Exhibit 2.6





                            SHARE PURCHASE AGREEMENT

                                      AMONG

                    PHOENIX INTERNATIONAL LIFE SCIENCES INC.

                                       AND

                          PROF. DR. KLAUS-GEORG BUHRENS

                                       AND

                                  MARTIN GEIST

                                       AND

                                 DR. BERND BLOHM

                                       AND

                              CHRISTIAN HILGENSTOCK

                                       AND

                                  CLAUS HEMKER

                                       AND

                                 DR. IVAN KOZAK

                                       AND

                            DR. BERNHARD VENS-CAPPELL

                                       AND

                                WOLFGANG TETZLOFF

                                       AND

                                DR. JURGEN HENKE

                                       AND

                                 DR. LOTTE HENKE

                                       AND

                            TREND FINANZANALYSEN GMBH

                                       AND

                           MCKNIGHT LABORATORIES GMBH

                             ----------------------

                          DATED AS OF NOVEMBER 6, 1998

                             ----------------------








SHARE PURCHASE AGREEMENT dated as of November 6, 1998


AMONG:          PHOENIX INTERNATIONAL LIFE SCIENCES INC., a corporation
                incorporated under the Canada Business Corporations Act, having
                its head office at 2350, Cohen Street, Saint-Laurent, Quebec,
                Canada, H4R 2N6, herein acting and represented by John Hooper,
                its duly authorized representative;

                (hereinafter "Phoenix")


AND:            PROF. DR. KLAUS-GEORG BUHRENS, residing at Buchtallee 4a, 21465
                Reinbek, Germany;

                (hereinafter "Buhrens")


AND:            MARTIN GEIST, residing at Georgiweg 43, 22453 Hamburg, Germany;

                (hereinafter "Geist")


AND:            DR. BERND BLOHM, residing at Buchtallee 23, 21465 Reinbek,
                Germany;

                (hereinafter "Blohm")


AND:            CHRISTIAN HILGENSTOCK, residing at Gronenweg 73, 22549 Hamburg,
                Germany;

                (hereinafter "Hilgenstock")


AND:            CLAUS HEMKER, residing at Feldblick 2, 22397 Hamburg, Germany;

                (hereinafter "Hemker")


AND:            DR. IVAN KOZAK, residing at Kopeniker Str. 15, 22045 Hamburg,
                Germany;

                (hereinafter "Kozak")



AND:            DR. BERNHARD VENS-CAPPELL, residing at Wurtkamp 12, 22527
                Hamburg, Germany;

                (hereinafter "Vens-Cappell")




                                     - 2 -


AND:            WOLFGANG TETZLOFF, residing at Friedenstrasse 56, 82194
                Grobenzell, Germany;

                (hereinafter "Tetzloff")


AND:            DR. JURGEN HENKE, residing at Hohenzollernring 57, 50672 Koln,
                Germany, herein acting and represented by Ulrike Schafer, his
                duly authorized representative;

                (hereinafter "J. Henke")


AND:            DR. LOTTE HENKE, residing at Hohenzollernring 57, 50672 Koln,
                Germany, herein acting and represented by Ulrike Schafer, her
                duly authorized representative;

                (hereinafter "L. Henke")


AND:            TREND FINANZANALYSEN GMBH, a German corporation with capital of
                DM150,000, registered in the Commercial Register of the
                Amtsgericht Dusseldorf under number HRB 18161 and having its
                head office at Berliner Allee 21, 40212 Dusseldorf, Germany,
                herein acting and represented by Ulrike Schafer, its duly
                authorized representative;

                (hereinafter "TREND")


                (Buhrens, Geist, Blohm, Hilgenstock, Hemker, Kozak,
                Vens-Cappell, Tetzloff, J. Henke, L. Henke and TREND are
                hereinafter collectively referred to as the "Vendors")

AND:            MCKNIGHT LABORATORIES GMBH, a German corporation with capital of
                DM1,100,000, registered in the Commercial Register of the
                Amtsgericht Hamburg under number HRB 28004 and having its head
                office at Osterstrasse 86, 20259 Hamburg, Germany, herein acting
                and represented by Prof. Dr. Klaus - Georg Buhrens, its duly
                authorized representative;

                (hereinafter "MKL")


        WHEREAS, the Vendors hold, directly or indirectly, as more fully set out
in Schedule A, all of the outstanding shares and voting rights of MKL;

        WHEREAS, IPHAR Institut fur Klinische Pharmakologie GmbH ("IPHAR"), a
German corporation, with capital of DM500,000, registered in the Commercial
Register of the Amtsgericht Munchen under number HRB 8768 and having its head
office at Arnikastrasse 4, 85631 Hohenkirchen -Siergertsbrunn, Germany, is a
subsidiary of MKL, held as to 100% by MKL. The capital structure of IPHAR is set
forth in Schedule B;




                                     - 3 -


        WHEREAS, McKnight Laboratories (U.S.A.) inc. ("MKL-USA"), a corporation
and having its head office at 122 Main Street, Flemington, New Jersey, United
States, is a subsidiary of MKL, held as to 100% by MKL. The capital structure of
MKL-USA is set forth in Schedule C;

        WHEREAS the Vendors have agreed to sell all of the outstanding shares of
MKL to Phoenix in consideration for the issuance to the Vendors of common shares
of Phoenix;

        NOW, THEREFORE, the parties hereto agree as follows:

1.      INTERPRETATION AND DEFINITIONS

        Except as the context otherwise explicitly requires, (a) the capitalized
term "Section" refers to sections of this Agreement; (b) the capitalized terms
"Schedules" and "Exhibit" refer to schedules and exhibits to this Agreement; (c)
references to a particular Section include all subsections thereof; (d) the word
"including" shall be construed as "including without limitation"; (e) accounting
terms not otherwise defined herein have the meaning provided under GAAP (as
defined below); (f) references to a particular law, statute or regulation
include all rules and regulations thereunder and any successor, law, statute,
regulation or rules, in each case as from time to time in effect; (g) references
to a particular Person include such Person's successors and assigns to the
extent not prohibited by this Agreement; (h) references to dollars or $ in this
Agreement are to Canadian dollars. In this Agreement, unless the context
otherwise requires, the following terms shall have the respective meanings
assigned to them:

        1.1     "AFFILIATE" means, with respect to any Person, any Person which,
                directly or indirectly through one or more intermediaries,
                controls, is controlled by, or is under common control with such
                Person. For the purposes of this Agreement, "Affiliate" also
                means an affiliate as such term is defined by the SEC.

        1.2     "ARTICLES" means the original or restated articles of
                incorporation, articles of amendment, articles of amalgamation,
                articles of continuance, articles of reorganization and articles
                of arrangement, including amendments thereto, as in effect from
                time to time, of MKL.

        1.3     "COMPENSATION" as applied to any Person means the aggregate of
                all salaries, compensation, remuneration or bonuses of any
                character, retirement or pension benefits of any kind, or other
                payments of any kind whatsoever (other than health and medical
                benefits made available to employees generally and advances and
                reimbursements of business expenses) made directly or indirectly
                by MKL, any of the Subsidiaries or other specified Persons to
                such Person and affiliates of such Person.

        1.4     "COMPLETION DATE" means the date of this Agreement, i.e.
                November 6, 1998.

        1.5     "CONSOLIDATED", when used with reference to any term, means that
                term as applied to the accounts of MKL or other indicated Person
                and each of its respective Subsidiaries, consolidated or
                combined in accordance with GAAP after eliminating all
                inter-company operations and with appropriate deductions for
                minority interests in Subsidiaries.

        1.6     "CONTRACTUAL OBLIGATION" means, with respect to any Person, any
                contracts, agreements, deeds, hypothecs, mortgages, indentures,
                leases, licenses, other instruments, commitments, undertakings,
                arrangements or understandings, written or oral, or other
                documents or instruments, including any provisions of its
                articles of incorporation or other constituting documents or
                by-laws and any document or instrument evidencing Indebtedness,
                to which any 




                                     - 4 -


                such Person is a party or otherwise subject to or bound by or to
                which any property or asset of any such Person is subject.

        1.7     "DISTRIBUTION" means (a) the declaration or payment of any
                dividend on or in respect of the shares of any class or series
                of shares of MKL, any of the Subsidiaries or other specified
                Person, other than dividends payable solely in common shares of
                the share capital of the payor; (b) the purchase, redemption or
                other retirement of any shares of any class of MKL, any of the
                Subsidiaries or other specified Person directly, or indirectly
                through a Subsidiary or otherwise; or (c) any other distribution
                on or in respect of any shares of any class or series of shares
                of MKL, any of the Subsidiaries or other specified Person.

        1.8     "ESCROW AGENT" means Montreal Trust Company.

        1.9     "ESCROW AGREEMENT" means the escrow agreement entered between
                the parties hereto and the Escrow Agent a copy of which is
                attached hereto as Schedule 1.9.

        1.10    "ESCROWED SECURITIES" means the Phoenix Shares escrowed pursuant
                to Section 2.4 together with all Proceeds (as defined in the
                Escrow Agreement).

        1.11    "ESCROWED SHARE PRICE" means the amount obtained by adding the
                opening and closing prices of the common shares of Phoenix on
                each of the Montreal Exchange and The Toronto Stock Exchange for
                the ten trading days preceding the date of execution of the
                present Agreement, divided by 40.

        1.12    "ENVIRONMENTAL LAWS" means all Legal Requirements (including
                consent decrees, administrative orders and contractual
                obligations) relating to public health and safety, workers
                health and safety and pollution or protection of the
                environment.

        1.13    "GAAP" means generally accepted accounting principles, as in
                effect from time to time, consistently applied.

        1.14    "GUARANTEE" means (a) any guarantee of the payment or
                performance of, or any contingent obligation in respect of, any
                indebtedness or other obligation of any other Person, (b) any
                other arrangement whereby credit or financial assistance is
                extended to one obligor on the basis of any promise or
                undertaking of another Person (i) to pay the Indebtedness of
                such obligor, (ii) to purchase any obligation owed by such
                obligor, or (iii) to maintain the capital, working capital,
                solvency or general financial condition of such obligor, whether
                or not such arrangement is disclosed in the balance sheet of
                such other Person or is referred to in a footnote thereto or
                appears in a "keep well" agreement, "comfort letter" or "take or
                pay" agreement, and (c) any liability of MKL or any of the
                Subsidiaries as general partner of a partnership or as a
                venturer in a joint venture in respect of Indebtedness or other
                obligations of such partnership or venture; provided, however,
                that in no event shall Guarantees include product warranties
                given or the endorsement of negotiable instruments for deposit
                or collection in the ordinary course of business.

        1.15    "INDEBTEDNESS" means (a) all indebtedness, obligations and
                liabilities for borrowed money and similar monetary obligations
                evidenced by bonds, notes debentures, evidences of indebtedness,
                capitalized lease obligations, deferred purchase price of
                property (other than ordinary trade payables) or otherwise,
                whether direct or indirect; and (b) all indebtedness,





                                     - 5 -


                obligations and liabilities secured by any Liens existing on
                property owned or acquired, whether or not the liability secured
                thereby shall have been assumed.

        1.16    "LEGAL REQUIREMENT" means any national, provincial, regional,
                municipal, local or foreign law, statute, standard, ordinance,
                code, order, rule, regulation, resolution, promulgation, by-law,
                policy, guideline, directive, standard and any other provision
                having the force or effect of law or any final order, judgment
                or decree of any court, arbitrator, tribunal or governmental
                authority, or any license, franchise, permit, certificate,
                authorization, registration or similar right granted under any
                of the foregoing.

        1.17    "LIEN" means (a) any hypothec, priority, mortgage, pledge, lien,
                charge, security interest or other similar encumbrance upon any
                property or assets of any character, or upon the income or
                profits therefrom, whether arising by agreement or under law, or
                otherwise (b) any conditional sale or other title retention
                agreement or arrangement (including a capitalized lease); (c)
                any sale, assignment, pledge or other transfer for security of
                any accounts, general intangibles, or chattel paper, with or
                without recourse, or (d) any transaction (regardless of form)
                which is intended to create any charge or encumbrance on
                property to secure the payment or performance of an obligation.

