Exhibit 3.1

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                          BIOMARIN PHARMACEUTICAL INC.

     BioMarin  Pharmaceutical  Inc., a corporation  organized and existing under
the laws of the State of Delaware, hereby certifies as follows:

         A. The name of the Corporation is BioMarin Pharmaceutical Inc. The
Corporation was originally incorporated under the same name and the original
Certificate of Incorporation of the Corporation was filed with the Delaware
Secretary of State on October 25, 1996, and subsequently restated on May 6,
1997. An Amended and Restated Certificate of Incorporation was filed with the
Delaware Secretary of State on March 22, 1999, and was subsequently corrected on
April 21, 1999.

         B. Pursuant to Sections 242 and 245 of the General Corporation Law of
the State of Delaware, this Amended and Restated Certificate of Incorporation
restates and amends the provisions of the Amended and Restated Certificate of
Incorporation of this Corporation previously filed on March 22, 1999, as
corrected.

         C. The text of the Amended and Restated Certificate of Incorporation
previously filed on March 22, 1999, as corrected, is hereby amended and restated
in its entirety to read as follows:

                                   ARTICLE I.

         The name of the corporation (the "Corporation") is BioMarin
Pharmaceutical Inc.

                                  ARTICLE II.

         The address of the Corporation's registered office in the State of
Delaware is Corporation Trust Center, 1209 Orange Street, City of Wilmington,
County of New Castle, Delaware 19801. The name of its registered agent at such
address is The Corporation Trust Company.

                                  ARTICLE III.

         The purpose of the Corporation is to engage in any lawful act or
activity for which a corporation may be organized under the General Corporation
law of Delaware.

                                  ARTICLE IV.

         The Corporation is authorized to issue two classes of stock to be
designated, respectively, as "Common Stock" and "Preferred Stock." The number of
shares of Common Stock which the Corporation is authorized to issue is Seventy
Five Million (75,000,000) shares, par value $0.001 per share (the "Common
Stock"). The number of shares of Preferred Stock which the Corporation is
authorized to issue is one million (1,000,000) shares, par value $0.001 per
share (the "Preferred Stock").


         Shares of Common Stock may be issued from time to time for such
consideration as the Board of Directors may determine pursuant to a resolution
or resolutions providing for such issue duly adopted by the Board of Directors
(authority to do so being hereby expressly vested in the Board). Shares of
Preferred Stock may be issued from time to time in one or more series pursuant
to a resolution or resolutions providing for such issue duly adopted by the
Board of Directors (authority to do so being hereby expressly vested in the
Board). The Board of Directors is further authorized to determine or alter the
rights, preferences, privileges and restrictions granted to or imposed upon any
wholly unissued series of Preferred Stock and to fix the number of shares of any
series of Preferred Stock and the designation of any such series of Preferred
Stock. The Board of Directors, within the limits and restrictions stated in any
resolution or resolutions of the Board of Directors originally fixing the number
of shares constituting any series, may increase or decrease (but not below the
number of shares in any such series then outstanding) the number of shares of
any series subsequent to the issue of shares of that series.

         The Corporation shall from time to time in accordance with the laws of
the State of Delaware increase the authorized amount of its Common Stock if at
any time the number of shares of Common Stock remaining unissued and available
for issuance shall not be sufficient to permit conversion of the Preferred
Stock.

         Except as otherwise required by law or herein, the holder of each share
of Common Stock issued and outstanding shall have one vote with respect to such
share and the holder of each share of Preferred Stock shall be entitled with
respect to such share to a number of votes equal to the number of shares of
Common Stock into which such share of Preferred Stock could be converted at the
record date for determination of the stockholders entitled to vote on such
matters, or, if no such record date is established, at the date such vote is
taken or any written consent of stockholders is solicited, such votes to be
counted together with all other shares of stock of the Company having general
voting power and not separately as a class (except as required by the General
Corporation Law of Delaware). Holders of Common Stock and Preferred Stack shall
be entitled to notice of any stockholders' meeting in accordance with the Bylaws
of the Corporation. Fractional votes by the holders of Preferred Stock shall
not, however, be permitted and any fractional voting rights shall (after
aggregating all shares into which shares of Preferred Stock held by each holder
could be converted) be rounded to the nearest whole number.

                                   ARTICLE V.

         The Corporation reserves the right to amend, alter, change, or repeal
any provisions contained in this Certificate of Incorporation, in the manner now
or hereafter prescribed by statute, and all rights conferred upon the
stockholders herein are granted subject to this right.

                                  ARTICLE VI.

         The Corporation is to have perpetual existence.


                                  ARTICLE VII.

         1. Limitation of Liability. To the fullest extent permitted by the
General Corporation Law of the State of Delaware as the same exists or as may
hereafter be amended, a director of the Corporation shall not be personally
liable to the Corporation or its stockholders for monetary damages for breach of
fiduciary duty as a director.

         2. Indemnification. The Corporation shall indemnify to the fullest
extent permitted by law any person made or threatened to be made a party to an
action or proceeding, whether criminal, civil, administrative or investigative,
by reason of the fact that such person or his or her testator or intestate is or
was a director, officer or employee of the Corporation, or any predecessor of
the Corporation, or serves or served at any other enterprise as a director,
officer or employee at the request of the Corporation or any predecessor to the
Corporation.

