Exhibit 3.1

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                          BIOMARIN PHARMACEUTICAL INC.


     BioMarin  Pharmaceutical  Inc., a corporation  organized and existing under
the laws of the State of Delaware, hereby certifies as follows:

     A.    The name  of  the  Corporation is  BioMarin P harmaceutical Inc.  The
Corporation  was  originally  incorporated  under the same name and the original
Certificate  of  Incorporation  of the  Corporation  was filed with the Delaware
Secretary  of State on October 25,  1996,  and  subsequently  restated on May 6,
1997. An Amended and Restated  Certificate of  Incorporation  was filed with the
Delaware Secretary of State on March 22, 1999, and was subsequently corrected on
April 21, 1999.

     B.    Pursuant  to Sections  242 and 245 of the  General Corporation Law of
the State of Delaware,  this Amended and Restated  Certificate of  Incorporation
restates and amends the  provisions of the Amended and Restated  Certificate  of
Incorporation  of this  Corporation  previously  filed on  March  22,  1999,  as
corrected.

     C.    The  text of the  Amended and Restated  Certificate of  Incorporation
previously filed on March 22, 1999, as corrected, is hereby amended and restated
in its entirety to read as follows:

                                   ARTICLE I.

     The name of the corporation (the "Corporation") is BioMarin  Pharmaceutical
Inc.

                                   ARTICLE II.

     The address of the Corporation's registered office in the State of Delaware
is Corporation Trust Center, 1209 Orange Street,  City of Wilmington,  County of
New Castle,  Delaware 19801. The name of its registered agent at such address is
The Corporation Trust Company.

                                  ARTICLE III.

     The purpose of the  Corporation  is to engage in any lawful act or activity
for which a corporation  may be organized  under the General  Corporation law of
Delaware.


                                   ARTICLE IV.

     The  Corporation  is  authorized  to  issue  two  classes  of  stock  to be
designated, respectively, as "Common Stock" and "Preferred Stock." The number of
shares of Common Stock which the  Corporation  is authorized to issue is Seventy
Five  Million  (75,000,000)  shares,  par value  $0.001 per share  (the  "Common
Stock").  The  number of shares of  Preferred  Stock  which the  Corporation  is
authorized  to issue is one million  (1,000,000)  shares,  par value  $0.001 per
share (the "Preferred Stock").



     Shares  of  Common  Stock  may  be  issued  from  time  to  time  for  such
consideration  as the Board of Directors may determine  pursuant to a resolution
or  resolutions  providing for such issue duly adopted by the Board of Directors
(authority  to do so being  hereby  expressly  vested in the  Board).  Shares of
Preferred  Stock may be issued from time to time in one or more series  pursuant
to a  resolution  or  resolutions  providing  for such issue duly adopted by the
Board of  Directors  (authority  to do so being hereby  expressly  vested in the
Board).  The Board of Directors is further  authorized to determine or alter the
rights, preferences,  privileges and restrictions granted to or imposed upon any
wholly unissued series of Preferred Stock and to fix the number of shares of any
series of Preferred  Stock and the  designation  of any such series of Preferred
Stock. The Board of Directors,  within the limits and restrictions stated in any
resolution or resolutions of the Board of Directors originally fixing the number
of shares  constituting any series,  may increase or decrease (but not below the
number of shares in any such  series then  outstanding)  the number of shares of
any series subsequent to the issue of shares of that series.

     The Corporation  shall from time to time in accordance with the laws of the
State of Delaware  increase the authorized  amount of its Common Stock if at any
time the number of shares of Common Stock  remaining  unissued and available for
issuance shall not be sufficient to permit conversion of the Preferred Stock.

     Except as otherwise  required by law or herein, the holder of each share of
Common  Stock  issued and  outstanding  shall have one vote with respect to such
share and the holder of each share of  Preferred  Stock shall be  entitled  with
respect  to such  share to a number  of votes  equal to the  number of shares of
Common Stock into which such share of Preferred  Stock could be converted at the
record  date for  determination  of the  stockholders  entitled  to vote on such
matters,  or, if no such  record date is  established,  at the date such vote is
taken or any written  consent of  stockholders  is  solicited,  such votes to be
counted  together with all other shares of stock of the Company  having  general
voting power and not  separately  as a class  (except as required by the General
Corporation Law of Delaware).  Holders of Common Stock and Preferred Stock shall
be entitled to notice of any stockholders' meeting in accordance with the Bylaws
of the  Corporation.  Fractional  votes by the holders of Preferred  Stock shall
not,  however,  be  permitted  and any  fractional  voting  rights  shall (after
aggregating  all shares into which shares of Preferred Stock held by each holder
could be converted) be rounded to the nearest whole number.

                                   ARTICLE V.

     The Corporation  reserves the right to amend, alter,  change, or repeal any
provisions contained in this Certificate of Incorporation,  in the manner now or
hereafter  prescribed by statute, and all rights conferred upon the stockholders
herein are granted subject to this right.



                                   ARTICLE VI.

     The Corporation is to have perpetual existence.

                                  ARTICLE VII.

     1.    Limitation of  Liability.  To  the  fullest extent  permitted by  the
General  Corporation  Law of the State of  Delaware as the same exists or as may
hereafter  be amended,  a director of the  Corporation  shall not be  personally
liable to the Corporation or its stockholders for monetary damages for breach of
fiduciary duty as a director.