        1.18    "MANAGEMENT" means each of Barkworth, Buhrens, Geist, Hemker,
                Hilgenstock, Kozak, Dr. Mazur, Vens-Cappel, Schmieder and
                Tetzloff.

        1.19    "MATERIAL ADVERSE EFFECT" means any (a) material adverse effect
                whatsoever upon the validity, performance or enforceability of
                this Agreement, (b) material adverse effect upon the business,
                assets, financial condition, income or prospects of MKL and the
                Subsidiaries on a Consolidated basis, or (c) material adverse
                effect upon the ability of the Vendors to perform their
                obligations under this Agreement.

                For the purposes of this Agreement and the Schedules hereto, the
                expression "Material Adverse Effect" when used in reference to
                obligations, debts, effects, liabilities or claims, shall mean
                an obligation, debt, effect, liability or claim, as the case may
                be which involves an amount in excess of DM60,000.

        1.20    "MKL AFFILIATE" means any of Buhrens and TREND.

        1.21    "PERMITTED LIEN" means those Liens indicated on Schedule 1.21.

        1.22    "PERSON" means an individual, partnership, corporation, company,
                association, trust, joint venture, unincorporated organization,
                business trust, limited liability company and any governmental
                or administrative department or agency or political subdivision.

        1.23    "PHOENIX AFFILIATES" means John Hooper, Stephane Huguet, Heather
                Baker, Judy Zilber, Jean-Yves Caloz, Diane Bouchard, Carmen
                Discenza, Lucien Steru, Dominique Steru, Susan Thornton, Greg
                Holmes, Claude E. Forget, Bertran Spilker, Robert Raich, David
                Goldman, Suzanne Peeters, George Engelberg, Dr. Andreas Wicki
                and Cornelius P. McCarthy III.

        1.24    "SEC" means the United States Securities and Exchange
                Commission.

        1.25    "SECURITIES ACT" means the United States Securities Act of 1933,
                as amended, and all rules and regulations promulgated
                thereunder.




                                     - 6 -


        1.26    "SHARES" means shares in the nominal value of DM1,100,000 of MKL
                being all of the issued and outstanding shares of MKL.

        1.27    "SUBSIDIARIES" means IPHAR and MKL-USA and "SUBSIDIARY" means
                any of the Subsidiaries on an individual basis.

2.      SALE AND PURCHASE OF SHARES

        2.1     AGREEMENT TO PURCHASE AND SELL SHARES

                Upon the terms and subject to the conditions hereof and in
        reliance on the representations and warranties of Phoenix set forth in
        Section 4, the Vendors hereby sell to Phoenix and, upon the terms and
        subject to the conditions hereof and in reliance on the representations
        and warranties of the Vendors set forth in Section 3, Phoenix hereby
        purchases from the Vendors, the Shares, as set forth below:




        VENDOR                                        NUMBER OF SHARES
        ------                                        ----------------
                                                          
        Buhrens                                          DM550,500
        Geist                                             DM21,000
        Blohm                                             DM21,000
        Hilgenstock                                       DM55,500
        Hemker                                            DM55,500
        Kozak                                             DM55,500
        Vens-Cappell                                      DM55,500
        Tetzloff                                          DM55,500
        J. Henke                                          DM45,000
        L. Henke                                          DM45,000
        TREND                                            DM140,000
        TOTAL                                          DM1,100,000


        2.2     PRICE OF SHARES

                The purchase price of the Shares is payable by the issuance by
        Phoenix to the Vendors of an aggregate of 873,325 common shares of
        Phoenix. The aggregate purchase price for the Shares is to be allocated
        among the Vendors as follows:



        VENDOR                    NUMBER OF COMMON SHARES OF PHOENIX
        ------                    ----------------------------------
                                                
        Buhrens                                437,059
        Geist                                   16,673
        Blohm                                   16,673
        Hilgenstock                             44,063
        Hemker                                  44,063
        Kozak                                   44,063
        Vens-Cappell                            44,063
        Tetzloff                                44,063
        J. Henke                                35,727




                                     - 7 -




        VENDOR                    NUMBER OF COMMON SHARES OF PHOENIX
        ------                    ----------------------------------
                                                
        L. Henke                                35,727
        TREND                                  111,151
        TOTAL                                  873,325


        (The common shares of Phoenix issued to the Vendors pursuant to this
        Section 2.2 are hereinafter collectively referred to as the "Phoenix
        Shares".)

        2.3     TRANSFER OF SHARES AND PAYMENT OF PURCHASE PRICE

                2.3.1   Phoenix hereby acknowledges receipt from each of
                        Buhrens, Geist, Blohm, Hilgenstock, Hemker, Kozak,
                        Vens-Cappell, Tetzloff, J. Henke, L. Henke and TREND of
                        the Shares by notarial deed dated November 6, 1998 of
                        the Notary Dr. Werner Vogel duly signed, personally or
                        by his/her attorney with valid power of attorney, by
                        Buhrens, Geist, Blohm, Hilgenstock, Hemker, Kozak,
                        Vens-Cappell, Tetzloff, J. Henke, L. Henke and TREND.

                2.3.2   Buhrens, Geist, Blohm, Hilgenstock, Hemker, Kozak,
                        Vens-Cappell, Tetzloff, J. Henke, L. Henke and TREND
                        hereby acknowledge receipt from Phoenix of certificates
                        registered in the names of Buhrens, Geist, Blohm,
                        Hilgenstock, Hemker, Kozak, Vens-Cappell, Tetzloff, J.
                        Henke, L. Henke and TREND representing 90% of the
                        purchase price for the Shares.

        2.4     ISSUANCE INTO ESCROW

                Notwithstanding any provision of this Agreement, upon delivery
        of the Phoenix Shares pursuant to Section 2.3, 10% of the aggregate
        number of the Phoenix Shares shall be delivered immediately to the
        Escrow Agent, on a pro rata basis among the Vendors, to be held and
        released by the Escrow Agent pursuant to the terms of this Agreement and
        the Escrow Agreement. All such Phoenix Shares shall be issued in the
        name of the Escrow Agent, as escrow agent under the Escrow Agreement.
        The Vendors hereby acknowledge receipt of such 10% of the purchase price
        of the Shares on their behalf by the Escrow Agent.

3.      REPRESENTATIONS AND WARRANTIES OF VENDORS

        In order to induce Phoenix to enter into this Agreement and to purchase
the Shares hereunder, the Vendors hereby make the following representations and
warranties to Phoenix. The Vendors' liability for the following representations
and warranties shall be joint, and not solidary i.e. pro rata to the number of
Phoenix Shares received by each Vendor according to Section 2.2, except in the
event of fraud with respect thereto.

        3.1     SHARES

                Each of the Vendors declares that he owns the Shares free and
        clear of all Liens and there are no rights or other obstacles of any
        nature whatsoever to the sale of the Shares to Phoenix.

        3.2     ORGANIZATION

                3.2.1   DUE INCORPORATION, ETC. Each of MKL and the Subsidiaries
                        is duly incorporated or organized and validly exists
                        under the laws of its jurisdiction of incorporation, and




                                     - 8 -


                        is in good standing under the laws applicable to it and
                        has all necessary corporate capacity and power to own
                        and lease its property and assets and to carry on the
                        businesses now conducted or presently proposed to be
                        conducted by it.

                3.2.2   SUBSIDIARIES. MKL does not own or control, directly or
                        indirectly, or have an interest in, any other
                        corporation, partnership, association or business entity
                        other than the Subsidiaries.

                3.2.3   MANAGEMENT. The Management of MKL and the Subsidiaries
                        is exclusively comprised of the Persons referred to in
                        Section 1.18.

                3.2.4   AUTHORIZATIONS AND APPROVALS. All authorizations,
                        approvals, licences, permits, certificates,
                        registrations, consents, exemptions or declarations
                        required in order for each of MKL and the Subsidiaries
                        to own or lease their property and assets and to carry
                        on their business in all jurisdictions in which such
                        property and assets are located or such business is
                        carried on have been duly obtained or effected and are
                        in full force and effect except for authorizations,
                        approvals, licences, permits, certificates,
                        registrations, consents, exemptions or declarations, the
                        absence of which, individually or in the aggregate, does
                        not and shall not result in a Material Adverse Effect.

                        In particular:

                        (a)     except for permits, certificates, licences,
                                registrations and other authorizations, the
                                absence of which, individually or in the
                                aggregate, does not and shall not result in a
                                Material Adverse Effect, each of MKL and the
                                Subsidiaries hold all permits, certificates,
                                licenses, registrations and other authorizations
                                required under applicable Environmental Laws for
                                their operations (the "Environmental Permits");
                                each such Environmental Permit is valid and in
                                force and the operations of MKL and the
                                Subsidiaries are in compliance with the
                                conditions set out in such Environmental Permits
                                and their is no ground for revocation, expiry or
                                annulment of any such Environmental Permits;

                        (b)     except for permits, certificates, licences,
                                registrations and other authorizations, the
                                absence of which, individually or in the
                                aggregate, does not and shall not result in a
                                Material Adverse Effect, each of MKL and the
                                Subsidiaries hold all permits, certificates,
                                licenses, registrations and other authorizations
                                required under applicable Legal Requirement for
                                clinical research for the pharmaceutical
                                industry and pharmaceutical research (the
                                "Research Permits"); each such Research Permit
                                is valid and in force, the operations of MKL and
                                the Subsidiaries are in compliance with the
                                conditions set out in such Research Permits and
                                there is no ground for revocation, expiry or
                                annulment of any such Research Permits.

                3.2.5   CORPORATE RECORDS. The Corporate records of MKL and each
                        of the Subsidiaries are complete and up to date.




                                     - 9 -


                3.2.6   OFFICERS AND DIRECTORS. The officers and directors of
                        MKL and each of the Subsidiaries have been properly
                        elected or appointed in accordance with applicable laws
                        and the relevant articles of incorporation or other
                        constituting documents.

                3.2.7   CORPORATE ACTION. All necessary action has been taken by
                        MKL, to authorize the execution of this Agreement and
                        the consummation of the transactions contemplated
                        hereby.

        3.3     CAPITALIZATION

                3.3.1   SHARE CAPITAL OF MKL. The outstanding share capital of
                        MKL is exhaustively set forth in Schedule A, all of
                        which has been validly issued and is fully paid and
                        non-assessable. Each of the Vendors declares that his
                        Shares are subject to no Lien, adverse claim or
                        restriction on transfer, except restrictions on transfer
                        under this Agreement.

                3.3.2   OPTIONS, ETC. Other than as set forth in Schedule A and
                        Schedule 3.3.2, MKL does not have outstanding (a) any
                        rights (either preemptive or otherwise) or options to
                        subscribe for or purchase, or any warrants or other
                        agreements providing for or requiring the issuance of,
                        any shares or any securities convertible into or
                        exchangeable for its shares, (b) any obligation to
                        redeem, purchase or otherwise acquire or retire any of
                        its shares, any securities convertible into or
                        exchangeable for its shares or any rights, options or
                        warrants with respect thereto, (c) any rights to require
                        MKL to qualify for distribution for securities laws
                        purposes, or (d) any restrictions on voting.

                3.3.3   CAPITAL STOCK OF THE SUBSIDIARIES. The issued and
                        outstanding shares of each Subsidiary are as set forth
                        in Schedules B and C. The issued and outstanding shares
                        of each Subsidiary are validly issued, and paid and
                        non-assessable and subject to no Lien, adverse claim or
                        restriction on transfer, other than as set forth in
                        Schedule 3.3.3.

                3.3.4   SUBSIDIARY OPTIONS, ETC. Other than as set forth in
                        Schedule 3.3.4, none of the Subsidiaries has outstanding
                        (a) any rights (either preemptive or otherwise) or
                        options to subscribe for or purchase, or any warrants or
                        other agreements providing for or requiring the issuance
                        of, any shares or any securities convertible into or
                        exchangeable for its shares, (b) any obligation to
                        redeem, purchase or otherwise acquire or retire any of
                        its shares, any securities convertible into or
                        exchangeable for its shares or any rights, options or
                        warrants with respect thereto, (c) any rights to require
                        the Subsidiary to qualify for distribution for
                        securities laws purposes, or (d) any restrictions on
                        voting.