         3. Amendments. Neither any amendment nor repeal of this Article VII,
nor the adoption of any provision of the Corporation's Amended and Restated
Certificate of Incorporation inconsistent with this Article VII, shall eliminate
or reduce the effect of this Article VII, in respect of any matter occurring, or
any action or proceeding accruing or arising or that, but for this Article VII,
would accrue or arise, prior to such amendment, repeal, or adoption of an
inconsistent provision.

                                 ARTICLE VIII.

         Elections of Directors need not be by written ballot unless the Bylaws
of the Corporation shall at the time of any such election so provide.

                                  ARTICLE IX.

         In furtherance and not in limitation of the powers conferred by
statute, the Board of Directors is expressly authorized to make, alter, amend or
repeal the Bylaws of the Corporation.

                                   ARTICLE X.

         Following the date of the final prospectus in connection with the
initial public offering of the Corporation's Common Stock pursuant to a firm
commitment underwriting, no action shall be taken by the stockholders of the
Corporation except at an annual meeting of the stockholders or special meeting
of the stockholders called, in accordance with the Bylaws, by the Chairman of
the Board of Directors or by a majority of the then-current directors, and no
action shall be taken by the stockholders by written consent. The affirmative
vote of sixty-six and two-thirds percent (66 2/3%) of the then issued and
outstanding voting securities of the Corporation, voting together as a single
class, shall be required to amend, repeal or modify the provisions of this
Article X of this Amended and Restated Certificate of Incorporation or Sections
2.3 (Special Meeting), or 2.10 (Stockholder Action by Written Consent Without a
Meeting) of the Corporation's Bylaws.

                                  ARTICLE XI.

         Meetings of stockholders may be held within or without the State of
Delaware, as the Bylaws may provide. The books of the Corporation may be kept
(subject to any provision contained in the statutes) outside of the State of
Delaware at such place or places as may be designated from time to time by the
Board of Directors or in the Bylaws of the Corporation.


                                  ARTICLE XII.

         The name and mailing address of the incorporator are:

                        Wilson Sonsini Goodrich & Rosati
                        650 Page Mill Road
                        Palo Alto, California 94304 1050
                        Attn: Francis S. Currie, Esq.

         D. The Amended and Restated Certificate of Incorporation set forth
herein has been duly approved by the Board of Directors of the Corporation
pursuant to Section 242 of the Delaware General Corporation Law. This Amended
and Restated Certificate of Incorporation has been duly approved by the required
vote of stockholders in accordance with Sections 228 and 242 of the Delaware
General Corporation Law. The number of shares of Common Stock voting in favor of
the amendment and restatement equaled or exceeded the vote required. The
percentage vote required was more than 50% of the outstanding Common Stock

         E. I declare under penalty of perjury under the laws of the State of
Delaware that the matters set forth in the foregoing Amended and Restated
Certificate of Incorporation are true and correct of my own knowledge.

         IN WITNESS WHEREOF, the Corporation has caused this certificate to be
signed by John C. Klock, its President and Secretary, this 22nd day of July,
1999.



                                         /s/ John C. Klock
                                         --------------------------------------
                                         John C. Klock, President and Secretary



                           CERTIFICATE OF DESIGNATION

                                       OF

               SERIES A NON-VOTING NON-CONVERTIBLE PREFERRED STOCK

                                       OF

                           BIOMARIN PHARMACEUTICAL INC

 (Pursuant to Section 151 of the General Corporation Law of the State of
  Delaware)

     The undersigned,  Louis Drapeau,  the Secretary of BioMarin  Pharmaceutical
Inc., a corporation  organized  and existing  under and by virtue of the General
Corporation  Law of the  State of  Delaware  (the  "Corporation"),  does  hereby
certify,  in the name of and on behalf of the Corporation,  and as its corporate
act, that in accordance with the Corporation's Bylaws, the Board of Directors of
the Corporation  has adopted the following  preamble and resolution at a meeting
of the Board of Directors held on August 13, 2002:

     WHEREAS,  the Amended and  Restated  Certificate  of  Incorporation  of the
Corporation  as filed with the  Secretary  of State of the State of  Delaware on
March 22, 1999  provides  for a class of shares of stock  designated  "Preferred
Stock;" issuable from time to time in one or more series, and vests in the Board
of Directors of the  Corporation the authority to fix the  designations  and the
powers,   preferences  and  rights,  and  the  qualifications,   limitations  or
restrictions  thereof,  and to fix the  number of shares  constituting  any such
series.

     NOW,  THEREFORE,  BE IT RESOLVED  that there shall be a series of Preferred
Stock of the  Corporation  to be  designated  as  follows  and that the  powers,
preferences and relative, participating,  optional or other rights of the shares
of such  series of  Preferred  Stock  and the  qualifications,  limitations  and
restrictions thereof shall be as follows:

     Section 1.  Designation.  There is hereby  provided  a series of  Preferred
Stock  designated the Series A Non-Voting  Non-Convertible  Preferred Stock (the
"Series A Preferred Stock").

     Section 2. Number. The number of shares constituting the Series A Preferred
Stock is fixed at one hundred  thirteen and six hundred  seventy-six  thousandth
(113.676) shares.

     Section 3. Definitions. For purposes of this Certificate of Designation the
following definitions shall apply:

       (a)    "Board" shall mean the Board of Directors of the Corporation.