     2.    Indemnification.  The  Corporation  shall  indemnify  to the  fullest
extent  permitted by law any person made or  threatened to be made a party to an
action or proceeding,  whether criminal, civil, administrative or investigative,
by reason of the fact that such person or his or her testator or intestate is or
was a director,  officer or employee of the  Corporation,  or any predecessor of
the  Corporation,  or serves or served at any other  enterprise  as a  director,
officer or employee at the request of the  Corporation or any predecessor to the
Corporation.

     3.    Amendments.  Neither any  amendment nor  repeal of  this Article VII,
nor the  adoption of any  provision  of the  Corporation's  Amended and Restated
Certificate of Incorporation inconsistent with this Article VII, shall eliminate
or reduce the effect of this Article VII, in respect of any matter occurring, or
any action or proceeding  accruing or arising or that, but for this Article VII,
would  accrue or arise,  prior to such  amendment,  repeal,  or  adoption  of an
inconsistent provision.

                                  ARTICLE VIII.

     Elections of Directors  need not be by written  ballot unless the Bylaws of
the Corporation shall at the time of any such election so provide.

                                   ARTICLE IX.

     In  furtherance  and not in limitation of the powers  conferred by statute,
the Board of Directors is expressly  authorized to make, alter,  amend or repeal
the Bylaws of the Corporation.


                                   ARTICLE X.

     Following the date of the final  prospectus in connection  with the initial
public offering of the Corporation's  Common Stock pursuant to a firm commitment
underwriting,  no action shall be taken by the  stockholders  of the Corporation
except at an annual  meeting  of the  stockholders  or  special  meeting  of the
stockholders called, in accordance with the Bylaws, by the Chairman of the Board
of Directors or by a majority of the then-current directors, and no action shall
be taken  by the  stockholders  by  written  consent.  The  affirmative  vote of
sixty-six and  two-thirds  percent (66 2/3%) of the then issued and  outstanding
voting securities of the Corporation,  voting together as a single class,  shall
be required to amend,  repeal or modify the provisions of this Article X of this
Amended and  Restated  Certificate  of  Incorporation  or Sections  2.3 (Special
Meeting),  or 2.10 (Stockholder  Action by Written Consent Without a Meeting) of
the Corporation's Bylaws.



                                   ARTICLE XI.

     Meetings  of  stockholders  may be held  within  or  without  the  State of
Delaware,  as the Bylaws may provide.  The books of the  Corporation may be kept
(subject to any  provision  contained in the  statutes)  outside of the State of
Delaware at such place or places as may be  designated  from time to time by the
Board of Directors or in the Bylaws of the Corporation.

                                  ARTICLE XII.

     The name and mailing address of the incorporator are:

                          Wilson Sonsini Goodrich & Rosati
                          650 Page Mill Road
                          Palo Alto, California 94304-1050
                          Attn:  Francis S. Currie, Esq.

     D.    The  Amended  and  Restated  Certificate  of Incorporation  set forth
herein  has been duly  approved  by the Board of  Directors  of the  Corporation
pursuant to Section 242 of the Delaware  General  Corporation  Law. This Amended
and Restated Certificate of Incorporation has been duly approved by the required
vote of  stockholders  in  accordance  with Sections 228 and 242 of the Delaware
General Corporation Law. The number of shares of Common Stock voting in favor of
the  amendment  and  restatement  equaled or  exceeded  the vote  required.  The
percentage vote required was more than 50% of the outstanding Common Stock.

     E.    I  declare under  penalty of  perjury under the  laws of the State of
Delaware  that the  matters  set forth in the  foregoing  Amended  and  Restated
Certificate of Incorporation are true and correct of my own knowledge.

     IN WITNESS  WHEREOF,  the  Corporation  has caused this  certificate  to be
signed by John C. Klock,  its  President and  Secretary,  this 22nd day of July,
1999.


                                       /s/ John C. Klock
                                       ------------------
                                          John C. Klock, President and Secretary







                           CERTIFICATE OF DESIGNATION

                                       OF

               SERIES A NON-VOTING NON-CONVERTIBLE PREFERRED STOCK

                                       OF

                          BIOMARIN PHARMACEUTICAL INC.

    (Pursuant to Section 151 of the General Corporation Law of the State of
                                   Delaware)

     The undersigned,  Louis Drapeau,  the Secretary of BioMarin  Pharmaceutical
Inc., a corporation  organized  and existing  under and by virtue of the General
Corporation  Law of the  State of  Delaware  (the  "Corporation"),  does  hereby
certify,  in the name of and on behalf of the Corporation,  and as its corporate
act, that in accordance with the Corporation's Bylaws, the Board of Directors of
the Corporation  has adopted the following  preamble and resolution at a meeting
of the Board of Directors held on August 13, 2002:

     WHEREAS,  the Amended and  Restated  Certificate  of  Incorporation  of the
Corporation  as filed with the  Secretary  of State of the State of  Delaware on
March 22, 1999  provides  for a class of shares of stock  designated  "Preferred
Stock," issuable from time to time in one or more series, and vests in the Board
of Directors of the  Corporation the authority to fix the  designations  and the
powers,   preferences  and  rights,  and  the  qualifications,   limitations  or
restrictions  thereof,  and to fix the  number of shares  constituting  any such
series.