                3.3.5   NO COMMITMENTS AFFECTING SHARES, ETC. Other than as set
                        forth in Schedule 3.3.5, neither MKL nor any of the
                        Subsidiaries is a party to or bound by any agreement,
                        commitment or understanding, whether verbal or written,
                        affecting its shares or the participating or voting
                        rights attached thereto.




                                     - 10 -


        3.4     REPORTS, FINANCIAL STATEMENTS AND OTHER DOCUMENTS

                Phoenix has been provided with complete and correct copies of
        audited financial statements of MKL and IPHAR for the years ended
        December 31, 1995, 1996 and 1997 and for the eight-month period ended
        August 31, 1998, copies of which are attached hereto as Schedule 3.4A.

                The financial statements of MKL and the Subsidiaries referred to
        above have been prepared in accordance with German GAAP and all such
        financial statements fairly present the financial condition of MKL and
        the Subsidiaries at the dates thereof and the results of their
        operations for the periods covered thereby. Other than as set forth in
        Schedule 3.5, neither MKL nor any of the Subsidiaries has material
        liabilities, contingent or otherwise, which are not referred to in the
        financial statements.

                The financial statements for the year ended December 31, 1995,
        1996 and 1997, copies of which are attached hereto as Schedule 3.4A have
        been properly approved by the annual general meetings of shareholders of
        the relevant entities in due form without reservation. The last general
        meeting of the shareholders of each of MKL and IPHAR were held on May
        13, 1998 and May 13, 1998, respectively and there has been no meeting of
        shareholders of MKL and IPHAR since then.

                For purposes of financial presentation, MKL and the subsidiaries
        recognize net revenue from their contracts on a percentage of completion
        basis as work is performed. The percentage of completion, and
        consequently the revenue to be recorded, of each individual contract is
        determined through detailed analysis and discussion between all
        appropriate operational and financial department management. Although
        MKL and the subsidiaries do not require collateral for unpaid balances,
        credit losses have consistently been within Management's expectations.
        Certain contracts contain provisions for price adjustment for cost
        overruns. Such adjusted amounts are included in service revenue when
        realization is assured and the amounts can be reasonably determined. In
        the period in which it is determined that a loss will result from the
        performance of a contract, the entire amount of the estimated ultimate
        loss is charged against income.

                Since January 1, 1998, the business of MKL and the Subsidiaries
        has been operated in the customary fashion and no revenues that would
        have been earned by MKL or the Subsidiaries have been earned by any
        Person who is an Affiliate of any of the Vendors.

                Notwithstanding anything else in this Agreement, including,
        without limitation, the provisions of this Section 3.4, the Vendors make
        no representation or warranty of any kind whatsoever with respect to
        future business, financial performance or future profitability of MKL.

        3.5     OFF BALANCE SHEET OBLIGATIONS

                Schedule 3.5 contains a complete list of the off-balance sheet
        obligations of MKL and the Subsidiaries, including all guarantees and
        obligations to the benefit of the Vendors, members of their families or
        third parties.

        3.6     CHANGES IN CONDITION

                Since January 1, 1998:

                3.6.1   MATERIAL ADVERSE EFFECT. No event having a Material
                        Adverse Effect has occurred.




                                     - 11 -


                3.6.2   EXTRAORDINARY TRANSACTIONS, ETC. Other than as set forth
                        in Schedule 3.4A, neither MKL nor any of the
                        Subsidiaries has (a) made any Distribution, (b) other
                        than as set forth in Schedule 3.6.2, made any payment
                        (other than Compensation of its directors, officers and
                        employees in amounts in effect prior to January 1, 1998
                        or for bonuses accrued in accordance with normal
                        practice prior to January 1, 1998) to any of the
                        Vendors, (c) other than as set forth in Schedule 3.6.2,
                        increased the Compensation, including bonuses, payable
                        or to be payable to any of its directors, officers or
                        employees by more than 5%, or (d) entered into any
                        Contractual Obligation, or entered into or performed any
                        other transaction, not in the ordinary and usual course
                        of business and consistent with past practice.

                3.6.3   INVENTORY AND WORK-IN-PROGRESS. The value of inventory
                        and work-in-progress reflected in the financial
                        statements of MKL and the Subsidiaries has been
                        established in accordance with German GAAP and there has
                        been no material change in the period subsequent to
                        December 31, 1997, other than in the ordinary and usual
                        courses of business.

                3.6.4   REVENUES. The business of MKL and the Subsidiaries has
                        been operated in the customary fashion and no revenues
                        that would have been earned by MKL or the Subsidiaries
                        have been earned by any Person which is an Affiliate of
                        any of the Vendors.

        3.7     SOLVENCY

                Each of MKL and the Subsidiaries shall be able to pay its
        liabilities existing at the time of the signing of this Agreement as
        they become due.

        3.8     CONTRACTUAL OBLIGATIONS, ETC.

                3.8.1   CERTAIN CONTRACTS. Schedule 3.8.1 contains, together
                        with a reference to the subparagraph pursuant to which
                        each item is being disclosed, a correct and complete
                        list of all Contractual Obligations of MKL and the
                        Subsidiaries of the types described below:

                        (a)     All collective bargaining agreements; all
                                agreements with any member of the Management, a
                                list of all employees, all profit sharing,
                                profit participation, deferred compensation,
                                bonus, stock option, stock purchase, pension,
                                retainer, consulting, retirement, welfare or
                                incentive plans or agreements; and all plans,
                                agreements or practices which constitute
                                Compensation or "fringe benefits" to any of the
                                employees of MKL or the Subsidiaries, including
                                vacation programs, sick leave programs, group
                                medical insurance, group life insurance,
                                disability insurance and related benefits.

                        (b)     All Contractual Obligations under which MKL or
                                the Subsidiaries are restricted from carrying on
                                any business, venture or other activities
                                anywhere in the world.

                        (c)     All Contractual Obligations (including options)
                                to sell, lease (as lessor), exchange or
                                otherwise dispose of or transfer any of the
                                properties or assets of MKL or the Subsidiaries
                                except in the ordinary course of business.




                                     - 12 -


                        (d)     All Contractual Obligations pursuant to which
                                MKL or the Subsidiaries guarantees or otherwise
                                assumes any liability of or gives financial
                                assistance to any Person, or pursuant to which
                                any Person guarantees or otherwise assumes any
                                liability of MKL or the Subsidiaries.

                        (e)     All Contractual Obligations constituting license
                                agreements, service agreements, consulting
                                agreements or other similar arrangements, the
                                termination of which, individually or in the
                                aggregate, would result in a Material Adverse
                                Effect.

                        (f)     All Contractual Obligations under which MKL or
                                any of the Subsidiaries leases immovable
                                property or is obligated to lease or purchase
                                immovable property or incur capital expenditures
                                in excess of DM60,000 annually.

                        (g)     All Contractual Obligations of MKL or the
                                Subsidiaries relating to the borrowing of money
                                or to the creation of a Lien, other than a
                                Permitted Lien, on any property or asset of MKL,
                                or the Subsidiaries.

                        (h)     All Contractual Obligations of MKL or any of the
                                Subsidiaries requiring a notice exceeding six
                                months for termination and involving
                                expenditures in excess of DM60,000.

                3.8.2   NATURE OF CONTRACTS. All of the Contractual Obligations
                        of MKL and the Subsidiaries at the Completion Date are
                        enforceable against MKL and the Subsidiaries, the other
                        parties thereto, in accordance with their terms, except
                        as such enforcement may be limited by bankruptcy,
                        insolvency or other laws of general application
                        affecting the rights of creditors and except that
                        specific performance is an equitable remedy which may
                        only be awarded in the discretion of the court; and
                        except for Contractual Obligations the failure of which
                        to be so enforceable does not and shall not,
                        individually or in the aggregate, result in a Material
                        Adverse Effect. Except for breaches, defaults and
                        liabilities which do not and shall not individually or
                        in the aggregate result in a Material Adverse Effect,
                        neither MKL nor any of the Subsidiaries is now in
                        default, and no event has occurred which with notice or
                        lapse of time or both would constitute a default under,
                        nor are there any liabilities arising from any breach or
                        default by any of them or event which with notice or
                        lapse of time or both would constitute a default by any
                        of them prior to the Completion Date of, any provision
                        of any such Contractual Obligation.

                3.8.3   ARTICLES. Neither MKL nor any of the Subsidiaries is in
                        violation of, or in default under, any provision of its
                        articles or constituting documents and Phoenix has been
                        provided with complete and correct copies of such
                        articles or constituting documents.

                3.8.4   INSURANCE. Each of MKL and IPHAR carries insurance
                        policies with independent third party insurers according
                        to Schedule 3.8.4. All such policies are in full force
                        and effect and free from any present right of
                        termination on the part of the applicable insurance
                        carriers. There are no outstanding unpaid premiums
                        except in the ordinary course of business, and neither
                        MKL nor any Subsidiary has received any notice of
                        cancellation or non-renewal of any such policy. Neither
                        MKL nor any Subsidiary is aware of any risks,
                        situations, occurrences or other matters which have been
                        disclosed, or should have been disclosed, to insurance
                        carriers or brokers in 

                                     - 13 -


                        connection with any application for such insurance as a
                        result of which an insurance carrier would have a right
                        to cancel the corresponding insurance policy or deny
                        coverage with respect to any rights under any such
                        policies. There exists no event of default or event,
                        occurrence, condition or act (including the transactions
                        contemplated by this Agreement) which, with the giving
                        of notice, the lapse of time or the happening of any
                        further event or condition, would become a default or
                        occasion a material premium increase under any such
                        policy or give rise to, and neither MKL nor any
                        Subsidiary has any anticipation of, any termination or
                        cancellation thereof or material premium increase
                        therefor.

                3.8.5   INSURANCE CLAIM. Each of the Vendors declares that after
                        thorough internal investigation, there is no known fact,
                        situation or circumstance involving the Company or one
                        of the Subsidiaries or their directors or officers,
                        which would reasonably be expected to result in any
                        future claim being made against the Company or any
                        Subsidiaries.

                3.8.6   DISPUTE. Neither MKL nor any of the Subsidiaries has
                        received any notice from any supplier, vendor,
                        contractor, customer or client with which MKL or such
                        Subsidiary has conducted business during the one-year
                        period ending on the date of this Agreement confirming
                        such Person's intention to reduce the volume under,
                        terminate or otherwise alter any Contractual Obligation
                        with MKL or any Subsidiary, the effect of which,
                        individually or in the aggregate, would result in a
                        Material Adverse Effect.

        3.9     OPERATIONS IN CONFORMITY WITH LAW, ETC.

                The operations of MKL and the Subsidiaries as now conducted, and
        their properties, assets, equipments, buildings, immoveables and leased
        or occupied properties, are not, and have not been, in violation of, nor
        is MKL or any of the Subsidiaries in default and no event has occurred
        which with notice or lapse of time or both would constitute a default
        under, any applicable Legal Requirements including, in particular, any
        applicable Environmental Laws or applicable Legal Requirements regarding
        clinical research and experimentation on humans, except for such
        violations and defaults as do not and shall not, in the aggregate, have
        a Material Adverse Effect. Neither MKL nor any of the Subsidiaries has
        received notice of any such violation or default and neither the Vendors
        nor the Management have knowledge of any basis on which the operations
        of MKL or any of the Subsidiaries, when conducted as currently proposed
        to be conducted after the Completion Date, would be held so as to
        violate or to give rise to any such violation or default. MKL and the
        Subsidiaries have all franchises, licenses, permits, certificates,
        authorizations, registrations or other authority presently necessary for
        the conduct of their business as now conducted, except for franchises,
        licences, permits, certificates, authorizations, registrations or other
        authority, the absence of which, individually or in the aggregate, does
        not and shall not result in a Material Adverse Effect. Based on the
        facts presently known to the Vendors and Management, all future
        expenditures on the part of MKL and the Subsidiaries required to meet
        the provisions of any presently existing applicable Legal Requirements
        (including Legal Requirements relating to employment practices or to
        occupational or health standards or to environmental considerations)
        shall not, in the aggregate, have a Material Adverse Effect. MKL and the
        Subsidiaries have complied and are in compliance with applicable
        competition regulations and have, to the best of Vendors' and
        Management's knowledge, never infringed fair competition in the markets
        where they operate, either with or towards third companies or between
        themselves. MKL and the Subsidiaries do not hold separately or together
        a dominant position on the markets involved and their market share and
        net aggregate turnover do not meet the European or German thresholds
        which





                                     - 14 -


        authorizes European or domestic competition authorities to control the
        operation and impede the completion of the transaction contemplated
        hereby.

