POLYDEX PHARMACEUTICALS LIMITED - ------------------------------------------------------------------------------- 421 COMSTOCK ROAD TORONTO, ONTARIO CANADA M1L 2H5 TELEPHONE: (416) 755-2231 FAX: (416) 755-0334 WEBSITE: www.polydex.com BAHAMAS OFFICE: 284 BAY STREET, NASSAU, BAHAMAS AMENDMENT TO EMPLOYEE CONTRACT To: Mr. George G. Usher From: Ms. Sharon Wardlaw Date: February 4, 1999 Subject: Employment Contract Number of Pages: 1 - ------------------------------------------------------------------------------- Dear Sir, Please be advised that your employment contract that commenced on February 1, 1994, expiring on January 31, 1999, has been extended, as of February 1, 1999, for a further period of five years as agreed by the Board of Directors at our recent meeting January 29-30, 1999. The conditions remain the same for this extension. Yours Sincerely, /s/ Sharon Wardlaw /s/ George G. Usher Sharon Wardlaw George G. Usher CFO President, CEO