       (b)    "Common Stock" shall mean the Common Stock, $0.001 par value per
              share, of this Corporation.

       (c)    "Corporation" shall mean BioMarin Pharmaceutical Inc.

       (d)    "Original Issue Date" shall mean the date this Certificate of
              Designation is filed with the Secretary of State of the State of
              Delaware.

       (e)    "Original Issue Price" shall mean $425,000 per share of the Series
              A Preferred Stock.

       (f)    "Redemption Date" shall have the meaning set forth in Section
              8(b).

       (g)    "Redemption Notice" shall have the meaning set forth in Section
              8(b).

       (h)    "Series A Liquidation Preference" shall have the meaning set forth
              in Section 5(a).

     Section 4.  Dividends.  The holders of shares of Series A  Preferred  Stock
shall be  entitled to receive,  when and as  declared at the  discretion  of the
Board, out of funds legally available for that purpose,  noncumulative dividends
payable at a per annum rate of five percent (5%) of the Original  Issue Price on
each share of Series A Preferred  Stock  outstanding  (as adjusted for any stock
dividends,  combinations, splits, recapitalizations and the like with respect to
such shares). Dividends on the Series A Preferred Stock shall not be cumulative,
and no rights shall accrue to the holders of the Series A Preferred Stock in the
event that the Corporation shall not declare dividends on the Series A Preferred
Stock.

     Section 5.   Liquidation. Dissolution or Winding Up.

     (a) In the event of a Liquidation Event (as defined in Section 5(c)) of the
Corporation,  the holders of the Series A  Preferred  Stock shall be entitled to
receive,  prior and in  preference to any  distribution  of any of the assets or
surplus funds of the  Corporation to the holders of the Common Stock,  an amount
per share equal to the Original Issue Price and, in addition, an amount equal to
all declared but unpaid dividends on the Series A Preferred Stock (the "Series A
Liquidation  Preference").  If the assets and funds to be distributed  among the
holders of the Series A Preferred  Stock are  insufficient  to permit payment to
the holders of the Series A Preferred Stock of their full preferential  amounts,
then the assets and funds of the Corporation  legally available for distribution
shall be distributed ratably in proportion to the full preferential amounts each
Series A Preferred  Stock holder would be entitled to receive.  After payment of
the full amount of the liquidating  distribution to which any holder of Series A
Preferred  Stock is entitled  pursuant to this Section 5(a),  the holder of such
share or shares  shall  not be  entitled  to any  further  participation  in any
distribution of assets of the Corporation.


     (b) After  payment  has been made to the  holders of the Series A Preferred
Stock, the remaining assets of the Corporation available for distribution to the
stockholders shall be distributed among the holders of the Common Stock pro rata
based on the number of shares of Common Stock held by each such holder.

     (c) For  purposes  of  Section  5(a),  a  Liquidation  Event  shall  mean a
voluntary  or  involuntary  liquidation,   dissolution  or  winding  up  of  the
Corporation.

     (d) The  dollar  amounts  specified  in  Section  5(a)  shall be  equitably
adjusted   in  the  event  of  any  stock   dividends,   combinations,   splits,
recapitalizations  and the like with respect to the Common Stock or the Series A
Preferred Stock after the filing of this Certificate of Designation.

     (e) Insofar  as any  distribution  pursuant  to Section  5(a)  consists  of
property  other  than  cash,  the  value  thereof  shall,  for  purposes  of the
provisions of Section 5(a), be the fair value at the time of such  distribution,
as determined in good faith by the Board, and provided that any securities shall
be valued as follows:

          (i)  Securities not subject to investment letter or other similar
restrictions on free marketability covered by (ii) below:

               (1) If traded on a  securities  exchange  or through  the  Nasdaq
National Market, the value shall be deemed to be the average of the closing
prices of the securities on such quotation system over the thirty (30) day
period ending three (3) days prior to the date of distribution;

               (2) if actively  traded  over-the-counter,  the value shall be
deemed to be the average of the closing bid or sale prices (whichever is
applicable) over the thirty (30) day period ending three (3) days prior to the
date of  distribution; and

               (3) If there is no active public market, the value shall be the
fair market value thereof, as determined in good faith by the Board.

          (ii) The method of valuation of securities  subject to investment
letter or other restrictions on free marketability (other than restrictions
arising solely by virtue of a stockholder's  status as an affiliate or former
affiliate) shall be to make an appropriate discount from the market value
determined as above in (i) (1), (2) or (3) to reflect the  approximate fair
market value thereof, as determined in good faith by the Board.

     Section 6. Voting. Except as required by applicable law, the holders of the
Series A Preferred  Stock shall not be entitled as such to receive  notice of or
to attend any meeting of the  stockholders  of the Corporation or to vote at any
such meeting.


     Section 7. Conversion.  The shares of Series A Preferred Stock shall not be
convertible  into  shares  of  Common  Stock  or  any  other  securities  of the
Corporation.

     Section 8. Redemption.

