Exhibit 8.1

                               LATHROP & GAGE L.C.
                                   LAW OFFICES

                                                                      Suite 2800
RUSSELL D. JONES                                            2345 Grand Boulevard
(816) 460-5725                                  Kansas City, Missouri 64108-2684
EMAIL: RJONES@LATHROPGAGE.COM                     816-292-2000, Fax 816-292-2001

                                 June 16, 1999

Lab Holdings, Inc.
5000 West 95th Street
Suite 260, Box 7568
Shawnee Mission, Kansas  66207

LabOne, Inc.
10101 Renner Boulevard
Lenexa, Kansas  66219

         Re:      Merger of LabOne, Inc. into Lab Holdings, Inc.

Dear Sirs:

         We  represent  Lab  Holdings,   Inc.,  a  Missouri   corporation  ("Lab
Holdings"),  in  connection  with the merger (the  "Merger") of LabOne,  Inc., a
Delaware  corporation  ("Lab One"),  into Lab Holdings  pursuant to that certain
Agreement and Plan of Merger dated as of March 7, 1999 (as amended to date,  the
"Merger   Agreement").    The   Merger   is   described   in   a   Joint   Proxy
Statement/Prospectus  of Lab  Holdings  and  LabOne  (as  amended  to date,  the
"Prospectus")  that  is  included  in  a  Registration  Statement  on  Form  S-4
(Registration No.  333-76131) filed with the Securities and Exchange  Commission
with respect to the Merger (as amended to date, the "Registration Statement").

         Section 6.1(g) of the Merger Agreement  provides that the obligation of
each of you to effect the Merger  shall be subject to your receipt of an opinion
letter of counsel to the effect that the Merger will have certain federal income
tax consequences. This opinion letter is being delivered to each of you pursuant
to such Section 6.1(g).

         We have examined such  documents and records and made such inquiries as
we consider  relevant and  necessary  for purposes of this  opinion  letter.  In
particular  we have  reviewed  the Merger  Agreement,  the  Prospectus,  and the
Registration  Statement.  Also in  particular we have reviewed and relied upon a
Certificate  of Fact  that has  been  provided  to us by you.  Based  upon  such
examination and inquiry, and further based on the assumptions and subject to the
qualifications  set forth below,  we are of the opinion that the federal  income
tax consequences of the Merger include the following.






Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 2



Holdings

         With  respect  to  Holdings,  the  Merger  will  qualify  as a tax-free
liquidation  of LabOne under  Section 332 of the  Internal  Revenue Code of 1986
(the "Code").1  Accordingly,  and taking into account other applicable rules, no
gain or loss will be  recognized  by  Holdings  upon the receipt by it of all of
LabOne's  property  and the  cancellation  of its LabOne  stock  pursuant to the
Merger or as a result of the stock split that precedes the Merger.

         Holdings'  initial tax basis in each of the  properties  received by it
from  LabOne  pursuant  to the  Merger  will be the same as  LabOne's  tax basis
therein immediately before the Merger. Holdings' holding period for the property
received  by it from LabOne  pursuant to the Merger will  include the period for
which the property was held by LabOne.

LabOne

         With  respect  to  LabOne,  the  Merger  will  qualify  as  a  tax-free
liquidation  of LabOne under Section 332.  Accordingly,  no gain or loss will be
recognized  by LabOne  upon the  distribution  by it of all of its  property  to
Holdings pursuant to the Merger.

