EXHIBIT 32.1


                             CERTIFICATE PURSUANT TO
                               18 U.S.C. ss. 1350,
                             AS ADOPTED PURSUANT TO
                    ss. 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection  with the Annual  Report on Form 10-K of Mission West  Properties,
Inc.  (the  "Company")  for the year ended  December  31, 2005 as filed with the
Securities and Exchange  Commission on the date hereof (the  "Report"),  each of
Carl E. Berg,  Chairman of the Board and Chief Executive Officer of the Company,
Raymond V. Marino,  President  and Chief  Operating  Officer ,and Wayne N. Pham,
Vice  President  of Finance  and  Controller  of the  Company,  hereby  certify,
pursuant  to 18  U.S.C.  ss.  1350,  as  adopted  pursuant  to  ss.  906  of the
Sarbanes-Oxley Act of 2002, to the best of his knowledge, that:

     (1) The Report fully  complies  with the  requirements  of Section 13(a) or
15(d) of the Securities Exchange Act of 1934, as amended; and
     (2)  The  information  contained  in the  Report  fairly  presents,  in all
material  respects,  the  financial  condition  and result of  operations of the
Company.

/s/ Carl E. Berg
- ----------------------------------------
Carl E. Berg
Chairman of the Board and Chief Executive Officer
March 14, 2006

/s/ Raymond V. Marino
- ----------------------------------------
Raymond V. Marino
President and Chief Operating Officer
March 14, 2006

/s/ Wayne N. Pham
- ----------------------------------------
Wayne N. Pham
Vice President of Finance and Controller
March 14, 2006


This  certification   accompanies  this  Report  pursuant  to  ss.  906  of  the
Sarbanes-Oxley  Act of 2002 and shall not,  except to the extent required by the
Sarbanes-Oxley  Act of 2002,  or  otherwise  required,  be  deemed  filed by the
Company  for  purposes  of ss. 18 of the  Securities  Exchange  Act of 1934,  as
amended.

A signed  original of this  written  statement  required by section 906 has been
provided to the Company and will be retained by the Company and furnished to the
Securities and Exchange Commission or its staff upon request.


                                    - 100 -