<ARTICLE> 5 <CIK> 0000912183 <NAME> CUBIST PHARMACEUTICALS, INC <PERIOD-TYPE> 3-MOS <FISCAL-YEAR-END> DEC-31-1999 <PERIOD-START> JAN-01-1999 <PERIOD-END> MAR-31-1999 <CASH> 8,776,803 <SECURITIES> 10,289,311 <RECEIVABLES> 354,375 <ALLOWANCES> 0 <INVENTORY> 0 <CURRENT-ASSETS> 15,768,093 <PP&E> 7,841,191 <DEPRECIATION> (4,205,410) <TOTAL-ASSETS> 23,361,957 <CURRENT-LIABILITIES> 2,277,739 <BONDS> 0 <PREFERRED-MANDATORY> 0 <PREFERRED> 0 <COMMON> 17,516 <OTHER-SE> 19,840,278 <TOTAL-LIABILITY-AND-EQUITY> 23,361,957 <SALES> 0 <TOTAL-REVENUES> 604,375 <CGS> 0 <TOTAL-COSTS> 0 <OTHER-EXPENSES> 5,206,435 <LOSS-PROVISION> 0 <INTEREST-EXPENSE> (163,657) <INCOME-PRETAX> (4,438,403) <INCOME-TAX> 0 <INCOME-CONTINUING> (4,438,403) <DISCONTINUED> 0 <EXTRAORDINARY> 0 <CHANGES> 0 <NET-INCOME> (4,438,403) <EPS-PRIMARY> (.26) <EPS-DILUTED> (.26)