Holdings Stockholders

         In general  the Merger  will have no effect on  Holdings  stockholders.
However,  and  notwithstanding  this general  rule,  Holdings  stockholders  who
receive cash in lieu of  fractional  shares in  connection  with the stock split
that precedes the Merger will be treated as if they had received the  fractional
shares and such shares were then redeemed by Holdings.  Such a deemed redemption
will be treated in the case of each such  stockholder  as a sale or  exchange of
the fractional  share,  and thus will trigger  capital gain or loss in an amount
equal  to  the   difference   between  the  amount  of  cash  received  and  the
stockholder's tax basis in such fractional share, if it is considered to be "not
essentially  equivalent  to a  dividend"  under  Section  302(b)(1)  or if it is
considered  to be  "substantially  disproportionate"  with  respect to the stock
holder under Section 302(b)(2); otherwise the cash received will be treated
- --------
         1 Hereinafter the words "Section" and "Sections," as used herein, refer
to a section or sections, respectively, of the Code, unless otherwise noted.





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 3



as a dividend. In determining whether the deemed redemption will be treated as a
sale or exchange the  constructive  ownership rules of Section 318,  pursuant to
which a stockholder is treated as owning stock that is actually owned by certain
other related parties, are generally applicable.

         A deemed  redemption of a fractional  share of Holdings stock held by a
Holdings  stockholder will be considered to be "not essentially  equivalent to a
dividend"  under Section  302(b)(1) if the  redemption  results in a "meaningful
reduction"  in the  stockholder's  proportionate  interest in Holdings.  U.S. v.
Davis, 397 U.S. 301, 313, reh'g denied,  397 U.S. 1071 (1970). The existence and
extent of any  decrease  in voting  control  appears to be the most  significant
factor to be taken into account in applying this  "meaningful  reduction"  test,
although the  existence  and extent of decreases in economic  ownership are also
relevant considerations.  The Internal Revenue Service (the "IRS") generally has
ruled under Section  302(b)(1) that a stockholder who receives cash in lieu of a
fractional  share in  connection  with a stock  dividend  or stock split will be
treated  as  having  sold or ex  changed  such  fractional  share  (causing  the
recognition  of gain or loss in an amount  equal to the  difference  between the
amount of cash  received  and the  stockholder's  tax  basis in such  fractional
share),  provided that the cash is distributed  solely for the purpose of saving
the  corporation  the expense  and  inconvenience  of issuing  and  transferring
fractional shares and is not separately bargained-for consideration.

         A deemed  redemption of a fractional  share of Holdings stock held by a
Holdings stockholder will be considered to be "substantially  dispropor tionate"
with respect to the  stockholder  under  Section  302(b)(2)  if the  stockholder
actually and constructively owns less than 50 percent of the voting power of the
outstanding  Holdings stock after the deemed redemption and if the percentage of
Holdings stock actually and  constructively  owned by such stockholder after the
deemed  redemption is less than 80 percent of the  percentage of Holdings  stock
actually and  constructively  owned by such stockholder  immediately  before the
deemed redemption.  It is perhaps unlikely,  but not impossible,  that this test
will be satisfied in the case of a deemed  redemption  of less than a full share
of Holdings stock.

         Under the "not  essentially  equivalent to a dividend  test" of Section
302(b)(1) and the  "substantially  disproportionate"  test of Section 302(b)(2),
the specific tax  consequences to Holdings  stockholders of a deemed redemp tion
of fractional shares of Holdings stock will depend on each stockholder's





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 4



individual  circumstances.  Therefore, we express no opinion with respect to the
specific tax consequences to any Holdings  stockholder of the receipt of cash in
lieu of a fractional  share of Holdings  stock in the stock split that  precedes
the Merger.

         Also  notwithstanding  the  general  rule that the Merger  will have no
effect on Holdings  stockholders,  a Holdings stockholder who receives cash as a
result of his exercise of statutory dissenters' rights will be treated as if his
Holdings stock were redeemed by Holdings. This deemed redemption will be treated
as a sale or  exchange  of such  stockholder's  Holdings  stock,  and thus  will
trigger  capital gain or loss in an amount equal to the  difference  between the
amount of cash received and the  stockholder's tax basis in such stock, if it is
considered  to be "not  essentially  equivalent  to a  dividend"  under  Section
302(b)(1) or if it is considered  to be  "substantially  disproportionate"  with
respect  to the  stockholder  under  Section  302(b)(2)  or if it  results  in a
complete  termination  of the  stockholder's  interest in Holdings under Section
302(b)(3);  otherwise  the cash  received  will be  treated  as a  dividend.  In
determining whether the deemed redemption will be treated as a sale or exchange,
the  constructive   ownership  rules  of  Section  318  are,  again,   generally
applicable.

