AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 15, 1999

                                               Registration No. 333-____________

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                ----------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                               ENZO BIOCHEM, INC.
                              --------------------
             (Exact name of Registrant as specified in its charter)

                                    NEW YORK
                              --------------------
         (State or other jurisdiction of incorporation or organization)

                                   13-2866202
                              --------------------
                      (I.R.S. Employer Identification No.)

            60 EXECUTIVE BOULEVARD, FARMINGDALE, NEW YORK      11735
            -----------------------------------------------------------
            (Address of Principal Executive Offices)         (Zip Code)

                    ENZO BIOCHEM, INC. 1999 STOCK OPTION PLAN
                            (Full Title of the Plan)

                                 Barry W. Weiner
                               Enzo Biochem, Inc.
                             60 Executive Boulevard
                           FARMINGDALE, NEW YORK 11735
                           ---------------------------
                     (Name and Address of Agent For Service)

                                 (516) 755-5500
                                 --------------
          (Telephone Number, Including Area Code, of Agent For Service)

                        Copies to: Robert H. Cohen, Esq.
                     Morrison Cohen Singer & Weinstein, LLP
                              750 Lexington Avenue
                            New York, New York 10022
                                 (212) 735-8600

================================================================================


                         CALCULATION OF REGISTRATION FEE



==================================================================================================================
    Title of Securities     Amount to be        Proposed Maximum           Proposed Maximum          Amount of
     to be Registered        Registered     Offering Price Per Share   Aggregate Offering Price   Registration Fee
     ----------------        ----------     ------------------------   ------------------------   ----------------
==================================================================================================================
                                                                                      
Common Stock, par value
$0.01 per share             335,500(1)(2)           $9.74(3)                  $3,267,770             $908.44(6)
==================================================================================================================
Common Stock, par value
$0.01 per share             614,500(2)(4)          $26.9375(5)               $16,553,094           $4,601.76(6)
==================================================================================================================

                                               Total Registration Fee . . . . . . . . . . . . . .  $5,510.20(6)

==================================================================================================================


- ----------
(1)   Shares of common stock of Enzo Biochem, Inc. issuable upon stock options
      which have been granted under the Enzo Biochem, Inc. 1999 Stock Option
      Plan.

(2)   In addition, pursuant to Rule 416(c) under the Securities Act of 1933,
      this registration statement also covers an indeterminate amount of
      interests to be offered or sold pursuant to the employee benefit plan
      described herein.

(3)   Calculated solely for the purpose of determining the registration fee
      pursuant to Rule 457(h)(1) promulgated under the Securities Act of 1933
      upon the average exercise price.

(4)   Shares of common stock of Enzo Biochem, Inc. issuable upon the grant of
      stock options available for grant under the Enzo Biochem, Inc. 1999 Stock
      Option Plan.

(5)   Calculated solely for the purpose of determining the registration fee
      pursuant to Rule 457(c) under the Securities Act of 1933 based upon the
      average of the high and low prices for the common stock on The American
      Stock Exchange September 8, 1999.

(6)   Calculated pursuant to Section 6 under the Securities Act of 1933.


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.

         Enzo Biochem, Inc., a New York corporation, incorporates by reference
the documents listed below into this Registration Statement on Form S-8. All
documents subsequently filed by Enzo Biochem, Inc. pursuant to Section 13(a),
13(c), 14 and 15(d) of the Securities Exchange Act of 1934, prior to the filing
of a post-effective amendment which indicates that all securities offered have
been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference in this Registration Statement and to be
part thereof from the date of filing of such documents:

                  1.    Annual Report on Form 10-K for the fiscal year ended
                        July 31, 1998;

                  2.    Quarterly Report on Form 10-Q for the fiscal quarter
                        ended October 31, 1998;

                  3.    Quarterly Report on Form 10-Q for the fiscal quarter
                        ended January 31, 1999;

                  4.    Quarterly Report on Form 10-Q for the fiscal quarter
                        ended April 30, 1999;

                  5.    Definitive proxy statement filed with the SEC on
                        November 25, 1998 pursuant to Regulation 14A under the
                        Securities Exchange Act of 1934; and

                  6.    The description of our common stock set forth in our
                        Registration Statement filed under Section 12 of the
                        Securities Exchange Act of 1934 on Form 8-A on, and any
                        amendment or report filed for the purpose of updating
                        any such description.

ITEM 4. DESCRIPTION OF SECURITIES.

