rata to their respective
                  interests in the Escrowed Shares, Distributions and Proceeds,
                  if any.

4.       VOTING RIGHTS

         4.1      The Escrow Agent shall provide to each of the Vendors a proxy
                  entitling such Vendor to vote those of the Escrowed Shares
                  which are owned by it, forthwith upon the Escrow Agent's
                  receipt thereof in its capacity as registered shareholder of
                  Phoenix, in order to allow each Vendor to vote its Escrowed
                  Shares in the same manner as if it were the registered owner
                  thereof.

5.       RIGHTS AND OBLIGATIONS OF THE ESCROW AGENT

         5.1      The Escrow Agent is not a party to, and is not bound by, any
                  provisions which may be evidenced by, or arise out of, any
                  agreement other than as therein set forth under the express
                  provisions of this Agreement.

         5.2      The Escrow Agent acts hereunder as a depositary only and is
                  not responsible or liable in any manner whatever for the
                  sufficiency, correctness, genuineness or validity of any
                  instrument deposited with it, or for the form of execution of
                  such instrument or for the identity or authority or right of
                  any person or party executing or depositing it.

         5.3      The Escrow Agent shall not be under any duty to give the
                  Escrowed Shares, Distributions and Proceeds, if any, held by
                  it hereunder any greater degree of care than it gives its own
                  similar property and shall not be required to invest any funds
                  held hereunder except as directed in this Agreement.
                  Uninvested funds held hereunder shall not earn or accrue
                  interest.

         5.4      The Escrow Agent shall not be liable, except for its own gross
                  negligence or willful misconduct and, except with respect to
                  claims based upon such gross negligence or willful misconduct
                  that are successfully asserted against the Escrow Agent, the
                  other parties hereto shall solidarily indemnify and hold
                  harmless the Escrow Agent (and any successor Escrow Agent)
                  from and against any and all losses, liabilities, claims,
                  actions, damages and 

                                      -6-


                  expenses, including reasonable attorney's fees and
                  disbursements, arising out of and in connection with this
                  Agreement. Without limiting the foregoing, the Escrow Agent
                  shall in no event be liable in connection with its investment
                  or reinvestment of any cash held by it hereunder in good
                  faith, in accordance with the terms hereof.

         5.5      The Escrow Agent shall be entitled to rely upon any order,
                  judgment, certification, demand, notice, instrument or other
                  writing delivered to it hereunder without being required to
                  determine the authenticity or the correctness of any fact
                  stated therein or the propriety or validity of the service
                  thereof. The Escrow Agent may act in reliance upon any
                  instrument or signature believed by it to be genuine and may
                  assume that the person purporting to give receipt or advice or
                  make any statement or execute any document in connection with
                  the provisions hereof has been duly authorized to do so. The
                  Escrow Agent may conclusively presume that the undersigned
                  representative of any party hereto which is an entity other
                  than a natural person has full power and authority to instruct
                  the Escrow Agent on behalf of that party unless written notice
                  to the contrary is delivered to the Escrow Agent.

         5.6      The Escrow Agent may act pursuant to the advice of counsel
                  with respect to any matter relating to this Agreement and
                  shall not be liable for any action taken or omitted by it in
                  good faith in accordance with such advice.

         5.7      The Escrow Agent makes no representation as to the validity,
                  value, genuineness or the collectability of any security or
                  other document or instrument held by or delivered to it.

         5.8      The Escrow Agent shall not be called upon to advise any party
                  as to the wisdom in selling or retaining or taking or
                  refraining from any action with respect to any securities or
                  other property deposited hereunder.