     NOW,  THEREFORE,  BE IT RESOLVED  that there shall be a series of Preferred
Stock of the  Corporation  to be  designated  as  follows  and that the  powers,
preferences and relative, participating,  optional or other rights of the shares
of such  series of  Preferred  Stock  and the  qualifications,  limitations  and
restrictions thereof shall be as follows:

     Section 1.   Designation.  There  is hereby  provided a series of Preferred
Stock designated  the Series A  Non-Voting Non-Convertible  Preferred Stock (the
"Series A Preferred Stock").

     Section 2.   Number.  The  number  of  shares  constituting  the  Series  A
Preferred Stock is  fixed at one hundred  thirteen and  six hundred  seventy-six
thousandth (113.676) shares.

     Section 3.   Definitions.  For purposes of this Certificate  of Designation
the following definition shall apply:



            (a)    "Board" shall mean the Board of Directors of the Corporation.

            (b)    "Common Stock" shall mean  the Common Stock, $0.001 par value
per share, of this Corporation.

            (c)    "Corporation" shall mean BioMarin Pharmaceutical Inc.

            (d)    "Original Issue Date" shall mean the date this Certificate of
Designation is filed with the Secretary of State of the State of Delaware.

            (e)    "Original Issue Price" shall mean $425,000  per share of  the
Series A Preferred Stock.

            (f)    "Redemption Date" shall have the meaning set forth in Section
 8(b).

            (g)    "Redemption Notice"  shall  have  the  meaning  set  forth in
Section 8(b).

            (h)    "Series A Liquidation Preference"  shall have the meaning set
forth in Section 5(a).

     Section 4.   Dividends. The holders of  shares of Series A  Preferred Stock
shall be  entitled to receive,  when and as  declared at the  discretion  of the
Board, out of funds legally available for that purpose,  noncumulative dividends
payable at a per annum rate of five percent (5%) of the Original  Issue Price on
each share of Series A Preferred  Stock  outstanding  (as adjusted for any stock
dividends,  combinations, splits, recapitalizations and the like with respect to
such shares). Dividends on the Series A Preferred Stock shall not be cumulative,
and no rights shall accrue to the holders of the Series A Preferred Stock in the
event that the Corporation shall not declare dividends on the Series A Preferred
Stock.

     Section 5.   Liquidation, Dissolution or Winding Up.

                  (a) In the event of a Liquidation Event (as defined in Section
5(c)) of the  Corporation,  the holders of the Series A Preferred Stock shall be
entitled to receive,  prior and in preference to any  distribution of any of the
assets or surplus funds of the  Corporation  to the holders of the Common Stock,
an amount per share  equal to the  Original  Issue Price and,  in  addition,  an
amount  equal to all  declared  but unpaid  dividends  on the Series A Preferred
Stock (the  "Series A  Liquidation  Preference").  If the assets and funds to be
distributed  among the holders of the Series A Preferred Stock are  insufficient
to permit  payment to the holders of the Series A Preferred  Stock of their full
preferential  amounts,  then the  assets  and funds of the  Corporation  legally
available for  distribution  shall be  distributed  ratably in proportion to the
full preferential amounts each Series A Preferred Stock holder would be entitled
to receive. After payment of the full amount of the liquidating  distribution to
which any  holder of  Series A  Preferred  Stock is  entitled  pursuant  to this
Section  5(a),  the holder of such share or shares  shall not be entitled to any
further participation in any distribution of assets of the Corporation.



                  (b) After payment has been made to the holders of the Series A
Preferred  Stock,  the  remaining  assets  of  the  Corporation   available  for
distribution to the stockholders  shall be distributed  among the holders of the
Common Stock pro rata based on the number of shares of Common Stock held by each
such holder.

                  (c) For purposes  of Section 5(a),  a Liquidation  Event shall
mean a voluntary or  involuntary  liquidation,  dissolution or winding up of the
Corporation.

                  (d) The  dollar  amounts specified  in Section  5(a) shall  be
equitably  adjusted in the event of any stock dividends,  combinations,  splits,
recapitalizations  and the like with respect to the Common Stock or the Series A
Preferred Stock after the filing of this Certificate of Designation.

                  (e) Insofar  as  any  distribution  pursuant to  Section  5(a)
consists of property other than cash,  the value thereof shall,  for purposes of
the  provisions  of  Section  5(a),  be the  fair  value  at the  time  of  such
distribution,  as determined  in good faith by the Board,  and provided that any
securities shall be valued as follows:

                         (i)    Securities not  subject to  investment letter or
other similar restrictions on free marketability covered by (ii) below:

                                (1)   If  traded on  a  securities  exchange  or
through the Nasdaq National Market,  the value shall be deemed to be the average
of the closing prices of the securities on such quotation system over the thirty
(30) day period ending three (3) days prior to the date of distribution;

                                (2)   If actively traded  over-the-counter,  the
value  shall be deemed  to be the  average  of the  closing  bid or sale  prices
(whichever is applicable)  over the thirty (30) day period ending three (3) days
prior to the date of distribution; and

                                (3)   If there is  no active  public market, the
value shall be the fair market value thereof, as determined in good faith by the
Board.