                  Not applicable.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

                  Not Applicable.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         The Company's Certificate of Incorporation states the following:

                  "Article 8. The Corporation shall, to the fullest extent
                  permitted by the Business Corporation Law of the States of New
                  York, indemnify any and all persons whom it shall have power
                  to indemnify from and against any and all of the expenses,
                  liabilities or other matters as provided under Articles of
                  Seven of the Business Corporation Law of the State of New
                  York.

                  "Article 12. No director of the Corporation shall be liable to
                  the Corporation or its shareholders for damage for any breach
                  of duty in such capacity, provided that nothing contained in
                  this Article shall eliminate or limit the liability of a
                  director (i) if a judgment or other final adjudication adverse
                  to him


                  establishes that his acts or omissions were in bad faith or
                  involved acts or omissions were in bad faith or involved
                  intentional misconduct or a knowing violation of law or that
                  he personally gained in fact a financial profit or other
                  advantage to which he was not legally entitled or that his
                  acts violated Section 719 of the New York Business Corporation
                  Law or (ii) for any act or omission prior to July 8, 1988."

         ARTICLE V of the Registrant's By-Laws provides as follows:

                  "Section 1. INDEMNIFICATION-THIRD PARTY AND DERIVATIVE
                  ACTIONS.

                  "(a) The Corporation shall indemnify any person made, or
threatened to be made, a party to an action or proceeding (other than one by or
in the right of the Corporation to procure a judgment in its favor), whether
civil or criminal, including an action by or in the right of any other
corporation of any type or kind, domestic or foreign, or any partnership, joint
venture, trust, employee benefit plan or other enterprise, which any director or
officer of the Corporation served in any capacity at the request of the
Corporation, by reason of the fact that he, his testator or intestate, is or was
a director or officer of the Corporation, by reason of the fact that he, his
corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise in any capacity, against judgments, fines, amounts paid in settlement
and expenses (including attorneys' fees) incurred in connection with any such
action or proceeding, or any appeal therein, provided that no indemnification
may be made to or on behalf of such person if (i) his acts were committed in bad
faith or were the result of his active and deliberate dishonesty and were
material to such action or proceeding or (ii) he personally gained in fact a
financial profit or other advantage to which he was not legally entitled.

                   "(b) The Corporation shall indemnify any person made, or
threatened to be made, a party to an action by or in the right of the
Corporation to procure a judgment in its favor by reason of the fact that he,
his testator or intestate, is or was a director or officer of the Corporation,
or is or was serving at the request of the Corporation as a director or officer
of any other corporation of any type or kind, domestic or foreign, or of any
partnership, joint venture, trust, employee benefit plan or other enterprise,
against judgments, fines, amounts paid in settlement and expenses (including
attorneys' fees) incurred in connection with such action, or any appeal therein,
provided that no indemnification may be made to or on behalf of such person if
(i) his acts were committed in bad faith or were the result of his active and
deliberate dishonesty and were material to such action or (ii) he personally
gained in fact a financial profit or other advantage to which he was not legally
entitled.

                  "(c) The termination of any civil or criminal action or
proceeding by judgment, settlement, conviction or upon a plea of nolo
contendere, or its equivalent, shall not in itself create a presumption that any
such person has not met the standard of conduct set forth in this Section 1. (d)
For the purpose of this Section 1: (i) the Corporation shall be deemed to have
requested a person to serve an employee benefit plan where the performance by
such person of his duties to the Corporation also imposes duties on, or
otherwise involve services by, such person to the plan or participants or
beneficiaries of the plan; and (ii) excise taxes assessed on a person with
respect to an employee benefit plan pursuant to applicable law shall be
considered fines.

         "Section 2. PAYMENT OF INDEMNIFICATION; REPAYMENT

                  "(a) A person who has been successful, on the merits or
otherwise, in the defense of a civil or criminal action or proceeding of the
character described in Section I of this Article V shall be entitled to
indemnification as authorized in such Section.

                  "(b) Except as provided in paragraph (a) of this Section 2,
any indemnification under Section 1 of this Article V, unless ordered by a
court, shall be made by the Corporation only if authorized in the specific case:
(i) by the Board of Directors acting by a quorum consisting of directors who are
not parties to the action or proceeding giving rise to the indemnity claim upon
a finding that the director or officer has met the standard of conduct set forth
in Section I of this Article V; or (ii) if a quorum under the foregoing clause
(i) is not obtainable or, even if obtainable, a quorum of disinterested
directors so directs: (A) by the Board of Directors upon the opinion in writing
of independent legal


                                        2


counsel that indemnification is proper in the circumstances because the standard
of conduct set forth in Section I of this Article V has been met by such
director or officer, or (B) by the shareholders of the Corporation upon a
finding that the director or officer has met such standard of conduct.