         A deemed  redemption of all of the Holdings stock held by a dissent ing
Holdings  stockholder  will generally  result in a complete  termination of such
stockholder's  interest in Holdings under Section 302(b)(3). A deemed redemption
that  results  in  such a  complete  termination  will be  treated  as a sale or
exchange of the  redeemed  stock,  and thus will  trigger  capital gain or loss.
However,  and notwithstanding  the foregoing,  a deemed redemption of all of the
Holdings stock held by a dissenting  Holdings  stockholder  who is treated under
the constructive ownership rules of Section 318 as owning Holdings stock that is
actually owned by other related parties may not result in a complete termination
of the  stockholder's  interest in Holdings  under Section  302(b)(3).  A deemed
redemption that does not result in such a complete  termination may nevertheless
be treated as a sale or  exchange  under the "not  essentially  equivalent  to a
dividend"   test   of   Section   302(b)(1)   or   under   the    "substantially
disproportionate" test of Section 302(b)(2),  both of which are discussed above;
however, if the redemption does not satisfy these tests, then it will be treated
as the payment of a dividend.

         As  indicated  in the  foregoing  discussion,  the  specific  tax conse
quences of a deemed redemption of all of the Holdings stock held by a





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 5



Holdings  stockholder who exercises statutory  dissenters' rights will depend on
such stockholder's  individual  circumstances.  Therefore, we express no opinion
with  respect  to the  specific  tax  consequences  of  such  deemed  redemption
treatment to any particular Holdings stockholder.

LabOne Stockholders (Other Than Holdings)

         With respect to LabOne stockholders  (other than Holdings),  the Merger
will qualify as a tax-free reorganization under Section 368(a) and both Holdings
and  LabOne  will  be  parties  to such  reorganization  under  Section  368(b).
Accordingly,  the principal tax consequences of the Merger to such  stockholders
are as follows.

         No gain or loss will be recognized by LabOne  stockholders  who receive
only Holdings stock in exchange for their LabOne stock pursuant to the Merger.

         LabOne  stockholders who receive only cash in exchange for their LabOne
stock  pursuant  to the Merger  will  likely be treated as if they had  received
Holdings stock in the Merger and such stock was redeemed by Holdings immediately
thereafter. However, the law in this regard is unclear and such stockholders may
be treated as if they had sold their LabOne stock to Holdings.

         A deemed  redemption of Holdings  stock that is considered to have been
received by a LabOne  stockholder  who receives  only cash in the Merger will be
treated as a sale or exchange of such stock,  and thus will trigger capital gain
or loss in an amount equal to the difference between the amount of cash received
and the  stockholder's  tax basis in such stock,  if it is considered to be "not
essentially  equivalent  to a  dividend"  under  Section  302(b)(1)  or if it is
considered  to  be   "substantially   disproportionate"   with  respect  to  the
stockholder under Section  302(b)(2) or if it results in a complete  termination
of the stockholder's interest in Holdings under Section 302(b)(3); otherwise the
cash received will be treated as a dividend.  In determining  whether the deemed
redemption  will be treated as a sale or  exchange  the  constructive  ownership
rules of Section 318 are, again, generally applicable.