     (a) Redemption and Redemption  Price.  At any time after the Original Issue
Date  either  (i) the  Corporation  may,  at its  option,  redeem  the  Series A
Preferred  Stock,  in whole  or in part,  at the  Redemption  Price  hereinafter
specified;  or (ii) any holder of the shares of Series A Preferred Stock may, at
its option,  require the Corporation to redeem the Series A Preferred  Stock, in
whole or in part,  owned  by such  holder  at the  Redemption  Price;  provided,
however,  that the  Corporation  shall not redeem or be  required  to redeem any
shares of Series A Preferred  Stock or give notice of any redemption  unless the
Corporation has sufficient and lawful funds to redeem the shares to be redeemed.
The  redemption  price of the Series A  Preferred  Stock  shall be an amount per
share equal to the  Original  Issue Price plus all accrued and unpaid  dividends
thereon, up to and including the Redemption Date (the "Redemption  Price").  The
Redemption  Price may be paid in cash,  by delivery of a promissory  note in the
principal amount of the Redemption  Price, by transfer of property having a fair
market value equal to the  Redemption  Price (as determined in good faith by the
Board of Directors of the Corporation), or any combination of the foregoing.

     (b) Redemption  Notice.  The Corporation  shall,  not less than thirty (30)
days nor more than sixty (60) days prior to the date of redemption, give written
notice to each holder of record of Series A Preferred  Stock to be  redeemed.  A
holder of Series A  Preferred  Stock  shall,  not less than thirty (30) days nor
more than sixty (60) days prior to the date of  redemption,  give written notice
to the  Corporation  of the shares of Series A  Preferred  Stock  required to be
redeemed.  For purposes of this Certificate of Designation,  the date upon which
the  Corporation  or a holder of Series A Preferred  Stock,  as the case may be,
desires the redemption to take effect,  shall be the "Redemption  Date," and the
written  notice  given by the  Corporation  to each holder of Series A Preferred
Stock or by a holder of Series A Preferred Stock to the Corporation, as the case
may be, in connection with such  redemption,  shall be the "Redemption  Notice."
The Redemption Notice shall state:

     (i) The  total  number of  shares  being  redeemed  by the  Corporation  or
required by a holder of Series A Preferred Stock to be redeemed, as applicable;

     (ii) In the  case of a  Redemption  Notice  given by the  Corporation,  the
number of  shares  of Series A  Preferred  Stock  held by the  holder  which the
Corporation intends to redeem;


     (iii) The Redemption Date and Redemption Price; and

     (iv) In the case of a Redemption Notice given by the Corporation, the time,
place and  manner in which the holder is to  surrender  to the  Corporation  the
certificate or certificates  representing the shares of Series A Preferred Stock
called  for  redemption  by the  Corporation.  Promptly  following  receipt of a
Redemption Notice given by a holder of Series A Preferred Stock, the Corporation
shall notify such holder of the time, place and manner in which the holder is to
surrender to the Corporation the  certificate or certificates  representing  the
shares of Series A Preferred Stock required to be redeemed.

     (c) Payment of Redemption  Price and Surrender of Stock.  On the Redemption
Date, the Redemption Price of the Series A Preferred Stock called for redemption
by the Corporation or required by the holder thereof to be redeemed, as the case
may be, shall be payable to the holder(s) of the Series A Preferred  Stock being
so redeemed. On or before the Redemption Date, each holder of Series A Preferred
Stock to be redeemed by the  Corporation or required by the holder thereof to be
redeemed,  as the case may be, shall  surrender the  certificate or certificates
representing  such  shares to the  Corporation,  in the  manner and at the place
designated in the Redemption  Notice (given by the Corporation) or in the notice
of the  Corporation  described in Section  8(b)(iv)  above,  and  thereupon  the
Redemption  Price for such  shares  shall be  payable to the order of the person
whose name appears on such certificate or certificates as the owner thereof, and
each surrendered certificate shall be cancelled and retired.

     (d) Termination of Rights.  If the Redemption  Notice is duly given, and if
at least ten (10) days  prior to the  Redemption  Date the  Redemption  Price is
either paid or made available for payment through the  arrangement  specified in
subsection (e) below, then notwithstanding that the certificates  evidencing any
of the  shares  of Series A  Preferred  Stock so called  for  redemption  by the
Corporation or required by a holder thereof to be redeemed,  as the case may be,
have  not been  surrendered,  all  rights  with  respect  to such  shares  shall
forthwith after the Redemption Date cease,  except only the right of the holders
to receive  the  Redemption  Price  without  interest  upon  surrender  of their
certificates therefor.

     (e) Deposit of Funds. At least ten (10) days prior to the Redemption  Date,
the  Corporation  may, but shall not be obligated  to,  deposit with any bank or
trust company in San Francisco,  California,  having a capital and surplus of at
least $1 billion as a trust fund, a sum equal to the aggregate  Redemption Price
of all shares of the Series A  Preferred  Stock  called  for  redemption  by the
Corporation or required by a holder thereof to be redeemed,  as the case may be,
and not yet redeemed, with irrevocable instructions and authority to the bank or
trust  company to pay, on or after the  Redemption  Date or prior  thereto,  the
Redemption  Price to the  respective  holders upon the  surrender of their share
certificates.  The deposit, if made, shall constitute full payment of the shares
to their holders,  and from and after the date of such deposit (even if prior to
the  Redemption  Date),  the shares shall be deemed to be redeemed and no longer
outstanding, and the holders thereof shall cease to be shareholders with respect
to such shares and shall have no rights with respect  thereto,  except the right
to receive from the bank or trust company payment of the Redemption Price of the
shares,  without interest,  upon surrender of their certificates  therefor.  Any
monies so deposited and unclaimed at the end of one (1) year from the Redemption
Date (or earlier at the election of the Corporation) shall be released or repaid
to the  Corporation,  after which the holders of shares called for redemption by
the Corporation or required by a holder thereof to be redeemed,  as the case may
be, shall be entitled to receive  payment of the Redemption  Price only from the
Corporation.