                  "(c) Expenses Incurred by a director or officer in defending a
civil or criminal action or proceeding shall be paid by the Corporation in
advance of the final disposition of such action or proceeding upon receipt of an
undertaking by or on behalf of such director or officer to repay such amount
incase he is ultimately found, in accordance with this Article V, not to be
entitled to indemnification or, where indemnity is granted, to the extent the
expenses so paid exceed the indemnification to which he is entitled.

                  "(d) Any indemnification of a director or officer of the
Corporation under Section I of this Article V, or advancement of expenses under
paragraph(c) of this Section 2, shall be made promptly, and in any event within
60 days, upon the written request of the director of officer.

         "Section 3. ENFORCEMENT; DEFENSES.

                  "The right to indemnification or advancement of expenses
granted by this Article V shall be enforceable by the director or officer in any
court of competent jurisdiction if the Corporation denies such request, in whole
or in part, or if no disposition thereof is made within 60 days after written
request by the director or officer. Such person's expenses incurred in
connection with successfully establishing his right to indemnification, in whole
or in part, in any such action shall also be indemnified by the Corporation. It
shall be a defense to any such action (other than an action brought to enforce a
claim for the advancement of expenses under Section 2 of this Article V where
the required undertaking has been received by the Corporation) that the claimant
has not met the standard of conduct set forth in Section I of this Article V,
but the burden of providing such defense shall be on the Corporation. Neither
the failure of the Corporation (including its Board of Directors, its
independent legal counsel, and its shareholders) to have made a determination
that indemnification of the claimant is proper in the circumstances, nor the
fact that there has been an actual determination by the Corporation (including
its Board of Directors, its independent legal counsel, and its shareholders)
that indemnification of the claimant is not proper in the circumstances, shall
be a defense to the action or create a presumption that the claimant is not
entitled to indemnification.

         "Section 4. SURVIVAL, SAVINGS CLAUSE; PRESERVATION OF OTHER RIGHTS.

                  "(a) The foregoing indemnification provisions shall be deemed
to be a contract between the Corporation and each director and officer who
serves in such capacity at any time while these provisions, as well as the
relevant provisions of the New York Business Corporation Law, are in effect and
any repeal or modification thereof shall not affect any right or obligation then
existing with respect to any state of facts then or previously existing or any
action or proceeding previously or thereafter brought or threatened based in
whole or in part upon any such state of facts. Such a contract fight may not be
modified retroactively without the consent of such director or officer.

                  "(b) If this Article V or any portion hereof shall be
invalidated on any ground by any court of competent jurisdiction, then the
Corporation shall nevertheless indemnify each director or officer of the
Corporation against judgments, fines, amounts paid in settlement and expenses
(including attorneys' fees) incurred in connection with any actual or threatened
action or proceeding, whether civil or criminal, including any actual or
threatened action by or in the right of the Corporation, or any appeal therein,
to the full extent permitted by any applicable portion of this Article V that
shall not have been invalidated and to the full extent permitted by applicable
law.

                  "(c) The indemnification provided by this Article V shall not
be deemed exclusive of any other rights to which those indemnified may be
entitled under any by-law, agreement, vote of shareholders or directors or
otherwise, both as to action in his official capacity and as to action in
another capacity while holding such office, and shall continue as to a person
who has ceased to be a director or officer and shall inure to the benefit of the
heirs, executors and


                                        3


administrators of such a person. The Corporation is hereby authorized to provide
further indemnification if it deems advisable by resolution of shareholders or
directors, by amendment of these by-laws or by agreement.

         "Section 5. INSURANCE.

                  "The Corporation may purchase and maintain insurance:

                  "(a) to indemnify the Corporation for any obligation which it
incurs as a result of the indemnification of directors and officers under the
provisions of this Article V,

                  "(b) to indemnify directors and officers in instances in which
they may be indemnified by the Corporation under the provisions of this Article
V, and

                  "(c) to indemnify directors and officers in instances in which
they may not otherwise be indemnified by the Corporation under the provisions of
this Article V, provided that the contract of insurance covering such directors
and officers pursuant to the foregoing paragraph (c) of Section 4 of this
Article V shall provide, in a manner acceptable to the superintendent of
insurance, for retention amount and for co-insurance, and provided, further,
that no insurance under this Article V may provide for any payment, other than
the cost of defense, to or on behalf of any director or officer if a judgment or
other final adjudication adverse to the insured director or officer establishes
(i) that his acts of active and deliberate dishonesty were material to the cause
of action so adjudicated or (ii) that the director or officer personally gained
in fact a financial profit or other advantage to which he was not legally
entitled.