                         (ii)   The method of valuation of securities subject to
investment  letter  or other  restrictions  on free  marketability  (other  than
restrictions  arising solely by virtue of a stockholder's status as an affiliate
or former  affiliate)  shall be to make an appropriate  discount from the market
value determined as above in (i) (1), (2) or (3) to reflect the approximate fair
market value thereof, as determined in good faith by the Board.



     Section 6.   Voting.  Except as required by applicable law, the holders  of
the Series A Preferred  Stock shall not be entitled as such to receive notice of
or to attend any meeting of the  stockholders  of the  Corporation or to vote at
any such meeting.

     Section 7.   Conversion.  The shares  of Series A Preferred Stock shall not
be  convertible  into  shares of Common  Stock or any  other  securities  of the
Corporation.

     Section 8.   Redemption.


                  (a) Redemption and  Redemption Price.  At any time  after  the
Original Issue Date either (i) the  Corporation  may, at its option,  redeem the
Series  A  Preferred  Stock,  in  whole  or in  part,  at the  Redemption  Price
hereinafter  specified;  or (ii) any holder of the shares of Series A  Preferred
Stock  may,  at its  option,  require  the  Corporation  to redeem  the Series A
Preferred  Stock,  in whole or in part,  owned by such holder at the  Redemption
Price;  provided,  however, that the Corporation shall not redeem or be required
to  redeem  any  shares  of  Series  A  Preferred  Stock or give  notice  of any
redemption  unless the Corporation has sufficient and lawful funds to redeem the
shares to be  redeemed.  The  redemption  price of the Series A Preferred  Stock
shall be an amount per share equal to the Original  Issue Price plus all accrued
and unpaid  dividends  thereon,  up to and  including the  Redemption  Date (the
"Redemption  Price"). The Redemption Price may be paid in cash, by delivery of a
promissory note in the principal amount of the Redemption  Price, by transfer of
property having a fair market value equal to the Redemption Price (as determined
in good faith by the Board of Directors of the Corporation),  or any combination
of the foregoing.

                  (b) Redemption Notice.  The  Corporation shall, not  less than
thirty (30) days nor more than sixty (60) days prior to the date of  redemption,
give written  notice to each holder of record of Series A Preferred  Stock to be
redeemed.  A holder of Series A Preferred Stock shall, not less than thirty (30)
days nor more than sixty (60) days prior to the date of redemption, give written
notice to the  Corporation of the shares of Series A Preferred Stock required to
be redeemed.  For purposes of this  Certificate  of  Designation,  the date upon
which the  Corporation or a holder of Series A Preferred  Stock, as the case may
be, desires the redemption to take effect,  shall be the "Redemption  Date," and
the written notice given by the Corporation to each holder of Series A Preferred
Stock or by a holder of Series A Preferred Stock to the Corporation, as the case
may be, in connection with such  redemption,  shall be the "Redemption  Notice."
The Redemption Notice shall state:

                         (i) The total  number of  shares being redeemed  by the
         Corporation or  required by a holder of Series A  Preferred Stock to be
         redeemed, as applicable;



                         (ii) In the case of  a Redemption  Notice given  by the
         Corporation, the  number of shares of  Series A Preferred Stock held by
         the holder which the Corporation intends to redeem;

                         (iii) The Redemption Date and Redemption Price; and

                         (iv) In the  case of a  Redemption Notice given  by the
         Corporation, the  time, place  and  manner in  which the  holder is  to
         surrender   to   the  Corporation   the  certificate   or  certificates
         representing  the  shares  of  Series  A  Preferred  Stock  called  for
         redemption   by  the  Corporation.  Promptly  following  receipt  of  a
         Redemption  Notice given  by a  holder of Series A Preferred Stock, the
         Corporation  shall notify such holder  of the time, place and manner in
         which the holder is to surrender  to the Corporation the certificate or
         certificates  representing  the  shares  of  Series  A Preferred  Stock
         required to be redeemed.

                  (c) Payment of Redemption Price and Surrender of Stock. On the
Redemption Date, the Redemption Price of the Series A Preferred Stock called for
redemption by the  Corporation or required by the holder thereof to be redeemed,
as the case may be, shall be payable to the  holder(s) of the Series A Preferred
Stock being so redeemed. On or before the Redemption Date, each holder of Series
A Preferred  Stock to be redeemed by the  Corporation  or required by the holder
thereof to be redeemed,  as the case may be, shall  surrender the certificate or
certificates  representing such shares to the Corporation,  in the manner and at
the place  designated in the Redemption  Notice (given by the Corporation) or in
the notice of the Corporation described in Section 8(b)(iv) above, and thereupon
the Redemption Price for such shares shall be payable to the order of the person
whose name appears on such certificate or certificates as the owner thereof, and
each surrendered certificate shall be cancelled and retired.

                  (d) Termination of Rights.  If the  Redemption Notice  is duly
given, and if at least ten (10) days prior to the Redemption Date the Redemption
Price is either  paid or made  available  for payment  through  the  arrangement
specified in subsection (e) below,  then  notwithstanding  that the certificates
evidencing  any of the  shares  of  Series  A  Preferred  Stock  so  called  for
redemption by the Corporation or required by a holder thereof to be redeemed, as
the case may be,  have not been  surrendered,  all rights  with  respect to such
shares shall forthwith after the Redemption Date cease, except only the right of
the holders to receive the Redemption  Price without  interest upon surrender of
their certificates therefor.