     Section  9. No Re-issuance  of  Preferred  Stock.  No  shares  of  Series A
Preferred  Stock  redeemed,  purchased or acquired by the  Corporation  shall be
reissued,  and all such shares shall be canceled and eliminated  from the shares
the Corporation shall be authorized to issue.

     Section 10.  Amendment.  Supplement and Waiver.  Without the consent of any
holder or holders of the Series A Preferred  Stock, the Corporation may amend or
supplement  this  Certificate of Designation to make any change that would grant
any additional rights or benefits to the holders of the Series A Preferred Stock
or that does not affect the legal rights under this  Certificate  of Designation
of any such holder.


                            [SIGNATURE PAGE FOLLOWS]




         IN WITNESS WHEREOF, the Corporation has caused this Certificate of
Designation to be executed by the below named officer of the Corporation.

         Dated: August 23, 2002



                                                BIOMARIN PHARMACEUTICAL INC.,
                                                a Delaware corporation

                                                By: /s/ Louis Drapeau
                                                -------------------------------
                                                Name:  Louis Drapeau
                                                Title:  Secretary




                          BIOMARIN PHARMACEUTICAL INC.

               Certificate Of Designation, Preferences And Rights

                                       of

                  Series B Junior Participating Preferred Stock

                                       of

                          BioMarin Pharmaceutical Inc.

                        --------------------------------

                       The undersigned officer of BioMarin Pharmaceutical Inc.
       (the "Corporation"), a corporation organized and existing under the
       Delaware General Corporation Law (the "DGCL"), does hereby certify that,
       pursuant to the authority conferred upon the Board of Directors of the
       Corporation (the "Board of Directors") by Article IV of the Amended and
       Restated Certificate of Incorporation of the Corporation (the
       "Certificate of Incorporation"), the Board of Directors on September 11,
       2002 adopted the following resolution creating a series of 750,000 shares
       of preferred stock designated as Series B Junior Participating Preferred
       Stock:


                       RESOLVED, that pursuant to the authority vested in the
       Board of Directors by Article IV of the Certificate of Incorporation of
       the Corporation, a series of preferred stock of the Corporation be, and
       it hereby is, created, and that the designation and amount thereof and
       the voting powers, preferences and relative, participating, optional and
       other special rights of the shares of such series, and the
       qualifications, limitations or restrictions thereof are as follows:

                  SERIES B JUNIOR PARTICIPATING PREFERRED STOCK

     Section 1.  Designation  and  Amount.  The shares of such  series  shall be
designated as Series B Junior Participating Preferred Stock, $.001 par value per
share (the "Series B Preferred  Stock"),  and the number of shares  constituting
the Series B Preferred Stock shall be  seven-hundred  fifty thousand  (750,000).
Such number of shares may be increased or decreased by  resolution  of the Board
of Directors:  provided,  that no decrease  shall reduce the number of shares of
Series B  Preferred  Stock to a number  less  than the  number  of  shares  then
outstanding plus the number of shares reserved for issuance upon the exercise of
outstanding  options,   rights  or  warrants  or  upon  the  conversion  of  any
outstanding  securities  issued by the  Corporation  convertible  into  Series B
Preferred Stock.


Section 2.        Dividends and Distributions.

     (A) Subject to the prior and  superior  rights of the holders of any shares
of any class or series of stock of this  Corporation  ranking prior and superior
to the Series B Preferred Stock with respect to dividends, the holders of shares
of Series B Preferred  Stock, in preference to the holders of Common Stock,  par
value $.001 per share (the "Common Stock"), of the Corporation, and of any other
stock  ranking  junior to the Series B  Preferred  Stock,  shall be  entitled to
receive,  when,  as and if  authorized  by the Board of  Directors  out of funds
legally  available for the purpose,  quarterly  dividends payable in cash on the
fifteenth day of January,  April,  July and October of each year (each such date
being referred to herein as a "Quarterly Dividend Payment Date'),  commencing on
the first Quarterly Dividend Payment Date after the first issuance of a share or
fraction of a share of Series B Preferred Stock, in an amount per share (rounded
to the nearest cent) equal to the greater of (a) $0.01 or (b) an amount, subject
to the provision for adjustment  hereinafter  set forth,  equal to 100 times the
aggregate  per share amount of all cash  dividends,  and 100 times the aggregate
per  share  amount  (payable  in  kind)  of  all  non-cash  dividends  or  other
distributions,  other  than a dividend  payable  in shares of Common  Stock or a
subdivision of the outstanding  shares of Common Stock (by  reclassification  or
otherwise),  declared  on the  Common  Stock  since  the  immediately  preceding
Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend
Payment  Date,  since the first  issuance of any share or fraction of a share of
Series B Preferred Stock. In the event the Corporation shall at any time declare
or pay any dividend on the Common Stock  payable in shares of Common  Stock,  or
effect a subdivision,  combination or consolidation of the outstanding shares of
Common Stock (by  reclassification or otherwise than by payment of a dividend in
shares of Common  Stock)  into a  greater  or lesser  number of shares of Common
Stock,  then in each such case the amount to which holders of shares of Series B
Preferred Stock were entitled  immediately  prior to such event under clause (b)
of the  preceding  sentence  shall be adjusted by  multiplying  such amount by a
fraction,  the  numerator  of which is the  number of  shares  of  Common  Stock
outstanding  immediately  after such event and the  denominator  of which is the
number of shares of Common Stock that were outstanding immediately prior to such
event.