         5.9      The Escrow Agent (and any successor Escrow Agent) may at any
                  time resign as such by delivering the Escrowed Shares,
                  Distributions and Proceeds, if any, to any successor Escrow
                  Agent jointly designated by the other parties hereto in
                  writing, or to any court of competent jurisdiction, whereupon
                  Escrow Agent shall be discharged of and from any and all
                  further obligations arising in connection with this Agreement.
                  The resignation of Escrow Agent will take effect on the
                  earlier of (a) the appointment of a successor (including a
                  court of competent jurisdiction) or (b) the day which is 30
                  days after the date of delivery of its written notice of
                  resignation to the other parties hereto. If at that time
                  Escrow Agent has not received a designation of a successor
                  Escrow Agent, Escrow Agent's sole responsibility after that
                  time shall be to retain and safeguard the Escrowed Shares and
                  Proceeds, if any, until receipt of a designation of successor
                  Escrow Agent or a joint written disposition instruction by the
                  other parties hereto or a final non-appealable order of a
                  court of competent jurisdiction.

         5.10     Phoenix and the Vendors shall pay Escrow Agent compensation
                  (as payment in full) for the services to be rendered by Escrow
                  Agent hereunder in the amount of $1,500 at the time of
                  execution of this Agreement and agree to reimburse Escrow
                  Agent for all reasonable expenses, disbursements and advances
                  incurred or made by Escrow Agent in performance of its duties
                  hereunder (including reasonable fees, expenses and
                  disbursements of its counsel).

                                      -7-


6.       LIMITED RESPONSIBILITY

         This Agreement expressly sets forth all the duties of Escrow Agent with
         respect to any and all matters pertinent hereto. No implied duties or
         obligations shall be read into this Agreement against the Escrow Agent.
         The Escrow Agent shall not be bound by the provisions of any agreement
         among the other parties hereto except this Agreement. No trust is
         created by this Agreement and the Escrow Agent does not act in any
         capacity as a trustee. In the event of any disagreement between any of
         the parties to this Agreement, or between them or either of them and
         any other person, resulting in demands or adverse claims being made in
         connection with or for any asset involved herein or affected hereby,
         the Escrow Agent shall be entitled, at its discretion, to refuse to
         comply with any demands or claims on it, as long as such disagreement
         shall continue, and in so refusing the Escrow Agent may make no
         delivery or other disposition of any asset involved herein or affected
         hereby, and in so doing the Escrow Agent shall not be or become liable
         in any way or to any person or party for its failure or refusal to
         comply with such conflicting demands or adverse claims, and it shall be
         entitled to continue so to refrain from acting and so to refuse to act
         until the right of person or party shall have been finally settled as
         provided in Section 12 hereof, or all differences shall have been
         adjusted by agreement and the Escrow Agent shall have been notified
         thereof in writing signed by all persons and parties interested.

7.       NOTICES

         All notices, consents, waivers and other communications under this
         Agreement must be in writing and will be deemed to have been duly given
         when (a) delivered by hand (with written confirmation of receipt), (b)
         sent by telecopier (with written confirmation of receipt) provided that
         a copy is mailed by registered mail, return receipt requested, or (c)
         when received by the addressee, if sent by a nationally recognized
         overnight delivery service (receipt requested), in each case the
         appropriate addresses and telecopier numbers set forth below (or to
         such other addresses and telecopier numbers as a party may designate by
         notice to the other parties):

         7.1      To Phoenix:

                  Phoenix International Life Sciences Inc.
                  2350, Cohen Street
                  Saint-Laurent, Quebec
                  H4R 2N6 Canada

                  Telecopier No.: (514) 333-7306

                  ATTENTION: JEAN-YVES CALOZ

         7.2      To the Vendors:

                  TO FROREICH:

                  Dr. Andre von Froreich
                  Forsthohe 33
                  21149 Hamburg, Germany

                                      -8-


                  TO WICKI:

                  Dr. Andreas Wicki
                  Hohestrasse 39
                  8702 Zollikon, Switzerland

         7.3      To the Escrow Agent:

                  Montreal Trust Company
                  1800 McGill College Avenue
                  Montreal (Quebec)
                  H3A 3K9

                  Telecopier No.:  (514) 982-7677

8.       GOVERNING LAW

         This Agreement shall be governed by the laws of the Province of Quebec
         and the laws of Canada applicable therein.