        3.10    INTELLECTUAL PROPERTY

                Schedule 3.10 contains a list of all the trade-marks, trade
        names and patents used by any of MKL or the Subsidiaries (collectively
        "Used Intellectual Property"). The entity indicated in said Schedule as
        owner of Used Intellectual Property is the registered and beneficial
        owner of such Used Intellectual Property or the registration thereof, if
        applicable, (except as set forth in Schedule 3.10), with good and
        marketable title, unencumbered (except for Permitted Liens), and with
        full right to sell, assign or otherwise transfer or license to others
        and subject to no pending challenge, refutation, expiry or termination
        other than as set forth in Schedule 3.10. To the Vendors' and
        Management's knowledge, other than as set forth in Schedule 3.10, none
        of MKL or the Subsidiaries uses any intellectual property not owned by
        it, other than software purchased "off the shelf", all of which each
        entity using said property has the right to use (collectively "Licenced
        Intellectual Property"). (Used Intellectual Property and Licensed
        Intellectual Property are sometimes hereinafter referred to collectively
        as "Intellectual Property"). None of MKL or the Subsidiaries is required
        to pay royalties, fees or other consideration to any other person with
        respect to the use of any of the Intellectual Property or in connection
        with the conduct of its business or otherwise. To the Vendors' and
        Management's knowledge, none of MKL or the Subsidiaries has infringed
        the intellectual or industrial property rights of any other person, nor
        has any of them used any intellectual or industrial property (including,
        without limitation, trademarks, trade names, patents, models, designs
        and copyrights) which it does not own or have the right to use other
        than as set forth in Schedule 3.10. There are no outstanding claims
        asserted against any of MKL or the Subsidiaries alleging the
        infringement or the misappropriation by any of them of any intellectual
        or industrial property. None of MKL or the Subsidiaries has granted any
        licences or sub-licences to third parties with respect to any of the
        Intellectual Property other than as set forth in Schedule 3.10 and
        neither the Vendors nor Management has any knowledge of any infringement
        or misappropriation by any other Person of any of the Intellectual
        Property. Neither the execution nor delivery of this Agreement will
        constitute a breach of or a default under any agreement relating to the
        Intellectual Property.

        3.11    ENVIRONMENTAL MATTERS

                3.11.1  MKL and the Subsidiaries, their employees, agents,
                        shareholders, directors and officers (acting in their
                        capacity of employees, agents, shareholders, directors
                        or officers of MKL or of one of the Subsidiaries) have
                        never been declared guilty of committing an offence for
                        a violation of Environmental Laws and have never been
                        fined for such an offence or have otherwise settled such
                        a prosecution in connection with the activities of MKL
                        and the Subsidiaries;

                3.11.2  There are no contaminants, waste or pollutants of any
                        kind whatsoever in, on or under the equipment,
                        buildings, immoveables or properties owned, leased or
                        occupied by MKL or any of the Subsidiaries and caused by
                        MKL, the Subsidiaries or their employees, agents,
                        shareholders, directors or officers (acting in their
                        capacity of employees, agents, shareholders, directors
                        or officers of MKL or one of the Subsidiaries), the
                        presence of which constitutes a violation of applicable
                        Environmental Laws and the presence of which,
                        individually or in the aggregate, constitutes a Material
                        Adverse Effect;




                                     - 15 -


                3.11.3  Neither MKL nor any of the Subsidiaries has received any
                        written notice or request for information in the context
                        of any national, supra-national, provincial, regional,
                        local or municipal environmental investigation or
                        inspection;

                3.11.4  There are no PCBs, asbestos or urea formaldehyde
                        insolation in, on or under the equipment, buildings,
                        immoveables or properties owned, leased or occupied by
                        MKL or the Subsidiaries;

                3.11.5  There is no action, suit or proceeding pending in
                        relation to environmental matters against MKL or the
                        Subsidiaries, its employees, agents, shareholders,
                        directors and officers (acting in their capacity of
                        employees, agents, shareholders, directors or officers
                        of MKL or of one of the Subsidiaries), or involving MKL
                        or the Subsidiaries or its assets, before any judicial
                        body, tribunal, commission, agency or other governmental
                        entity, and to the Vendors' knowledge and to the
                        knowledge of Management, there is no threat of, or event
                        or fact based on which, such action, suit or proceeding
                        may be instituted;

                3.11.6  To the knowledge of Management and the Vendors, MKL and
                        the Subsidiaries are in compliance with all applicable
                        Environmental Laws.

        3.12    LABOUR AND EMPLOYMENT MATTERS

                3.12.1  Without limiting the generality of Section 3.9, each of
                        MKL and the Subsidiaries has complied with all
                        applicable laws relating to the employment of labour,
                        including provisions thereof relating to wages, hours
                        and collective bargaining rights.

                3.12.2  Other than as disclosed under Section 3.8, there is no
                        collective agreement by which MKL or any of the
                        Subsidiaries is bound which relates to the employees of
                        MKL or the Subsidiaries. To the knowledge of the Vendors
                        and to the knowledge of Management, there are no
                        threatened or pending attempts to organize or establish
                        any labour union or employee association in connection
                        with the business of MKL or any of the Subsidiaries. To
                        the knowledge of the Vendors and to the knowledge of
                        Management, there is no pending or threatened labour
                        dispute, grievance, strike, or work stoppage materially
                        affecting the business of any of MKL or any of the
                        Subsidiaries. Neither MKL nor any of the Subsidiaries is
                        a party to any other written employment agreement,
                        contract, arrangement, management contract or service
                        contract affecting employees other than as set forth in
                        Schedule 3.8.1, nor are any such contracts, agreements,
                        arrangements, management contracts or service contracts
                        being currently negotiated or proposed other than in the
                        ordinary course of business.

                3.12.3  There exist no retirement plans, profit sharing, option
                        or incentive plans, or other employee benefit plans for
                        employees of MKL or any of the Subsidiaries other than
                        as set forth in Schedule 3.8.1 for which adequate
                        arrangements have been made since January 1, 1998 to set
                        aside the requisite amounts in the prescribed fashion,
                        and neither MKL nor any of the Subsidiaries has promised
                        or intends to implement other such plans.

                3.12.4  Other than as set forth in Schedule 3.12.4, neither MKL
                        nor any of the Subsidiaries has any employee who cannot
                        be dismissed without further liability upon such notice
                        period not exceeding what it is required by the
                        applicable Legal Requirement.




                                     - 16 -


                3.12.5  Each of MKL's or any of the Subsidiary's employees who
                        is practising as a physician, nurse or pharmacist is
                        identified in Schedule 3.12.5, and each such employee is
                        duly licensed and in good standing to practice as a
                        physician, nurse or pharmacist, as the case may be, in
                        each jurisdiction in which such employee renders
                        services for or on behalf of MKL or any Subsidiary. None
                        of the employees listed on Schedule 3.12.5 is or has
                        been subject to any claim in connection with his or her
                        practice as physician, nurse or pharmacist while
                        employed by MKL or the Subsidiary, as the case may be,
                        and no fact or occurrence is known to the Management to
                        exist which is likely to give rise to the revocation of
                        any such licence.

                3.12.6  None of MKL's or any of the Subsidiary's employees has
                        signed non-compete covenants in favour of MKL or the
                        Subsidiary.

        3.13    TAXES

                Other than as set forth in Schedule 3.13, all tax returns
        required to be filed by MKL and the Subsidiaries in any jurisdiction
        have been filed and all taxes, assessments, levies and other
        governmental charges upon MKL and the Subsidiaries or upon any of their
        properties or income, including any tax in respect of value added, have
        been paid if and when due unless such payment is being contested in good
        faith and by appropriate proceedings and adequate reserves with respect
        thereto determined in accordance with applicable policies have been
        established by MKL and the Subsidiaries. There is no tax revision
        threatened in writing against MKL and any of the Subsidiaries and there
        is no basis for such assessment.

        3.14    WITHHOLDINGS

                Each of MKL and the Subsidiaries has withheld from each payment
        made to any of its shareholders, officers, directors, non-resident
        creditors and employees the amount of all taxes and other deductions
        required to be withheld and has remitted all such amounts to the
        appropriate authorities within the prescribed times, and has otherwise
        fulfilled all requirements of all Legal Requirements governing such
        deductions and withholdings. Each of MKL and the Subsidiaries has
        remitted to the proper authorities all employer contributions due and
        payable under all social security, occupational health and safety and
        pension plans.

        3.15    GOOD TITLE

                Other than as set forth in Schedule 3.15 and Schedule 1.21, each
        of MKL and the Subsidiaries has good and marketable title to all assets
        in the balance sheets as per December 31, 1998 and August 31, 1998 free
        and clear of Liens and other adverse claims.

        3.16    LITIGATION

                Other than as set forth in Schedule 3.16, no litigation or
        proceeding before, or investigation by, any foreign, national,
        supra-national or municipal, judicial, tax or customs tribunal or board
        or other governmental or administrative agency or any arbitrator, is
        pending or threatened (or, according to Management's knowledge, does any
        basis exist therefor), against MKL or the Subsidiaries or, to the
        Vendors' knowledge or to the knowledge of Management, any director or
        officer of MKL or any of the Subsidiaries, which individually or in the
        aggregate could result in a Material Adverse Effect, or which seeks
        rescission of, seeks to enjoin the consummation of, or which questions
        the validity of, this Agreement or any of the transactions contemplated
        hereby. Neither MKL nor the Subsidiaries has 





                                     - 17 -


        been charged, nor to the Vendors' knowledge or to the knowledge of
        Management, is it threatened to be charged, with infringement of any
        trademark, trade name, service mark, copyright, patent, patent right or
        other proprietary right of any Person.

        3.17    PRESS COVERAGE

                Neither MKL nor any of the Subsidiaries has been the object of
        any demonstrations, press campaigns or other attacks due to the nature
        of its activities.

        3.18    VIOLATION OF OTHER INSTRUMENTS

                Neither the execution and delivery of this Agreement by the
        Vendors, the consummation of any of the transactions contemplated hereby
        or in Schedule 3.18, shall (a) constitute a breach of or a default or an
        event which with notice or lapse of time or both would constitute a
        default under any Contractual Obligation of MKL or any of the
        Subsidiaries, (b) result in acceleration in the time for performance of
        any obligation of MKL or the Subsidiaries under any such Contractual
        Obligation, (c) result in the creation of any Lien upon any property or
        asset of MKL or the Subsidiaries, (d) require any consent, waiver or
        amendment to any such Contractual Obligation that has not been obtained
        and remains in full force and effect, (e) give rise to any severance
        payment, right of termination, securities purchase or redemption right
        or other right under any such Contractual Obligation, or (f) violate or
        give rise to a default or an event which with notice or lapse of time or
        both could constitute a default under any Legal Requirements, except for
        events or conditions described in clauses (a) through (f) above which
        shall not, individually or in the aggregate, have any Material Adverse
        Effect or (g) result in any state of facts which could have a Material
        Adverse Effect, and except for events or conditions described in
        Schedule 3.18.

        3.19    APPROVALS, CONSENTS, ETC.

                Other than as set forth in Schedule 3.19, no approval, consent,
        authorization or other order of, and no declaration, filing,
        registration, qualification or recording with, any governmental
        authority or any other Person is required to be made by or on behalf of
        the Vendors, MKL or any of the Subsidiaries in connection with the
        execution, delivery or performance of this Agreement or any of the
        transactions contemplated hereby.

        3.20    INVESTMENT OR DIVESTITURE

                Schedule 3.20 contains a complete list of all investments and
        divestitures in process which are not mentioned in the financial
        statements of MKL and the Subsidiaries (balance sheet, statement of
        earnings and schedules) for the period ended August 31, 1998 and which
        are not in the ordinary course of business.