     (B) The Corporation  shall declare a dividend or distribution on the Series
B Preferred  Stock as provided in paragraph  (A) of this  Section 2  immediately
after it declares a dividend or  distribution  on the Common Stock (other than a
dividend  payable in shares of Common  Stock);  provided  that,  in the event no
dividend or distribution shall have been declared on the Common Stock during the
period  between any  Quarterly  Dividend  Payment  Date and the next  subsequent
Quarterly  Dividend  Payment Date, a dividend of $0.01 per share on the Series B
Preferred  Stock  shall  nevertheless  be payable on such  subsequent  Quarterly
Dividend Payment' Date.

     (C) Dividends shall begin to accrue and be cumulative on outstanding shares
of Series B  Preferred  Stock  from the  Quarterly  Dividend  Payment  Date next
preceding  the date of issue of such  shares,  unless  the date of issue of such
shares is prior to the  record  date for the first  Quarterly  Dividend  Payment
Date, in which case dividends on such shares shall begin to accrue from the date
of issue of such  shares,  or unless the date of issue is a  Quarterly  Dividend
Payment Date or is a date after the record date for the determination of holders
of shares of Series B Preferred  Stock entitled to receive a quarterly  dividend
and before such Quarterly  Dividend Payment Date, in either of which events such
dividends shall begin to accrue and be cumulative  from such Quarterly  Dividend
Payment Date.  Accrued but unpaid  dividends shall not bear interest.  Dividends
paid on the shares of Series B Preferred  Stock in an amount less than the total
amount of such dividends at the time accrued and payable on such shares shall be
allocated pro rata on a  share-by-share  basis among all such shares at the time
outstanding.  The Board of Directors may fix a record date for the determination
of holders of shares of Series B Preferred  Stock entitled to receive payment of
a dividend or distribution declared thereon, which record date shall be not more
than 60 days prior to the date fixed for the payment thereof.


     (D) In  determining  whether a  distribution  (other than upon voluntary or
involuntary liquidation), by dividend, redemption or other acquisition of shares
of stock of the Corporation or otherwise,  is permitted under the DGCL,  amounts
that would be needed, if the Corporation were to be dissolved at the time of the
distribution,  to satisfy the preferential rights upon dissolution of holders of
the  Series B  Preferred  Stock  shall not be added to the  Corporation's  total
liabilities.

     Section 3. Voting Rights. The holders of shares of Series B Preferred Stock
shall have the following voting rights:

     (A) Subject to the provision for  adjustment  hereinafter  set forth,  each
share of Series B Preferred  Stock shall entitle the holder thereof to 100 votes
on all matters  submitted to a vote of the holders of Common Stock. In the event
the  Corporation  shall at any time  declare or pay any  dividend  on the Common
Stock payable in shares of Common Stock, or effect a subdivision, combination or
consolidation of the outstanding shares of Common Stock (by  reclassification or
otherwise  than by  payment  of a  dividend  in shares of Common  Stock)  into a
greater or lesser number of shares of Common  Stock,  then in each such case the
number of votes per share to which holders of shares of Series B Preferred Stock
were entitled  immediately  prior to such event shall be adjusted by multiplying
such number by a  fraction,  the  numerator  of which is the number of shares of
Common Stock  outstanding  immediately  after such event and the  denominator of
which is the number of shares of Common Stock that were outstanding  immediately
prior to such event.

     (B)  Except  as  otherwise   provided   herein,   in  the   Certificate  of
Incorporation,  or in any other  Certificate  of  Designation,  Preferences  and
Rights creating a series of Preferred Stock or any similar stock, the holders of
shares of Series B Preferred Stock and the holders of shares of Common Stock and
any other shares of stock of the Corporation  having general voting rights shall
vote together as one class on all matters submitted to a vote of stockholders of
the Corporation.

     (C) Except as set forth herein, or as otherwise provided by law, holders of
Series B Preferred  Stock shall have no special  voting rights and their consent
shall not be  required  (except to the  extent  they are  entitled  to vote with
holders of Common Stock as set forth herein) for taking any corporate action.


Section 4.        Certain Restrictions.

     (A)  Whenever  quarterly  dividends  or other  dividends  or  distributions
payable on the Series B Preferred Stock as provided in Section 2 are in arrears,
thereafter and until all accrued and unpaid dividends and distributions, whether
or not declared,  on shares of Series B Preferred Stock  outstanding  shall have
been paid in full, the Corporation shall not:

          (i)  declare or pay dividends, or make any other distributions, on any
               shares of stock ranking junior (either as to dividends or upon
               liquidation, dissolution or winding up) to the Series B
               Preferred Stock;

         (ii)  declare or pay dividends, or make any other distributions, on any
               shares of stock ranking on a parity (either as to dividends or
               upon liquidation, dissolution or winding up) with the Series B
               Preferred Stock, except dividends paid ratably on the Series B
               Preferred Stock and all such parity stock on which dividends are
               payable or in arrears in proportion to the total amounts to which
               the holders of all such shares are then entitled;