         A deemed  redemption of Holdings  stock that is considered to have been
received by a LabOne stockholder who receives only cash in the Merger





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 6



will generally result in a complete  termination of such stockholder's  interest
in Holdings under Section 302(b)(3).  A deemed redemption that results in such a
complete  termination  will be treated  as a sale or  exchange  of the  redeemed
stock, and thus will trigger capital gain or loss.  However, a deemed redemption
of  Holdings  stock  that  is  considered  to have  been  received  by a  LabOne
stockholder  who receives  only cash in the Merger and who is treated  under the
constructive  ownership  rules of Section 318 as owning  Holdings  stock that is
actually owned by other related parties may not result in a complete termination
of the  stockholder's  interest in Holdings  under Section  302(b)(3).  A deemed
redemption that does not result in such a complete  termination may nevertheless
be treated as a sale or exchange  un der the "not  essentially  equivalent  to a
dividend" test of Section 302(b)(1) or the "substantially disproportionate" test
of Section  302(b)(2),  both of which are discussed above, but if the redemption
does not  satisfy  these  tests  then it will be  treated  as the  payment  of a
dividend.

         A deemed sale of LabOne stock to Holdings by a LabOne  stockholder  who
receives only cash in the Merger will cause the  recognition  of capital gain or
loss in an amount equal to the  difference  between the amount of cash  received
and the stockholder's tax basis in such stock.

         Because  of the  uncertainty  in the law,  and  because  of the  LabOne
stockholders' varying  circumstances,  we express no opinion with respect to the
specific tax consequences of the Merger to LabOne  stockholders who receive only
cash in exchange for their LabOne stock pursuant thereto.

         LabOne  stockholders  who receive some Holdings  stock and some cash in
exchange for their LabOne stock pursuant to the Merger will recognize  gain, but
not  loss,  on such  exchange.  The  amount  of the  gain  recognized  by such a
stockholder will be equal to the lesser of: one, the total gain realized by such
stockholder  on the  exchange  (i.e.,  the  value  of the  Merger  consideration
received by such stockholder,  including both cash and Holdings stock, less such
stockholder's  tax basis in the LabOne stock that is given up in the  exchange);
or two,  the  amount of cash  received.  The gain that is  realized  by a LabOne
stockholder may be capital gain or a dividend (i.e., ordinary income), depending
on the stockholder's individual circum stances.

         For  purposes  of  determining  whether  the gain  realized by a LabOne
stockholder who receives some Holdings stock and some cash in exchange





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 7



for his LabOne stock  pursuant to the Merger will be capital gain or a dividend,
the  stockholder  will be treated as if he exchanged all of his LabOne stock for
Holdings  stock and  Holdings  immediately  redeemed a portion of such  Holdings
stock for cash. The gain realized by the stockholder will be capital gain if the
deemed  redemption  of  a  portion  of  such  stockholder's  Holdings  stock  is
considered to be a sale or exchange of such stock because it is "not essentially
equivalent   to  a  dividend"   under   Section   302(b)(1)  or  because  it  is
"substantially  disproportionate"  with respect to the stockholder under Section
302(b)(2);  otherwise  the gain that is  realized  by the stock  holder  will be
treated as a dividend.  In  determining  whether the deemed  redemption  will be
treated as a sale or exchange the  constructive  ownership  rules of Section 318
are, again, generally applicable.

         The "not essentially  equivalent to a dividend" and  "substantially dis
proportionate"   tests  prescribed  by  Sections  302(b)(1)  and  302(b)(2)  are
discussed  above.  In this regard,  the IRS has taken the position that the "not
essentially  equivalent to a dividend  test" may be satisfied  with respect to a
redemption  of a  portion  of a  stockholder's  stock  in a  corporation  if the
stockholder's percentage stock ownership interest in the corporation is minimal,
the  stockholder  exercises no control over  corporate  affairs,  and there is a
meaningful reduction in the stockholder's percentage stock ownership.

         Because of the LabOne stockholders' varying  circumstances,  we express
no opinion with respect to the  character  of the gain,  if any,  recog nized by
LabOne  stockholders  who receive some Holdings  stock and some cash in exchange
for their LabOne stock pursuant to the Merger.