        3.21    FULL DISCLOSURE

                Disclosure made by the Vendors in respect of one of the
        representations contained in this Section 3 is considered being made in
        respect of all other representations. There is no fact that the Vendors,
        to the best of their knowledge, have not disclosed to Phoenix which
        could have a Material Adverse Effect on the properties, business,
        prospects or condition (financial or otherwise) of MKL or any of the
        Subsidiaries. Neither the reports, financial statements and other
        documents referred to in Section 3.4, nor any certificate, statement or
        document forming part of this Agreement contains any 





                                     - 18 -


        untrue statement of a fact or omits to state any fact necessary to keep
        the statements contained herein or therein from being misleading in a
        manner that would constitute a Material Adverse Effect.

4.      REPRESENTATIONS AND WARRANTIES OF PHOENIX

        Phoenix represents and warrants to the Vendors that:

        4.1     DUE INCORPORATION, ETC.

                Phoenix is duly incorporated, validly exists and is in good
        standing under the Canada Business Corporations Act and has all
        necessary corporate capacity and power to own and lease its property and
        assets and to carry on the business now conducted by it.

        4.2     SHARE CAPITAL OF PHOENIX

                The authorized share capital of Phoenix is composed of an
        unlimited number of common shares and an unlimited number of preferred
        shares issuable in series of which, as at November 4, 1998, there were
        24,857,059 common shares issued and outstanding.

        4.3     OPTIONS

                Other than the options to acquire common shares of Phoenix
        granted pursuant to Phoenix's Key Employee Share Option Plan, shares to
        be issued to Dorn Cook under an earn-out formula which has been
        disclosed to the Vendors and an approximate number of 1,800,000 common
        shares of Phoenix to be issued in connection with proposed acquisitions,
        Phoenix does not have any rights or options to subscribe for, or any
        warrants or other agreements providing for or requiring the issuance of
        common shares or preferred shares.

        4.4     DUE AUTHORIZATION

                All necessary corporate action has been taken by Phoenix to
        authorize the execution of this Agreement and the consummation of the
        transactions contemplated hereby, including the issuance of the Phoenix
        Shares as fully paid and non-assessable in consideration for the
        purchase of the Shares.

        4.5     STOCK EXCHANGE APPROVALS

                The listing of the Phoenix Shares on The Montreal Exchange and
        the Toronto Stock Exchange has been approved by such exchanges, subject
        to Phoenix fulfilling all of the standard requirements of such exchanges
        before November 27, 1998 and the Phoenix Shares are not subject to any
        statutory hold period or resale restrictions under the SECURITIES ACT
        (Quebec) or any other contractual resale restrictions other than as
        mentioned in this Agreement. However, the sale of the Shares in the
        province of Quebec will constitute a distribution requiring the
        establishment of a prospectus or an exemption therefrom except if such
        sale is effected on a stock exchange or on the over-the-counter-market.
        Phoenix is a reporting issuer in good standing under the SECURITIES ACT
        (Quebec).




                                     - 19 -


        4.6     PHOENIX SHARES

                The Phoenix Shares will at the time of issuance be duly
        authorized, validly issued, fully paid and non-assessable common shares
        in the share capital of Phoenix and registered in the names of the
        Vendors or the Escrow Agent, as the case may be, on the share registers
        of Phoenix.

        4.7     UNDERTAKING

                Phoenix undertakes, on a best effort basis, to obtain a release
        of the guarantee provided by Buhrens to Hamburger Sparkasse in favour of
        MKL.

5.      POOLING OF INTERESTS

        5.1     ACCOUNTING TREATMENT

                Phoenix, MKL and the Vendors intend and desire for the
        transactions contemplated by this Agreement to qualify for "pooling of
        interests" treatment for US GAAP purposes in accordance with Accounting
        Principles Board Opinion No. 16.

        5.2     POOLING LETTERS

                On or prior to the Completion Date, MKL shall cause to be
        executed and delivered to Ernst & Young, auditors to Phoenix, and to
        Phoenix a letter or letters, dated the Completion Date, from MKL's
        shareholders in form and substance reasonably satisfactory to Phoenix
        and its auditors relating to "pooling of interests" accounting (the "MKL
        Pooling Letter"). On or prior to the Completion Date, Phoenix shall
        deliver to Ernst & Young, auditors to Phoenix, a letter or letters,
        dated the Completion Date, from Phoenix's management in form and
        substance reasonably satisfactory to its auditors relating to "pooling
        of interests" accounting.

        5.3     OPINIONS OF ACCOUNTANTS AND AUDITORS OF PHOENIX

                On or prior to the Completion Date, Phoenix shall have received
        a letter, dated the Completion Date, from Ernst & Young, accountants and
        auditors to Phoenix, in form and substance satisfactory to Phoenix,
        regarding the appropriateness of pooling of interests treatment for the
        transactions contemplated herein.

        5.4     OPINIONS OF ACCOUNTANTS AND AUDITORS OF MKL

                On or prior to the Completion Date, MKL and Phoenix shall have
        received a letter, dated the Completion Date, from Bernd Rohrberg,
        accountant and auditor of MKL, attesting to the validity of the MKL
        Pooling Letter referred to in Section 5.2, in form and substance
        satisfactory to MKL and Phoenix.

        5.5     PLACEMENT AND STOCK TRANSFER RESTRICTIONS AND RELATED MATTERS

                Each party to this Agreement agrees that from and after the date
        of this Agreement, such party shall not knowingly take any action, or
        knowingly fail to take any action, which action or failure is reasonably
        likely to disqualify the transactions contemplated by this Agreement
        from pooling of interests accounting treatment by Phoenix, and that such
        party shall take all reasonable actions necessary to cause the
        transactions contemplated by this Agreement to qualify as a pooling of
        interest, 




                                     - 20 -


        if such characterization shall be jeopardized by action taken by such
        party. Without limiting the foregoing, each Vendor who is a Pooling
        Affiliate of MKL agrees that such Vendor shall not sell, transfer,
        pledge, or otherwise dispose of such Vendor's interests in or reduce
        such Vendor's risk relative to any of the Phoenix Shares until Phoenix
        shall have published financial results (including combined sales and net
        income) covering at least thirty (30) days of combined operations of
        Phoenix and MKL after the Completion Date. No later than April 30, 1999,
        Phoenix shall prepare and publish such financial results for the first
        full month of operations following the Completion Date. Each of the
        Vendors and MKL acknowledge and agree with Phoenix that none of the
        Vendors or MKL is a party to any agreement or arrangement among
        themselves or with third parties regarding the transactions contemplated
        by this Agreement or the subject matter hereof.

                Prior to the Completion Date, Phoenix shall deliver to MKL a
        list of names and addresses of those persons who are or may be, in
        Phoenix's reasonable judgement, Affiliates of Phoenix within the meaning
        of Rule 145 of the rules and regulations promulgated under the
        Securities Act or applicable SEC accounting releases with respect to
        pooling of interests accounting treatment (each such persons, a "Pooling
        Affiliate"). Phoenix also shall provide MKL with such information and
        documents as MKL shall reasonably request for purposes of reviewing such
        list. Prior to the Completion Date, Phoenix shall deliver to MKL an
        affiliate letter, in form and substance reasonably satisfactory to MKL,
        executed by each of the Pooling Affiliates identified in the foregoing
        list.

                Prior to the Completion Date, MKL shall deliver to Phoenix a
        list of names and addresses of those persons who are or may be, in MKL's
        reasonable judgment, Pooling Affiliates of MKL. MKL also shall provide
        Phoenix with such information and documents as Phoenix shall reasonably
        request for purposes of reviewing such list. Prior to the Completion
        Date, MKL shall deliver to Phoenix an affiliate letter, in form and
        substance reasonably satisfactory to Phoenix, executed by each of the
        Pooling Affiliate of MKL identified in the foregoing list.

6.      EMPLOYMENT AGREEMENT

        6.1     EMPLOYMENT AGREEMENTS WITH BUhrens and Tetzloff

                Buhrens and MKL shall execute an employment agreement
        satisfactory in form and content to Phoenix and MKL.

                Tetzloff and MKL shall execute an employment agreement
        satisfactory in form and content to Phoenix and IPHAR.

7.      SURVIVAL OF REPRESENTATIONS; INDEMNITY

        7.1     SURVIVAL OF REPRESENTATIONS

                The respective representations and warranties of the Vendors
        contained in this Agreement or in any schedule attached hereto shall
        survive the consummation of the transactions contemplated hereby and
        shall remain in full force and effect notwithstanding any investigation
        or examination of, or knowledge with respect to, the subject matter
        thereof by or on behalf of Phoenix until the earlier of November 6, 1999
        or the date of completion of the audit of the combined financial
        statements of Phoenix and MKL (the period ending on such date being
        referred to herein as the "Representations Period"), except that such
        representations and warranties shall survive indefinitely in the event
        of fraud with respect thereto. No claim for indemnification pursuant to
        Section 7.2.1 below may be brought after the expiration of the
        Representations Period, except for claims made in good faith in 





                                     - 21 -


        writing prior to such expiration and setting forth in reasonable detail
        the claim, regardless of whether any action or demand has been commenced
        against Phoenix (it being understood without limitation, that any and
        all Losses (as defined below) arising after the expiration of the
        Representations Period shall be recoverable upon notice properly given
        prior to the expiration of the Representations Period in accordance with
        this Section 7.1). The representations and warranties of Phoenix
        contained in this Agreement or in any schedule attached hereto shall
        terminate upon and not survive the Completion Date, except in the event
        of fraud by Phoenix with respect thereto, in which case they shall
        survive indefinitely.

        7.2     INDEMNIFICATION

                7.2.1   From and after the Completion Date, Phoenix and its
                        Affiliates (including MKL and the Subsidiaries) and all
                        of their respective officers, directors, employees,
                        agents and shareholders (each, an "Indemnitee") shall be
                        defended, indemnified and held harmless by the Vendors
                        pursuant to this Agreement and the Escrow Agreement to
                        the full extent permitted by law, from and against any
                        and all losses, evictions, claims, actions, damages,
                        liabilities, costs and expenses (including attorneys'
                        fees and expenses) (collectively, "Losses") relating to
                        or arising from or in connection with (i) any
                        misrepresentation or any non-fulfilment of any
                        representation, warranty, covenant, obligation or
                        agreement by any Vendor contained in or made pursuant to
                        this Agreement or any other document, agreement,
                        officer's certificate or other certificate delivered to
                        Phoenix in connection with this Agreement, and (ii) the
                        enforcement by Phoenix of its rights pursuant to this
                        Section 7.2, or any litigation, proceeding or
                        investigation relating to any of the foregoing. The
                        indemnification obligations of the Vendors pursuant
                        hereto shall be joint and not solidary, i.e. prorata to
                        the number of Phoenix Shares received by each Vendor in
                        accordance with Section 2.2.

                7.2.2   Notwithstanding the foregoing provisions of this Section
                        7.2, but except with respect to any Losses resulting
                        from or arising out of fraud or other intentional or
                        willful misconduct or misrepresentation, (i) the maximum
                        aggregate recourse by the Indemnitees pursuant to
                        Section 7.2.1 above shall not exceed the aggregate value
                        (calculated by adding together the opening and closing
                        prices of the common shares of Phoenix on each of the
                        Toronto Stock Exchange and The Montreal Exchange for
                        each of the ten trading days preceding the Completion
                        Date, and dividing this sum by 40) of the Escrowed
                        Securities (the "Indemnity Cap"), and (ii) the sole
                        recourse of any Indemnitee in respect of Losses (but not
                        in respect of fraud or other intentional or willful
                        misconduct or misrepresentation) shall be from, out of,
                        and to the extent of the Escrowed Securities. It being
                        understood that the Indemnitees shall in no
                        circumstances be entitled to recover the property of the
                        Phoenix Shares transferred under this Agreement. Any
                        indemnification shall be payable by the return of
                        Escrowed Securities to Phoenix in accordance with the
                        provisions of the Escrow Agreement. In particular, the
                        number of Escrowed Shares to be remitted to Phoenix in
                        payment of any indemnification obligation shall be
                        calculated on the basis of the average price of the
                        Escrowed Shares obtained by adding together the opening
                        and closing prices of the common shares of Phoenix on
                        each of the Toronto Stock Exchange and The Montreal
                        Exchange for each of the ten trading days preceding the
                        Completion Date, and dividing this sum by 40. All
                        dividends or other distributions received by a Vendor in
                        respect of common shares of Phoenix which are remitted
                        to 





                                     - 22 -


                        Phoenix in satisfaction of an indemnification obligation
                        under this Section 7, shall also be repaid to Phoenix at
                        the time of payment of indemnification.