         (iii) redeem or purchase or otherwise acquire for consideration
               shares of any stock ranking junior (either as to dividends
               or upon liquidation, dissolution or winding up) to the Series
               B Preferred Stock, provided that the Corporation may at any
               time redeem, purchase or otherwise acquire shares of any such
               junior stock in exchange for shares of any stock of the
               Corporation ranking junior (both as to dividends and upon
               dissolution, liquidation or winding up) to the Series B Preferred
               Stock; or

          (iv) redeem or purchase or otherwise acquire for consideration any
               shares of Series B Preferred Stock, or any shares of stock
               ranking on a parity with the Series B Preferred Stock, except
               in accordance with a purchase offer made in writing or by
               publication (as determined by the Board of Directors) to all
               holders of such shares upon such terms as the Board of
               Directors, after consideration of the respective annual
               dividend rates and other relative rights and preferences of the
               respective series and classes, shall determine in good faith
               will result in fair and equitable treatment among the respective
               series or classes.


     (B) The  Corporation  shall not permit any subsidiary of the Corporation to
purchase  or  otherwise  acquire  for  consideration  any shares of stock of the
Corporation unless the Corporation could, under paragraph (A) of this Section 4,
purchase or otherwise acquire such shares at such time and in such manner.

     Section  5.  Reacquired  Shares.  Any  shares of Series B  Preferred  Stock
purchased  or otherwise  acquired by the  Corporation  in any manner  whatsoever
shall  become  authorized  but  unissued  shares of  Preferred  Stock and may be
reissued as part of a new series of Preferred  Stock  subject to the  conditions
and   restrictions  on  issuance  set  forth  herein,   in  the  Certificate  of
Incorporation,  or in any other  Certificate  of  Designation,  Preferences  and
Rights creating a series of Preferred Stock or any similar stock or as otherwise
required by law.

Section 6.        Liquidation. Dissolution or Winding Up.

     (A) Upon any  liquidation,  dissolution  or winding up of the  Corporation,
voluntary  or  otherwise  no  distribution  shall be made (1) to the  holders of
shares of stock  ranking  junior  (either as to dividends  or upon  liquidation,
dissolution  or  winding  up) to the  Series B  Preferred  Stock  unless,  prior
thereto,  the holders of shares of Series B Preferred  Stock shall have received
an amount per share (the "Series B Liquidation Preference") equal to $10,000 per
share,  plus an amount equal to accrued and unpaid  dividends and  distributions
thereon, whether or not declared, to the date of such payment, provided that the
holders of shares of Series B  Preferred  Stock  shall be entitled to receive an
aggregate amount per share, subject to the provision for adjustment  hereinafter
set forth,  equal to 100 times the aggregate  amount to be distributed per share
to holders of shares of Common  Stock,  or (2) to the holders of shares of stock
ranking on a parity (either as to dividends or upon liquidation,  dissolution or
winding up) with the Series B Preferred Stock, except distributions made ratably
on the Series B Preferred  Stock and all such parity stock in  proportion to the
total  amounts to which the  holders of all such shares are  entitled  upon such
liquidation,  dissolution or winding up. In the event the  Corporation  shall at
any time declare or pay any  dividend on the Common  Stock  payable in shares of
Common Stock,  or effect a  subdivision,  combination  or  consolidation  of the
outstanding  shares of Common Stock (by  reclassification  or otherwise  than by
payment of a dividend in shares of Common Stock) into a greater or lesser number
of shares of Common Stock,  then in each such case the aggregate amount to which
holders of shares of Series B Preferred Stock were entitled immediately prior to
such event under the proviso in clause (1) of the  preceding  sentence  shall be
adjusted by multiplying  such amount by a fraction the numerator of which is the
number of shares of Common Stock  outstanding  immediately  after such event and
the  denominator  of which is the  number of shares  of  Common  Stock  that are
outstanding immediately prior to such event.


     (B) In the event,  however,  that there are not sufficient assets available
to  permit  payment  in full of the  Series  B  Liquidation  Preference  and the
liquidation  preferences  of all  other  classes  and  series  of  stock  of the
Corporation,  if any, that rank on a parity with the Series B Preferred Stock in
respect  thereof,  then the  assets  available  for such  distribution  shall be
distributed  ratably  to the  holders of the  Series B  Preferred  Stock and the
holders of such parity  shares in  proportion  to their  respective  liquidation
preferences.

     (C) Neither the merger or  consolidation  of the  Corporation  into or with
another  corporation nor the merger or  consolidation  of any other  corporation
into or with the Corporation shall be deemed to be a liquidation, dissolution or
winding up of the Corporation within the meaning of this Section 6.