         The aggregate tax basis of the shares of Holdings  stock  received by a
LabOne stockholder  pursuant to the Merger will equal the aggregate tax basis of
such stockholder's shares of LabOne stock exchanged in the Merger,  increased by
the amount of any gain  recognized  by such  stockholder  and  decreased  by the
amount of any cash received by such  stockholder.  The holding period for shares
of Holdings stock received by a LabOne stock holder  pursuant to the Merger will
include  the  holding  period for the shares of LabOne  stock  exchanged  in the
Merger.

         The foregoing opinions are based on the Code, its legislative  history,
Treasury  Regulations,   judicial  authority,  and  administrative  rulings  and
practice,  all as currently  existing and in effect.  This opinion letter is not
binding on the IRS or upon the courts, and





Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 8



if the IRS challenges any of the opinions that are expressed herein, substantial
expense  may  be  incurred  in  dealing  therewith.  Legislative,  judicial,  or
administrative changes or interpretations may be forthcoming that could alter or
modify the opinions  expressed by us herein. Any such changes may be retroactive
and could affect, possibly adversely, the tax consequences of the Merger.

         In rendering the foregoing opinions, we have assumed that the necessary
approval of the Merger by the  stockholders of Holdings and LabOne will be given
at the  "Stockholder  Meetings" (as defined in the Merger  Agreement),  that the
Merger  Agreement  will  remain  in full  force and  effect at all time  periods
relevant to the  foregoing  opinions,  and that the Merger  will be  consummated
exactly as described in the Merger  Agreement.  In rendering these opinions,  we
have also assumed that all  stockholders of Holdings and LabOne hold their stock
as a capital  asset and did not acquire  their stock as  compensation,  and that
such  stockholders  are not taxpayers  that are subject to special rules such as
financial  institutions,  regulated investment  companies,  insurance companies,
tax-exempt organizations, and foreign persons.

         In  rendering  the  foregoing  opinions  we have  further  assumed  the
accuracy  of all  statements  of fact  contained  in the Merger  Agreement,  the
Prospectus,  the Registration  Statement,  and other documents examined by us or
made to us by officers or other  representatives  of Lab  Holdings and LabOne in
response to our inquiries, and we have assumed that there . We have also assumed
the due  authorization,  execution  and  delivery,  and  binding  effect  of all
contracts examined by us by and on all parties thereto.  We have further assumed
the genuineness of all signatures on all contracts and other documents  examined
by us, the authenticity of all documents  submitted to us as originals,  and the
conformity to original documents of all documents submitted to us as copies.

         We express no opinion as to the federal income tax  consequences of the
Merger  if any of the  assumptions  that we are  relying  upon in  issuing  this
opinion  letter  are  incorrect.  We  also  express  no  opinion  as to the  tax
consequences of the Merger under any state, local, or foreign tax law.

         The  opinions  set forth in this  letter are  effective  as of the date
hereof. We express no opinions other than those expressly set forth herein,  and
no expansion of our opinions may be made by implication or otherwise.  We do not
undertake  to advise you of any matter  within  the scope of this  letter  which
comes to our  attention  after the  delivery  of this  letter and  disclaim  any
responsibility  to advise you of future  changes in law or fact which may affect
the above opinions.






Lab Holdings, Inc.
LabOne, Inc.
June 16, 1999
Page 9


         This opinion letter may not be filed with any governmental agency or be
used for any other purpose without our prior written  consent,  except that this
opinion letter may be filed as an exhibit to the Registration  Statement.  Also,
we  consent  to the  reference  that  is  made to  this  opinion  letter  in the
Prospectus   under  the  caption  "The  Proposed   Merger--Federal   Income  Tax
Consequences."

                                             Very truly yours,

                                            LATHROP & GAGE L.C.


                                             s/ Russell D. Jones
                                       By:
                                             Russell D. Jones




637423.2