                7.2.3   Notwithstanding any other provision of this Agreement,
                        as of and after the Completion Date, MKL shall not have
                        any liability under this Agreement, and no Vendor shall
                        threaten or bring any claim or action whatsoever against
                        MKL for contribution to any amounts payable under this
                        Section 7.2 by such Vendor.

8.      NOTICES

        Any demand, notice or other communication to be given in connection with
this Agreement shall be given in writing and shall be given by personal
delivery, by registered mail or by electronic means of communication addressed
to the recipient as follows:

        8.1     To Phoenix:

                Phoenix International Life Sciences Inc.
                2350, Cohen Street
                Saint-Laurent, Quebec
                H4R 2N6 Canada

                Telecopier No.: (514) 333-7306

                ATTENTION: JEAN-YVES CALOZ

        8.2     To Buhrens

                Prof. Dr. Klaus-Georg Buhrens
                Buchtallee 4a
                21465 Reinbek, Germany

        8.3     To Geist:

                Dr. Martin Geist
                Georgiweg 43
                22453 Hamburg, Germany

        8.4     To Blohm:

                Dr. Bernk Blohm
                Buchtallee 23
                21465 Reinbek, Germany

        8.5     To Hilgenstock:

                Dr. Christian Hilgenstock
                Gronenweg 73
                22549 Hamburg, Germany




                                     - 23 -


        8.6     To Hemker:

                Dr. Claus Hemker
                Feldblick 2
                22397 Hamburg, Germany

        8.7     To Kozak:

                Dr. Ivan Kozak
                Kopeniker Str. 15
                22045 Hamburg, Germany

        8.8     To Vens-Cappell:

                Dr. Bernhard Vens-Cappell
                Wurtkamp 12
                22527 Hamburg, Germany

        8.9     To Tetzloff:

                Dr. Wolfgang Tetzloff
                Friedenstrasse 56
                82194 Grobenzell, Germany

        8.10    To J. Henke:

                Dr. Jurgen Henke
                Hohenzollernring 57
                50672 Koln, Germany

        8.11    To L. Henke:

                Dr. Lotte Henke
                Hohenzollernring 57
                50672 Koln, Germany

        8.12    To TREND:

                TREND Finanzanalysen GmbH
                Berliner Allee 21
                40212 Dusseldorf, Germany




                                     - 24 -


        8.13    To MKL:

                McKnight Laboratories GmbH
                Osterstrasse 86
                20259 Hamburg, Germany

                Telecopier No.: 011-49-40-490-5055

                ATTENTION:        PROF. DR. KLAUS-GEORG BUHRENS

9.      MODIFICATION

        All modifications or amendments of any provision of this Agreement shall
be effective only if the same shall be in writing and then shall be effective
only in the specific instance and for the purpose for which given.

10.     WAIVER

        No failure to exercise, and no delay in exercising, on the part of a
party hereto, any right hereunder shall operate as a waiver thereof, nor shall
any single or partial exercise thereof preclude any other or further exercise
thereof or the exercise of any other right. No waiver of any provision of this
Agreement shall be effective unless in writing. No notice or demand given in any
case shall constitute a waiver of the right to take other action in the same,
similar or other instances without such notice or demand.

11.     CONFIDENTIALITY

        The parties agree to treat this Agreement as confidential and not to
disclose its contents to third parties other than their advisers, except to the
extent necessary to enforce performance of obligations hereunder, or as is
required to comply with applicable laws or regulations, including regulations of
any stock exchange on which the securities of Phoenix are listed following
consultations with the Vendors.

12.     FURTHER ASSURANCES

        The parties shall, with all reasonable diligence, do all such things and
provide all such reasonable assurances as may be required to consummate the
transactions contemplated hereby, and each party shall provide such further
documents or instruments required by another party as may be reasonably
necessary or desirable to give effect to the purpose of this Agreement and to
carry out its provisions.

13.     GOVERNING LAWS

        This Agreement shall be governed by the laws of the Province of Quebec
and the laws of Canada applicable therein.

14.     ARBITRATION

        All disputes arising out of or in connection with the present Agreement
shall be finally settled under the Rules of Arbitration of the International
Chamber of Commerce by one or more arbitrators appointed in accordance with the
said Rules.

        The place of arbitration shall be Montreal.




                                     - 25 -


        The language of the arbitration shall be English.

15.     GENERAL

        The invalidity or unenforceability of any term or provision hereof shall
not affect the validity or enforceability of any other term or provision hereof.
The headings in this Agreement are for convenience of reference only and shall
not alter or otherwise affect the meaning hereof. This Agreement and the other
documents and instruments referred to herein constitute the entire understanding
of the parties hereto with respect to the subject matter hereof and thereof and
supersede all present and prior agreements, whether written or oral. No
investigation made by or on behalf of a party hereto shall mitigate, diminish or
affect the representations and warranties made herein by the Vendors. This
Agreement may be executed in any number of counterparts which together shall
constitute one instrument and shall be governed by and construed in accordance
with the laws of the Province of Quebec and the laws of Canada applicable
therein, and shall bind and inure to the benefit of the parties hereto and their
respective heirs, executors, administrators, personal representatives,
successors and assigns. The parties hereto have expressly required that this
Agreement and all documents and notices related hereto be drafted in English.
LES PARTIES AUX PRESENTES ONT EXPRESSEMENT EXIGE QUE LE PRESENT CONTRAT ET TOUS
LES DOCUMENTS ET AVIS Y AFFERENTS SOIENT REDIGES EN ANGLAIS.


        IN WITNESS WHEREOF, the parties hereto caused this Agreement to be duly
executed as of the Completion Date.



PHOENIX INTERNATIONAL LIFE
SCIENCES INC.

By:            /s/ John Hooper                   /s/ Klaus-Georg Buhrens
      -------------------------------------    -------------------------------
       John Hooper, Ph.D.                      PROF. DR. KLAUS-GEORG BUHRENS
Title: Chairman and Chief Executive Officer

       /s/ Martin Geist                             /s/ Bernd Blohm
- -----------------------------------        -----------------------------------
DR. MARTIN GEIST                           DR. BERND BLOHM
                                       
                                       
    /s/ Christian Hilgenstock                      /s/ Claus Hemker
- -----------------------------------        -----------------------------------
DR. CHRISTIAN HILGENSTOCK                  DR. CLAUS HEMKER
                                       
                                       
          /s/ Ivan Kozak                       /s/ Bernard Vens-Cappell
- -----------------------------------        -----------------------------------
DR. IVAN KOZAK                             DR. BERNHARD VENS-CAPPELL
                                       
                                       
       /s/ Wolfgang Tetzloff                       /s/ Ulrike Schafer
- -----------------------------------        -----------------------------------
DR. WOLFGANG TETZLOFF                      DR. JURGEN HENKE, by Ulrike Schafer
                                       


                                     - 26 -


       /s/ Ulrike Schafer
- -----------------------------------        TREND FINANZANALYSEN GMBH
DR. LOTTE HENKE, by Ulrike Schafer
                                       By:       /s/ Ulrike Schafer
                                           -----------------------------------
                                           Ulrike Schafer

MCKNIGHT LABORATORIES GMBH


By:     /s/ Klaus-Georg Buhrens
    -------------------------------
    Prof. Dr. Klaus-Georg Buhrens







                                LIST OF SCHEDULES



                        
Schedule A                 Outstanding shares and voting rights of MKL

Schedule B                 The capital structure of IPHAR

Schedule C                 The capital structure of MKL/USA

Schedule 1.9               Escrow Agreement

Schedule 1.21              Permitted Lien

Schedule 3.3.2             Options

Schedule 3.3.3             Capital Stock of the Subsidiaries

Schedule 3.3.4             Subsidiary Options

Schedule 3.3.5             Commitments affecting shares or voting rights of MKL or the Subsidiaries

Schedule 3.4A              Financial Statements

Schedule 3.5               Material liabilities, contingent or otherwise of MKL or any of the Subsidiaries
                           and off-balance sheet obligations of MKL and the Subsidiaries

Schedule 3.6.2             Extraordinary Transactions after January 1, 1998

Schedule 3.8.1             Contractual Obligations

Schedule 3.8.4             Insurance

Schedule 3.10              Intellectual Property

Schedule 3.12.4            Liability for employee dismissal

Schedule 3.12.5            Physicians, nurses or pharmacists employed by MKL and the Subsidiaries

Schedule 3.13              Taxes

Schedule 3.15              Title to assets

Schedule 3.16              Litigation

Schedule 3.18              Violation of Other Instruments

Schedule 3.19              Approvals, Consents, etc.

Schedule 3.20              Investment or Divestiture




                                                                  Schedule 1.09

ESCROW AGREEMENT dated as of November 6, 1998.



AMONG:          PHOENIX INTERNATIONAL LIFE SCIENCES INC., a corporation
                incorporated under the Canada Business Corporations Act, having
                its head office at 2350, Cohen Street, Saint-Laurent, Quebec,
                Canada, H4R 2N6, herein acting and represented by John Hooper,
                its duly authorized representative;

                (hereinafter "Phoenix")


AND:            PROF. DR. KLAUS-GEORG BUHRENS, residing at Buchtallee 4a, 21465
                Reinbek, Germany;

                (hereinafter "Buhrens")


AND:            MARTIN GEIST, residing at Georgiweg 43, 22453 Hamburg, Germany;

                (hereinafter "Geist")


AND:            DR. BERND BLOHM, residing at Buchtallee 23, 21465 Reinbek,
                Germany;

                (hereinafter "Blohm")


AND:            CHRISTIAN HILGENSTOCK, residing at Gronenweg 73, 22549 Hamburg,
                Germany;

                (hereinafter "Hilgenstock")


AND:            CLAUS HEMKER, residing at Feldblick 2, 22397 Hamburg, Germany;

                (hereinafter "Hemker")


AND:            DR. IVAN KOZAK, residing at Kopeniker Str. 15, 22045 Hamburg,
                Germany;

                (hereinafter "Kozak")



                                     - 2 -


AND:            DR. BERNHARD VENS-CAPPELL, residing at Wurtkamp 12, 22527
                Hamburg, Germany;

                (hereinafter "Vens-Cappell")


AND:            WOLFGANG TETZLOFF, residing at Friedenstrasse 56, 82194
                Grobenzell, Germany;

                (hereinafter "Tetzloff")


AND:            DR. JURGEN HENKE, residing at Hohenzollernring 57, 50672 Koln,
                Germany;

                (hereinafter "J. Henke")


AND:            DR. LOTTE HENKE, residing at Hohenzollernring 57, 50672 Koln,
                Germany;

                (hereinafter "L. Henke")


AND:            TREND FINANZANALYSEN GMBH, a German corporation with capital of
                DM150,000, registered in the Commercial Register of the
                Amtsgericht Dusseldorf under number HRB 18161 and having its
                head office at Berliner Allee 21, 40212 Dusseldorf, Germany,
                herein acting and represented by Peter Martin, its duly
                authorized representative;

                (hereinafter "TREND")


AND:            MONTREAL TRUST COMPANY, 1800 McGill College Avenue, Montreal,
                Quebec, H3A 3K9, as escrow agent, herein represented by its duly
                authorized representatives Rose Marie Labbe and Guy L'Esperance;

                (hereinafter the "Escrow Agent")



        WHEREAS Phoenix and the Vendors are parties to a share purchase
agreement dated November 6, 1998 (the "Purchase Agreement");

        WHEREAS the Purchase Agreement provides that certain shares of Phoenix
issued to the Vendors pursuant thereto are to be held in escrow for the purposes
described therein;

        NOW THEREFORE the parties hereby agree as follows:




                                     - 3 -


1.      INTERPRETATION AND DEFINITIONS

        1.1     Whenever used in this Agreement:

                1.1.1   "AFFILIATE" means any of Buhrens and TREND and
                        "Affiliates" means more than one of them;

                1.1.2   "CLAIM" means any claim by Phoenix against and the
                        Vendors under Section 7.2 of the Purchase Agreement;

                1.1.3   "DISTRIBUTIONS" has the meaning ascribed thereto in
                        Section 2.3 hereof;