     Section 7. Consolidation.  Merger, etc. In case the Corporation shall enter
into any  consolidation,  merger,  combination or other transaction in which the
shares  of  Common  Stock are  exchanged  for or  changed  into  other  stock or
securities,  cash and/or any other property, then in any such case each share of
Series B  Preferred  Stock  shall at the same  time be  similarly  exchanged  or
changed  into an amount  per  share,  subject to the  provision  for  adjustment
hereinafter  set  forth,  equal to 100  times  the  aggregate  amount  of stock,
securities,  cash and/or any other property  (payable in kind),  as the case may
be, into which or for which each share of Common Stock is changed or  exchanged.
In the event the  Corporation  shall at any time  declare or pay any dividend on
the Common Stock  payable in shares of Common  Stock,  or effect a  subdivision,
combination  or  consolidation  of the  outstanding  shares of Common  Stock (by
reclassification  or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common  Stock,  then in each
such case the amount set forth in the  preceding  sentence  with  respect to the
exchange  or change of shares of Series B  Preferred  Stock shall be adjusted by
multiplying  such amount by a fraction,  the numerator of which is the number of
shares  of  Common  Stock  outstanding  immediately  after  such  event  and the
denominator  of  which is the  number  of  shares  of  Common  Stock  that  were
outstanding immediately prior to such event.

     Section 8. No Redemption.  The shares of Series B Preferred Stock shall not
be redeemable by the Company.

     Section 9. Rank. The Series B Preferred  Stock shall rank,  with respect to
the  payment of  dividends  and the  distribution  of assets  upon  liquidation,
dissolution  or winding up,  junior to the Series A  Non-Voting  Non-Convertible
Preferred  Stock and all other  series of any other  class of the  Corporation's
Preferred  Stock,  except to the extent that any such other series  specifically
provides that it shall rank on a parity with or junior to the Series B Preferred
Stock.

     Section 10.  Amendment.  At any time any shares of Series B Preferred Stock
are outstanding,  neither the Certificate of Incorporation  nor this Certificate
of  Designation,  Preferences  and Rights  shall be amended in any manner  which
would  materially  alter or change the powers,  preferences or special rights of
the  Series B  Preferred  Stock,  as set  forth  herein,  so as to  affect  them
adversely  without the affirmative vote of the holders of at least two-thirds of
the  outstanding  shares of Series B Preferred  Stock,  voting  separately  as a
single class.


     Section  11.  Fractional  Shares.  Series B Preferred  Stock  maybe  issued
infractions  of a share that shall  entitle the holder,  in  proportion  to such
holder's  fractional  shares,  to exercise  voting  rights,  receive  dividends,
participate  in  distributions  and to have the  benefit of all other  rights of
holders of Series B Preferred Stock.


                    ----------------------------------------



                           1.       The shares of Series B Preferred Stock have
                                    been classified and designated by the Board
                                    of Directors under the authority contained
                                    in the Certificate of Incorporation.


                           2.       This Certificate of Designation, Preferences
                                    and Rights has been approved by the Board of
                                    Directors in the manner and by the vote
                                    required by law.


                           3.       The undersigned officer acknowledges this
                                    Certificate of Designation, Preferences and
                                    Rights to be the corporate act of the
                                    Corporation and, as to all matters of fact
                                    required to be verified under oath, the
                                    undersigned officer acknowledges that to the
                                    best of his knowledge, information and
                                    belief, these matters and facts are true in
                                    all material respects and that this
                                    statement is made under the penalties for
                                    perjury.

         IN WITNESS WHEREOF, the undersigned has executed this Certificate of
Designation, Preferences and Rights on September 11, 2002.



                               By:      /s/ Fredric D. Price
                                        --------------------------------------
                                        Fredric D. price
                                        Chairman and Chief Executive Officer of
                                        BioMarin Pharmaceutical Inc.




                            CERTIFICATE OF AMENDMENT
             TO AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF

                          BIOMARIN PHARMACEUTICAL INC.

     BioMarin  Pharmaceutical  Inc., a corporation  duly  organized and existing
under the General Corporation Law of the State of Delaware (the  "Corporation"),
does hereby certify that:


     1. By unanimous written consent,  the Board of Directors of the Corporation
duly  adopted   resolutions   setting  forth  the  following  amendment  to  the
Corporation's   Amended  and  Restated   Certificate   of   Incorporation   (the
"Certificate  of  Incorporation"),  declaring said amendment to be advisable and
providing for the  consideration of such amendment at the  Corporation's  annual
meeting of stockholders.


     2.  Thereafter,  pursuant to the resolution of the  Corporation's  Board of
Directors, the annual meeting of stockholders of the Corporation was duly called
and held, upon notice in accordance with Section 222 of the General  Corporation
Law of the State of Delaware,  at which meeting the  necessary  number of shares
required by statute were voted in favor of the amendment.


     3. Said  amendment  was duly adopted in accordance  with the  provisions of
Section 242 of the General Corporation Law of the State of Delaware.


     4. Article of IV of the Certificate of  Incorporation is hereby amended and
restated in its entirety to read as follows:


         "The Corporation is authorized to issue two classes of stock to be
designated, respectively, "Common Stock" and "Preferred Stock." The number of
shares of Common Stock which the Corporation is authorized to issue is One
Hundred Fifty Million (150,000,000) shares, par value $0.001 per share (the
"Common Stock"). The number of shares of Preferred Stock which the Corporation
is authorized to issue is One Million (1,000,000) shares, par value $0.001 per
share (the "Preferred Stock")."

     5. The capital of the  Corporation  shall not be reduced under or by reason
of said amendment.

         IN WITNESS WHEREOF, BioMarin Pharmaceutical Inc. has caused this
Certificate of Amendment to be executed by its authorized officer, on this 12th
day of June, 2003.


                                               /s/ Louis Drapeau
                                               --------------------------------
                                               Louis Drapeau, Secretary