                  (e) Deposit of Funds.  At  least  ten (10) days  prior to  the
Redemption  Date,  the  Corporation  may, but shall not be obligated to, deposit
with any bank or trust company in San  Francisco,  California,  having a capital
and surplus of at least $1 billion as a trust fund, a sum equal to the aggregate
Redemption  Price of all  shares of the  Series A  Preferred  Stock  called  for
redemption by the Corporation or required by a holder thereof to be redeemed, as
the  case  may be,  and not yet  redeemed,  with  irrevocable  instructions  and
authority to the bank or trust company to pay, on or after the  Redemption  Date
or prior  thereto,  the  Redemption  Price to the  respective  holders  upon the
surrender of their share  certificates.  The deposit,  if made, shall constitute
full payment of the shares to their holders, and from and after the date of such
deposit (even if prior to the Redemption Date), the shares shall be deemed to be
redeemed and no longer  outstanding,  and the holders  thereof shall cease to be
shareholders  with  respect to such shares and shall have no rights with respect
thereto,  except the right to receive from the bank or trust company  payment of
the Redemption Price of the shares,  without  interest,  upon surrender of their
certificates  therefor.  Any monies so deposited and unclaimed at the end of one
(1)  year  from  the  Redemption  Date  (or  earlier  at  the  election  of  the
Corporation)  shall be  released or repaid to the  Corporation,  after which the
holders of shares  called for  redemption  by the  Corporation  or required by a
holder thereof to be redeemed,  as the case may be, shall be entitled to receive
payment of the Redemption Price only from the Corporation.

     Section 9.   No  Re-issuance  of  Preferred Stock. No  shares  of Series  A
Preferred  Stock  redeemed,  purchased or acquired by the  Corporation  shall be
reissued,  and all such shares shall be canceled and eliminated  from the shares
the Corporation shall be authorized to issue.

     Section 10.   Amendment, Supplement and Waiver.  Without the consent of any
holder or holders of the Series A Preferred  Stock, the Corporation may amend or
supplement  this  Certificate of Designation to make any change that would grant
any additional rights or benefits to the holders of the Series A Preferred Stock
or that does not affect the legal rights under this  Certificate  of Designation
of any such holder.





     IN  WITNESS  WHEREOF,  the  Corporation  has  caused  this  Certificate  of
Designation to be executed by the below named officer of the Corporation.

Dated:  August 23, 2002


                                                BIOMARIN PHARMACEUTICAL INC.,
                                                a Delaware corporation

                                                By: /s/ Louis Drapeau
                                                   ------------------------
                                                Name: Louis Drapeau
                                                Title: Secretary







                          BIOMARIN PHARMACEUTICAL INC.

               Certificate Of Designation, Preferences And Rights

                                       of

                  Series B Junior Participating Preferred Stock

                                       of

                          BioMarin Pharmaceutical Inc.

                          ----------------------------

     The   undersigned   officer   of   BioMarin    Pharmaceutical   Inc.   (the
"Corporation"),  a corporation organized and existing under the Delaware General
Corporation  Law  (the  "DGCL"),  does  hereby  certify  that,  pursuant  to the
authority  conferred upon the Board of Directors of the Corporation  (the "Board
of  Directors")  by  Article  IV of the  Amended  and  Restated  Certificate  of
Incorporation of the Corporation (the "Certificate of Incorporation"), the Board
of Directors on September 11, 2002 adopted the following  resolution  creating a
series  of  750,000  shares of  preferred  stock  designated  as Series B Junior
Participating Preferred Stock:

     RESOLVED,  that pursuant to the authority  vested in the Board of Directors
by Article IV of the Certificate of Incorporation  of the Corporation,  a series
of preferred stock of the  Corporation  be, and it hereby is, created,  and that
the  designation  and amount  thereof  and the voting  powers,  preferences  and
relative, participating, optional and other special rights of the shares of such
series,  and the  qualifications,  limitations  or  restrictions  thereof are as
follows:

                  SERIES B JUNIOR PARTICIPATING PREFERRED STOCK

     Section 1.  Designation  and  Amount.  The shares of such  series  shall be
designated as Series B Junior Participating Preferred Stock, $.001 par value per
share (the "Series B Preferred  Stock"),  and the number of shares  constituting
the Series B Preferred Stock shall be  seven-hundred  fifty thousand  (750,000).
Such number of shares may be increased or decreased by  resolution  of the Board
of Directors;  provided,  that no decrease  shall reduce the number of shares of
Series B  Preferred  Stock to a number  less  than the  number  of  shares  then
outstanding plus the number of shares reserved for issuance upon the exercise of
outstanding  options,   rights  or  warrants  or  upon  the  conversion  of  any
outstanding  securities  issued by the  Corporation  convertible  into  Series B
Preferred Stock.



     Section 2.        Dividends and Distributions.