                1.1.4   "ESCROWED SHARES" has the meaning ascribed thereto in
                        Section 2.1 hereof;

                1.1.5   "ESCROWED SHARE PRICE" means the amount obtained by
                        adding the opening and closing prices of the common
                        shares of Phoenix on each of the Montreal Exchange and
                        The Toronto Stock Exchange for the ten trading days
                        preceding the date of execution of the Purchase
                        Agreement, divided by 40;

                1.1.6   "NON-AFFILIATE" means Geist, Blohm, Hilgenstock, Hemker,
                        Kozak, Vens- Cappell, Tetzloff, J. Henke and L. Henke;

                1.1.7   "NOTICE OF CLAIM" means a written notice of any Claim
                        given by Phoenix setting forth the details of each Claim
                        referred to therein including the amount thereof, if
                        known to Phoenix, or Phoenix's reasonable estimate
                        thereof, as well as the provisions of the Purchase
                        Agreement upon which such Claim is based;

                1.1.8   "OBJECTION" means, in respect of any Claim, any
                        objection raised in the Response by any of the Vendors
                        to such Claim;

                1.1.9   "PROCEEDS" has the meaning ascribed thereto in Section
                        3.2 hereof;

                1.1.10  "PURCHASE AGREEMENT" has the meaning ascribed thereto in
                        the preamble to this Agreement;

                1.1.11  "RELEASED SHARES" has the meaning ascribed thereto in
                        Section 3.5.1.1 hereof;

                1.1.12  "RESPONSE" means, in respect of any Claim, the joint
                        written response of the representatives of the Vendors
                        duly appointed in the manner set forth in Section 3.1
                        hereof indicating whether they accept or dispute such
                        Claim; and

                1.1.13  "VENDORS" means Buhrens, Geist, Blohm, Hilgenstock,
                        Hemker, Kozak, Vens-Cappell, Tetzloff, J. Henke, L.
                        Henke and TREND.

        1.2     Each capitalized term used in this Agreement but not defined
                herein as the meaning ascribed thereto in the Purchase
                Agreement.




                                     - 4 -


        1.3     In the event of (i) any subdivision, consolidation or
                reclassification of the class of shares comprising the Escrowed
                Shares or (ii) any reorganization of the share capital of
                Phoenix affecting the Escrowed Shares or (iii) the amalgamation
                of Phoenix with any other company, the number of Escrowed Shares
                and Escrowed Share Price shall be adjusted, if required, so that
                none of the parties hereto shall be in a position less favorable
                to it than as provided in this Agreement as a result of any of
                the foregoing actions.

        1.4     For all purposes of this Agreement, the amount of any Claim in a
                currency other than Canadian dollars shall be converted to
                Canadian dollars at the exchange rate between Canadian and such
                currency shall be the "Spot Rate" of the alternate currency on
                the business day preceding the day as of which the conversion
                from one currency to the other is to be effected, as reported in
                the Financial Post of Canada on that day.

        1.5     In any calculation hereunder of the applicable number of
                Escrowed Shares results in fractional shares, the result shall
                be rounded up or down, as the case may be, to the nearest whole
                number and, if such result represents exactly one-half of a
                whole number, then such fraction shall be rounded up to the next
                whole number.

2.      ESTABLISHMENT OF ESCROW

        2.1     Phoenix hereby delivers in escrow to the Escrow Agent
                certificates representing an aggregate of 87,332 common shares
                of Phoenix registered in the name of the Escrow Agent, as escrow
                agent (the "Escrowed Shares"). The Vendors' interests in the
                Escrowed Shares are as set forth below:




        VENDOR                          ESCROWED SHARES
        ------                          ---------------
                                     
        Buhrens                             47,707
        Geist                                1,667
        Blohm                                1,667
        Hilgenstock                          4,406
        Hemker                               4,406
        Kozak                                4,406
        Vens-Cappell                         4,406
        Tetzloff                             4,406
        J. Henke                             3,573
        
        L. Henke                             3,573
        TREND                               11,115






                                     - 5 -


        2.2     The Escrow Agent hereby accepts delivery and acknowledges
                receipt of the Escrowed Shares and agrees to act as escrow agent
                and to hold, safeguard and release the Escrowed Shares in
                accordance with the provisions of this Agreement. The Escrowed
                Shares shall not be assigned, hypothecated, alienated, released
                from escrow, transferred within escrow or dealt with in any
                manner whatsoever except as provided in this Agreement.

        2.3     Notwithstanding the registration of the Escrowed Shares in the
                name of the Escrow Agent, the Vendors shall, subject to the
                provisions hereof, remain the owners thereof in the proportion
                contemplated by Section 2.1 hereof and be entitled to the
                exercise of all voting rights related thereto and to receive all
                dividends, income and other distributions in respect thereof
                (collectively, "Distributions"). In the event that any Escrowed
                Shares are remitted to Phoenix for cancellation pursuant to the
                provisions of Section 3 hereof, the Vendors shall repay to
                Phoenix any Distributions received in respect of such Escrowed
                Shares.

3.      INSTRUCTIONS TO ESCROW AGENT

        3.1     All communications made by the Vendors, including instructions
                to the Escrow Agent or Responses hereunder, shall be made by
                Buhrens and Dr. Ulrike Schafer jointly on behalf of the Vendors.
                All of the Vendors hereby authorize Buhrens and Dr. Ulrike
                Schafer to duly represent them in accordance with all
                communications under this Agreement. Should the Vendors wish to
                withdraw this authorization and to designate new
                representatives, they have to do so jointly by notifying Phoenix
                and the Escrow Agent in accordance with Section 7 hereof.

        3.2     At any time while the Escrowed Shares are held by the Escrow
                Agent, a Non-Affiliate may instruct the Escrow Agent in writing
                to sell all or part of such Non-Affiliate's portion of the
                Escrowed Shares. Upon receipt of such written instruction, the
                Escrow Agent shall sell such Escrowed Shares on the open market
                and shall retain the proceeds of sale, less any expenses
                incurred in realizing such sale (the "Proceeds") as escrowed
                property for such Non-Affiliate. The Escrow Agent shall invest
                such Proceeds according to the written instructions of such
                Non-Affiliate for the duration of the escrow. The Escrow Agent
                shall keep complete records of any such sales of Escrowed
                Shares.

        3.3     At any time after receipt by the Escrow Agent of written notice
                by Phoenix of the release, in the format prescribed by the SEC,
                of at least 30 days of post-combination financial results of
                Phoenix and McKnight Laboratories GmbH, and provided that the
                Escrowed Shares are not then subject to any restrictions on
                transfer imposed by any Regulatory Authority, an Affiliate may
                also instruct the Escrow Agent to sell all or part of their
                portion of the Escrowed Shares in the manner set forth in
                Section 3.2. In such event, the Escrow Agent shall proceed as
                set forth in Section 3.2.

        3.4     Whenever Phoenix has a Claim it shall promptly give a Notice of
                Claim in respect thereof to the Vendors and the Escrow Agent.
                Upon receipt of a Notice of Claim, the Escrow Agent shall
                immediately reserve for distribution in accordance with the
                provisions of Section 3.5 hereof (but shall not release from
                escrow except in accordance with the provisions hereof) 





                                     - 6 -


                that number of the Escrowed Shares which is equal in value to
                the amount provided for in the Notice of Claim, calculated on
                the basis of the Escrowed Share Price for such Claim.

        3.5     Within 15 days of receipt of a Notice of Claim, the Vendors (or
                any of them) shall give to Phoenix and the Escrow Agent a
                Response with respect to each Claim set forth therein. If:

                3.5.1   the Response indicates that the Vendors accept a Claim
                        set forth in the Notice of Claim, or if the Escrow Agent
                        does not receive a Response with respect to a Claim
                        within said 15 day period, the Vendors shall be deemed
                        to have irrevocably consented to each Claim so accepted
                        or in respect of which no Response is so received, as
                        made, and the Escrow Agent shall forthwith give written
                        notice thereof to Phoenix:

                        3.5.1.1 setting forth the total amount of all Claims
                                which have been consented to and the number of
                                shares from the Escrowed Shares to be released
                                from escrow for the benefit of Phoenix (the
                                "Released Shares"), being that number of the
                                Escrowed Shares which is equal in value to the
                                amount of the admitted Claims set forth in such
                                Notice of Claim, calculated on the basis of the
                                Escrowed Share Price for such Claim; and

                        3.5.1.2 surrender for cancellation to Phoenix the share
                                certificate(s) in its possession representing
                                the Released Shares, duly endorsed for transfer,
                                and the Escrow Agent shall retain in its
                                possession the other share certificate(s)
                                representing the balance of the Escrowed Shares,
                                if any, to be held by it in escrow and dealt
                                with in accordance with the terms hereof; or

                3.5.2   the Response indicates that the Vendors (or any of them)
                        dispute a Claim set forth in the Notice of Claim
                        (whether or nor arbitration proceedings have been
                        instituted), the Escrow Agent shall retain in its
                        possession and continue to hold in escrow that number of
                        the Escrowed Shares which is equal in value to the
                        amount provided for in the disputed Claims, calculated
                        on the basis of the Escrowed Share Price for such Claim:

                        3.5.2.1 until the Escrow Agent receives a joint written
                                notice from Phoenix and the Vendors directing
                                the Escrow Agent as to the manner in which such
                                Escrowed Shares and the share certificate(s)
                                representing same are to be dealt with, in which
                                case the Escrow Agent shall deal with same in
                                accordance with such joint written instructions;
                                or

                        3.5.2.2 in the absence of such a joint written notice
                                within 10 business days of the Escrow Agent's
                                receipt of the Response, the Escrow Agent shall
                                deal with such Escrowed Shares and the share
                                certificate(s) representing same in accordance
                                with a final arbitration order in respect of
                                such disputed Claim(s) pursuant to the
                                arbitration contemplated by Section 12 hereof.
                                Any arbitration order shall be accompanied by a
                                legal opinion by counsel for the presenting
                                party satisfactory to the Escrow Agent to the
                                effect that the said order is final and
                                non-appealable.




                                     - 7 -


        3.6     If, at the time of receipt by the Escrow Agent of any Notice of
                Claim as provided for in Section 3.4 hereof, the Escrowed Shares
                remaining in escrow for the account of any Vendor calculated on
                the basis of the Escrowed Share Price is insufficient to meet
                such Vendor's pro rata portion of the number of Released Shares
                to be remitted to Phoenix, the balance of such Vendor's pro rata
                portion of the admitted Claims shall be satisfied by payment in
                cash from the Proceeds of those Escrowed Shares sold by the
                Escrow Agent at the direction of such Vendor pursuant to Section
                3.2 or 3.3 hereof.

        3.7     On the earlier of (i) November 6, 1999, or (ii) the date at
                which the Escrow Agent receives a notice from Phoenix confirming
                that the audit of the combined financial statements of Phoenix
                and McKnight Laboratories GmbH has been completed, the Escrow
                Agent will deliver the Escrowed Shares and all Distributions and
                Proceeds to the Vendors, pro rata to their respective interests
                in the Escrowed Shares, Distributions and Proceeds if any.

4.      VOTING RIGHTS

        4.1     The Escrow Agent shall provide to each of the Vendors a proxy
                entitling such Vendor to vote those of the Escrowed Shares which
                are owned by it, forthwith upon the Escrow Agent's receipt
                thereof in its capacity as registered shareholder of Phoenix, in
                order to allow each Vendor to vote its Escrowed Shares in the
                same manner as if it were the registered owner thereof.

5.      RIGHTS AND OBLIGATIONS OF THE ESCROW AGENT

        5.1     The Escrow Agent is not a party to, and is not bound by, any
                provisions which may be evidenced by, or arise out of, any
                agreement other than as therein set forth under the express
                provisions of this Agreement.

        5.2     The Escrow Agent acts hereunder as a depositary only and is not
                responsible or liable in any manner whatever for the
                sufficiency, correctness, genuineness or validity of any
                instrument deposited with it, or for the form of execution of
                such instrument or for the identity or authority or right of any
                person or party executing or depositing it.

        5.3     The Escrow Agent shall not be under any duty to give the
                Escrowed Shares, Distributions and Proceeds, if any, held by it
                hereunder any greater degree of care than it gives its own
                similar property and shall not be required to invest any funds
                held hereunder except as directed in this Agreement. Uninvested
                funds held hereunder shall not earn or accrue interest.