9.       COUNTERPARTS

         This Agreement may be executed in one or more counterparts, each of
         which will be deemed to be an original and all of which, when taken
         together, will be deemed to constitute one and the same.

10.      SECTION HEADINGS

         The headings of sections in this Agreement are provided for convenience
         only and will not affect its construction or interpretation.

11.      WAIVER

         The rights and remedies of the parties to this Agreement are cumulative
         and not alternative. Neither the failure nor any delay by any party in
         exercising any right, power, or privilege under this Agreement or the
         documents referred to in this Agreement will operate as a waiver of
         such right, power or privilege, and no single or partial exercise of
         any such right, power, or privilege will preclude any other or further
         exercise of such right, power, or privilege or the exercise of any
         other right, power, or privilege. To the maximum extent permitted by
         applicable law, (a) no claim or right arising out of this Agreement or
         the documents referred to in this Agreement can be discharged by one
         party, in whole or in part, by a waiver or renunciation of the claim or
         right unless in writing signed by the other parties; (b) no waiver that
         may be given by a party will be applicable except in the specific
         instance for which it is given; and (c) no notice to or demand on one
         party will be deemed to be a waiver of any obligation of such party or
         of the right of the party giving such notice or demand to take further
         action without notice or demand as provided in this Agreement or the
         documents referred to in this Agreement.

                                      -9-


12.      ARBITRATION

         All disputes arising out of or in connection with the present Agreement
         shall be finally settled under the Rules of Arbitration of the
         International Chamber of Commerce by one or more arbitrators appointed
         in accordance with the said Rules. The place of arbitration shall be
         Montreal. The language of the arbitration shall be English.

13.      CONFIDENTIALITY

         The parties agree to treat this Agreement as confidential and not to
         disclose its contents to third parties other than their advisers,
         except to the extent necessary to enforce performance of obligations
         hereunder, or as is required to comply with applicable laws or
         regulations, including regulations of any stock exchange on which the
         securities of Phoenix are listed.

14.      FURTHER ASSURANCES

         The parties shall, with all reasonable diligence, do all such things
         and provide all such reasonable assurances as may be required to
         consummate the transactions contemplated hereby, and each party shall
         provide such further documents or instruments required by another party
         as may be reasonably necessary or desirable to give effect to the
         purpose of this Agreement and to carry out its provisions.

15.      GENERAL

         The invalidity or unenforceability of any term or provision hereof
         shall not affect the validity or enforceability of any other term or
         provision hereof. This Agreement and the other documents and
         instruments referred to herein constitute the entire understanding of
         the parties hereto with respect to the subject matter hereof and
         thereof and supersede all present and prior agreements, whether written
         or oral. This Agreement shall bind and inure to the benefit of the
         parties hereto and their respective heirs, executors, administrators,
         personal representatives, successors and assigns.


         IN WITNESS WHEREOF, the parties have executed and delivered this
Agreement as of the date first written above.


                                  PHOENIX INTERNATIONAL LIFE SCIENCES INC.


                                  By:              /s/ John W. Hooper
                                           -------------------------------------
                                          John Hooper, Ph.D.
                                  Title:  Chairman and Chief Executive Officer



                                                   /s/ Andre Von Froreich
                                           -------------------------------------
                                            DR. ANDRE VON FROREICH




                                      -10-



                                                   /s/ Andreas Wicki
                                           -------------------------------------
                                            DR. ANDREAS WICKI



                                            MONTREAL TRUST COMPANY

                                            By:       /s/ Rose Marie Labbe
                                                 -------------------------------
                                                     ROSE MARIE LABBE
                                            Title:   Trust Officer

                                            By:        /s/ Guy L'Esperance
                                                 -------------------------------
                                                     GUY L'ESPERANCE
                                            Title:   Manager, Client Servicing