     (A)   Subject to the prior and superior rights of the holders of any shares
of any class or series of stock of this  Corporation  ranking prior and superior
to the Series B Preferred Stock with respect to dividends, the holders of shares
of Series B Preferred  Stock, in preference to the holders of Common Stock,  par
value $.001 per share (the "Common Stock"), of the Corporation, and of any other
stock  ranking  junior to the Series B  Preferred  Stock,  shall be  entitled to
receive,  when,  as and if  authorized  by the Board of  Directors  out of funds
legally  available for the purpose,  quarterly  dividends payable in cash on the
fifteenth day of January,  April,  July and October of each year (each such date
being referred to herein as a "Quarterly Dividend Payment Date"),  commencing on
the first Quarterly Dividend Payment Date after the first issuance of a share or
fraction of a share of Series B Preferred Stock, in an amount per share (rounded
to the nearest cent) equal to the greater of (a) $0.01 or (b) an amount, subject
to the provision for adjustment  hereinafter  set forth,  equal to 100 times the
aggregate  per share amount of all cash  dividends,  and 100 times the aggregate
per  share  amount  (payable  in  kind)  of  all  non-cash  dividends  or  other
distributions,  other  than a dividend  payable  in shares of Common  Stock or a
subdivision of the outstanding  shares of Common Stock (by  reclassification  or
otherwise),  declared  on the  Common  Stock  since  the  immediately  preceding
Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend
Payment  Date,  since the first  issuance of any share or fraction of a share of
Series B Preferred Stock. In the event the Corporation shall at any time declare
or pay any dividend on the Common Stock  payable in shares of Common  Stock,  or
effect a subdivision,  combination or consolidation of the outstanding shares of
Common Stock (by  reclassification or otherwise than by payment of a dividend in
shares of Common  Stock)  into a  greater  or lesser  number of shares of Common
Stock,  then in each such case the amount to which holders of shares of Series B
Preferred Stock were entitled  immediately  prior to such event under clause (b)
of the  preceding  sentence  shall be adjusted by  multiplying  such amount by a
fraction,  the  numerator  of which is the  number of  shares  of  Common  Stock
outstanding  immediately  after such event and the  denominator  of which is the
number of shares of Common Stock that were outstanding immediately prior to such
event.

     (B)   The Corporation  shall  declare a  dividend or  distribution  on  the
Series  B  Preferred  Stock as  provided  in  paragraph  (A) of this  Section  2
immediately  after it declares a dividend or  distribution  on the Common  Stock
(other than a dividend payable in shares of Common Stock); provided that, in the
event no dividend or  distribution  shall have been declared on the Common Stock
during the period  between  any  Quarterly  Dividend  Payment  Date and the next
subsequent Quarterly Dividend Payment Date, a dividend of $0.01 per share on the
Series B  Preferred  Stock  shall  nevertheless  be payable  on such  subsequent
Quarterly Dividend Payment Date.

     (C)   Dividends shall  begin  to accrue  and be  cumulative on  outstanding
shares of Series B Preferred Stock from the Quarterly Dividend Payment Date next
preceding  the date of issue of such  shares,  unless  the date of issue of such
shares is prior to the  record  date for the first  Quarterly  Dividend  Payment
Date, in which case dividends on such shares shall begin to accrue from the date
of issue of such  shares,  or unless the date of issue is a  Quarterly  Dividend
Payment Date or is a date after the record date for the determination of holders
of shares of Series B Preferred  Stock entitled to receive a quarterly  dividend
and before such Quarterly  Dividend Payment Date, in either of which events such
dividends



shall begin to accrue and be cumulative  from such  Quarterly  Dividend  Payment
Date.  Accrued but unpaid  dividends shall not bear interest.  Dividends paid on
the shares of Series B Preferred  Stock in an amount less than the total  amount
of such  dividends  at the time  accrued  and  payable on such  shares  shall be
allocated pro rata on a  share-by-share  basis among all such shares at the time
outstanding.  The Board of Directors may fix a record date for the determination
of holders of shares of Series B Preferred  Stock entitled to receive payment of
a dividend or distribution declared thereon, which record date shall be not more
than 60 days prior to the date fixed for the payment thereof.

     (D)   In determining  whether a distribution  (other than upon voluntary or
involuntary liquidation), by dividend, redemption or other acquisition of shares
of stock of the Corporation or otherwise,  is permitted under the DGCL,  amounts
that would be needed, if the Corporation were to be dissolved at the time of the
distribution,  to satisfy the preferential rights upon dissolution of holders of
the  Series B  Preferred  Stock  shall not be added to the  Corporation's  total
liabilities.

     Section 3.       Voting Rights. The holders of shares of Series B Preferred
 Stock shall have the following voting rights:

     (A)   Subject to  the provision for  adjustment hereinafter set forth, each
share of Series B Preferred  Stock shall entitle the holder thereof to 100 votes
on all matters  submitted to a vote of the holders of Common Stock. In the event
the  Corporation  shall at any time  declare or pay any  dividend  on the Common
Stock payable in shares of Common Stock, or effect a subdivision, combination or
consolidation of the outstanding shares of Common Stock (by  reclassification or
otherwise  than by  payment  of a  dividend  in shares of Common  Stock)  into a
greater or lesser number of shares of Common  Stock,  then in each such case the
number of votes per share to which holders of shares of Series B Preferred Stock
were entitled  immediately  prior to such event shall be adjusted by multiplying
such number by a  fraction,  the  numerator  of which is the number of shares of
Common Stock  outstanding  immediately  after such event and the  denominator of
which is the number of shares of Common Stock that were outstanding  immediately
prior to such event.

