Exhibit 24.1
POWER OF ATTORNEY

	Know all by these presents that the undersigned hereby
constitutes and appoints Albert P. Parker as the undersigned's
true and lawful attorney-in-fact to:

       1) execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer and/or director of Zynerba
Pharmaceuticals, Inc. (the "Company"), Forms 3, 4 and 5, in
accordance with Section 16(a) of the Securities Exchange Act
of 1934 and the rules thereunder;

       2) do and perform any and all acts for and on behalf
of the undersigned which may be necessary or desirable to
(A) complete and execute any such Forms 3, 4 or 5, (B) complete
and execute any amendmentor amendments thereto and (C) timely
file such forms with the United States Securities and Exchange
Commission and any stock exchange or similar authority; and

       3) take any other action of any type whatsoever in
connection with the foregoing which, in the opinion of such
attorney-in-fact, may be of benefit to, in the best interest
of, or legally required by, the undersigned, it being understood
that the documents executed by such attorney-in-fact on behalf
of the undersigned pursuant to this Power of Attorney shall be
in such form and shall contain such terms and conditions as
such attorney-in-fact may approve in such attorney-in-fact's
discretion.

       The undersigned hereby grants to each such attorney-in-fact
full power and authority to do and perform any and every act and
thing whatsoever requisite, necessary or proper to be done in the
exercise of any of the rights and powers herein granted, as fully
to all intents and purposes as the undersigned might or could do if
personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or
such attorney-in-fact's substitute or substitutes, shall lawfully
do or cause to be done by virtue of this Power of Attorney and the
rights and powers herein granted.

       The undersigned acknowledges that the foregoing
attorneys-in-fact, in serving in such capacity at the request of
the undersigned, are not assuming, nor is the Company assuming,
any of the undersigned's responsibilities to comply with Section
16 of the Securities Exchange Act of 1934.

       This Power of Attorney shall remain in full force and effect
until the undersigned is no longer required to file Forms 3, 4
and 5 with respect to the undersigned's holdings of and transactions
in securities issued by the Company, unless earlier revoked by the
undersigned in a signed writing delivered to the foregoing
attorneys-in-fact.

       IN WITNESS WHEREOF, the undersigned has caused this Power
of Attorney to be executed as of this 16th day of June, 2022.


/s/ Daniel L. Kisner, MD
Signature

Daniel L. Kisner, MD
Print Name