        5.4     The Escrow Agent shall not be liable, except for its own gross
                negligence or willful misconduct and, except with respect to
                claims based upon such gross negligence or willful misconduct
                that are successfully asserted against the Escrow Agent, the
                other parties hereto shall solidarily indemnify and hold
                harmless the Escrow Agent (and any successor Escrow Agent) from
                and against any and all losses, liabilities, claims, actions,
                damages and expenses, including reasonable attorney's fees and
                disbursements, arising out of and in connection with this
                Agreement. Without limiting the foregoing, the Escrow Agent
                shall 





                                     - 8 -


                in no event be liable in connection with its investment or
                reinvestment of any cash held by it hereunder in good faith, in
                accordance with the terms hereof.

        5.5     The Escrow Agent shall be entitled to rely upon any order,
                judgment, certification, demand, notice, instrument or other
                writing delivered to it hereunder without being required to
                determine the authenticity or the correctness of any fact stated
                therein or the propriety or validity of the service thereof. The
                Escrow Agent may act in reliance upon any instrument or
                signature believed by it to be genuine and may assume that the
                person purporting to give receipt or advice or make any
                statement or execute any document in connection with the
                provisions hereof has been duly authorized to do so. The Escrow
                Agent may conclusively presume that the undersigned
                representative of any party hereto which is an entity other than
                a natural person has full power and authority to instruct the
                Escrow Agent on behalf of that party unless written notice to
                the contrary is delivered to the Escrow Agent.

        5.6     The Escrow Agent may act pursuant to the advice of counsel with
                respect to any matter relating to this Agreement and shall not
                be liable for any action taken or omitted by it in good faith in
                accordance with such advice.

        5.7     The Escrow Agent makes no representation as to the validity,
                value, genuineness or the collectability of any security or
                other document or instrument held by or delivered to it.

        5.8     The Escrow Agent shall not be called upon to advise any party as
                to the wisdom in selling or retaining or taking or refraining
                from any action with respect to any securities or other property
                deposited hereunder.

        5.9     The Escrow Agent (and any successor Escrow Agent) may at any
                time resign as such by delivering the Escrowed Shares,
                Distributions and Proceeds, if any, to any successor Escrow
                Agent jointly designated by the other parties hereto in writing,
                or to any court of competent jurisdiction, whereupon Escrow
                Agent shall be discharged of and from any and all further
                obligations arising in connection with this Agreement. The
                resignation of Escrow Agent will take effect on the earlier of
                (a) the appointment of a successor (including a court of
                competent jurisdiction) or (b) the day which is 30 days after
                the date of delivery of its written notice of resignation to the
                other parties hereto. If at that time Escrow Agent has not
                received a designation of a successor Escrow Agent, Escrow
                Agent's sole responsibility after that time shall be to retain
                and safeguard the Escrowed Shares and Proceeds, if any, until
                receipt of a designation of successor Escrow Agent or a joint
                written disposition instruction by the other parties hereto or a
                final non-appealable order of a court of competent jurisdiction.

        5.10    Phoenix and the Vendors shall pay Escrow Agent compensation (as
                payment in full) for the services to be rendered by Escrow Agent
                hereunder in the amount of $1,500 at the time of execution of
                this Agreement and agree to reimburse Escrow Agent for all
                reasonable expenses, disbursements and advances incurred or made
                by Escrow Agent in performance of its duties hereunder
                (including reasonable fees, expenses and disbursements of its
                counsel).




                                     - 9 -


6.      LIMITED RESPONSIBILITY

        This Agreement expressly sets forth all the duties of Escrow Agent with
        respect to any and all matters pertinent hereto. No implied duties or
        obligations shall be read into this Agreement against the Escrow Agent.
        The Escrow Agent shall not be bound by the provisions of any agreement
        among the other parties hereto except this Agreement. No trust is
        created by this Agreement and the Escrow Agent does not act in any
        capacity as a trustee. In the event of any disagreement between any of
        the parties to this Agreement, or between them or either of them and any
        other person, resulting in demands or adverse claims being made in
        connection with or for any asset involved herein or affected hereby, the
        Escrow Agent shall be entitled, at its discretion, to refuse to comply
        with any demands or claims on it, as long as such disagreement shall
        continue, and in so refusing the Escrow Agent may make no delivery or
        other disposition of any asset involved herein or affected hereby, and
        in so doing the Escrow Agent shall not be or become liable in any way or
        to any person or party for its failure or refusal to comply with such
        conflicting demands or adverse claims, and it shall be entitled to
        continue so to refrain from acting and so to refuse to act until the
        right of person or party shall have been finally settled as provided in
        Section 12 hereof, or all differences shall have been adjusted by
        agreement and the Escrow Agent shall have been notified thereof in
        writing signed by all persons and parties interested.

7.      NOTICES

        All notices, consents, waivers and other communications under this
        Agreement must be in writing and will be deemed to have been duly given
        when (a) delivered by hand (with written confirmation of receipt), (b)
        sent by telecopier (with written confirmation of receipt) provided that
        a copy is mailed by registered mail, return receipt requested, or (c)
        when received by the addressee, if sent by a nationally recognized
        overnight delivery service (receipt requested), in each case the
        appropriate addresses and telecopier numbers set forth below (or to such
        other addresses and telecopier numbers as a party may designate by
        notice to the other parties):

        7.1     To Phoenix:

                Phoenix International Life Sciences Inc.
                2350, Cohen Street
                Saint-Laurent, Quebec
                H4R 2N6 Canada

                Telecopier No.: (514) 333-7306

                ATTENTION: JEAN-YVES CALOZ

        7.2     To the Vendors:

                TO BUHRENS

                Prof. Dr. Klaus-Georg Buhrens
                Buchtallee 4a
                21465 Reinbek, Germany





                                     - 10 -


                TO GEIST:

                Dr. Martin Geist
                Georgiweg 43
                22453 Hamburg, Germany

                TO BLOHM:

                Dr. Bernk Blohm
                Buchtallee 23
                21465 Reinbek, Germany

                TO HILGENSTOCK:

                Dr. Christian Hilgenstock
                Gronenweg 73
                22549 Hamburg, Germany

                TO HEMKER:


                Dr. Claus Hemker
                Feldblick 2
                22397 Hamburg, Germany

                TO KOZAK:

                Dr. Ivan Kozak
                Kopeniker Str. 15
                22045 Hamburg, Germany

                TO VENS-CAPPELL:

                Dr. Bernhard Vens-Cappell
                Wurtkamp 12
                22527 Hamburg, Germany

                TO TETZLOFF:

                Dr. Wolfgang Tetzloff
                Friedenstrasse 56
                82194 Grobenzell, Germany

                TO J. HENKE:

                Dr. Jurgen J. Henke
                Hohenzollernring 57
                50672 Koln, Germany




                                     - 11 -


                TO L. HENKE:

                Dr. L. Henke J. Henke
                Hohenzollernring 57
                50672 Koln, Germany

                TO TREND:

                TREND Finanzanalysen GmbH
                Berliner Allee 21
                40212 Dusseldorf, Germany

                ATTENTION:  PETER MARTIN

        7.3     To the Escrow Agent:

                Montreal Trust Company
                1800 McGill College Avenue
                Montreal (Quebec)
                H3A 3K9

                Telecopier No.:  (514) 982-7677

        7.4     To Dr. Ulrike Schafer:

                Schafer Pott
                Berlinerallee 26
                40212 Dusseldorf, Germany


8.      GOVERNING LAW

        This Agreement shall be governed by the laws of the Province of Quebec
        and the laws of Canada applicable therein.

9.      COUNTERPARTS

        This Agreement may be executed in one or more counterparts, each of
        which will be deemed to be an original and all of which, when taken
        together, will be deemed to constitute one and the same.

10.     SECTION HEADINGS

        The headings of sections in this Agreement are provided for convenience
        only and will not affect its construction or interpretation.

11.     WAIVER





                                     - 12 -


        The rights and remedies of the parties to this Agreement are cumulative
        and not alternative. Neither the failure nor any delay by any party in
        exercising any right, power, or privilege under this Agreement or the
        documents referred to in this Agreement will operate as a waiver of such
        right, power or privilege, and no single or partial exercise of any such
        right, power, or privilege will preclude any other or further exercise
        of such right, power, or privilege or the exercise of any other right,
        power, or privilege. To the maximum extent permitted by applicable law,
        (a) no claim or right arising out of this Agreement or the documents
        referred to in this Agreement can be discharged by one party, in whole
        or in part, by a waiver or renunciation of the claim or right unless in
        writing signed by the other parties; (b) no waiver that may be given by
        a party will be applicable except in the specific instance for which it
        is given; and (c) no notice to or demand on one party will be deemed to
        be a waiver of any obligation of such party or of the right of the party
        giving such notice or demand to take further action without notice or
        demand as provided in this Agreement or the documents referred to in
        this Agreement.

12.     ARBITRATION

        All disputes arising out of or in connection with the present Agreement
        shall be finally settled under the Rules of Arbitration of the
        International Chamber of Commerce by one or more arbitrators appointed
        in accordance with the said Rules. The place of arbitration shall be
        Montreal. The language of the arbitration shall be English.

13.     CONFIDENTIALITY

        The parties agree to treat this Agreement as confidential and not to
        disclose its contents to third parties other than their advisers, except
        to the extent necessary to enforce performance of obligations hereunder,
        or as is required to comply with applicable laws or regulations,
        including regulations of any stock exchange on which the securities of
        Phoenix are listed.

14.     FURTHER ASSURANCES

        The parties shall, with all reasonable diligence, do all such things and
        provide all such reasonable assurances as may be required to consummate
        the transactions contemplated hereby, and each party shall provide such
        further documents or instruments required by another party as may be
        reasonably necessary or desirable to give effect to the purpose of this
        Agreement and to carry out its provisions.

15.     GENERAL

        The invalidity or unenforceability of any term or provision hereof shall
        not affect the validity or enforceability of any other term or provision
        hereof. This Agreement and the other documents and instruments referred
        to herein constitute the entire understanding of the parties hereto with
        respect to the subject matter hereof and thereof and supersede all
        present and prior agreements, whether written or oral. This Agreement
        shall bind and inure to the benefit of the parties hereto and their
        respective heirs, executors, administrators, personal representatives,
        successors and assigns.


        IN WITNESS WHEREOF, the parties have executed and delivered this
Agreement as of the date first written above.




                                     - 13 -


PHOENIX INTERNATIONAL LIFE
SCIENCES INC.


By:               /s/ John Hooper                    /s/ Klaus-Georg Buhrens
    ---------------------------------------------  -----------------------------
     John Hooper, Ph.D.                            PROF. DR. KLAUS-GEORG BUHRENS
     Title: Chairman and Chief Executive Officer

          /s/ Martin Geist                         /s/ Bernd Blohm
- ------------------------------------    ---------------------------------------
DR. MARTIN GEIST                        DR. BERND BLOHM

      /s/ Christian Hilgenstock                   /s/ Claus Hemker
- ------------------------------------    ---------------------------------------
DR. CHRISTIAN HILGENSTOCK               DR. CLAUS HEMKER

         /s/ Ivan Kozak                      /s/ Bernhard Vens-Cappell
- ------------------------------------    ---------------------------------------
DR. IVAN KOZAK                          DR. BERNHARD VENS-CAPPELL

       /s/ Wolfgang Tetzloff                  /s/ Ulrike Schafer
- ------------------------------------    ---------------------------------------
DR. WOLFGANG TETZLOFF                   DR. JURGEN HENKE, by Ulrike Schafer

                                        TREND FINANZANALYSEN GMBH


         /s/ Ulrike Schafer             By:        /s/ Ulrike Schafer
- ------------------------------------        -----------------------------------
DR. L. HENKE, by Ulrike Schafer             Ulrike Schafer

                                        MONTREAL TRUST COMPANY


                                        By:    /s/ Rose Marie Labbe
                                            -----------------------------------
                                            Rose Marie Labbe
                                            Title:  Trust Officer


                                        By:    /s/ Guy L'Esperance
                                            -----------------------------------
                                            Guy L'Esperance
                                            Title: Manager, Client Servicing