     (B)   Except   as  otherwise   provided  herein,  in   the  Certificate  of
Incorporation,  or in any other  Certificate  of  Designation,  Preferences  and
Rights creating a series of Preferred Stock or any similar stock, the holders of
shares of Series B Preferred Stock and the holders of shares of Common Stock and
any other shares of stock of the Corporation  having general voting rights shall
vote together as one class on all matters submitted to a vote of stockholders of
the Corporation.

     (C)   Except as set forth herein, or as otherwise provided by  law, holders
of Series B  Preferred  Stock  shall  have no  special  voting  rights and their
consent  shall not be required  (except to the extent they are  entitled to vote
with  holders of Common  Stock as set forth  herein)  for  taking any  corporate
action.



     Section 4.        Certain Restrictions.


     (A)   Whenever  quarterly dividends  or other  dividends  or  distributions
payable on the Series B Preferred Stock as provided in Section 2 are in arrears,
thereafter and until all accrued and unpaid dividends and distributions, whether
or not declared,  on shares of Series B Preferred Stock  outstanding  shall have
been paid in full, the Corporation shall not:

           (i)       declare or pay dividends, or make any other  distributions,
                     on  any  shares  of  stock  ranking  junior  (either as  to
                     dividends or  upon liquidation,  dissolution or winding up)
                     to the Series B Preferred Stock;


           (ii)      declare or  pay dividends, or make any other distributions,
                     on any shares  of stock  ranking on a parity  (either as to
                     dividends or  upon liquidation,  dissolution or winding up)
                     with  the Series B  Preferred Stock, except  dividends paid
                     ratably on the Series B Preferred Stock and all such parity
                     stock  on  which  dividends are  payable or  in arrears  in
                     proportion to the total amounts to which the holders of all
                     such shares are then entitled;

           (iii)     redeem or  purchase or otherwise acquire  for consideration
                     shares of any stock ranking  junior (either as to dividends
                     or  upon  liquidation,  dissolution or  winding up) to  the
                     Series B Preferred Stock, provided that the Corporation may
                     at any time redeem, purchase or otherwise acquire shares of
                     any  such junior  stock in exchange for shares of any stock
                     of the Corporation ranking junior (both as to dividends and
                     upon dissolution, liquidation or winding  up) to the Series
                     B Preferred Stock; or

          (iv)       redeem or purchase or  otherwise acquire  for consideration
                     any shares  of Series B  Preferred Stock, or  any shares of
                     stock  ranking  on a  parity  with the  Series B  Preferred
                     Stock, except in accordance  with a purchase offer made  in
                     writing  or by  publication (as determined  by the Board of
                     Directors) to all holders of such shares upon such terms as
                     the   Board  of  Directors,  after  consideration   of  the
                     respective annual dividend rates and other  relative rights
                     and preferences of the respective series and classes, shall
                     determine in good  faith will result in fair and  equitable
                     treatment among the respective series or classes.

     (B)   The Corporation shall not permit any subsidiary of the Corporation to
purchase  or  otherwise  acquire  for  consideration  any shares of stock of the
Corporation unless the Corporation could, under paragraph (A) of this Section 4,
purchase or otherwise acquire such shares at such time and in such manner.

     Section 5.   Reacquired  Shares. Any  shares of  Series B  Preferred  Stock
purchased  or otherwise  acquired by the  Corporation  in any manner  whatsoever
shall  become  authorized  but  unissued  shares of  Preferred  Stock and may be
reissued as part of a new series of Preferred  Stock  subject to the  conditions
and   restrictions  on  issuance  set  forth  herein,   in  the  Certificate  of
Incorporation,  or in any other  Certificate  of  Designation,  Preferences  and
Rights creating a series of Preferred Stock or any similar stock or as otherwise
required by law.



     Section 6.   Liquidation, Dissolution or Winding Up.

     (A)   Upon any  liquidation, dissolution  or winding up of the Corporation,
voluntary  or  otherwise  no  distribution  shall be made (1) to the  holders of
shares of stock  ranking  junior  (either as to dividends  or upon  liquidation,
dissolution  or  winding  up) to the  Series B  Preferred  Stock  unless,  prior
thereto,  the holders of shares of Series B Preferred  Stock shall have received
an amount per share (the "Series B Liquidation Preference") equal to $10,000 per
share,  plus an amount equal to accrued and unpaid  dividends and  distributions
thereon, whether or not declared, to the date of such payment, provided that the
holders of shares of Series B  Preferred  Stock  shall be entitled to receive an
aggregate amount per share, subject to the provision for adjustment  hereinafter
set forth,  equal to 100 times the aggregate  amount to be distributed per share
to holders of shares of Common  Stock,  or (2) to the holders of shares of stock
ranking on a parity (either as to dividends or upon liquidation,  dissolution or
winding up) with the Series B Preferred Stock, except distributions made ratably
on the Series B Preferred  Stock and all such parity stock in  proportion to the
total  amounts to which the  holders of all such shares are  entitled  upon such
liquidation,  dissolution or winding up. In the event the  Corporation  shall at
any time declare or pay any  dividend on the Common  Stock  payable in shares of
Common Stock,  or effect a  subdivision,  combination  or  consolidation  of the
outstanding  shares of Common Stock (by  reclassification  or otherwise  than by
payment of a dividend in shares of Common Stock) into a greater or lesser number
of shares of Common Stock,  then in each such case the aggregate amount to which
holders of shares of Series B Preferred Stock were entitled immediately prior to
such event under the proviso in clause (1) of the  preceding  sentence  shall be
adjusted by multiplying  such amount by a fraction the numerator of which is the
number of shares of Common Stock  outstanding  immediately  after such event and
the  denominator  of which is the  number of shares  of  Common  Stock  that are
outstanding immediately prior to such event.