         "Section 6. INDEMNIFICATION OF PERSONS NOT DIRECTORS OR OFFICERS OF THE
CORPORATION.

                  "The Corporation may, by resolution adopted by the Board of
directors of the Corporation, indemnify any person not a director or officer of
the Corporation, who is made, or threatened to be made, a party to an action or
proceeding, whether civil or criminal, by reason of the fact that he, his
testator or intestate, is or was an employee or other agent of the Corporation,
against judgments, fines, amounts paid in settlement and expenses (including
attorneys' fees) incurred in connection with such action or proceeding, or any
appeal therein, provided that no indemnification may be made to or on behalf of
such person if (i) his acts were committed in bad faith or were the result of
active and deliberate dishonesty, and such acts were material to such action or
proceeding, or (ii) he personally gained in fact a financial profit or other
advantage to which he was not legally entitled.

         "Section 7. RETROACTIVITY.

                  "The right to indemnification conferred by this Article V
shall be retroactive to events occurring prior to the adoption f this Article V
to the fullest extent permitted by law.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

                  Not Applicable.

ITEM 8. EXHIBITS.

      4.1   Enzo Biochem, Inc. 1999 Stock Option Plan.

      5.1   Opinion of Morrison Cohen Singer & Weinstein, LLP


                                        4


      23.1  Consent of Morrison Cohen Singer & Weinstein, LLP (included in its
            Opinion filed as Exhibit 5 hereto)

      23.2  Consent of Ernst & Young LLP, independent auditors

      24.1  Powers of Attorney (included on the signature page of this
            Registration Statement)

ITEM 9. UNDERTAKINGS.

         The undersigned registrant hereby undertakes:

         (a) Rule 415 Offering.

                  (2) That, for the purpose of determining any liability under
the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered therein,
and the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

                  (3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

          (b) The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934 (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934) that is incorporated by reference in the registration statement shall be
deemed to be a new registration statement relating to the securities offered
therein, and the offering of such securities at that time shall be deemed to be
in the initial bona fide offering thereof.

          (h) Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission, such indemnification is against public policy as expressed
in the Act, and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.


                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK.]


                                        5


                                   SIGNATURES

                  Pursuant to the requirements of the Securities Act of 1933, as
amended, the registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Farmingdale, State of New York, on this 14th day
of September 1999.


                                              ENZO BIOCHEM, INC.


                                              /s/ ELAZAR RABBANI
                                              ------------------
                                              Elazar Rabbani, Ph.D.
                                              Chairman of the Board

                                POWER OF ATTORNEY

                  KNOW ALL PERSONS BY THESE PRESENTS, that each person whose
signature appears below constitutes and appoints Elazar Rabbani, with the power
of substitution, his or her attorney-in-fact, to sign any amendments to this
Registration Statement and to file the same, with exhibits thereto and other
documents in connection therewith, with the Securities and Exchange Commission,
hereby ratifying and confirming all that said attorney-in-fact, or his or her
substitute, may do or choose to be done by virtue hereof.

                  Pursuant to the requirements of the Securities Act of 1933, as
amended, this registration statement has been signed below by the following
persons in the capacities and on the dates indicated:



       Signature                          Title                          Date
       ---------                          -----                          ----
                                                            
/s/ ELAZAR RABBANI, PH.D.    Chairman of the Board and Chief      September 14, 1999
- -------------------------    Executive Officer (principal
Elazar Rabbani               executive officer)


/s/ SHAHRAM K. RABBANI       Chief Operating Officer, Treasurer,  September 14, 1999
- -------------------------    Secretary and Director (principal
Shahram K. Rabbani           financial and accounting officer)


/s/ BARRY W. WEINER          President and Director               September 14, 1999
- -------------------------
Barry W. Weiner


/s/ JOHN J. DELUCCA          Director                             September 14, 1999
- -------------------------
John J. Delucca


/s/ JOHN B. SIAS             Director                             September 14, 1999
- -------------------------
John B. Sias



                                        6


                                  EXHIBIT INDEX

No.   Description
- ---   -----------

4.1   Enzo Biochem, Inc. 1999 Stock Option Plan.

5.1   Opinion of Morrison Cohen Singer & Weinstein, LLP.

23.1  Consent of Morrison Cohen Singer & Weinstein, LLP (included in its Opinion
      filed as Exhibit 5 hereto).

23.2  Consent of Ernst & Young, LLP

24.1  Powers of Attorney (included on the signature page of this Registration
      Statement).


                                        7