Exhibit 10.2




                               AMENDMENT NO. 1 TO

                         COMMON STOCK PURCHASE AGREEMENT


     This AMENDMENT NO. 1 to COMMON STOCK PURCHASE  AGREEMENT (the  "Amendment")
is dated as of September 24, 2002 by and between BioMarin Pharmaceutical Inc., a
Delaware  corporation  (the  "Company")  and  Acqua  Wellington  North  American
Equities Fund, Ltd., a limited liability company organized under the laws of the
Commonwealth  of The  Bahamas  (the  "Purchaser")  and is an  amendment  to that
certain  Common  Stock  Purchase  Agreement  dated as of  August  15,  2001 (the
"Agreement") by and between the Company and the Purchaser.

         The parties hereto agree as follows:

                                  Article I.
                            Definitions/Construction

                1.1      Definitions.  Except  as  otherwise  defined  in  this
Amendment, all capitalized terms shall have the meaning ascribed to them in the
Agreement.

                1.2      Scope of Amendment.  To the  extent necessary  to give
effect to the matters set forth in this Amendment, this Amendment shall serve to
amend the Agreement and shall  be considered part  of the Agreement.  Subject to
the  foregoing, the  Agreement shall  remain  in full force  and effect  without
modification.

                1.3      Counterparts.  This  Amendment  may  be  executed  in
counterparts,  all  of  which  together  shall  constitute  one  and  the  same
instrument.

                                   Article II.
                           Amendments to the Agreement

                2.1      Section  7.1  of  the  Agreement  is hereby  amended by
deleting  the section  in its  entirety and  substituting in  lieu thereof   the
following Section 7.1:

                          "7.1 Termination by Mutual Consent.  The term of  this
Agreement shall expire on the earlier of (i) twenty-six (26) consecutive  months
from the date of  execution of this  Agreement, (ii) the  date that  all  of the
shares of Common  Stock registered  under the  Registration Statement  have been
issued and  sold and  (iii) the  date that  the Purchaser  has purchased  in the
aggregate $27,700,000  pursuant to all  Draw Downs and Call Options  granted and
exercised  (the "Investment  Period"). This  Agreement may be  terminated at any
time by mutual written consent of the parties."



                2.2      Address For Notice.  The address for  communications to
the Company, as contemplated by Section 9.4 of the Agreement shall be:

If to the Company:                     BioMarin Pharmaceutical Inc.
                                       371 Bel Marin Keys Boulevard, Suite 210
                                       Novato, California 94949
                                       Tel. No.:  (415) 884-6700
                                       Fax No.:  (415) 382-7427
                                       Attention: Louis Drapeau/ Kim Tsuchimoto

With copies to:                        Paul, Hastings, Janofsky & Walker LLP
                                       515 South Flower Street, 25th Floor
                                       Los Angeles, California 90071-2228
                                       Tel. No.:  (213) 683-6000
                                       Fax No.:  (213) 627-0705
                                       Attention: Siobhan McBreen Burke



















                  IN  WITNESS  WHEREOF, the  parties  hereto  have  caused  this
Amendment to be  duly executed by their  respective authorized officer as of the
date first above written.

                             BIOMARIN PHARMACEUTICAL INC.


                             By: /s/ Fredric D. Price
                                ---------------------
                                Name: Fredric D. Price
                                Title: Chairman and Chief Executive Officer

                             ACQUA WELLINGTON NORTH AMERICAN EQUITIES FUND, LTD.


                             By: /s/ R. Perry Pindser / /s/ Helen A Forb
                                 ---------------------------------------
                                 Name: R. Perry Pindser / Helen A Forb
                                 Title: Vice President / Secretary