     (B)   In the event, however, that there are not sufficient assets available
to  permit  payment  in full of the  Series  B  Liquidation  Preference  and the
liquidation  preferences  of all  other  classes  and  series  of  stock  of the
Corporation,  if any, that rank on a parity with the Series B Preferred Stock in
respect  thereof,  then the  assets  available  for such  distribution  shall be
distributed  ratably  to the  holders of the  Series B  Preferred  Stock and the
holders of such parity  shares in  proportion  to their  respective  liquidation
preferences.

     (C)   Neither the merger  or consolidation  of the Corporation into or with
another  corporation nor the merger or  consolidation  of any other  corporation
into or with the Corporation shall be deemed to be a liquidation, dissolution or
winding up of the Corporation within the meaning of this Section 6.



     Section 7.  Consolidation, Merger, etc. In case the Corporation shall enter
into any  consolidation,  merger,  combination or other transaction in which the
shares  of  Common  Stock are  exchanged  for or  changed  into  other  stock or
securities,  cash and/or any other property, then in any such case each share of
Series B  Preferred  Stock  shall at the same  time be  similarly  exchanged  or
changed  into an amount  per  share,  subject to the  provision  for  adjustment
hereinafter  set  forth,  equal to 100  times  the  aggregate  amount  of stock,
securities,  cash and/or any other property  (payable in kind),  as the case may
be, into which or for which each share of Common Stock is changed or  exchanged.
In the event the  Corporation  shall at any time  declare or pay any dividend on
the Common Stock  payable in shares of Common  Stock,  or effect a  subdivision,
combination  or  consolidation  of the  outstanding  shares of Common  Stock (by
reclassification  or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common  Stock,  then in each
such case the amount set forth in the  preceding  sentence  with  respect to the
exchange  or change of shares of Series B  Preferred  Stock shall be adjusted by
multiplying  such amount by a fraction,  the numerator of which is the number of
shares  of  Common  Stock  outstanding  immediately  after  such  event  and the
denominator  of  which is the  number  of  shares  of  Common  Stock  that  were
outstanding immediately prior to such event.

     Section 8.   No Redemption.  The shares of  Series  B Preferred Stock shall
not be redeemable by the Company.

     Section 9.   Rank. The Series B Preferred Stock shall rank, with respect to
the  payment of  dividends  and the  distribution  of assets  upon  liquidation,
dissolution  or winding up,  junior to the Series A  Non-Voting  Non-Convertible
Preferred  Stock and all other  series of any other  class of the  Corporation's
Preferred  Stock,  except to the extent that any such other series  specifically
provides that it shall rank on a parity with or junior to the Series B Preferred
Stock.

     Section 10.   Amendment. At any time any shares of Series B Preferred Stock
are outstanding,  neither the Certificate of Incorporation  nor this Certificate
of  Designation,  Preferences  and Rights  shall be amended in any manner  which
would  materially  alter or change the powers,  preferences or special rights of
the  Series B  Preferred  Stock,  as set  forth  herein,  so as to  affect  them
adversely  without the affirmative vote of the holders of at least two-thirds of
the  outstanding  shares of Series B Preferred  Stock,  voting  separately  as a
single class.

     Section 11.  Fractional Shares.  Series B  Preferred Stock may be issued in
fractions  of a share that shall  entitle  the  holder,  in  proportion  to such
holder's  fractional  shares,  to exercise  voting  rights,  receive  dividends,
participate  in  distributions  and to have the  benefit of all other  rights of
holders of Series B Preferred Stock.

                    ----------------------------------------



1.       The  shares  of  Series  B Preferred  Stock  have  been  classified and
         designated by  the Board of  Directors under the authority contained in
         the Certificate of Incorporation.

2.       This  Certificate  of  Designation,  Preferences and  Rights  has  been
         approved  by the  Board of  Directors in  the manner  and by  the  vote
         required by law.

3.       The undersigned  officer acknowledges this  Certificate of Designation,
         Preferences  and Rights to be the corporate act of the Corporation and,
         as  to all  matters  of fact  required to be  verified under oath,  the
         undersigned  officer acknowledges  that to the  best of his  knowledge,
         information  and  belief,  these  matters  and facts  are  true  in all
         material respects  and that this statement  is made under the penalties
         for perjury.

         IN WITNESS WHEREOF,  the undersigned has  executed this  Certificate of
Designation, Preferences and Rights on September 11, 2002.



                                      By: /s/ Fredric D. Price
                                         ---------------------------------------
                                         Fredric D. Price
                                         Chairman and Chief Executive Officer of
                                         BioMarin Pharmaceutical Inc.